GREMLIN Database
Tail_tube - Phage tail tube protein
PFAM: PF10618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (114)
Sequences: 1488 (1212)
Seq/√Len: 113.5
META: 0.799

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_I74_A3.1401.00
56_T105_E2.8181.00
33_E47_T2.3651.00
52_Y109_R2.2741.00
54_E109_R2.2641.00
73_D90_N2.1391.00
32_R46_E2.0281.00
33_E45_K2.0221.00
34_T111_E1.9221.00
36_V50_A1.9031.00
64_D67_D1.9021.00
34_T92_W1.7901.00
24_T98_E1.7881.00
31_K47_T1.7771.00
15_E67_D1.7511.00
20_K105_E1.7411.00
9_Y79_E1.7231.00
88_L91_A1.6511.00
39_D42_H1.6491.00
37_G42_H1.6451.00
34_T50_A1.6421.00
26_N52_Y1.5901.00
26_N98_E1.5871.00
56_T107_E1.5791.00
24_T54_E1.5581.00
20_K58_T1.5381.00
54_E107_E1.5321.00
79_E85_T1.5041.00
42_H58_T1.4831.00
22_G56_T1.4431.00
88_L112_G1.4411.00
76_V110_F1.4141.00
95_G109_R1.4131.00
41_V92_W1.4101.00
31_K49_R1.3951.00
4_I18_P1.3801.00
31_K96_E1.3481.00
13_D74_A1.3321.00
59_D84_K1.3141.00
23_F55_G1.3141.00
100_N105_E1.3081.00
30_V46_E1.2920.99
11_K16_Q1.2710.99
25_Y86_Y1.2660.99
26_N49_R1.2630.99
24_T100_N1.2510.99
94_T111_E1.1970.99
31_K95_G1.1710.99
93_V97_P1.1530.99
77_T85_T1.1270.99
38_Q101_T1.1260.99
51_P88_L1.1230.99
37_G43_G1.1100.98
11_K79_E1.0960.98
19_L55_G1.0890.98
66_E70_A1.0750.98
23_F78_A1.0450.98
52_Y111_E1.0400.98
9_Y16_Q1.0370.97
22_G102_E1.0300.97
93_V108_V1.0250.97
51_P113_L1.0170.97
25_Y78_A1.0150.97
34_T94_T0.9800.96
8_A19_L0.9800.96
53_I88_L0.9720.96
53_I78_A0.9680.96
71_I110_F0.9550.96
32_R72_T0.9510.96
12_V17_L0.9360.95
36_V41_V0.9340.95
49_R96_E0.9260.95
4_I60_T0.9190.95
18_P60_T0.9070.95
45_K102_E0.8990.94
4_I35_V0.8950.94
27_P115_C0.8920.94
5_A59_D0.8920.94
8_A76_V0.8870.94
53_I112_G0.8700.93
4_I58_T0.8700.93
11_K77_T0.8680.93
88_L115_C0.8580.93
19_L23_F0.8540.93
35_V58_T0.8420.92
32_R44_Y0.8380.92
2_N72_T0.8360.92
35_V45_K0.8190.91
50_A111_E0.8080.90
3_R81_A0.8020.90
90_N113_L0.8020.90
46_E72_T0.7980.90
10_I55_G0.7940.90
51_P115_C0.7920.90
65_L106_I0.7910.89
20_K56_T0.7870.89
7_T38_Q0.7850.89
51_P112_G0.7830.89
59_D82_N0.7810.89
44_Y92_W0.7720.88
20_K35_V0.7700.88
59_D99_V0.7590.87
22_G100_N0.7550.87
59_D63_L0.7490.87
99_V106_I0.7330.86
77_T87_V0.7300.85
76_V91_A0.7230.85
27_P86_Y0.7200.85
69_N97_P0.7170.84
38_Q48_P0.7160.84
28_G51_P0.7150.84
12_V71_I0.7010.83
34_T41_V0.6970.83
56_T100_N0.6850.82
3_R7_T0.6840.81
53_I76_V0.6830.81
86_Y115_C0.6820.81
13_D67_D0.6750.81
100_N103_E0.6740.80
44_Y72_T0.6720.80
3_R46_E0.6670.80
46_E92_W0.6660.80
10_I57_I0.6620.79
69_N93_V0.6590.79
29_G69_N0.6460.78
71_I93_V0.6420.77
9_Y77_T0.6370.77
36_V48_P0.6330.76
5_A104_G0.6280.76
47_T102_E0.6190.75
59_D106_I0.6120.74
13_D71_I0.6080.73
37_G58_T0.6030.73
68_L71_I0.6030.73
55_G110_F0.6020.73
28_G115_C0.5890.71
25_Y99_V0.5840.70
92_W111_E0.5780.69
93_V110_F0.5760.69
78_A86_Y0.5760.69
80_L86_Y0.5710.69
26_N96_E0.5710.69
32_R92_W0.5700.68
23_F57_I0.5650.68
38_Q47_T0.5650.68
98_E107_E0.5630.67
16_Q77_T0.5620.67
89_R114_S0.5600.67
28_G97_P0.5600.67
63_L68_L0.5560.67
50_A94_T0.5550.66
17_L57_I0.5500.66
57_I108_V0.5490.66
37_G41_V0.5460.65
27_P65_L0.5440.65
12_V74_A0.5380.64
52_Y98_E0.5330.63
30_V48_P0.5320.63
7_T30_V0.5260.62
54_E111_E0.5260.62
8_A23_F0.5250.62
97_P108_V0.5230.62
63_L106_I0.5210.62
26_N109_R0.5180.61
8_A78_A0.5160.61
5_A35_V0.5150.61
17_L108_V0.5150.61
91_A115_C0.5110.60
55_G108_V0.5100.60
100_N107_E0.5030.59
64_D84_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q1zA 1 0.5214 16.4 0.902 Contact Map
4aynA 2 0.7179 11.7 0.908 Contact Map
2x8kA 5 0.906 11 0.909 Contact Map
4xinA 2 0.906 9 0.913 Contact Map
2vf1A 10 0.8889 9 0.913 Contact Map
1v7wA 2 0.3162 7.1 0.917 Contact Map
2ypvA 1 0.906 5.7 0.92 Contact Map
1r6vA 1 0.4786 5.7 0.92 Contact Map
3w7tA 1 0.9487 5.2 0.922 Contact Map
2lfuA 1 0.4872 4.9 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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