GREMLIN Database
Germane - Sporulation and spore germination
PFAM: PF10646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (102)
Sequences: 24795 (19454)
Seq/√Len: 1926.3
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_V93_R3.0841.00
61_T97_L2.3831.00
95_Q102_P2.3581.00
63_D97_L2.2871.00
51_L63_D2.2231.00
42_S80_Q2.2041.00
26_R30_E2.0791.00
79_A83_N2.0741.00
66_G99_D2.0271.00
31_A34_A2.0031.00
43_A80_Q1.8791.00
59_V95_Q1.8761.00
82_V86_T1.7881.00
61_T95_Q1.7731.00
28_A84_T1.7691.00
55_V60_A1.7391.00
29_L85_L1.6961.00
60_A91_V1.6641.00
27_A31_A1.6241.00
54_T61_T1.6181.00
49_K65_S1.6031.00
25_A85_L1.5411.00
25_A53_V1.4861.00
15_R18_P1.4801.00
28_A88_F1.4201.00
16_L19_E1.4121.00
71_S74_E1.4061.00
5_L43_A1.4001.00
51_L99_D1.3601.00
83_N86_T1.3131.00
58_G92_K1.2991.00
73_S76_L1.2981.00
21_T24_L1.2821.00
56_E61_T1.2571.00
71_S75_R1.2441.00
63_D100_G1.2411.00
11_Y14_V1.2331.00
29_L33_L1.2311.00
72_A75_R1.2261.00
70_G74_E1.2041.00
97_L102_P1.2031.00
52_S63_D1.1991.00
17_V20_T1.1831.00
29_L81_I1.1791.00
68_F77_A1.1681.00
27_A30_E1.0981.00
10_T13_P1.0971.00
62_V85_L1.0941.00
23_A26_R1.0871.00
32_L84_T1.0851.00
64_L68_F1.0841.00
6_D9_G1.0481.00
25_A90_G1.0481.00
33_L64_L1.0321.00
66_G69_L1.0291.00
44_I77_A1.0161.00
16_L20_T0.9981.00
15_R19_E0.9931.00
60_A85_L0.9831.00
70_G73_S0.9751.00
72_A76_L0.9431.00
50_L53_V0.9381.00
70_G75_R0.9371.00
4_F35_G0.9361.00
26_R50_L0.9291.00
45_P48_T0.9281.00
78_V96_I0.9281.00
71_S76_L0.8911.00
48_T68_F0.8891.00
73_S77_A0.8851.00
25_A60_A0.8831.00
78_V82_V0.8711.00
64_L81_I0.8701.00
5_L76_L0.8541.00
98_V103_V0.8461.00
74_E77_A0.8381.00
33_L50_L0.8311.00
81_I96_I0.8301.00
29_L50_L0.8271.00
68_F78_V0.8261.00
55_V91_V0.8011.00
79_A82_V0.7881.00
26_R53_V0.7821.00
25_A88_F0.7711.00
5_L9_G0.7691.00
82_V94_V0.7661.00
30_E34_A0.7641.00
80_Q83_N0.7581.00
32_L44_I0.7571.00
86_T94_V0.7501.00
75_R79_A0.7491.00
10_T14_V0.7491.00
51_L65_S0.7441.00
24_L28_A0.7351.00
53_V60_A0.7311.00
6_D10_T0.7301.00
53_V85_L0.7201.00
54_T57_D0.7151.00
24_L90_G0.7101.00
80_Q84_T0.7021.00
55_V58_G0.6991.00
64_L96_I0.6991.00
69_L103_V0.6971.00
82_V96_I0.6881.00
23_A27_A0.6871.00
74_E78_V0.6851.00
88_F91_V0.6841.00
32_L80_Q0.6831.00
50_L62_V0.6821.00
5_L80_Q0.6771.00
83_N87_Q0.6761.00
4_F36_P0.6711.00
69_L98_V0.6651.00
44_I81_I0.6601.00
15_R20_T0.6581.00
70_G76_L0.6531.00
77_A80_Q0.6521.00
30_E33_L0.6501.00
86_T93_R0.6271.00
2_L31_A0.6181.00
62_V94_V0.6111.00
48_T64_L0.6091.00
81_I94_V0.6031.00
25_A28_A0.6011.00
86_T91_V0.5991.00
55_V90_G0.5971.00
78_V83_N0.5941.00
29_L32_L0.5871.00
36_P40_L0.5871.00
47_G67_E0.5751.00
14_V17_V0.5681.00
25_A55_V0.5661.00
24_L27_A0.5591.00
44_I68_F0.5571.00
22_E26_R0.5551.00
53_V62_V0.5531.00
54_T97_L0.5501.00
33_L44_I0.5481.00
49_K67_E0.5401.00
28_A87_Q0.5401.00
60_A94_V0.5331.00
58_G93_R0.5331.00
84_T87_Q0.5321.00
14_V40_L0.5321.00
29_L62_V0.5291.00
50_L65_S0.5241.00
42_S46_A0.5141.00
77_A81_I0.5121.00
6_D11_Y0.5101.00
63_D99_D0.5071.00
65_S68_F0.5051.00
37_T40_L0.5011.00
68_F98_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cq1A 2 0.8173 50.7 0.827 Contact Map
1uwdA 1 0.8269 49.7 0.828 Contact Map
3lnoA 1 0.8558 47 0.831 Contact Map
4b0mA 1 0.4135 22.2 0.857 Contact Map
2e0gA 1 0.7692 16.1 0.866 Contact Map
1jfuA 1 0.3173 15.5 0.867 Contact Map
3lorA 3 0.3365 14.6 0.869 Contact Map
3eytA 4 0.3654 14 0.869 Contact Map
3cmiA 1 0.3365 13.3 0.871 Contact Map
3ny5A 2 0.7308 12.9 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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