GREMLIN Database
DUF2497 - Protein of unknown function (DUF2497)
PFAM: PF10691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (70)
Sequences: 4459 (2506)
Seq/√Len: 299.5
META: 0.939

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_L69_I3.8521.00
51_E55_E3.7991.00
35_R39_D2.7191.00
66_R70_E2.2311.00
50_K54_D2.1251.00
62_E66_R2.0571.00
60_L64_L1.9711.00
44_M48_M1.9151.00
64_L67_A1.7781.00
41_V44_M1.7541.00
45_L49_L1.7421.00
16_F73_A1.7351.00
6_E10_A1.6991.00
41_V45_L1.5281.00
4_L8_T1.5121.00
16_F20_A1.4801.00
43_E46_R1.4501.00
38_E42_R1.4391.00
2_A6_E1.3971.00
39_D42_R1.3841.00
68_E71_R1.3351.00
18_A66_R1.2741.00
36_T40_L1.2481.00
37_L40_L1.2451.00
22_A25_A1.2131.00
9_A12_A1.2051.00
6_E9_A1.2041.00
36_T39_D1.1861.00
34_G37_L1.1541.00
5_S8_T1.1151.00
8_T12_A1.0671.00
38_E41_V1.0651.00
12_A15_A1.0441.00
7_A10_A1.0101.00
10_A14_S0.9921.00
56_N59_G0.9861.00
8_T11_A0.9821.00
18_A21_A0.9801.00
31_G34_G0.9721.00
53_L57_L0.9471.00
65_V69_I0.9351.00
2_A9_A0.9191.00
5_S50_K0.9161.00
12_A16_F0.8801.00
31_G35_R0.8611.00
58_P62_E0.8531.00
18_A25_A0.8311.00
66_R72_I0.8141.00
52_W56_N0.8041.00
21_A25_A0.8001.00
11_A18_A0.7880.99
15_A19_L0.7740.99
55_E59_G0.7700.99
53_L71_R0.7540.99
62_E68_E0.7540.99
4_L72_I0.7530.99
23_V26_P0.7410.99
35_R43_E0.7340.99
13_A17_A0.7280.99
40_L44_M0.7270.99
60_L63_R0.7190.99
24_A27_R0.7160.99
59_G63_R0.7130.99
15_A18_A0.7080.99
67_A72_I0.6930.99
27_R34_G0.6780.98
25_A40_L0.6710.98
2_A7_A0.6660.98
7_A11_A0.6590.98
44_M58_P0.6560.98
35_R42_R0.6550.98
4_L9_A0.6520.98
11_A15_A0.6510.98
39_D43_E0.6380.98
46_R58_P0.6350.98
69_I73_A0.6270.97
5_S49_L0.6190.97
34_G39_D0.6110.97
70_E73_A0.6070.97
21_A28_A0.6070.97
3_L10_A0.6070.97
57_L65_V0.6060.97
4_L53_L0.6030.97
13_A72_I0.6000.97
18_A23_V0.5970.97
17_A21_A0.5950.96
64_L70_E0.5940.96
17_A23_V0.5910.96
11_A17_A0.5800.96
16_F69_I0.5760.96
23_V37_L0.5680.95
28_A33_G0.5640.95
8_T58_P0.5620.95
12_A17_A0.5560.95
61_V65_V0.5530.95
37_L41_V0.5460.94
19_L48_M0.5200.93
50_K64_L0.5200.93
38_E45_L0.5180.93
5_S14_S0.5120.92
5_S55_E0.5100.92
60_L69_I0.5060.92
67_A73_A0.5050.92
14_S21_A0.5010.91
25_A28_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hy1A 1 0.9865 38.6 0.818 Contact Map
3lnuA 1 0.973 32.4 0.826 Contact Map
4wubA 2 0.973 30.4 0.828 Contact Map
3zkbA 5 0.9865 27.8 0.831 Contact Map
4urlA 1 0.9459 27.1 0.832 Contact Map
1kijA 2 0.973 24.1 0.836 Contact Map
1s16A 2 0.9595 21.1 0.841 Contact Map
4i3hA 2 0.9595 15.3 0.851 Contact Map
3i1iA 3 0.7838 14.1 0.853 Contact Map
3ewtE 1 0.1892 12.4 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.