GREMLIN Database
DUF2480 - Protein of unknown function (DUF2480)
PFAM: PF10652 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 165 (164)
Sequences: 4078 (2864)
Seq/√Len: 223.6
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_E52_N3.2551.00
115_S118_K2.9301.00
91_K107_E2.8901.00
62_Y91_K2.7961.00
27_V61_K2.7861.00
53_H58_Y2.7661.00
28_V66_T2.6441.00
50_L84_Y2.5831.00
99_E102_T2.4871.00
56_S59_Q2.4541.00
96_D99_E2.4441.00
63_V85_L2.4331.00
25_E61_K2.3901.00
148_A151_I2.2971.00
113_D116_E2.2131.00
139_E142_K2.1411.00
121_R149_K2.1131.00
34_W49_A2.0211.00
156_P159_T2.0111.00
29_F34_W1.9931.00
86_Q145_Q1.9271.00
32_K38_G1.8971.00
46_F81_V1.8961.00
83_S162_L1.8601.00
4_V9_N1.8361.00
114_L147_V1.7051.00
11_G121_R1.6751.00
53_H57_Q1.6551.00
64_A100_L1.6471.00
33_D38_G1.6071.00
62_Y90_K1.5741.00
54_D57_Q1.5461.00
114_L143_K1.5111.00
75_T153_Y1.4901.00
106_L139_E1.4861.00
124_I140_L1.4491.00
28_V64_A1.4331.00
36_F40_I1.4331.00
82_A92_V1.4311.00
26_R101_E1.4271.00
102_T135_S1.4161.00
51_K84_Y1.4071.00
28_V97_L1.3971.00
62_Y100_L1.3811.00
107_E110_S1.3601.00
141_T145_Q1.3561.00
123_V156_P1.3471.00
65_I138_V1.3391.00
103_A106_L1.3381.00
94_F138_V1.3271.00
89_A92_V1.2941.00
36_F42_K1.2821.00
16_D19_D1.2811.00
93_V100_L1.2781.00
64_A97_L1.2731.00
110_S143_K1.2541.00
100_L104_L1.2441.00
108_A111_K1.2161.00
83_S141_T1.2151.00
31_I81_V1.1921.00
48_E51_K1.1911.00
123_V159_T1.1761.00
59_Q88_F1.1711.00
119_D149_K1.1621.00
119_D165_K1.1591.00
15_I20_Y1.1531.00
29_F49_A1.1251.00
37_M42_K1.1241.00
26_R100_L1.1221.00
97_L101_E1.1211.00
83_S145_Q1.1171.00
79_M141_T1.1061.00
60_D90_K1.1031.00
36_F45_D1.1001.00
22_P108_A1.0931.00
13_I120_K1.0801.00
103_A107_E1.0761.00
34_W53_H1.0751.00
75_T134_E1.0751.00
101_E105_F1.0681.00
73_I78_Y1.0681.00
104_L108_A1.0541.00
29_F33_D1.0431.00
23_K130_K1.0411.00
105_F132_V1.0391.00
62_Y104_L1.0311.00
87_P145_Q1.0121.00
38_G69_A0.9981.00
17_L136_A0.9811.00
12_L123_V0.9791.00
109_I114_L0.9761.00
21_Y105_F0.9681.00
49_A53_H0.9641.00
20_Y112_I0.9541.00
45_D48_E0.9531.00
55_W84_Y0.9531.00
17_L140_L0.9461.00
32_K68_S0.9431.00
107_E111_K0.9411.00
110_S139_E0.9331.00
82_A138_V0.9321.00
32_K69_A0.9291.00
31_I34_W0.9291.00
85_L88_F0.9130.99
109_I143_K0.9110.99
24_G90_K0.9060.99
15_I112_I0.8990.99
18_E129_D0.8890.99
122_V148_A0.8650.99
15_I140_L0.8590.99
40_I69_A0.8570.99
20_Y117_Y0.8490.99
101_E104_L0.8480.99
22_P62_Y0.8400.99
21_Y130_K0.8310.99
91_K142_K0.8260.99
39_L69_A0.8240.99
73_I77_A0.8170.99
56_S88_F0.8130.99
94_F134_E0.8110.99
139_E143_K0.8000.99
65_I81_V0.7930.99
99_E103_A0.7870.98
91_K103_A0.7830.98
29_F81_V0.7780.98
109_I139_E0.7720.98
150_S164_K0.7670.98
32_K36_F0.7580.98
21_Y101_E0.7570.98
