CotE - PFAM28P - GREMLIN Contacts

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CotE - Outer spore coat protein E (CotE)

PFAM:	PF10628	Sequences: EYREIITKAVCGKGKKFFQSTHTITPPHKPTSILGCWVINHKYEAKKSGDKVEVNGSYDINIWYSYDNNTKTEVAKETVSYVDVVPLSYRDPNHLSDDEEVIARVLQQPNCVEATISNGNKIVVRVEREFGVEVVGETKVCVAVNPDGEDDWDDIDDEEDDEEIEDLDPDFLDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	174 (171)
Sequences:	731 (493)
Seq/√Len:	37.7
META:	0.64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_A	138_T	4.667	1.00
141_C	149_E	4.348	1.00
66_Y	73_E	3.400	1.00
166_D	170_D	3.284	1.00
163_E	166_D	3.011	1.00
24_I	62_I	2.846	1.00
22_H	58_Y	2.791	1.00
75_A	122_I	2.701	1.00
83_D	128_R	2.646	1.00
44_E	55_N	2.554	1.00
117_S	123_V	2.512	1.00
41_H	81_Y	2.495	1.00
2_Y	145_N	2.433	1.00
164_I	167_L	2.406	1.00
159_E	162_E	2.282	0.99
38_V	126_V	2.118	0.99
57_S	78_T	2.114	0.99
7_T	140_V	2.102	0.99
106_L	131_G	1.982	0.99
11_C	86_P	1.918	0.98
73_E	76_K	1.819	0.97
168_D	171_F	1.773	0.97
9_A	126_V	1.748	0.97
107_Q	110_N	1.700	0.96
54_V	85_V	1.696	0.96
45_A	137_E	1.685	0.96
72_T	133_E	1.680	0.96
54_V	97_D	1.659	0.96
30_P	33_I	1.625	0.95
152_W	155_I	1.588	0.94
26_P	33_I	1.557	0.94
161_D	164_I	1.521	0.93
55_N	67_D	1.490	0.92
18_F	83_D	1.481	0.92
47_K	110_N	1.470	0.92
37_W	61_N	1.449	0.91
166_D	169_P	1.399	0.90
168_D	172_L	1.368	0.88
165_E	168_D	1.333	0.87
13_K	37_W	1.262	0.84
114_A	133_E	1.258	0.84
11_C	24_I	1.256	0.84
158_E	161_D	1.247	0.83
91_D	107_Q	1.242	0.83
57_S	80_S	1.233	0.83
45_A	103_A	1.230	0.82
28_H	66_Y	1.221	0.82
28_H	119_G	1.219	0.82
36_C	104_R	1.214	0.82
85_V	132_V	1.213	0.81
10_V	92_P	1.209	0.81
165_E	169_P	1.208	0.81
39_I	70_T	1.202	0.81
51_K	84_V	1.188	0.80
17_F	23_T	1.187	0.80
39_I	71_K	1.187	0.80
164_I	171_F	1.186	0.80
157_D	160_D	1.182	0.80
115_T	125_R	1.176	0.79
20_S	58_Y	1.172	0.79
53_E	82_V	1.169	0.79
37_W	40_N	1.161	0.79
103_A	130_F	1.160	0.78
153_D	158_E	1.156	0.78
68_N	120_N	1.149	0.78
45_A	81_Y	1.131	0.77
125_R	135_V	1.127	0.76
95_L	114_A	1.125	0.76
21_T	24_I	1.124	0.76
61_N	65_S	1.124	0.76
55_N	82_V	1.120	0.76
124_V	137_E	1.108	0.75
167_L	171_F	1.105	0.75
60_I	167_L	1.092	0.74
50_D	79_V	1.092	0.74
118_N	123_V	1.083	0.73
2_Y	17_F	1.069	0.72
159_E	164_I	1.069	0.72
