AIPR - PFAM28P - GREMLIN Contacts

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AIPR - AIPR protein

PFAM:	PF10592	Sequences: FERNVRSFLGATGKVNKGIRETLLNEPEMFFAYNNGITITADSVELDRGNDGGLGILKLKNLQIVNGGQTTASIYEARKKDADLSDVFVLVKIIVVPEKDEELVPKISRATNSQNKVKAADLRSNDPFQKRLEELSRQRETGWFYERKRGQYKNELKFKPKSQIITKTDLAKALNAAWLGKPHIASRGKQKIFKEWEKDLKFGKLYNEIFNDSLNYKKLIAKAILFRKLEKLIKKQYDGGYRANIVYYILALLSYLLKKKIDLDKIWKKQKISEELEEALEKIAKEVNDVITNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	294 (280)
Sequences:	6229 (5143)
Seq/√Len:	307.3
META:	0.812

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_Q	145_Y	4.956	1.00
42_D	61_N	4.413	1.00
21_E	25_N	4.171	1.00
43_S	60_K	4.025	1.00
43_S	95_V	3.757	1.00
18_G	113_S	3.050	1.00
20_R	24_L	2.862	1.00
45_E	58_K	2.851	1.00
41_A	44_V	2.833	1.00
177_A	247_Y	2.817	1.00
192_I	196_W	2.786	1.00
156_L	159_K	2.731	1.00
33_Y	110_A	2.711	1.00
133_E	151_Q	2.698	1.00
103_L	107_I	2.692	1.00
64_I	71_T	2.475	1.00
39_I	91_V	2.447	1.00
23_L	87_V	2.429	1.00
39_I	62_L	2.395	1.00
109_R	119_A	2.205	1.00
1_F	68_G	2.182	1.00
133_E	147_R	2.127	1.00
20_R	77_A	2.048	1.00
181_K	184_I	2.034	1.00
230_E	242_R	2.033	1.00
131_R	134_E	2.011	1.00
106_K	109_R	1.999	1.00
193_F	197_E	1.998	1.00
33_Y	106_K	1.967	1.00
193_F	196_W	1.950	1.00
173_A	223_A	1.931	1.00
23_L	74_I	1.881	1.00
206_Y	210_F	1.865	1.00
252_L	256_L	1.860	1.00
121_D	149_R	1.859	1.00
92_K	111_T	1.794	1.00
248_Y	251_A	1.756	1.00
18_G	109_R	1.752	1.00
223_A	227_R	1.748	1.00
227_R	230_E	1.679	1.00
225_L	229_L	1.675	1.00
20_R	73_S	1.664	1.00
38_T	94_I	1.662	1.00
26_E	29_M	1.653	1.00
23_L	77_A	1.647	1.00
131_R	135_L	1.621	1.00
18_G	21_E	1.613	1.00
230_E	234_K	1.610	1.00
18_G	110_A	1.606	1.00
26_E	106_K	1.580	1.00
279_A	282_K	1.556	1.00
28_E	86_D	1.530	1.00
262_D	265_K	1.508	1.00
265_K	269_K	1.499	1.00
8_F	11_A	1.478	1.00
219_L	222_K	1.458	1.00
41_A	95_V	1.448	1.00
180_G	255_Y	1.447	1.00
232_L	235_K	1.445	1.00
228_K	232_L	1.434	1.00
228_K	231_K	1.414	1.00
68_G	72_A	1.407	1.00
177_A	250_L	1.395	1.00
13_G	115_N	1.391	1.00
274_E	278_E	1.379	1.00
22_T	33_Y	1.366	1.00
34_N	70_T	1.365	1.00
264_D	268_K	1.364	1.00
274_E	277_E	1.356	1.00
211_N	214_L	1.351	1.00
123_R	126_D	1.345	1.00
133_E	137_R	1.338	1.00
21_E	24_L	1.337	1.00
127_P	131_R	1.334	1.00
44_V	95_V	1.333	1.00
136_S	170_L	1.315	1.00
59_L	93_I	1.314	1.00
29_M	103_L	1.290	1.00
146_E	152_Y	1.285	1.00
48_R	51_D	1.282	1.00
35_N	66_N	1.281	1.00
130_K	134_E	1.279	1.00
244_N	248_Y	1.271	1.00
120_A	167_K	1.257	1.00
250_L	254_S	1.253	1.00
59_L	62_L	1.247	1.00
226_F	230_E	1.241	1.00
206_Y	209_I	1.240	1.00
195_E	198_K	1.218	1.00
42_D	60_K	1.210	1.00
24_L	81_D	1.208	1.00
177_A	180_G	1.201	1.00