135_S139_E0.7560.98
12_L159_T0.7430.98
65_I85_L0.7420.98
132_V137_Y0.7360.98
13_I122_V0.7310.97
86_Q142_K0.7290.97
106_L135_S0.7280.97
102_T106_L0.7280.97
137_Y140_L0.7230.97
134_E138_V0.7200.97
50_L80_L0.7170.97
14_T125_K0.7130.97
75_T94_F0.7070.97
64_A96_D0.7020.97
93_V103_A0.7000.97
149_K165_K0.6910.96
20_Y108_A0.6910.96
18_E21_Y0.6890.96
140_L144_L0.6890.96
146_P151_I0.6880.96
121_R150_S0.6860.96
131_P134_E0.6810.96
118_K147_V0.6790.96
26_R62_Y0.6740.96
94_F135_S0.6730.96
36_F39_L0.6700.96
49_A84_Y0.6600.95
133_P136_A0.6570.95
34_W81_V0.6570.95
157_C160_V0.6560.95
106_L110_S0.6560.95
21_Y26_R0.6540.95
101_E130_K0.6500.95
26_R104_L0.6460.95
128_S132_V0.6430.95
19_D23_K0.6430.95
144_L151_I0.6430.95
157_C161_P0.6420.95
98_E102_T0.6410.95
138_V141_T0.6400.95
24_G62_Y0.6400.95
11_G120_K0.6390.95
117_Y144_L0.6390.95
14_T156_P0.6360.94
18_E130_K0.6360.94
158_S161_P0.6340.94
8_A11_G0.6310.94
65_I92_V0.6290.94
75_T78_Y0.6240.94
31_I46_F0.6210.94
26_R97_L0.6210.94
79_M124_I0.6200.94
22_P90_K0.6180.94
84_Y88_F0.6160.93
34_W50_L0.6120.93
34_W84_Y0.6120.93
109_I112_I0.6120.93
105_F133_P0.6050.93
15_I109_I0.6020.93
145_Q151_I0.6010.93
114_L140_L0.6000.92
45_D72_I0.5980.92
53_H88_F0.5960.92
135_S138_V0.5940.92
34_W38_G0.5910.92
116_E120_K0.5880.92
112_I116_E0.5880.92
47_R80_L0.5870.92
109_I136_A0.5850.92
150_S159_T0.5830.91
84_Y87_P0.5820.91
50_L81_V0.5820.91
62_Y101_E0.5800.91
66_T97_L0.5760.91
130_K133_P0.5750.91
67_C71_A0.5730.91
24_G60_D0.5730.91
37_M69_A0.5720.91
3_I16_D0.5700.90
14_T140_L0.5650.90
42_K45_D0.5540.89
42_K46_F0.5530.89
79_M162_L0.5520.89
41_L77_A0.5520.89
98_E131_P0.5490.89
68_S71_A0.5470.89
95_G103_A0.5470.89
143_K146_P0.5460.89
58_Y85_L0.5450.88
120_K123_V0.5420.88
12_L121_R0.5420.88
146_P163_Y0.5410.88
55_W58_Y0.5400.88
41_L45_D0.5380.88
30_D68_S0.5370.88
12_L120_K0.5350.88
118_K165_K0.5340.87
33_D49_A0.5280.87
24_G101_E0.5280.87
65_I82_A0.5260.87
91_K100_L0.5240.86
14_T123_V0.5220.86
3_I6_K0.5220.86
25_E60_D0.5190.86
66_T96_D0.5190.86
26_R64_A0.5180.86
140_L143_K0.5170.86
112_I117_Y0.5160.86
125_K156_P0.5150.85
73_I79_M0.5140.85
129_D132_V0.5140.85
75_T138_V0.5120.85
93_V99_E0.5110.85
6_K11_G0.5110.85
150_S163_Y0.5020.84
114_L118_K0.5010.84
141_T162_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h5jA 1 0.5818 27.6 0.957 Contact Map
3q3wA 1 0.6364 11.4 0.964 Contact Map
4i9fA 2 0.9697 11.3 0.964 Contact Map
2cunA 2 0.3333 9.9 0.965 Contact Map
5bt8A 1 0.3576 8.9 0.966 Contact Map
1v6sA 1 0.3333 8 0.966 Contact Map
1zkrA 2 0.4788 8 0.966 Contact Map
4jgtA 1 0.6303 7.1 0.967 Contact Map
1vpeA 1 0.3333 6.9 0.967 Contact Map
1t3kA 1 0.6364 6.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.