GREMLIN Database
DUF2512 - Protein of unknown function (DUF2512)
PFAM: PF10710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (115)
Sequences: 751 (633)
Seq/√Len: 59.0
META: 0.49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_M101_G5.3041.00
3_H45_Y4.0061.00
66_F99_A3.8811.00
17_V101_G2.6921.00
52_I64_A2.6151.00
37_S41_T2.5501.00
64_A67_G2.2531.00
11_F41_T2.1971.00
2_K5_K2.0771.00
29_S32_D2.0341.00
45_Y58_N2.0101.00
66_F95_A1.9481.00
23_G33_I1.9411.00
73_I94_S1.8090.99
23_G26_F1.6170.99
52_I61_A1.5770.99
42_V46_L1.5650.98
18_L73_I1.5280.98
18_L94_S1.5270.98
49_D58_N1.5220.98
92_L95_A1.5210.98
58_N61_A1.5100.98
41_T101_G1.4750.98
9_I12_I1.4580.98
49_D61_A1.4250.97
22_L73_I1.4130.97
70_F88_F1.3840.97
70_F95_A1.3560.96
65_D102_E1.3190.96
90_A94_S1.3010.95
87_I91_A1.2850.95
89_T93_I1.2740.95
88_F92_L1.2630.94
39_V76_L1.2390.94
91_A99_A1.2210.93
107_R111_R1.2100.93
96_L100_V1.2060.93
92_L96_L1.1900.92
50_L54_P1.1710.92
11_F38_L1.1500.91
9_I105_F1.1480.91
42_V64_A1.1320.90
21_I94_S1.1220.90
19_Y23_G1.1080.89
36_I76_L1.0800.88
8_L77_G1.0780.88
17_V97_L1.0770.88
49_D105_F1.0720.88
39_V43_V1.0680.88
11_F37_S1.0630.87
58_N62_T1.0610.87
56_T60_V1.0530.87
65_D106_H1.0510.87
40_L72_V1.0340.86
21_I97_L1.0330.86
15_L30_F1.0310.86
72_V76_L1.0200.85
27_D104_F1.0110.85
91_A95_A0.9930.84
23_G76_L0.9900.83
70_F74_W0.9870.83
45_Y50_L0.9660.82
15_L37_S0.9590.81
91_A94_S0.9590.81
14_T44_A0.9510.81
15_L19_Y0.9360.80
7_L14_T0.9160.78
41_T97_L0.9130.78
39_V72_V0.9060.77
33_I37_S0.9040.77
15_L33_I0.9000.77
13_M107_R0.8880.76
14_T17_V0.8860.76
7_L11_F0.8810.75
16_V99_A0.8720.75
22_L56_T0.8440.72
28_V66_F0.8390.72
5_K12_I0.8370.72
36_I95_A0.8330.71
23_G30_F0.8300.71
2_K114_L0.8270.71
6_A50_L0.8200.70
25_F93_I0.8110.69
82_G85_V0.8090.69
8_L107_R0.8080.69
75_L79_L0.8010.68
104_F109_L0.7970.68
4_V104_F0.7960.68
35_L38_L0.7960.68
77_G80_L0.7960.68
47_I51_L0.7920.67
12_I38_L0.7910.67
35_L96_L0.7870.67
4_V8_L0.7850.67
48_G61_A0.7730.66
19_Y33_I0.7540.64
43_V72_V0.7530.63
23_G27_D0.7500.63
6_A113_V0.7490.63
49_D57_G0.7430.62
105_F109_L0.7430.62
62_T99_A0.7400.62
44_A65_D0.7380.62
46_L76_L0.7350.62
66_F73_I0.7320.61
44_A99_A0.7280.61
16_V36_I0.7250.61
19_Y30_F0.7170.60
80_L109_L0.7010.58
41_T44_A0.7000.58
7_L42_V0.6790.56
109_L115_E0.6780.55
19_Y38_L0.6740.55
61_A65_D0.6660.54
27_D30_F0.6640.54
74_W78_S0.6610.54
41_T98_I0.6590.53
9_I25_F0.6570.53
20_I104_F0.6500.52
110_L114_L0.6490.52
15_L34_L0.6470.52
33_I103_Y0.6460.52
69_A99_A0.6370.51
6_A82_G0.6350.51
22_L40_L0.6280.50
7_L38_L0.6270.50
31_G46_L0.6240.49
63_I70_F0.6220.49
45_Y49_D0.6210.49
46_L114_L0.6160.49
18_L40_L0.6150.48
28_V83_N0.6150.48
76_L86_P0.6120.48
66_F91_A0.6110.48
5_K8_L0.6090.48
51_L64_A0.6070.48
26_F90_A0.6050.47
48_G58_N0.6050.47
22_L53_L0.6040.47
40_L73_I0.6000.47
48_G62_T0.5980.47
90_A98_I0.5970.46
30_F33_I0.5830.45
74_W102_E0.5820.45
36_I87_I0.5820.45
43_V47_I0.5760.44
58_N65_D0.5750.44
9_I42_V0.5740.44
59_T103_Y0.5720.44
20_I24_L0.5710.44
103_Y107_R0.5680.43
44_A66_F0.5670.43
52_I90_A0.5660.43
57_G110_L0.5570.42
29_S95_A0.5570.42
109_L113_V0.5570.42
53_L110_L0.5560.42
34_L75_L0.5530.42
2_K27_D0.5510.41
10_K102_E0.5490.41
30_F111_R0.5480.41
22_L45_Y0.5450.41
32_D77_G0.5440.41
10_K106_H0.5430.41
27_D52_I0.5360.40
35_L70_F0.5330.39
100_V104_F0.5310.39
15_L49_D0.5260.39
2_K60_V0.5120.37
73_I98_I0.5080.37
36_I73_I0.5070.37
13_M97_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ldfA 3 0.7426 38.8 0.905 Contact Map
1ciiA 1 0.4191 11.3 0.927 Contact Map
4aw6A 2 0.4485 10.2 0.928 Contact Map
1lnqA 6 0.6691 9.7 0.929 Contact Map
2i88A 1 0.4412 6.6 0.934 Contact Map
1j4nA 4 0.7794 6.2 0.935 Contact Map
4il3A 1 0.3603 5.8 0.935 Contact Map
3c02A 3 0.7647 5.2 0.937 Contact Map
2b6oA 6 0.8088 4.6 0.939 Contact Map
3d9sA 3 0.8088 4.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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