GREMLIN Database
CotE - Outer spore coat protein E (CotE)
PFAM: PF10628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 174 (171)
Sequences: 731 (493)
Seq/√Len: 37.7
META: 0.64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A138_T4.6671.00
141_C149_E4.3481.00
66_Y73_E3.4001.00
166_D170_D3.2841.00
163_E166_D3.0111.00
24_I62_I2.8461.00
22_H58_Y2.7911.00
75_A122_I2.7011.00
83_D128_R2.6461.00
44_E55_N2.5541.00
117_S123_V2.5121.00
41_H81_Y2.4951.00
2_Y145_N2.4331.00
164_I167_L2.4061.00
159_E162_E2.2820.99
38_V126_V2.1180.99
57_S78_T2.1140.99
7_T140_V2.1020.99
106_L131_G1.9820.99
11_C86_P1.9180.98
73_E76_K1.8190.97
168_D171_F1.7730.97
9_A126_V1.7480.97
107_Q110_N1.7000.96
54_V85_V1.6960.96
45_A137_E1.6850.96
72_T133_E1.6800.96
54_V97_D1.6590.96
30_P33_I1.6250.95
152_W155_I1.5880.94
26_P33_I1.5570.94
161_D164_I1.5210.93
55_N67_D1.4900.92
18_F83_D1.4810.92
47_K110_N1.4700.92
37_W61_N1.4490.91
166_D169_P1.3990.90
168_D172_L1.3680.88
165_E168_D1.3330.87
13_K37_W1.2620.84
114_A133_E1.2580.84
11_C24_I1.2560.84
158_E161_D1.2470.83
91_D107_Q1.2420.83
57_S80_S1.2330.83
45_A103_A1.2300.82
28_H66_Y1.2210.82
28_H119_G1.2190.82
36_C104_R1.2140.82
85_V132_V1.2130.81
10_V92_P1.2090.81
165_E169_P1.2080.81
39_I70_T1.2020.81
51_K84_V1.1880.80
17_F23_T1.1870.80
39_I71_K1.1870.80
164_I171_F1.1860.80
157_D160_D1.1820.80
115_T125_R1.1760.79
20_S58_Y1.1720.79
53_E82_V1.1690.79
37_W40_N1.1610.79
103_A130_F1.1600.78
153_D158_E1.1560.78
68_N120_N1.1490.78
45_A81_Y1.1310.77
125_R135_V1.1270.76
95_L114_A1.1250.76
21_T24_I1.1240.76
61_N65_S1.1240.76
55_N82_V1.1200.76
124_V137_E1.1080.75
167_L171_F1.1050.75
60_I167_L1.0920.74
50_D79_V1.0920.74
118_N123_V1.0830.73
2_Y17_F1.0690.72
159_E164_I1.0690.72
162_E165_E1.0680.72
19_Q125_R1.0490.71
101_V113_E1.0410.70
147_D150_D1.0360.70
92_P96_S1.0270.69
37_W41_H1.0090.68
149_E152_W0.9990.67
2_Y132_V0.9970.67
147_D151_D0.9930.67
50_D87_L0.9890.66
159_E166_D0.9870.66
8_K34_L0.9800.66
41_H99_E0.9710.65
10_V100_E0.9580.64
70_T85_V0.9520.63
97_D159_E0.9430.63
33_I171_F0.9430.63
160_D168_D0.9360.62
6_I15_K0.9320.62
48_S163_E0.9310.62
30_P72_T0.9300.62
13_K16_K0.9260.61
69_N152_W0.9250.61
43_Y130_F0.9030.59
160_D163_E0.9010.59
48_S70_T0.9010.59
39_I102_I0.8980.59
36_C108_Q0.8960.59
164_I169_P0.8950.59
30_P108_Q0.8930.58
68_N163_E0.8910.58
48_S53_E0.8870.58
160_D164_I0.8830.58
56_G81_Y0.8830.58
59_D65_S0.8830.58
40_N59_D0.8740.57
78_T153_D0.8720.57
101_V138_T0.8700.56
50_D132_V0.8680.56
62_I76_K0.8670.56
12_G99_E0.8530.55
55_N168_D0.8500.55
81_Y128_R0.8490.55
59_D74_V0.8300.53
46_K100_E0.8290.53
27_P82_V0.8210.52
120_N172_L0.8200.52
56_G109_P0.8140.51
46_K76_K0.7950.50
58_Y130_F0.7900.49
17_F127_E0.7870.49
79_V134_V0.7860.49
88_S103_A0.7850.49
111_C172_L0.7850.49
13_K140_V0.7750.48
83_D107_Q0.7750.48
149_E164_I0.7730.48