162_E	165_E	1.068	0.72
19_Q	125_R	1.049	0.71
101_V	113_E	1.041	0.70
147_D	150_D	1.036	0.70
92_P	96_S	1.027	0.69
37_W	41_H	1.009	0.68
149_E	152_W	0.999	0.67
2_Y	132_V	0.997	0.67
147_D	151_D	0.993	0.67
50_D	87_L	0.989	0.66
159_E	166_D	0.987	0.66
8_K	34_L	0.980	0.66
41_H	99_E	0.971	0.65
10_V	100_E	0.958	0.64
70_T	85_V	0.952	0.63
97_D	159_E	0.943	0.63
33_I	171_F	0.943	0.63
160_D	168_D	0.936	0.62
6_I	15_K	0.932	0.62
48_S	163_E	0.931	0.62
30_P	72_T	0.930	0.62
13_K	16_K	0.926	0.61
69_N	152_W	0.925	0.61
43_Y	130_F	0.903	0.59
160_D	163_E	0.901	0.59
48_S	70_T	0.901	0.59
39_I	102_I	0.898	0.59
36_C	108_Q	0.896	0.59
164_I	169_P	0.895	0.59
30_P	108_Q	0.893	0.58
68_N	163_E	0.891	0.58
48_S	53_E	0.887	0.58
160_D	164_I	0.883	0.58
56_G	81_Y	0.883	0.58
59_D	65_S	0.883	0.58
40_N	59_D	0.874	0.57
78_T	153_D	0.872	0.57
101_V	138_T	0.870	0.56
50_D	132_V	0.868	0.56
62_I	76_K	0.867	0.56
12_G	99_E	0.853	0.55
55_N	168_D	0.850	0.55
81_Y	128_R	0.849	0.55
59_D	74_V	0.830	0.53
46_K	100_E	0.829	0.53
27_P	82_V	0.821	0.52
120_N	172_L	0.820	0.52
56_G	109_P	0.814	0.51
46_K	76_K	0.795	0.50
58_Y	130_F	0.790	0.49
17_F	127_E	0.787	0.49
79_V	134_V	0.786	0.49
88_S	103_A	0.785	0.49
111_C	172_L	0.785	0.49
13_K	140_V	0.775	0.48
83_D	107_Q	0.775	0.48
149_E	164_I	0.773	0.48
140_V	143_A	0.768	0.47
163_E	167_L	0.767	0.47
31_T	152_W	0.764	0.47
14_G	124_V	0.764	0.47
161_D	166_D	0.761	0.47
39_I	61_N	0.760	0.47
58_Y	110_N	0.759	0.47
35_G	63_W	0.757	0.46
83_D	137_E	0.756	0.46
49_G	133_E	0.753	0.46
30_P	65_S	0.746	0.45
67_D	71_K	0.745	0.45
20_S	54_V	0.735	0.44
153_D	159_E	0.730	0.44
159_E	171_F	0.730	0.44
24_I	74_V	0.728	0.44
47_K	50_D	0.725	0.44
3_R	53_E	0.724	0.44
2_Y	129_E	0.722	0.43
2_Y	143_A	0.714	0.43
4_E	8_K	0.705	0.42
13_K	40_N	0.705	0.42
76_K	83_D	0.704	0.42
25_T	121_K	0.702	0.42
52_V	62_I	0.698	0.41
4_E	7_T	0.695	0.41
160_D	166_D	0.692	0.41
12_G	87_L	0.690	0.41
46_K	121_K	0.684	0.40
107_Q	127_E	0.683	0.40
32_S	61_N	0.676	0.39
42_K	125_R	0.673	0.39
79_V	85_V	0.671	0.39
68_N	112_V	0.670	0.39
38_V	158_E	0.665	0.38
102_I	108_Q	0.665	0.38
78_T	119_G	0.664	0.38
85_V	124_V	0.662	0.38
11_C	99_E	0.657	0.38
26_P	120_N	0.657	0.38
138_T	144_V	0.657	0.38
163_E	168_D	0.656	0.38
8_K	39_I	0.644	0.37