46_L	57_L	1.195	1.00
15_V	19_I	1.193	1.00
19_I	73_S	1.187	1.00
186_S	244_N	1.180	1.00
220_I	224_I	1.174	1.00
141_T	163_Q	1.172	1.00
205_L	208_E	1.171	1.00
218_K	264_D	1.171	1.00
183_H	186_S	1.167	1.00
73_S	115_N	1.161	1.00
278_E	281_E	1.160	1.00
166_T	169_D	1.152	1.00
29_M	33_Y	1.151	1.00
192_I	197_E	1.148	1.00
9_L	149_R	1.146	1.00
196_W	200_L	1.134	1.00
74_I	87_V	1.110	1.00
271_K	277_E	1.105	1.00
24_L	80_K	1.104	1.00
136_S	216_Y	1.103	1.00
165_I	170_L	1.095	1.00
188_G	191_K	1.094	1.00
184_I	187_R	1.093	1.00
195_E	199_D	1.093	1.00
244_N	247_Y	1.092	1.00
249_I	283_I	1.087	1.00
120_A	168_T	1.087	1.00
218_K	222_K	1.085	1.00
17_K	21_E	1.084	1.00
261_I	266_I	1.080	1.00
170_L	219_L	1.071	1.00
77_A	81_D	1.058	1.00
12_T	115_N	1.057	1.00
15_V	115_N	1.047	1.00
223_A	233_I	1.041	1.00
228_K	271_K	1.032	1.00
8_F	73_S	1.031	1.00
15_V	113_S	1.023	1.00
22_T	34_N	1.016	1.00
210_F	215_N	1.014	1.00
247_Y	250_L	1.011	1.00
265_K	268_K	1.011	1.00
219_L	223_A	1.011	1.00
222_K	226_F	1.010	1.00
254_S	258_K	1.009	1.00
246_V	249_I	1.009	1.00
134_E	137_R	1.008	1.00
187_R	191_K	1.006	1.00
252_L	255_Y	1.004	1.00
271_K	274_E	1.003	1.00
16_N	115_N	0.998	1.00
174_L	179_L	0.997	1.00
192_I	195_E	0.988	1.00
224_I	228_K	0.978	1.00
246_V	251_A	0.977	1.00
143_W	148_K	0.976	1.00
73_S	77_A	0.974	1.00
253_L	283_I	0.974	1.00
143_W	147_R	0.973	1.00
275_E	279_A	0.971	1.00
172_K	189_K	0.970	1.00
5_V	108_S	0.969	1.00
126_D	129_Q	0.967	1.00
8_F	72_A	0.965	1.00
229_L	280_L	0.962	1.00
193_F	200_L	0.956	1.00
230_E	233_I	0.950	1.00
169_D	172_K	0.948	1.00
231_K	235_K	0.945	1.00
245_I	248_Y	0.944	1.00
35_N	114_Q	0.944	1.00
68_G	108_S	0.941	1.00
244_N	251_A	0.938	1.00
144_F	147_R	0.928	1.00
183_H	187_R	0.925	1.00
130_K	133_E	0.916	1.00
161_K	164_I	0.915	1.00
279_A	283_I	0.915	1.00
174_L	222_K	0.913	1.00
144_F	152_Y	0.912	1.00
168_T	189_K	0.909	1.00
278_E	282_K	0.909	1.00
200_L	206_Y	0.899	1.00
243_A	246_V	0.899	1.00
10_G	16_N	0.899	1.00
14_K	119_A	0.895	1.00
75_Y	79_K	0.894	1.00
280_L	283_I	0.891	1.00
272_I	277_E	0.890	1.00
39_I	59_L	0.887	1.00
38_T	111_T	0.886	1.00
277_E	281_E	0.878	1.00
96_V	100_D	0.876	1.00
27_P	87_V	0.873	1.00
263_L	266_I	0.872	1.00
49_G	52_G	0.872	1.00
2_E	7_S	0.872	1.00
39_I	93_I	0.871	1.00
220_I	223_A	0.870	1.00
255_Y	259_K	0.865	1.00
229_L	233_I	0.860	1.00
268_K	271_K	0.858	1.00
192_I	200_L	0.856	1.00
192_I	206_Y	0.854	1.00
150_G	153_K	0.854	1.00
269_K	273_S	0.853	1.00
45_E	60_K	0.851	1.00
186_S	189_K	0.850	1.00
251_A	254_S	0.847	1.00
228_K	277_E	0.845	1.00
5_V	117_V	0.844	1.00
243_A	248_Y	0.842	1.00
245_I	249_I	0.832	1.00
180_G	254_S	0.831	1.00
9_L	115_N	0.827	1.00
144_F	155_E	0.826	1.00
