DUF2491 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF2491 - Protein of unknown function (DUF2491)

PFAM:	PF10679	Sequences: MFKKLFGKKDAPEPLGLRIGGTVELDPLPFRLAGDDLKIELPAGTQIIEAVGEVDLGDGTTLHRFYLDDDAFLQVVTDGGDGDGHVDEVKLFVPYDSVTPASEAEWRRWLGPGGLIGAPTYTLDGKEYQRVWGSEGDAGRVPPVAFTETVYDDDGGTRRIDQFAMLYARELGGDRREYLLVSAEEDIVNEGGEASVEISVGIDLNPADLT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	210 (202)
Sequences:	592 (408)
Seq/√Len:	28.7
META:	0.713

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
6_F	9_K	3.956	1.00
74_Q	77_T	3.694	1.00
23_V	48_I	3.655	1.00
178_Y	203_D	3.425	1.00
132_W	166_L	3.422	1.00
169_R	179_L	3.389	1.00
74_Q	78_D	2.834	1.00
38_K	124_D	2.763	1.00
100_P	109_W	2.587	0.99
131_V	168_A	2.582	0.99
107_R	111_G	2.565	0.99
120_T	127_E	2.508	0.99
109_W	196_V	2.487	0.99
116_I	119_P	2.407	0.99
38_K	128_Y	2.361	0.99
97_S	197_E	2.347	0.99
106_W	110_L	2.239	0.98
18_R	21_G	2.228	0.98
171_L	174_D	2.112	0.98
94_P	197_E	2.102	0.98
53_E	61_T	2.099	0.97
5_L	8_K	2.039	0.97
103_E	107_R	2.016	0.97
64_R	165_M	1.880	0.95
128_Y	132_W	1.875	0.95
94_P	199_S	1.821	0.94
120_T	129_Q	1.810	0.94
126_K	169_R	1.759	0.93
181_V	196_V	1.727	0.92
101_A	105_E	1.718	0.92
100_P	196_V	1.714	0.92
51_V	63_H	1.701	0.92
21_G	48_I	1.684	0.91
49_E	70_D	1.609	0.89
100_P	105_E	1.575	0.88
92_F	166_L	1.562	0.88
7_G	11_A	1.519	0.87
170_E	176_R	1.512	0.86
181_V	198_I	1.506	0.86
146_F	164_A	1.503	0.86
72_F	94_P	1.499	0.86
90_K	178_Y	1.499	0.86
64_R	143_P	1.491	0.85
61_T	209_L	1.475	0.85
142_P	167_Y	1.472	0.85
193_E	202_I	1.437	0.83
54_V	199_S	1.390	0.81
166_L	207_A	1.384	0.81
53_E	63_H	1.351	0.79
28_L	31_R	1.336	0.78
50_A	91_L	1.323	0.78
159_R	185_E	1.302	0.77
169_R	177_E	1.293	0.76
180_L	201_G	1.268	0.75
143_P	165_M	1.260	0.74
55_D	59_G	1.250	0.74
147_T	161_D	1.243	0.73
28_L	144_V	1.234	0.73
164_A	174_D	1.225	0.72
106_W	194_A	1.222	0.72
16_G	21_G	1.220	0.72
179_L	182_S	1.200	0.70
5_L	9_K	1.198	0.70
183_A	190_E	1.189	0.70
5_L	128_Y	1.188	0.70
179_L	198_I	1.184	0.69
13_E	29_P	1.183	0.69
130_R	166_L	1.177	0.69
52_G	66_Y	1.155	0.67
30_F	186_D	1.144	0.67
78_D	87_D	1.138	0.66
177_E	201_G	1.138	0.66
122_T	178_Y	1.130	0.66
48_I	194_A	1.125	0.65
15_L	181_V	1.116	0.65
179_L	200_V	1.113	0.64
57_G	87_D	1.113	0.64
68_D	139_G	1.111	0.64
190_E	198_I	1.096	0.63
52_G	63_H	1.090	0.63
14_P	167_Y	1.089	0.63
54_V	131_V	1.083	0.62
96_D	123_L	1.082	0.62
113_G	140_R	1.080	0.62
91_L	150_V	1.079	0.62
59_G	78_D	1.074	0.62
9_K	120_T	1.068	0.61
54_V	146_F	1.068	0.61
6_F	10_D	1.067	0.61
160_I	164_A	1.067	0.61
18_R	178_Y	1.065	0.61
62_L	175_R	1.062	0.61
