GREMLIN Database
AIPR - AIPR protein
PFAM: PF10592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 294 (280)
Sequences: 6229 (5143)
Seq/√Len: 307.3
META: 0.812

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_Q145_Y4.9561.00
42_D61_N4.4131.00
21_E25_N4.1711.00
43_S60_K4.0251.00
43_S95_V3.7571.00
18_G113_S3.0501.00
20_R24_L2.8621.00
45_E58_K2.8511.00
41_A44_V2.8331.00
177_A247_Y2.8171.00
192_I196_W2.7861.00
156_L159_K2.7311.00
33_Y110_A2.7111.00
133_E151_Q2.6981.00
103_L107_I2.6921.00
64_I71_T2.4751.00
39_I91_V2.4471.00
23_L87_V2.4291.00
39_I62_L2.3951.00
109_R119_A2.2051.00
1_F68_G2.1821.00
133_E147_R2.1271.00
20_R77_A2.0481.00
181_K184_I2.0341.00
230_E242_R2.0331.00
131_R134_E2.0111.00
106_K109_R1.9991.00
193_F197_E1.9981.00
33_Y106_K1.9671.00
193_F196_W1.9501.00
173_A223_A1.9311.00
23_L74_I1.8811.00
206_Y210_F1.8651.00
252_L256_L1.8601.00
121_D149_R1.8591.00
92_K111_T1.7941.00
248_Y251_A1.7561.00
18_G109_R1.7521.00
223_A227_R1.7481.00
227_R230_E1.6791.00
225_L229_L1.6751.00
20_R73_S1.6641.00
38_T94_I1.6621.00
26_E29_M1.6531.00
23_L77_A1.6471.00
131_R135_L1.6211.00
18_G21_E1.6131.00
230_E234_K1.6101.00
18_G110_A1.6061.00
26_E106_K1.5801.00
279_A282_K1.5561.00
28_E86_D1.5301.00
262_D265_K1.5081.00
265_K269_K1.4991.00
8_F11_A1.4781.00
219_L222_K1.4581.00
41_A95_V1.4481.00
180_G255_Y1.4471.00
232_L235_K1.4451.00
228_K232_L1.4341.00
228_K231_K1.4141.00
68_G72_A1.4071.00
177_A250_L1.3951.00
13_G115_N1.3911.00
274_E278_E1.3791.00
22_T33_Y1.3661.00
34_N70_T1.3651.00
264_D268_K1.3641.00
274_E277_E1.3561.00
211_N214_L1.3511.00
123_R126_D1.3451.00
133_E137_R1.3381.00
21_E24_L1.3371.00
127_P131_R1.3341.00
44_V95_V1.3331.00
136_S170_L1.3151.00
59_L93_I1.3141.00
29_M103_L1.2901.00
146_E152_Y1.2851.00
48_R51_D1.2821.00
35_N66_N1.2811.00
130_K134_E1.2791.00
244_N248_Y1.2711.00
120_A167_K1.2571.00
250_L254_S1.2531.00
59_L62_L1.2471.00
226_F230_E1.2411.00
206_Y209_I1.2401.00
195_E198_K1.2181.00
42_D60_K1.2101.00
24_L81_D1.2081.00
177_A180_G1.2011.00
46_L57_L1.1951.00
15_V19_I1.1931.00
19_I73_S1.1871.00
186_S244_N1.1801.00
220_I224_I1.1741.00
141_T163_Q1.1721.00
205_L208_E1.1711.00
218_K264_D1.1711.00
183_H186_S1.1671.00
73_S115_N1.1611.00
278_E281_E1.1601.00
166_T169_D1.1521.00
29_M33_Y1.1511.00
192_I197_E1.1481.00
9_L149_R1.1461.00
196_W200_L1.1341.00
74_I87_V1.1101.00
271_K277_E1.1051.00
