GREMLIN Database
DUF2501 - Protein of unknown function (DUF2501)
PFAM: PF10696 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (74)
Sequences: 619 (395)
Seq/√Len: 45.9
META: 0.721

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S9_S2.8101.00
14_K18_L2.6921.00
69_L77_L2.3451.00
35_A38_A2.2051.00
36_A43_Q2.0881.00
59_K63_K1.7360.98
29_T32_S1.7130.98
14_K21_L1.7080.98
4_Y8_T1.6910.98
68_D72_K1.6000.97
27_E30_S1.5800.97
65_K69_L1.5350.96
1_K16_Q1.5330.96
6_S33_G1.5230.96
23_G63_K1.5200.96
68_D71_L1.4940.95
43_Q49_S1.4690.95
59_K65_K1.4670.95
4_Y7_G1.4400.94
42_L66_A1.3890.93
42_L54_G1.3860.93
11_S15_D1.3860.93
44_T73_Q1.3740.93
49_S65_K1.3650.93
69_L73_Q1.3640.93
2_N5_L1.3440.92
16_Q62_V1.2650.90
3_N53_S1.2630.89
49_S58_L1.2480.89
71_L75_K1.2210.88
9_S13_V1.1880.86
4_Y10_A1.1690.85
16_Q32_S1.1660.85
20_K66_A1.1640.85
41_L44_T1.1500.84
18_L23_G1.1480.84
55_L61_K1.1470.84
42_L52_L1.1260.83
6_S10_A1.0940.81
18_L58_L1.0600.79
65_K70_V1.0050.76
49_S74_A0.9850.74
64_T77_L0.9750.73
32_S36_A0.9710.73
50_L58_L0.9700.73
41_L73_Q0.9470.71
68_D74_A0.9420.71
66_A69_L0.9360.70
1_K30_S0.9230.69
46_D60_E0.9220.69
28_A32_S0.9130.68
22_G77_L0.9090.68
13_V68_D0.8960.67
54_G61_K0.8930.66
34_Y68_D0.8900.66
55_L60_E0.8800.65
43_Q66_A0.8620.64
45_G52_L0.8530.63
65_K71_L0.8480.62
64_T72_K0.8270.60
34_Y38_A0.8260.60
35_A39_K0.8180.60
10_A71_L0.8180.60
28_A35_A0.7960.58
63_K70_V0.7930.57
35_A49_S0.7890.57
36_A49_S0.7810.56
12_S18_L0.7800.56
16_Q65_K0.7560.54
50_L61_K0.7470.53
35_A77_L0.7260.51
41_L51_D0.7230.50
23_G38_A0.7190.50
3_N75_K0.7150.50
24_G34_Y0.7020.48
24_G27_E0.6960.48
18_L34_Y0.6920.47
19_G33_G0.6790.46
61_K65_K0.6620.44
62_V72_K0.6590.44
2_N11_S0.6480.43
31_D53_S0.6410.42
73_Q76_S0.6340.42
17_L76_S0.6290.41
43_Q46_D0.6210.41
15_D75_K0.6110.40
5_L17_L0.6070.39
1_K61_K0.6060.39
17_L59_K0.6040.39
42_L58_L0.5970.38
30_S56_G0.5960.38
50_L56_G0.5880.37
36_A39_K0.5840.37
42_L50_L0.5810.37
48_K52_L0.5730.36
21_L73_Q0.5700.36
9_S72_K0.5590.35
15_D18_L0.5590.35
59_K64_T0.5570.35
20_K29_T0.5430.33
34_Y43_Q0.5380.33
44_T76_S0.5320.32
16_Q35_A0.5290.32
69_L72_K0.5270.32
58_L74_A0.5240.32
34_Y77_L0.5210.32
30_S69_L0.5090.31
51_D69_L0.5080.30
7_G12_S0.5080.30
22_G50_L0.5050.30
11_S21_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rgwA 1 0.2987 4.2 0.906 Contact Map
2gezB 2 0.9481 2.5 0.916 Contact Map
1x9yA 1 0.4026 2.2 0.918 Contact Map
2kktA 1 0.2857 2.2 0.918 Contact Map
3c17A 2 0.974 2.2 0.919 Contact Map
4o0cA 2 0.974 2 0.92 Contact Map
5a0uA 2 0.9351 2 0.921 Contact Map
4u5aA 1 0.9091 1.9 0.922 Contact Map
4pv2B 2 0.9481 1.9 0.922 Contact Map
1p4kA 2 0.974 1.7 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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