GREMLIN Database
DUF2491 - Protein of unknown function (DUF2491)
PFAM: PF10679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (202)
Sequences: 592 (408)
Seq/√Len: 28.7
META: 0.713

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_F9_K3.9561.00
74_Q77_T3.6941.00
23_V48_I3.6551.00
178_Y203_D3.4251.00
132_W166_L3.4221.00
169_R179_L3.3891.00
74_Q78_D2.8341.00
38_K124_D2.7631.00
100_P109_W2.5870.99
131_V168_A2.5820.99
107_R111_G2.5650.99
120_T127_E2.5080.99
109_W196_V2.4870.99
116_I119_P2.4070.99
38_K128_Y2.3610.99
97_S197_E2.3470.99
106_W110_L2.2390.98
18_R21_G2.2280.98
171_L174_D2.1120.98
94_P197_E2.1020.98
53_E61_T2.0990.97
5_L8_K2.0390.97
103_E107_R2.0160.97
64_R165_M1.8800.95
128_Y132_W1.8750.95
94_P199_S1.8210.94
120_T129_Q1.8100.94
126_K169_R1.7590.93
181_V196_V1.7270.92
101_A105_E1.7180.92
100_P196_V1.7140.92
51_V63_H1.7010.92
21_G48_I1.6840.91
49_E70_D1.6090.89
100_P105_E1.5750.88
92_F166_L1.5620.88
7_G11_A1.5190.87
170_E176_R1.5120.86
181_V198_I1.5060.86
146_F164_A1.5030.86
72_F94_P1.4990.86
90_K178_Y1.4990.86
64_R143_P1.4910.85
61_T209_L1.4750.85
142_P167_Y1.4720.85
193_E202_I1.4370.83
54_V199_S1.3900.81
166_L207_A1.3840.81
53_E63_H1.3510.79
28_L31_R1.3360.78
50_A91_L1.3230.78
159_R185_E1.3020.77
169_R177_E1.2930.76
180_L201_G1.2680.75
143_P165_M1.2600.74
55_D59_G1.2500.74
147_T161_D1.2430.73
28_L144_V1.2340.73
164_A174_D1.2250.72
106_W194_A1.2220.72
16_G21_G1.2200.72
179_L182_S1.2000.70
5_L9_K1.1980.70
183_A190_E1.1890.70
5_L128_Y1.1880.70
179_L198_I1.1840.69
13_E29_P1.1830.69
130_R166_L1.1770.69
52_G66_Y1.1550.67
30_F186_D1.1440.67
78_D87_D1.1380.66
177_E201_G1.1380.66
122_T178_Y1.1300.66
48_I194_A1.1250.65
15_L181_V1.1160.65
179_L200_V1.1130.64
57_G87_D1.1130.64
68_D139_G1.1110.64
190_E198_I1.0960.63
52_G63_H1.0900.63
14_P167_Y1.0890.63
54_V131_V1.0830.62
96_D123_L1.0820.62
113_G140_R1.0800.62
91_L150_V1.0790.62
59_G78_D1.0740.62
9_K120_T1.0680.61
54_V146_F1.0680.61
6_F10_D1.0670.61
160_I164_A1.0670.61
18_R178_Y1.0650.61
62_L175_R1.0620.61
158_R162_Q1.0500.60
62_L119_P1.0420.59
145_A163_F1.0390.59
183_A202_I1.0300.58
182_S199_S1.0240.58
7_G10_D1.0220.58
54_V75_V1.0180.57
28_L56_L1.0150.57
41_L91_L0.9910.55
162_Q199_S0.9810.55
205_N209_L0.9790.54
149_T159_R0.9790.54
66_Y148_E0.9730.54
181_V200_V0.9700.54
173_G207_A0.9690.54
81_D107_R0.9620.53
78_D107_R0.9460.52
136_G139_G0.9460.52
122_T157_T0.9450.52
33_A172_G0.9370.51
5_L10_D0.9340.51
9_K149_T0.9330.51
179_L204_L0.9300.51
79_G162_Q0.9240.50
43_A171_L0.9210.50
26_D69_D0.9180.50
186_D196_V0.9160.50
129_Q181_V0.9150.50
106_W143_P0.9150.50
21_G207_A0.9140.49
16_G22_T0.9070.49
25_L159_R0.9040.49
88_E101_A0.9020.49
93_V200_V0.9000.48
36_D171_L0.8800.47
27_P44_G0.8770.47
25_L50_A0.8760.46
75_V84_G0.8720.46
23_V131_V0.8670.46
95_Y196_V0.8650.46
19_I36_D0.8640.46
48_I192_G0.8550.45
32_L146_F0.8510.45
110_L143_P0.8460.44
75_V79_G0.8370.43
86_V184_E0.8370.43
23_V56_L0.8310.43
71_A162_Q0.8300.43
52_G57_G0.8290.43
178_Y182_S0.8280.43
143_P183_A0.8230.42
157_T172_G0.8230.42
55_D175_R0.8140.42
185_E194_A0.8130.42
128_Y166_L0.8100.41
52_G91_L0.8070.41
181_V203_D0.8060.41
134_S137_D0.8020.41
82_G85_H0.8010.41
199_S208_D0.7980.41
90_K97_S0.7980.41
14_P108_R0.7980.41
50_A158_R0.7920.40
111_G205_N0.7900.40
63_H150_V0.7880.40
72_F77_T0.7880.40