140_V143_A0.7680.47
163_E167_L0.7670.47
31_T152_W0.7640.47
14_G124_V0.7640.47
161_D166_D0.7610.47
39_I61_N0.7600.47
58_Y110_N0.7590.47
35_G63_W0.7570.46
83_D137_E0.7560.46
49_G133_E0.7530.46
30_P65_S0.7460.45
67_D71_K0.7450.45
20_S54_V0.7350.44
153_D159_E0.7300.44
159_E171_F0.7300.44
24_I74_V0.7280.44
47_K50_D0.7250.44
3_R53_E0.7240.44
2_Y129_E0.7220.43
2_Y143_A0.7140.43
4_E8_K0.7050.42
13_K40_N0.7050.42
76_K83_D0.7040.42
25_T121_K0.7020.42
52_V62_I0.6980.41
4_E7_T0.6950.41
160_D166_D0.6920.41
12_G87_L0.6900.41
46_K121_K0.6840.40
107_Q127_E0.6830.40
32_S61_N0.6760.39
42_K125_R0.6730.39
79_V85_V0.6710.39
68_N112_V0.6700.39
38_V158_E0.6650.38
102_I108_Q0.6650.38
78_T119_G0.6640.38
85_V124_V0.6620.38
11_C99_E0.6570.38
26_P120_N0.6570.38
138_T144_V0.6570.38
163_E168_D0.6560.38
8_K39_I0.6440.37
143_A151_D0.6440.37
158_E166_D0.6410.36
152_W163_E0.6330.36
164_I170_D0.6320.36
49_G55_N0.6270.35
84_V160_D0.6250.35
64_Y109_P0.6230.35
51_K86_P0.6200.35
97_D120_N0.6180.35
108_Q116_I0.6170.34
156_D166_D0.6140.34
2_Y149_E0.6140.34
74_V85_V0.6130.34
24_I135_V0.6120.34
88_S165_E0.6070.34
90_R158_E0.6030.33
123_V170_D0.5980.33
20_S128_R0.5980.33
137_E140_V0.5970.33
145_N148_G0.5900.32
61_N72_T0.5900.32
34_L39_I0.5890.32
12_G50_D0.5850.32
104_R108_Q0.5840.32
38_V172_L0.5840.32
159_E167_L0.5830.32
161_D167_L0.5810.32
5_I9_A0.5800.32
24_I75_A0.5780.31
124_V142_V0.5750.31
70_T136_G0.5740.31
13_K39_I0.5740.31
132_V171_F0.5700.31
79_V111_C0.5690.31
6_I140_V0.5690.31
159_E172_L0.5620.30
26_P30_P0.5610.30
81_Y102_I0.5590.30
99_E135_V0.5590.30
32_S103_A0.5580.30
112_V125_R0.5560.30
43_Y128_R0.5550.30
7_T10_V0.5530.30
95_L122_I0.5530.30
117_S167_L0.5520.29
23_T38_V0.5510.29
52_V92_P0.5490.29
21_T31_T0.5470.29
3_R14_G0.5460.29
27_P55_N0.5450.29
52_V101_V0.5440.29
124_V171_F0.5430.29
13_K129_E0.5420.29
13_K81_Y0.5370.28
108_Q127_E0.5370.28
154_D157_D0.5340.28
47_K89_Y0.5310.28
22_H79_V0.5300.28
85_V146_P0.5290.28
48_S96_S0.5290.28
20_S42_K0.5280.28
57_S117_S0.5230.27
67_D73_E0.5230.27
61_N110_N0.5200.27
63_W142_V0.5200.27
12_G31_T0.5190.27
3_R6_I0.5170.27
8_K137_E0.5140.27
42_K134_V0.5140.27
11_C50_D0.5130.27
54_V107_Q0.5090.26
23_T167_L0.5080.26
18_F122_I0.5050.26
34_L137_E0.5050.26
47_K53_E0.5040.26
27_P149_E0.5040.26
156_D163_E0.5000.26
26_P137_E0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nqkA 2 0.592 5.4 0.961 Contact Map
3vu9A 1 0.4655 5.1 0.962 Contact Map
4qniA 5 0.5805 2.8 0.966 Contact Map
1l4tA 1 0.1552 2.4 0.968 Contact Map
1r75A 1 0.5402 2.4 0.968 Contact Map
3n0uA 1 0.3966 2.4 0.968 Contact Map
4ewcA 2 0.6609 2.3 0.968 Contact Map
2gpvG 1 0.069 2.1 0.968 Contact Map
3p02A 1 0.5632 1.9 0.969 Contact Map
3wa1A 4 0.4425 1.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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