20_R	76_E	0.823	1.00
11_A	76_E	0.820	1.00
65_V	108_S	0.818	1.00
223_A	228_K	0.816	1.00
106_K	110_A	0.805	1.00
3_R	7_S	0.805	1.00
108_S	122_L	0.803	1.00
147_R	151_Q	0.803	1.00
276_L	279_A	0.800	1.00
81_D	84_L	0.794	1.00
194_K	197_E	0.793	1.00
275_E	283_I	0.792	1.00
216_Y	219_L	0.783	1.00
109_R	122_L	0.781	0.99
205_L	210_F	0.779	0.99
123_R	129_Q	0.776	0.99
173_A	226_F	0.772	0.99
143_W	224_I	0.769	0.99
151_Q	154_N	0.768	0.99
262_D	268_K	0.768	0.99
143_W	220_I	0.764	0.99
96_V	103_L	0.764	0.99
102_E	106_K	0.754	0.99
165_I	220_I	0.752	0.99
194_K	198_K	0.748	0.99
146_E	150_G	0.747	0.99
265_K	270_Q	0.746	0.99
129_Q	167_K	0.745	0.99
226_F	229_L	0.744	0.99
222_K	230_E	0.744	0.99
248_Y	252_L	0.743	0.99
239_G	242_R	0.742	0.99
202_F	206_Y	0.734	0.99
31_F	92_K	0.733	0.99
57_L	93_I	0.731	0.99
187_R	190_Q	0.730	0.99
136_S	143_W	0.727	0.99
184_I	188_G	0.727	0.99
203_G	207_N	0.727	0.99
117_V	121_D	0.725	0.99
217_K	221_A	0.724	0.99
183_H	188_G	0.724	0.99
243_A	251_A	0.723	0.99
69_Q	114_Q	0.720	0.99
24_L	77_A	0.719	0.99
247_Y	251_A	0.718	0.99
145_Y	149_R	0.717	0.99
255_Y	258_K	0.712	0.99
160_P	163_Q	0.711	0.99
224_I	227_R	0.711	0.99
56_I	59_L	0.704	0.99
49_G	55_G	0.701	0.99
204_K	207_N	0.701	0.99
37_I	71_T	0.699	0.99
170_L	173_A	0.699	0.99
263_L	267_W	0.699	0.99
263_L	272_I	0.695	0.99
126_D	206_Y	0.695	0.99
47_D	55_G	0.695	0.99
121_D	167_K	0.693	0.99
169_D	227_R	0.689	0.99
132_L	219_L	0.688	0.99
203_G	206_Y	0.682	0.99
262_D	266_I	0.680	0.99
110_A	115_N	0.679	0.99
148_K	151_Q	0.679	0.99
74_I	89_V	0.679	0.99
63_Q	147_R	0.677	0.99
185_A	189_K	0.675	0.99
267_W	270_Q	0.673	0.98
16_N	35_N	0.672	0.98
59_L	63_Q	0.668	0.98
264_D	267_W	0.666	0.98
276_L	280_L	0.664	0.98
265_K	271_K	0.664	0.98
20_R	80_K	0.662	0.98
246_V	250_L	0.659	0.98
277_E	282_K	0.656	0.98
277_E	280_L	0.654	0.98
73_S	110_A	0.654	0.98
46_L	54_L	0.653	0.98
11_A	20_R	0.641	0.98
221_A	225_L	0.640	0.98
66_N	69_Q	0.639	0.98
94_I	111_T	0.635	0.98
263_L	269_K	0.635	0.98
102_E	105_P	0.634	0.98
143_W	146_E	0.634	0.98
113_S	116_K	0.633	0.98
40_T	63_Q	0.633	0.98
102_E	130_K	0.632	0.98
216_Y	220_I	0.630	0.98
128_F	131_R	0.629	0.98
142_G	163_Q	0.629	0.98
275_E	278_E	0.627	0.98
146_E	151_Q	0.626	0.98
72_A	75_Y	0.625	0.98
271_K	281_E	0.625	0.98
241_Y	244_N	0.625	0.98
16_N	73_S	0.622	0.97
26_E	33_Y	0.620	0.97
54_L	57_L	0.619	0.97
229_L	250_L	0.617	0.97
82_A	85_S	0.617	0.97
169_D	173_A	0.615	0.97
267_W	271_K	0.614	0.97
83_D	86_D	0.613	0.97
230_E	246_V	0.612	0.97
257_L	261_I	0.610	0.97
266_I	272_I	0.610	0.97
177_A	181_K	0.607	0.97
25_N	28_E	0.607	0.97
49_G	53_G	0.606	0.97
147_R	150_G	0.605	0.97
267_W	272_I	0.605	0.97
245_I	252_L	0.602	0.97
46_L	55_G	0.598	0.97