143_A	151_D	0.644	0.37
158_E	166_D	0.641	0.36
152_W	163_E	0.633	0.36
164_I	170_D	0.632	0.36
49_G	55_N	0.627	0.35
84_V	160_D	0.625	0.35
64_Y	109_P	0.623	0.35
51_K	86_P	0.620	0.35
97_D	120_N	0.618	0.35
108_Q	116_I	0.617	0.34
156_D	166_D	0.614	0.34
2_Y	149_E	0.614	0.34
74_V	85_V	0.613	0.34
24_I	135_V	0.612	0.34
88_S	165_E	0.607	0.34
90_R	158_E	0.603	0.33
123_V	170_D	0.598	0.33
20_S	128_R	0.598	0.33
137_E	140_V	0.597	0.33
145_N	148_G	0.590	0.32
61_N	72_T	0.590	0.32
34_L	39_I	0.589	0.32
12_G	50_D	0.585	0.32
104_R	108_Q	0.584	0.32
38_V	172_L	0.584	0.32
159_E	167_L	0.583	0.32
161_D	167_L	0.581	0.32
5_I	9_A	0.580	0.32
24_I	75_A	0.578	0.31
124_V	142_V	0.575	0.31
70_T	136_G	0.574	0.31
13_K	39_I	0.574	0.31
132_V	171_F	0.570	0.31
79_V	111_C	0.569	0.31
6_I	140_V	0.569	0.31
159_E	172_L	0.562	0.30
26_P	30_P	0.561	0.30
81_Y	102_I	0.559	0.30
99_E	135_V	0.559	0.30
32_S	103_A	0.558	0.30
112_V	125_R	0.556	0.30
43_Y	128_R	0.555	0.30
7_T	10_V	0.553	0.30
95_L	122_I	0.553	0.30
117_S	167_L	0.552	0.29
23_T	38_V	0.551	0.29
52_V	92_P	0.549	0.29
21_T	31_T	0.547	0.29
3_R	14_G	0.546	0.29
27_P	55_N	0.545	0.29
52_V	101_V	0.544	0.29
124_V	171_F	0.543	0.29
13_K	129_E	0.542	0.29
13_K	81_Y	0.537	0.28
108_Q	127_E	0.537	0.28
154_D	157_D	0.534	0.28
47_K	89_Y	0.531	0.28
22_H	79_V	0.530	0.28
85_V	146_P	0.529	0.28
48_S	96_S	0.529	0.28
20_S	42_K	0.528	0.28
57_S	117_S	0.523	0.27
67_D	73_E	0.523	0.27
61_N	110_N	0.520	0.27
63_W	142_V	0.520	0.27
12_G	31_T	0.519	0.27
3_R	6_I	0.517	0.27
8_K	137_E	0.514	0.27
42_K	134_V	0.514	0.27
11_C	50_D	0.513	0.27
54_V	107_Q	0.509	0.26
23_T	167_L	0.508	0.26
18_F	122_I	0.505	0.26
34_L	137_E	0.505	0.26
47_K	53_E	0.504	0.26
27_P	149_E	0.504	0.26
156_D	163_E	0.500	0.26
26_P	137_E	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nqkA	2	0.592	5.4	0.961	Contact Map
3vu9A	1	0.4655	5.1	0.962	Contact Map
4qniA	5	0.5805	2.8	0.966	Contact Map
1l4tA	1	0.1552	2.4	0.968	Contact Map
1r75A	1	0.5402	2.4	0.968	Contact Map
3n0uA	1	0.3966	2.4	0.968	Contact Map
4ewcA	2	0.6609	2.3	0.968	Contact Map
2gpvG	1	0.069	2.1	0.968	Contact Map
3p02A	1	0.5632	1.9	0.969	Contact Map
3wa1A	4	0.4425	1.8	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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