GREMLIN Database
DUF2508 - Protein of unknown function (DUF2508)
PFAM: PF10704 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (61)
Sequences: 1839 (1377)
Seq/√Len: 176.3
META: 0.697

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_N46_A3.4931.00
26_K30_E2.8491.00
15_D67_R2.4911.00
25_A53_A2.0181.00
63_E66_E2.0121.00
30_E33_K1.8551.00
63_E67_R1.7891.00
23_E26_K1.7751.00
57_Y61_L1.7311.00
42_L59_Y1.7241.00
18_L60_L1.5591.00
29_W53_A1.5181.00
32_A50_I1.5171.00
51_K54_E1.5121.00
33_K54_E1.4301.00
27_E30_E1.3841.00
28_E53_A1.3751.00
30_E34_S1.3721.00
12_K15_D1.3471.00
36_F47_I1.3001.00
32_A53_A1.2771.00
49_E56_K1.2681.00
27_E31_N1.2581.00
25_A32_A1.2521.00
29_W58_F1.1941.00
45_Y56_K1.1811.00
31_N34_S1.1711.00
24_K28_E1.1141.00
33_K37_E1.1001.00
44_D48_Y1.0230.99
20_E24_K1.0020.99
45_Y49_E0.9820.99
17_E21_E0.9810.99
25_A60_L0.9660.99
48_Y52_A0.9520.99
22_I64_A0.9430.99
36_F43_I0.9090.99
14_E17_E0.8990.99
12_K16_E0.8960.99
55_A58_F0.8890.98
51_K55_A0.8880.98
34_S38_N0.8810.98
36_F46_A0.8750.98
36_F39_V0.8610.98
26_K29_W0.8330.98
25_A57_Y0.8170.97
35_N45_Y0.8130.97
10_L13_E0.8120.97
36_F50_I0.8070.97
35_N49_E0.8000.97
45_Y52_A0.7950.97
19_L64_A0.7890.97
16_E23_E0.7580.96
60_L64_A0.7520.96
32_A36_F0.7510.96
13_E17_E0.7270.95
45_Y53_A0.7180.94
22_I60_L0.7170.94
9_K12_K0.7120.94
31_N35_N0.7110.94
39_V58_F0.6920.93
18_L21_E0.6770.92
39_V43_I0.6730.92
58_F62_K0.6720.92
44_D47_I0.6580.91
64_A68_G0.6570.91
36_F42_L0.6540.91
29_W57_Y0.6520.91
15_D19_L0.6510.91
35_N38_N0.6390.90
20_E23_E0.6320.90
28_E32_A0.6220.89
13_E27_E0.6100.88
23_E27_E0.6050.88
36_F52_A0.5960.87
13_E16_E0.5920.86
44_D52_A0.5910.86
39_V42_L0.5830.86
25_A28_E0.5720.84
46_A51_K0.5550.83
22_I35_N0.5520.82
19_L26_K0.5510.82
16_E20_E0.5440.81
61_L65_K0.5350.80
62_K66_E0.5210.79
48_Y61_L0.5200.78
38_N42_L0.5180.78
22_I57_Y0.5160.78
16_E31_N0.5150.78
36_F44_D0.5130.78
14_E67_R0.5050.76
59_Y63_E0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.2535 9.8 0.866 Contact Map
4abxA 2 0.9859 4.9 0.884 Contact Map
4mf9A 1 0.3521 4.8 0.884 Contact Map
1ccwB 2 0.8592 3.7 0.89 Contact Map
3vkgA 2 0.9577 3.5 0.891 Contact Map
4urjA 1 0.7183 3.3 0.893 Contact Map
2inrA 2 0.9155 3.2 0.893 Contact Map
4gelA 2 0.7746 3 0.895 Contact Map
2novA 2 0.9014 3 0.895 Contact Map
4rh7A 1 0.9014 2.9 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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