158_R	162_Q	1.050	0.60
62_L	119_P	1.042	0.59
145_A	163_F	1.039	0.59
183_A	202_I	1.030	0.58
182_S	199_S	1.024	0.58
7_G	10_D	1.022	0.58
54_V	75_V	1.018	0.57
28_L	56_L	1.015	0.57
41_L	91_L	0.991	0.55
162_Q	199_S	0.981	0.55
205_N	209_L	0.979	0.54
149_T	159_R	0.979	0.54
66_Y	148_E	0.973	0.54
181_V	200_V	0.970	0.54
173_G	207_A	0.969	0.54
81_D	107_R	0.962	0.53
78_D	107_R	0.946	0.52
136_G	139_G	0.946	0.52
122_T	157_T	0.945	0.52
33_A	172_G	0.937	0.51
5_L	10_D	0.934	0.51
9_K	149_T	0.933	0.51
179_L	204_L	0.930	0.51
79_G	162_Q	0.924	0.50
43_A	171_L	0.921	0.50
26_D	69_D	0.918	0.50
186_D	196_V	0.916	0.50
129_Q	181_V	0.915	0.50
106_W	143_P	0.915	0.50
21_G	207_A	0.914	0.49
16_G	22_T	0.907	0.49
25_L	159_R	0.904	0.49
88_E	101_A	0.902	0.49
93_V	200_V	0.900	0.48
36_D	171_L	0.880	0.47
27_P	44_G	0.877	0.47
25_L	50_A	0.876	0.46
75_V	84_G	0.872	0.46
23_V	131_V	0.867	0.46
95_Y	196_V	0.865	0.46
19_I	36_D	0.864	0.46
48_I	192_G	0.855	0.45
32_L	146_F	0.851	0.45
110_L	143_P	0.846	0.44
75_V	79_G	0.837	0.43
86_V	184_E	0.837	0.43
23_V	56_L	0.831	0.43
71_A	162_Q	0.830	0.43
52_G	57_G	0.829	0.43
178_Y	182_S	0.828	0.43
143_P	183_A	0.823	0.42
157_T	172_G	0.823	0.42
55_D	175_R	0.814	0.42
185_E	194_A	0.813	0.42
128_Y	166_L	0.810	0.41
52_G	91_L	0.807	0.41
181_V	203_D	0.806	0.41
134_S	137_D	0.802	0.41
82_G	85_H	0.801	0.41
199_S	208_D	0.798	0.41
90_K	97_S	0.798	0.41
14_P	108_R	0.798	0.41
50_A	158_R	0.792	0.40
111_G	205_N	0.790	0.40
63_H	150_V	0.788	0.40
72_F	77_T	0.788	0.40
119_P	139_G	0.787	0.40
152_D	160_I	0.787	0.40
31_R	105_E	0.782	0.39
21_G	167_Y	0.779	0.39
69_D	184_E	0.774	0.39
104_A	168_A	0.772	0.39
18_R	24_E	0.771	0.39
88_E	131_V	0.763	0.38
72_F	197_E	0.761	0.38
34_G	62_L	0.761	0.38
171_L	176_R	0.756	0.37
61_T	200_V	0.753	0.37
90_K	94_P	0.751	0.37
55_D	108_R	0.749	0.37
52_G	197_E	0.747	0.37
51_V	167_Y	0.746	0.37
40_E	70_D	0.743	0.36
67_L	161_D	0.740	0.36
111_G	127_E	0.731	0.36
97_S	123_L	0.730	0.36
87_D	173_G	0.730	0.36
140_R	146_F	0.729	0.35
81_D	85_H	0.725	0.35
59_G	87_D	0.723	0.35
96_D	108_R	0.717	0.35
168_A	197_E	0.709	0.34
151_Y	191_G	0.709	0.34
135_E	139_G	0.708	0.34
31_R	35_D	0.705	0.34
14_P	111_G	0.704	0.34
65_F	178_Y	0.704	0.34
18_R	27_P	0.701	0.34
24_E	45_T	0.699	0.33
52_G	65_F	0.698	0.33
138_A	167_Y	0.696	0.33
53_E	159_R	0.695	0.33
82_G	207_A	0.687	0.33
104_A	181_V	0.681	0.32
31_R	55_D	0.681	0.32
20_G	171_L	0.681	0.32
36_D	112_P	0.678	0.32
18_R	86_V	0.677	0.32
205_N	208_D	0.675	0.32
146_F	166_L	0.675	0.32
54_V	97_S	0.675	0.32
35_D	41_L	0.675	0.32
75_V	78_D	0.671	0.31
25_L	174_D	0.671	0.31
77_T	82_G	0.670	0.31
124_D	165_M	0.664	0.31
