GREMLIN Database
DUF2469 - Protein of unknown function (DUF2469)
PFAM: PF10611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (96)
Sequences: 1495 (403)
Seq/√Len: 41.1
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V27_M4.1021.00
6_L11_A3.6651.00
43_E62_T3.0241.00
8_R13_L2.6071.00
19_R23_D2.4741.00
47_Q60_T2.3751.00
45_D60_T2.3691.00
41_A61_L2.2841.00
11_A16_Q2.0600.99
46_V59_V2.0030.99
9_Y13_L1.9710.99
58_E80_R1.9180.99
3_A6_L1.8730.98
8_R11_A1.7780.98
49_R58_E1.7640.98
22_R25_V1.7410.97
2_S6_L1.6430.96
27_M69_M1.6060.96
46_V81_V1.5900.96
32_V44_V1.5590.95
6_L16_Q1.4800.94
13_L16_Q1.4200.92
79_V88_N1.3970.91
48_V57_F1.3440.90
33_E37_R1.3370.89
31_V79_V1.3080.88
6_L10_E1.2970.88
31_V38_F1.2970.88
3_A11_A1.2950.88
64_A73_A1.2830.87
2_S10_E1.2770.87
8_R12_E1.2570.86
91_E94_K1.1950.83
85_K94_K1.1860.83
61_L64_A1.1760.82
61_L81_V1.1730.82
53_G56_Y1.1700.82
5_D8_R1.1610.82
29_R76_V1.1410.80
18_Y31_V1.1380.80
56_Y77_K1.1250.79
3_A8_R1.1150.79
46_V54_D1.0940.77
57_F73_A1.0920.77
77_K93_P1.0880.77
62_T78_S1.0840.77
2_S11_A1.0810.77
70_Y76_V1.0580.75
69_M72_P1.0520.75
55_V64_A1.0320.73
36_R85_K1.0220.72
36_R66_V1.0050.71
33_E38_F1.0020.71
8_R26_P0.9770.69
47_Q51_E0.9760.69
18_Y22_R0.9650.68
52_G89_V0.9500.67
46_V72_P0.9170.64
41_A50_S0.9140.64
38_F88_N0.9090.63
4_E11_A0.8730.60
93_P97_L0.8710.60
55_V77_K0.8270.56
4_E13_L0.8170.55
7_E10_E0.8140.55
38_F67_W0.8140.55
14_E38_F0.7810.52
19_R31_V0.7740.51
46_V57_F0.7650.50
54_D77_K0.7640.50
50_S56_Y0.7550.49
70_Y82_L0.7280.47
72_P78_S0.7270.47
83_T86_D0.7270.47
37_R75_F0.7260.47
11_A18_Y0.7190.46
50_S55_V0.7180.46
45_D48_V0.7090.45
77_K95_K0.7080.45
49_R55_V0.7000.44
54_D61_L0.6980.44
50_S53_G0.6940.44
12_E28_F0.6910.43
56_Y72_P0.6900.43
67_W83_T0.6850.43
60_T78_S0.6840.43
35_E82_L0.6820.43
94_K97_L0.6800.42
19_R25_V0.6800.42
4_E29_R0.6790.42
19_R56_Y0.6780.42
56_Y84_F0.6730.42
26_P43_E0.6720.42
60_T80_R0.6680.41
61_L77_K0.6640.41
19_R29_R0.6630.41
2_S7_E0.6570.40
12_E18_Y0.6550.40
62_T81_V0.6550.40
73_A83_T0.6540.40
85_K93_P0.6510.40
23_D54_D0.6500.40
2_S5_D0.6430.39
82_L85_K0.6430.39
31_V67_W0.6330.38
3_A7_E0.6300.38
18_Y56_Y0.6290.38
15_L18_Y0.6210.37
48_V55_V0.6140.37
8_R25_V0.6090.36
67_W70_Y0.6070.36
51_E55_V0.6070.36
33_E75_F0.6040.36
76_V82_L0.6000.35
13_L17_L0.6000.35
21_Y34_T0.5990.35
55_V84_F0.5980.35
53_G64_A0.5940.35
48_V56_Y0.5910.35
12_E16_Q0.5730.33
84_F88_N0.5720.33
57_F62_T0.5660.33
24_V71_R0.5650.32
37_R44_V0.5640.32
34_T81_V0.5640.32
43_E47_Q0.5370.30
32_V84_F0.5360.30
49_R56_Y0.5340.30
79_V83_T0.5320.30
17_L76_V0.5280.30
50_S57_F0.5280.30
4_E7_E0.5250.29
48_V89_V0.5250.29
73_A77_K0.5220.29
7_E13_L0.5220.29
68_D90_E0.5180.29
69_M87_V0.5160.29
29_R78_S0.5140.28
51_E54_D0.5120.28
18_Y54_D0.5060.28
33_E71_R0.5050.28
52_G55_V0.5010.28
18_Y53_G0.5010.28
26_P97_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e6oA 1 0.29 6.2 0.95 Contact Map
3hymA 1 0.16 5 0.952 Contact Map
4rbnA 3 0.86 4.5 0.953 Contact Map
2v7yA 1 0.29 4.1 0.954 Contact Map
4rtfD 1 0 4 0.954 Contact Map
1gvnA 2 0.29 3.7 0.955 Contact Map
2op6A 1 0.34 3.3 0.956 Contact Map
2hbpA 1 0.23 3.3 0.956 Contact Map
3dqgA 2 0.34 3.2 0.957 Contact Map
2jshA 1 0.13 2.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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