GREMLIN Database
CsgE - Curli assembly protein CsgE
PFAM: PF10627 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (97)
Sequences: 992 (723)
Seq/√Len: 73.5
META: 0.716

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_D15_R3.3991.00
12_K16_D3.2261.00
21_F82_V3.0671.00
90_E93_K2.8261.00
60_Y78_A2.7111.00
39_K53_E2.5991.00
24_K76_E2.3331.00
75_A79_V2.0321.00
44_A47_G1.9841.00
8_E39_K1.9551.00
49_Q61_Q1.9221.00
5_V22_Y1.8081.00
54_V85_Y1.7851.00
6_I37_T1.7611.00
58_V61_Q1.7451.00
54_V82_V1.7201.00
20_Y68_Y1.6821.00
16_D20_Y1.6681.00
43_S47_G1.6541.00
20_Y72_E1.6511.00
41_R51_W1.5600.99
51_W58_V1.4870.99
13_I47_G1.4840.99
21_F38_I1.4800.99
1_I4_L1.4170.99
10_I41_R1.4120.99
53_E58_V1.3970.98
81_R84_Q1.3820.98
43_S46_R1.3660.98
84_Q87_Q1.3310.98
84_Q88_N1.3070.98
60_Y74_M1.2990.98
41_R49_Q1.2810.97
20_Y75_A1.2800.97
39_K51_W1.2290.97
2_D31_A1.1860.96
32_S36_I1.1840.96
28_P34_F1.1570.95
20_Y71_I1.1060.94
24_K79_V1.1020.94
52_V57_K1.0790.93
55_N89_L1.0680.93
15_R19_D1.0650.92
8_E37_T1.0590.92
5_V36_I1.0500.92
60_Y77_Q1.0440.92
10_I14_G1.0180.91
12_K22_Y1.0060.90
20_Y69_D0.9970.90
95_L98_T0.9660.88
16_D72_E0.9580.88
44_A48_T0.9380.87
65_Q69_D0.9360.87
6_I43_S0.9280.86
34_F42_P0.9250.86
36_I54_V0.9230.86
92_Q96_L0.9220.86
1_I15_R0.9110.85
42_P49_Q0.9060.85
7_D11_T0.8870.84
47_G51_W0.8850.83
60_Y81_R0.8850.83
74_M79_V0.8530.81
18_Y22_Y0.8500.81
11_T48_T0.8490.81
30_G37_T0.8450.80
73_E76_E0.8380.80
50_I72_E0.8360.80
16_D22_Y0.8310.79
10_I42_P0.8260.79
92_Q95_L0.8210.79
56_D94_K0.8100.78
88_N91_L0.8040.77
25_W28_P0.8030.77
18_Y21_F0.7940.76
48_T89_L0.7810.75
45_G56_D0.7690.74
28_P31_A0.7670.74
34_F55_N0.7650.73
85_Y89_L0.7560.73
83_Y87_Q0.7540.72
1_I14_G0.7230.69
52_V59_V0.7200.69
21_F36_I0.7010.67
91_L95_L0.7000.67
4_L55_N0.6960.66
19_D66_P0.6930.66
15_R63_F0.6900.66
81_R88_N0.6860.65
41_R48_T0.6860.65
11_T77_Q0.6860.65
71_I89_L0.6840.65
12_K15_R0.6830.65
2_D75_A0.6770.64
67_R70_Y0.6740.64
31_A55_N0.6720.64
33_N90_E0.6660.63
7_D13_I0.6650.63
25_W90_E0.6550.62
53_E57_K0.6460.61
24_K27_A0.6460.61
60_Y83_Y0.6450.60
49_Q65_Q0.6370.59
28_P80_R0.6370.59
3_G18_Y0.6370.59
59_V82_V0.6330.59
77_Q81_R0.6230.58
25_W64_L0.6220.58
2_D32_S0.6200.57
30_G79_V0.6180.57
32_S82_V0.6170.57
23_S64_L0.6160.57
57_K72_E0.6120.56
19_D36_I0.6090.56
25_W30_G0.5950.54
13_I64_L0.5930.54
78_A82_V0.5930.54
14_G17_F0.5890.54
64_L77_Q0.5810.53
73_E77_Q0.5800.52
77_Q80_R0.5790.52
25_W44_A0.5760.52
17_F59_V0.5730.52
89_L96_L0.5660.51
49_Q53_E0.5650.51
65_Q70_Y0.5620.50
30_G47_G0.5590.50
11_T14_G0.5580.50
25_W34_F0.5540.49
5_V25_W0.5510.49
28_P79_V0.5510.49
32_S86_L0.5450.48
9_T82_V0.5370.47
62_F77_Q0.5350.47
46_R63_F0.5330.47
55_N71_I0.5320.47
52_V92_Q0.5260.46
91_L94_K0.5200.45
21_F64_L0.5200.45
87_Q91_L0.5200.45
43_S68_Y0.5170.45
46_R66_P0.5170.45
25_W38_I0.5080.44
36_I62_F0.5030.43
12_K72_E0.5020.43
2_D55_N0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dwcA 3 0.9333 19.7 0.908 Contact Map
3ugfA 2 0.9048 14.8 0.913 Contact Map
2ac1A 1 0.8762 13.5 0.915 Contact Map
4c3xA 4 0.8952 11.7 0.917 Contact Map
2lfcA 1 0.8381 10.4 0.919 Contact Map
2o34A 1 0.7429 8 0.923 Contact Map
1st8A 1 0.9048 7.6 0.924 Contact Map
1gyxA 2 0.6571 7.6 0.924 Contact Map
3sksA 1 0.9333 7.3 0.924 Contact Map
4pwwA 2 0.4381 6.4 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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