GREMLIN Database
DUF2523 - Protein of unknown function (DUF2523)
PFAM: PF10734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (77)
Sequences: 1723 (1510)
Seq/√Len: 172.1
META: 0.762

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_G63_V3.4531.00
57_G62_D3.1791.00
56_L61_V2.8341.00
71_A75_R2.5361.00
38_K42_Q2.4291.00
33_L36_Q2.3841.00
31_D35_D2.0971.00
38_K69_L2.0751.00
66_S70_S1.8941.00
35_D39_S1.8781.00
41_I69_L1.7981.00
29_G32_A1.7841.00
63_V67_I1.6641.00
13_V16_V1.6501.00
45_F62_D1.5931.00
51_D54_Q1.5771.00
36_Q40_Q1.4891.00
11_S14_G1.4771.00
2_A8_L1.4411.00
14_G17_L1.4111.00
64_A67_I1.4021.00
6_A9_L1.3691.00
72_I75_R1.3431.00
28_T31_D1.3391.00
74_A77_A1.2981.00
9_L16_V1.2531.00
64_A68_I1.2171.00
70_S74_A1.2051.00
10_G13_V1.1871.00
15_R18_V1.1861.00
44_A47_G1.1831.00
67_I71_A1.1641.00
40_Q44_A1.1581.00
69_L73_V1.1301.00
3_G7_S1.1291.00
41_I65_L1.1201.00
12_L16_V1.0961.00
14_G18_V1.0701.00
8_L12_L1.0300.99
60_G64_A0.9990.99
39_S43_S0.9740.99
63_V66_S0.9440.99
55_L59_L0.9390.99
73_V77_A0.9270.99
16_V19_A0.9100.99
23_G27_Y0.8900.98
39_S42_Q0.8870.98
45_F57_G0.8760.98
48_L53_L0.8690.98
54_Q57_G0.8270.97
24_F28_T0.8230.97
28_T32_A0.8110.97
30_V34_L0.8050.97
68_I71_A0.7950.97
5_L9_L0.7930.97
31_D66_S0.7670.96
42_Q46_G0.7650.96
72_I76_L0.7600.96
9_L12_L0.7600.96
40_Q67_I0.7530.95
14_G19_A0.7490.95
62_D66_S0.7430.95
41_I45_F0.7340.95
53_L57_G0.7310.95
6_A11_S0.7270.94
42_Q47_G0.7220.94
13_V20_L0.7170.94
17_L22_L0.6980.93
48_L51_D0.6970.93
21_G24_F0.6890.93
65_L69_L0.6860.92
74_A78_L0.6830.92
5_L8_L0.6820.92
7_S10_G0.6790.92
26_T29_G0.6680.91
55_L58_L0.6670.91
37_L71_A0.6670.91
2_A9_L0.6630.91
6_A10_G0.6560.91
68_I75_R0.6550.91
15_R21_G0.6520.90
59_L70_S0.6510.90
53_L76_L0.6510.90
47_G50_A0.6480.90
49_P52_V0.6470.90
30_V72_I0.6460.90
43_S47_G0.6350.89
46_G50_A0.6330.89
56_L69_L0.6020.87
59_L74_A0.5980.86
24_F78_L0.5910.86
16_V21_G0.5880.85
27_Y70_S0.5850.85
73_V76_L0.5820.85
56_L63_V0.5770.84
43_S50_A0.5770.84
10_G16_V0.5720.84
29_G33_L0.5660.83
25_V29_G0.5660.83
15_R22_L0.5640.83
30_V74_A0.5610.83
20_L27_Y0.5600.82
45_F48_L0.5590.82
11_S18_V0.5480.81
40_Q43_S0.5470.81
45_F65_L0.5460.81
69_L72_I0.5460.81
40_Q47_G0.5410.80
3_G6_A0.5370.80
60_G67_I0.5350.80
51_D55_L0.5330.79
71_A78_L0.5230.78
23_G59_L0.5130.77
44_A68_I0.5060.76
5_L11_S0.5030.75
56_L59_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c9yA 1 0.6 2.2 0.884 Contact Map
1ciiA 1 0.5625 2 0.887 Contact Map
4aq5C 1 0.95 1.9 0.888 Contact Map
4aq5E 1 0.9375 1.9 0.888 Contact Map
4aq5B 1 0.9375 1.6 0.894 Contact Map
2bg9B 1 0.9875 1.5 0.895 Contact Map
3wo6A 1 0.6 1.5 0.896 Contact Map
4aq5A 1 0.95 1.4 0.898 Contact Map
1oedB 1 0.9875 1.3 0.898 Contact Map
1oedC 1 0.9875 1.3 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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