GREMLIN Database
DUF2492 - Protein of unknown function (DUF2492)
PFAM: PF10678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (76)
Sequences: 896 (638)
Seq/√Len: 73.1
META: 0.768

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E49_G4.1931.00
28_I38_F2.9681.00
2_S39_H2.9481.00
17_E27_A2.4521.00
3_I36_A2.4371.00
25_E52_V2.1261.00
47_T50_E2.0101.00
10_N14_E1.9221.00
21_H53_A1.9101.00
71_D74_K1.9011.00
70_T75_I1.8341.00
40_T46_M1.7441.00
5_G40_T1.6210.99
9_L70_T1.6040.99
53_A57_A1.4980.99
21_H56_A1.4900.99
46_M50_E1.4850.99
2_S45_G1.4510.99
7_E10_N1.3710.98
5_G51_L1.3680.98
39_H46_M1.3420.98
8_V51_L1.3310.98
19_Y23_S1.3310.98
19_Y27_A1.3020.98
28_I48_A1.2970.97
5_G48_A1.2920.97
62_I70_T1.2390.97
12_M61_F1.1520.95
56_A63_P1.1480.95
40_T43_A1.1420.95
74_K77_R1.1400.95
52_V61_F1.1050.94
48_A52_V1.0800.93
6_H9_L1.0710.93
70_T74_K1.0550.92
2_S44_E1.0480.92
12_M16_G1.0480.92
40_T51_L1.0440.92
37_R47_T1.0340.91
8_V28_I1.0150.90
63_P66_D1.0030.90
43_A46_M1.0030.90
26_A30_A0.9980.90
23_S68_F0.9200.86
37_R45_G0.9050.85
11_M27_A0.9000.84
53_A64_S0.8990.84
66_D77_R0.8720.82
15_S19_Y0.8660.82
28_I61_F0.8650.82
11_M15_S0.8640.82
22_A26_A0.8470.80
63_P67_G0.8380.80
55_L60_K0.8280.79
19_Y38_F0.8280.79
9_L12_M0.8270.79
11_M19_Y0.8180.78
22_A25_E0.8180.78
21_H63_P0.8080.77
10_N75_I0.7870.75
13_I70_T0.7800.75
63_P68_F0.7790.75
64_S73_S0.7730.74
72_Q75_I0.7620.73
25_E29_K0.7580.73
5_G43_A0.7440.71
49_G52_V0.7410.71
29_K49_G0.7340.70
40_T45_G0.7210.69
21_H68_F0.7180.69
14_E31_R0.7110.68
8_V48_A0.7030.67
2_S29_K0.7010.67
2_S36_A0.7000.67
71_D75_I0.6940.66
30_A65_K0.6910.66
34_E66_D0.6790.64
47_T51_L0.6530.61
40_T54_F0.6430.60
29_K34_E0.6380.59
37_R40_T0.6340.59
22_A66_D0.6190.57
23_S26_A0.6110.56
69_S74_K0.6020.55
8_V74_K0.5950.54
32_F38_F0.5930.54
56_A61_F0.5840.53
19_Y28_I0.5770.52
48_A61_F0.5740.52
42_S55_L0.5700.51
21_H32_F0.5670.51
13_I75_I0.5660.51
39_H45_G0.5590.50
65_K77_R0.5580.50
29_K64_S0.5450.48
64_S67_G0.5390.47
19_Y24_L0.5390.47
15_S18_Q0.5390.47
23_S27_A0.5360.47
8_V16_G0.5350.47
42_S58_K0.5290.46
9_L75_I0.5250.46
9_L14_E0.5240.45
10_N20_T0.5210.45
50_E53_A0.5170.45
17_E31_R0.5140.44
51_L55_L0.5140.44
11_M28_I0.5130.44
5_G8_V0.5110.44
30_A57_A0.5110.44
20_T23_S0.5090.44
46_M54_F0.5070.43
45_G64_S0.5000.42
17_E35_Q0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4trbA 2 0.7013 36.8 0.872 Contact Map
3g2bA 2 0.7143 30.4 0.877 Contact Map
2zo4A 1 0.7792 29.7 0.878 Contact Map
3dp7A 2 0.8312 20 0.888 Contact Map
2heoA 1 0.7662 15.2 0.893 Contact Map
3n75A 4 0.961 14.7 0.894 Contact Map
4y66A 1 0.8182 14.1 0.895 Contact Map
4ad9A 4 0.8831 13.5 0.896 Contact Map
1c4kA 2 1 13 0.897 Contact Map
4etsA 2 0.9091 12 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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