38_T	117_V	0.595	0.97
142_G	147_R	0.593	0.97
269_K	282_K	0.593	0.97
275_E	281_E	0.592	0.97
244_N	250_L	0.591	0.97
197_E	200_L	0.591	0.97
40_T	108_S	0.589	0.97
21_E	26_E	0.588	0.96
47_D	50_N	0.586	0.96
221_A	224_I	0.584	0.96
225_L	250_L	0.581	0.96
273_S	276_L	0.581	0.96
202_F	205_L	0.580	0.96
173_A	222_K	0.577	0.96
232_L	281_E	0.576	0.96
74_I	84_L	0.575	0.96
123_R	128_F	0.572	0.96
69_Q	124_S	0.571	0.96
129_Q	132_L	0.570	0.96
263_L	270_Q	0.570	0.96
125_N	175_N	0.568	0.96
208_E	212_D	0.568	0.96
35_N	69_Q	0.568	0.96
226_F	233_I	0.567	0.96
238_D	245_I	0.567	0.96
180_G	251_A	0.566	0.96
265_K	272_I	0.566	0.96
198_K	202_F	0.565	0.96
251_A	255_Y	0.565	0.96
247_Y	252_L	0.563	0.96
63_Q	68_G	0.562	0.95
84_L	87_V	0.560	0.95
224_I	230_E	0.557	0.95
212_D	215_N	0.557	0.95
245_I	250_L	0.555	0.95
32_A	103_L	0.555	0.95
272_I	276_L	0.554	0.95
264_D	271_K	0.551	0.95
237_Y	242_R	0.551	0.95
147_R	152_Y	0.550	0.95
45_E	57_L	0.550	0.95
167_K	171_A	0.548	0.95
29_M	106_K	0.548	0.95
40_T	104_V	0.547	0.95
210_F	214_L	0.545	0.95
222_K	225_L	0.545	0.95
31_F	113_S	0.544	0.95
19_I	22_T	0.544	0.95
109_R	113_S	0.542	0.95
175_N	192_I	0.540	0.94
47_D	58_K	0.539	0.94
48_R	52_G	0.539	0.94
142_G	145_Y	0.537	0.94
192_I	199_D	0.537	0.94
196_W	199_D	0.536	0.94
274_E	281_E	0.535	0.94
110_A	113_S	0.533	0.94
16_N	19_I	0.532	0.94
16_N	69_Q	0.532	0.94
271_K	282_K	0.532	0.94
249_I	253_L	0.531	0.94
47_D	57_L	0.526	0.94
236_Q	281_E	0.525	0.94
199_D	210_F	0.525	0.94
223_A	230_E	0.524	0.93
276_L	282_K	0.522	0.93
100_D	105_P	0.522	0.93
132_L	170_L	0.522	0.93
24_L	82_A	0.520	0.93
125_N	167_K	0.519	0.93
269_K	274_E	0.518	0.93
263_L	276_L	0.518	0.93
216_Y	222_K	0.517	0.93
246_V	253_L	0.517	0.93
277_E	283_I	0.515	0.93
265_K	275_E	0.515	0.93
37_I	64_I	0.512	0.93
171_A	175_N	0.512	0.93
124_S	148_K	0.511	0.93
253_L	280_L	0.509	0.92
9_L	12_T	0.508	0.92
116_K	187_R	0.508	0.92
261_I	264_D	0.507	0.92
202_F	210_F	0.506	0.92
75_Y	78_R	0.506	0.92
205_L	209_I	0.505	0.92
97_P	100_D	0.505	0.92
175_N	179_L	0.505	0.92
274_E	282_K	0.504	0.92
229_L	232_L	0.502	0.92
10_G	65_V	0.502	0.92
2_E	13_G	0.501	0.92
186_S	190_Q	0.500	0.92
31_F	94_I	0.500	0.92
232_L	236_Q	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nnoA	1	0.4456	7	0.958	Contact Map
4oxrA	2	0.4456	6.9	0.958	Contact Map
1pq4A	1	0.4286	5.7	0.96	Contact Map
4xrvA	1	0.4456	4.5	0.962	Contact Map
1el6A	3	0.2619	4.2	0.962	Contact Map
4utoA	1	0.449	4.2	0.962	Contact Map
1wh9A	1	0.2823	4.1	0.962	Contact Map
3zk9A	1	0.449	4	0.962	Contact Map
2o1eA	1	0.4422	3.4	0.964	Contact Map
4cl2A	1	0.4354	2.9	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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