GREMLIN Database
zf-LITAF-like - LITAF-like zinc ribbon domain
PFAM: PF10601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (68)
Sequences: 2310 (1926)
Seq/√Len: 233.6
META: 0.542

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V60_P3.1011.00
19_V55_V2.4811.00
10_H64_A2.4151.00
17_T57_H2.3961.00
28_W47_F2.2861.00
21_Y55_V2.2561.00
24_G54_D2.0271.00
22_E56_V1.9661.00
38_G41_P1.8931.00
3_P16_T1.8141.00
31_C47_F1.7261.00
13_Q61_N1.7171.00
18_R63_G1.6601.00
7_T14_E1.6111.00
18_R58_Y1.5971.00
44_L48_C1.5481.00
20_E58_Y1.5401.00
41_P44_L1.5151.00
5_Q14_E1.4591.00
56_V65_V1.4491.00
56_V68_T1.3581.00
23_P27_T1.3411.00
59_C62_C1.3411.00
7_T12_G1.3231.00
58_Y65_V1.3041.00
24_G27_T1.2561.00
23_P53_K1.2461.00
28_W31_C1.1811.00
21_Y53_K1.1671.00
34_L39_C1.1491.00
27_T52_C1.1351.00
26_L30_L1.1041.00
27_T31_C1.0861.00
4_V67_G1.0851.00
6_V15_V1.0811.00
50_D53_K1.0721.00
46_P49_I0.9651.00
25_T29_L0.9621.00
29_L33_L0.9511.00
8_C11_C0.9421.00
43_C46_P0.9241.00
65_V68_T0.9071.00
28_W32_L0.8960.99
26_L29_L0.8010.99
39_C42_C0.7980.99
11_C62_C0.7850.99
26_L69_Y0.7830.99
19_V57_H0.7820.99
42_C45_I0.7760.99
40_L44_L0.7740.98
9_P12_G0.7740.98
15_V57_H0.7650.98
6_V66_L0.7580.98
31_C35_C0.7440.98
27_T53_K0.7420.98
57_H67_G0.7330.98
4_V7_T0.7180.98
17_T66_L0.7130.97
21_Y50_D0.7080.97
42_C46_P0.7000.97
9_P66_L0.6960.97
35_C39_C0.6920.97
16_T60_P0.6870.97
32_L36_L0.6840.97
5_Q16_T0.6760.96
14_E21_Y0.6610.96
8_C59_C0.6590.96
34_L40_L0.6580.96
20_E56_V0.6500.96
27_T47_F0.6480.95
15_V61_N0.6430.95
11_C59_C0.6390.95
15_V66_L0.6380.95
27_T46_P0.6300.95
8_C62_C0.6260.95
46_P50_D0.6170.94
54_D68_T0.6020.93
5_Q12_G0.5940.93
58_Y63_G0.5910.93
58_Y66_L0.5900.93
38_G42_C0.5880.93
55_V69_Y0.5870.93
34_L38_G0.5860.92
7_T10_H0.5820.92
35_C38_G0.5820.92
23_P31_C0.5750.92
18_R60_P0.5630.91
21_Y56_V0.5560.90
13_Q18_R0.5480.90
31_C43_C0.5470.90
37_F40_L0.5410.89
7_T68_T0.5360.89
16_T20_E0.5360.89
2_E20_E0.5360.89
34_L44_L0.5330.88
42_C49_I0.5300.88
30_L46_P0.5270.88
4_V69_Y0.5240.88
2_E68_T0.5240.88
33_L38_G0.5210.87
38_G48_C0.5090.86
22_E37_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgyA 1 0 42 0.784 Contact Map
2jrpA 1 0.8857 35.6 0.792 Contact Map
2gaiA 1 0 32.8 0.796 Contact Map
3w0fA 1 0.4571 26.5 0.806 Contact Map
1k3xA 1 0.4714 19.8 0.817 Contact Map
1k82A 1 0.4714 19.3 0.818 Contact Map
2kdxA 1 0.5 17.6 0.821 Contact Map
1gh9A 1 0.4857 16.1 0.824 Contact Map
3u6pA 1 0.4714 16 0.824 Contact Map
1twfL 1 0.4286 13.4 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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