107_R	184_E	0.662	0.31
28_L	91_L	0.662	0.31
184_E	197_E	0.661	0.31
102_S	158_R	0.658	0.31
73_L	101_A	0.656	0.30
73_L	86_V	0.656	0.30
22_T	65_F	0.654	0.30
90_K	203_D	0.653	0.30
52_G	76_V	0.652	0.30
109_W	167_Y	0.650	0.30
175_R	204_L	0.647	0.30
70_D	146_F	0.645	0.30
127_E	153_D	0.644	0.30
147_T	184_E	0.640	0.29
25_L	115_L	0.639	0.29
74_Q	94_P	0.638	0.29
12_P	19_I	0.636	0.29
20_G	64_R	0.634	0.29
107_R	190_E	0.628	0.29
61_T	83_D	0.627	0.29
111_G	172_G	0.625	0.28
153_D	156_G	0.624	0.28
24_E	102_S	0.620	0.28
86_V	154_D	0.616	0.28
92_F	117_G	0.615	0.28
17_L	65_F	0.609	0.27
70_D	190_E	0.607	0.27
22_T	45_T	0.605	0.27
51_V	61_T	0.605	0.27
36_D	167_Y	0.602	0.27
43_A	53_E	0.601	0.27
163_F	185_E	0.601	0.27
6_F	11_A	0.599	0.27
144_V	165_M	0.599	0.27
99_T	208_D	0.597	0.27
95_Y	162_Q	0.597	0.27
122_T	202_I	0.596	0.27
67_L	88_E	0.595	0.27
164_A	209_L	0.593	0.26
191_G	196_V	0.593	0.26
102_S	105_E	0.592	0.26
23_V	93_V	0.592	0.26
31_R	56_L	0.591	0.26
106_W	130_R	0.586	0.26
141_V	144_V	0.579	0.26
167_Y	208_D	0.578	0.26
150_V	160_I	0.576	0.25
50_A	149_T	0.573	0.25
36_D	62_L	0.573	0.25
102_S	119_P	0.571	0.25
99_T	112_P	0.571	0.25
88_E	164_A	0.571	0.25
78_D	86_V	0.569	0.25
172_G	209_L	0.569	0.25
25_L	163_F	0.566	0.25
202_I	205_N	0.563	0.25
25_L	138_A	0.562	0.25
130_R	133_G	0.560	0.25
51_V	155_G	0.560	0.25
59_G	79_G	0.560	0.25
57_G	78_D	0.558	0.24
108_R	115_L	0.556	0.24
52_G	131_V	0.550	0.24
88_E	165_M	0.548	0.24
21_G	169_R	0.546	0.24
87_D	183_A	0.541	0.23
13_E	35_D	0.537	0.23
28_L	69_D	0.536	0.23
5_L	11_A	0.533	0.23
46_Q	199_S	0.531	0.23
52_G	150_V	0.526	0.23
14_P	117_G	0.525	0.23
24_E	86_V	0.525	0.23
121_Y	209_L	0.523	0.22
49_E	68_D	0.522	0.22
186_D	203_D	0.522	0.22
164_A	203_D	0.519	0.22
83_D	142_P	0.519	0.22
201_G	204_L	0.516	0.22
77_T	84_G	0.514	0.22
60_T	127_E	0.511	0.22
8_K	86_V	0.510	0.22
111_G	150_V	0.510	0.22
70_D	151_Y	0.508	0.22
60_T	146_F	0.507	0.22
171_L	175_R	0.506	0.22
57_G	60_T	0.505	0.22
134_S	139_G	0.504	0.21
39_I	134_S	0.504	0.21
17_L	48_I	0.503	0.21
30_F	101_A	0.503	0.21
122_T	200_V	0.502	0.21
160_I	163_F	0.501	0.21
119_P	122_T	0.501	0.21
81_D	127_E	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2kd2A	1	0.3619	14.2	0.954	Contact Map
3ix6A	2	0.6857	11	0.956	Contact Map
2k54A	1	0.3381	7.9	0.959	Contact Map
4m7cA	2	0.3095	7.2	0.96	Contact Map
3u7vA	3	0.4286	6.4	0.961	Contact Map
2oviA	2	0.3667	5.7	0.962	Contact Map
3bqoA	2	0.319	4.6	0.963	Contact Map
2lugA	1	0.1048	4.1	0.964	Contact Map
2ph0A	2	0.3667	3.6	0.965	Contact Map
4khbD	1	0.3952	3.6	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.