GREMLIN Database
DUF2489 - Protein of unknown function (DUF2489)
PFAM: PF10675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (130)
Sequences: 928 (674)
Seq/√Len: 59.1
META: 0.603

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_M57_G3.5791.00
100_L105_R3.2201.00
92_P108_L3.1461.00
109_D112_R2.9871.00
3_A7_Y2.7381.00
91_M108_L2.5801.00
87_A118_E2.4591.00
55_S88_T2.3951.00
90_H111_E2.3251.00
101_S104_E2.2521.00
8_A11_L2.2321.00
6_F10_Y2.2111.00
7_Y11_L2.1961.00
95_E99_A2.1671.00
97_R109_D2.0051.00
43_I61_I1.9071.00
120_E124_L1.8951.00
16_K20_Q1.8561.00
91_M97_R1.7700.99
30_Q34_A1.7680.99
55_S112_R1.7510.99
4_L8_A1.7330.99
10_Y14_Q1.7320.99
27_Q31_E1.6890.99
58_A84_L1.6260.99
8_A15_L1.6190.99
58_A81_F1.5820.99
97_R108_L1.5810.99
55_S97_R1.5410.98
12_L15_L1.4520.98
86_E89_K1.4510.98
11_L14_Q1.4360.97
104_E107_K1.4320.97
39_S43_I1.4040.97
6_F9_G1.4020.97
83_E122_A1.3920.97
103_K106_M1.3790.97
9_G13_R1.3620.96
52_C81_F1.3430.96
105_R108_L1.3130.95
61_I81_F1.2900.95
53_D113_E1.2740.95
15_L19_K1.2640.94
36_I67_Q1.2420.94
80_A126_A1.2410.94
43_I46_A1.2400.94
63_V67_Q1.2320.94
41_R45_R1.2010.93
39_S64_L1.1820.92
97_R105_R1.1610.91
106_M117_A1.1550.91
63_V66_D1.1340.90
77_D129_Q1.1300.90
53_D97_R1.1260.90
12_L16_K1.1000.89
7_Y18_Q1.0940.89
9_G12_L1.0910.89
84_L112_R1.0840.88
32_R35_N1.0750.88
83_E87_A1.0740.88
4_L11_L1.0650.88
100_L108_L1.0630.87
107_K111_E1.0590.87
87_A115_L1.0490.87
96_A99_A1.0330.86
106_M110_L1.0200.85
28_A31_E1.0010.84
47_M54_L1.0010.84
119_L122_A0.9900.83
62_K66_D0.9820.83
48_L128_K0.9790.83
59_I62_K0.9790.83
114_K118_E0.9630.82
91_M112_R0.9580.81
24_A28_A0.9510.81
35_N67_Q0.9450.80
122_A125_A0.9410.80
101_S106_M0.9390.80
106_M113_E0.9310.79
83_E119_L0.8870.76
16_K19_K0.8850.76
97_R112_R0.8840.76
108_L112_R0.8650.74
13_R17_K0.8620.74
52_C85_Y0.8570.73
39_S42_I0.8550.73
24_A27_Q0.8480.73
59_I84_L0.8410.72
40_I61_I0.8380.72
1_I4_L0.8220.70
33_R69_D0.7970.68
7_Y10_Y0.7960.68
4_L7_Y0.7910.67
47_M127_A0.7900.67
11_L15_L0.7770.66
55_S108_L0.7720.65
54_L57_G0.7680.65
84_L115_L0.7650.65
13_R16_K0.7610.64
53_D112_R0.7450.63
52_C57_G0.7440.63
22_Q26_Q0.7440.63
110_L117_A0.7300.61
97_R100_L0.7300.61
50_E106_M0.7300.61
43_I64_L0.7280.61
10_Y17_K0.7230.60
13_R19_K0.7230.60
32_R63_V0.7210.60
32_R36_I0.7190.60
55_S116_E0.7130.59
1_I31_E0.7100.59
40_I53_D0.7090.59
59_I67_Q0.6980.58
34_A38_E0.6980.58
3_A10_Y0.6970.58
79_P126_A0.6930.57
62_K82_F0.6920.57
43_I57_G0.6900.57
41_R127_A0.6890.57
100_L104_E0.6800.56
7_Y79_P0.6710.55
51_Q115_L0.6700.55
58_A80_A0.6670.54
36_I40_I0.6620.54
91_M105_R0.6610.54
40_I92_P0.6580.53
53_D94_H0.6560.53
52_C127_A0.6550.53
101_S107_K0.6530.53
39_S59_I0.6430.52
21_Q25_Q0.6400.51
59_I63_V0.6380.51
23_Q27_Q0.6330.51
83_E118_E0.6300.50
8_A14_Q0.6270.50
26_Q30_Q0.6260.50
113_E117_A0.6230.49
70_P129_Q0.6140.48
112_R123_I0.6100.48
70_P73_L0.6090.48
2_A27_Q0.6080.48
53_D96_A0.6070.48
5_A9_G0.6070.48
1_I5_A0.6050.47
47_M123_I0.6000.47
58_A73_L0.5990.47
11_L18_Q0.5980.47
29_L33_R0.5970.46
15_L18_Q0.5930.46
125_A128_K0.5930.46
38_E101_S0.5870.45
37_L40_I0.5860.45
47_M52_C0.5820.45
87_A119_L0.5800.45
117_A121_D0.5780.44
12_L17_K0.5770.44
84_L94_H0.5740.44
81_F127_A0.5740.44
53_D88_T0.5720.44
60_R100_L0.5720.44
126_A129_Q0.5710.44
7_Y12_L0.5700.44
5_A20_Q0.5660.43
70_P74_E0.5660.43
91_M115_L0.5530.42
2_A6_F0.5530.42
37_L66_D0.5530.42
6_F17_K0.5490.41
80_A83_E0.5470.41
87_A90_H0.5440.41
51_Q59_I0.5430.41
10_Y16_K0.5390.40
78_Y129_Q0.5380.40
85_Y89_K0.5380.40
88_T97_R0.5370.40
124_L128_K0.5330.40
102_K106_M0.5280.39
80_A119_L0.5260.39
14_Q18_Q0.5260.39
39_S112_R0.5250.39
32_R82_F0.5220.38
70_P77_D0.5210.38
55_S105_R0.5190.38
32_R46_A0.5190.38
80_A122_A0.5180.38
54_L124_L0.5140.38
31_E35_N0.5090.37
5_A8_A0.5080.37
1_I22_Q0.5050.37
52_C84_L0.5040.36
36_I78_Y0.5040.36
56_E60_R0.5020.36
5_A19_K0.5010.36
51_Q98_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2micA 2 0.1615 14.3 0.925 Contact Map
2ks1B 1 0.1615 10.3 0.929 Contact Map
2l2tA 2 0.1692 10 0.93 Contact Map
2x3vA 2 0.3769 8.3 0.932 Contact Map
3m3wA 2 0.3692 7.9 0.933 Contact Map
2jwaA 2 0.1538 7.4 0.934 Contact Map
1jv1A 2 0.4231 6.5 0.935 Contact Map
2yqcA 1 0.4231 6.4 0.936 Contact Map
4n3yB 2 0.3 6.1 0.936 Contact Map
3abhA 2 0.3692 5.6 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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