GREMLIN Database
DUF2484 - Protein of unknown function (DUF2484)
PFAM: PF10658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (76)
Sequences: 1010 (718)
Seq/√Len: 82.3
META: 0.781

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_S47_Q3.5351.00
45_T53_G3.3671.00
7_L43_W3.0671.00
18_V29_P2.7001.00
8_A44_V2.6071.00
2_S48_N2.2241.00
21_L29_P2.0911.00
43_W47_Q1.9961.00
42_G45_T1.9141.00
69_I73_R1.8301.00
44_V56_A1.8261.00
45_T50_P1.6871.00
3_L7_L1.6061.00
12_V16_N1.6051.00
4_S7_L1.5741.00
38_P45_T1.4920.99
9_C12_V1.4600.99
25_N29_P1.4320.99
66_W69_I1.4270.99
18_V21_L1.4020.99
41_L53_G1.3800.99
59_A62_S1.3540.99
29_P33_L1.3360.99
38_P42_G1.3160.98
42_G46_Y1.3100.98
37_G60_G1.2900.98
16_N20_M1.2600.98
34_I38_P1.1800.97
50_P54_L1.1670.97
38_P50_P1.1430.96
41_L56_A1.1340.96
15_A66_W1.1340.96
23_S30_A1.1230.96
19_A59_A1.0940.95
4_S43_W1.0910.95
27_W31_Y1.0820.95
12_V19_A1.0600.94
55_L58_A1.0590.94
70_Y73_R1.0110.93
72_W76_R0.9800.92
32_V36_L0.9790.92
9_C13_L0.9790.92
58_A61_A0.9780.91
71_L75_L0.9640.91
46_Y53_G0.9260.89
18_V33_L0.9160.89
25_N28_R0.9100.88
26_H63_M0.9000.88
28_R31_Y0.8860.87
61_A68_L0.8790.86
33_L62_S0.8480.84
3_L6_I0.8430.84
12_V56_A0.8390.84
5_L44_V0.8120.82
8_A40_L0.8070.81
29_P32_V0.7870.80
54_L58_A0.7440.76
25_N31_Y0.7420.76
42_G53_G0.7410.76
22_P62_S0.7340.75
4_S46_Y0.7300.74
15_A36_L0.7250.74
19_A63_M0.7240.74
18_V26_H0.7240.74
42_G50_P0.7210.74
53_G56_A0.7060.72
27_W34_I0.7050.72
57_L61_A0.6970.71
30_A63_M0.6900.70
14_A21_L0.6900.70
4_S48_N0.6840.70
51_W54_L0.6690.68
8_A59_A0.6650.67
45_T60_G0.6580.67
51_W55_L0.6500.66
72_W75_L0.6460.65
8_A56_A0.6440.65
27_W71_L0.6440.65
52_W55_L0.6440.65
34_I66_W0.6280.63
21_L28_R0.6280.63
19_A62_S0.6150.61
7_L40_L0.6140.61
28_R32_V0.6120.61
69_I72_W0.6120.61
60_G66_W0.6100.61
16_N23_S0.6090.61
46_Y50_P0.6060.60
3_L43_W0.6010.60
48_N52_W0.5890.58
22_P40_L0.5800.57
49_G52_W0.5760.56
24_R28_R0.5720.56
21_L24_R0.5660.55
35_A74_W0.5650.55
49_G55_L0.5590.54
41_L60_G0.5480.53
13_L17_V0.5450.52
70_Y74_W0.5330.51
1_M6_I0.5330.51
61_A72_W0.5190.49
62_S65_R0.5190.49
61_A76_R0.5160.49
30_A67_P0.5110.48
6_I10_L0.5110.48
68_L71_L0.5100.48
31_Y37_G0.5090.48
16_N63_M0.5080.47
40_L48_N0.5080.47
6_I13_L0.5060.47
27_W32_V0.5040.47
31_Y66_W0.5030.47
22_P65_R0.5030.47
56_A60_G0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zcdA 1 0.9868 2.5 0.921 Contact Map
4czbA 2 0.9605 1.1 0.936 Contact Map
2qi9A 2 0.8553 1 0.937 Contact Map
4p02B 1 0.3158 0.9 0.939 Contact Map
2nq2A 2 0.6316 0.9 0.939 Contact Map
4ev6A 3 0.7763 0.9 0.94 Contact Map
4hygA 3 0.9868 0.8 0.942 Contact Map
4p02A 1 1 0.7 0.944 Contact Map
2mv6A 1 0.4211 0.7 0.945 Contact Map
4q65A 1 0.9868 0.6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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