119_P139_G0.7870.40
152_D160_I0.7870.40
31_R105_E0.7820.39
21_G167_Y0.7790.39
69_D184_E0.7740.39
104_A168_A0.7720.39
18_R24_E0.7710.39
88_E131_V0.7630.38
72_F197_E0.7610.38
34_G62_L0.7610.38
171_L176_R0.7560.37
61_T200_V0.7530.37
90_K94_P0.7510.37
55_D108_R0.7490.37
52_G197_E0.7470.37
51_V167_Y0.7460.37
40_E70_D0.7430.36
67_L161_D0.7400.36
111_G127_E0.7310.36
97_S123_L0.7300.36
87_D173_G0.7300.36
140_R146_F0.7290.35
81_D85_H0.7250.35
59_G87_D0.7230.35
96_D108_R0.7170.35
168_A197_E0.7090.34
151_Y191_G0.7090.34
135_E139_G0.7080.34
31_R35_D0.7050.34
14_P111_G0.7040.34
65_F178_Y0.7040.34
18_R27_P0.7010.34
24_E45_T0.6990.33
52_G65_F0.6980.33
138_A167_Y0.6960.33
53_E159_R0.6950.33
82_G207_A0.6870.33
104_A181_V0.6810.32
31_R55_D0.6810.32
20_G171_L0.6810.32
36_D112_P0.6780.32
18_R86_V0.6770.32
205_N208_D0.6750.32
146_F166_L0.6750.32
54_V97_S0.6750.32
35_D41_L0.6750.32
75_V78_D0.6710.31
25_L174_D0.6710.31
77_T82_G0.6700.31
124_D165_M0.6640.31
107_R184_E0.6620.31
28_L91_L0.6620.31
184_E197_E0.6610.31
102_S158_R0.6580.31
73_L101_A0.6560.30
73_L86_V0.6560.30
22_T65_F0.6540.30
90_K203_D0.6530.30
52_G76_V0.6520.30
109_W167_Y0.6500.30
175_R204_L0.6470.30
70_D146_F0.6450.30
127_E153_D0.6440.30
147_T184_E0.6400.29
25_L115_L0.6390.29
74_Q94_P0.6380.29
12_P19_I0.6360.29
20_G64_R0.6340.29
107_R190_E0.6280.29
61_T83_D0.6270.29
111_G172_G0.6250.28
153_D156_G0.6240.28
24_E102_S0.6200.28
86_V154_D0.6160.28
92_F117_G0.6150.28
17_L65_F0.6090.27
70_D190_E0.6070.27
22_T45_T0.6050.27
51_V61_T0.6050.27
36_D167_Y0.6020.27
43_A53_E0.6010.27
163_F185_E0.6010.27
6_F11_A0.5990.27
144_V165_M0.5990.27
99_T208_D0.5970.27
95_Y162_Q0.5970.27
122_T202_I0.5960.27
67_L88_E0.5950.27
164_A209_L0.5930.26
191_G196_V0.5930.26
102_S105_E0.5920.26
23_V93_V0.5920.26
31_R56_L0.5910.26
106_W130_R0.5860.26
141_V144_V0.5790.26
167_Y208_D0.5780.26
150_V160_I0.5760.25
50_A149_T0.5730.25
36_D62_L0.5730.25
102_S119_P0.5710.25
99_T112_P0.5710.25
88_E164_A0.5710.25
78_D86_V0.5690.25
172_G209_L0.5690.25
25_L163_F0.5660.25
202_I205_N0.5630.25
25_L138_A0.5620.25
130_R133_G0.5600.25
51_V155_G0.5600.25
59_G79_G0.5600.25
57_G78_D0.5580.24
108_R115_L0.5560.24
52_G131_V0.5500.24
88_E165_M0.5480.24
21_G169_R0.5460.24
87_D183_A0.5410.23
13_E35_D0.5370.23
28_L69_D0.5360.23
5_L11_A0.5330.23
46_Q199_S0.5310.23
52_G150_V0.5260.23
14_P117_G0.5250.23
24_E86_V0.5250.23
121_Y209_L0.5230.22
49_E68_D0.5220.22
186_D203_D0.5220.22
164_A203_D0.5190.22
83_D142_P0.5190.22
201_G204_L0.5160.22
77_T84_G0.5140.22
60_T127_E0.5110.22
8_K86_V0.5100.22
111_G150_V0.5100.22
70_D151_Y0.5080.22
60_T146_F0.5070.22
171_L175_R0.5060.22
57_G60_T0.5050.22
134_S139_G0.5040.21
39_I134_S0.5040.21
17_L48_I0.5030.21
30_F101_A0.5030.21
122_T200_V0.5020.21
160_I163_F0.5010.21
119_P122_T0.5010.21
81_D127_E0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kd2A 1 0.3619 14.2 0.954 Contact Map
3ix6A 2 0.6857 11 0.956 Contact Map
2k54A 1 0.3381 7.9 0.959 Contact Map
4m7cA 2 0.3095 7.2 0.96 Contact Map
3u7vA 3 0.4286 6.4 0.961 Contact Map
2oviA 2 0.3667 5.7 0.962 Contact Map
3bqoA 2 0.319 4.6 0.963 Contact Map
2lugA 1 0.1048 4.1 0.964 Contact Map
2ph0A 2 0.3667 3.6 0.965 Contact Map
4khbD 1 0.3952 3.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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