24_L80_K1.1041.00
136_S216_Y1.1031.00
165_I170_L1.0951.00
188_G191_K1.0941.00
184_I187_R1.0931.00
195_E199_D1.0931.00
244_N247_Y1.0921.00
249_I283_I1.0871.00
120_A168_T1.0871.00
218_K222_K1.0851.00
17_K21_E1.0841.00
261_I266_I1.0801.00
170_L219_L1.0711.00
77_A81_D1.0581.00
12_T115_N1.0571.00
15_V115_N1.0471.00
223_A233_I1.0411.00
228_K271_K1.0321.00
8_F73_S1.0311.00
15_V113_S1.0231.00
22_T34_N1.0161.00
210_F215_N1.0141.00
247_Y250_L1.0111.00
265_K268_K1.0111.00
219_L223_A1.0111.00
222_K226_F1.0101.00
254_S258_K1.0091.00
246_V249_I1.0091.00
134_E137_R1.0081.00
187_R191_K1.0061.00
252_L255_Y1.0041.00
271_K274_E1.0031.00
16_N115_N0.9981.00
174_L179_L0.9971.00
192_I195_E0.9881.00
224_I228_K0.9781.00
246_V251_A0.9771.00
143_W148_K0.9761.00
73_S77_A0.9741.00
253_L283_I0.9741.00
143_W147_R0.9731.00
275_E279_A0.9711.00
172_K189_K0.9701.00
5_V108_S0.9691.00
126_D129_Q0.9671.00
8_F72_A0.9651.00
229_L280_L0.9621.00
193_F200_L0.9561.00
230_E233_I0.9501.00
169_D172_K0.9481.00
231_K235_K0.9451.00
245_I248_Y0.9441.00
35_N114_Q0.9441.00
68_G108_S0.9411.00
244_N251_A0.9381.00
144_F147_R0.9281.00
183_H187_R0.9251.00
130_K133_E0.9161.00
161_K164_I0.9151.00
279_A283_I0.9151.00
174_L222_K0.9131.00
144_F152_Y0.9121.00
168_T189_K0.9091.00
278_E282_K0.9091.00
200_L206_Y0.8991.00
243_A246_V0.8991.00
10_G16_N0.8991.00
14_K119_A0.8951.00
75_Y79_K0.8941.00
280_L283_I0.8911.00
272_I277_E0.8901.00
39_I59_L0.8871.00
38_T111_T0.8861.00
277_E281_E0.8781.00
96_V100_D0.8761.00
27_P87_V0.8731.00
263_L266_I0.8721.00
49_G52_G0.8721.00
2_E7_S0.8721.00
39_I93_I0.8711.00
220_I223_A0.8701.00
255_Y259_K0.8651.00
229_L233_I0.8601.00
268_K271_K0.8581.00
192_I200_L0.8561.00
192_I206_Y0.8541.00
150_G153_K0.8541.00
269_K273_S0.8531.00
45_E60_K0.8511.00
186_S189_K0.8501.00
251_A254_S0.8471.00
228_K277_E0.8451.00
5_V117_V0.8441.00
243_A248_Y0.8421.00
245_I249_I0.8321.00
180_G254_S0.8311.00
9_L115_N0.8271.00
144_F155_E0.8261.00
20_R76_E0.8231.00
11_A76_E0.8201.00
65_V108_S0.8181.00
223_A228_K0.8161.00
106_K110_A0.8051.00
3_R7_S0.8051.00
108_S122_L0.8031.00
147_R151_Q0.8031.00
276_L279_A0.8001.00
81_D84_L0.7941.00
194_K197_E0.7931.00
275_E283_I0.7921.00
216_Y219_L0.7831.00
109_R122_L0.7810.99
205_L210_F0.7790.99
123_R129_Q0.7760.99
173_A226_F0.7720.99
143_W224_I0.7690.99
151_Q154_N0.7680.99
262_D268_K0.7680.99
143_W220_I0.7640.99
96_V103_L0.7640.99
102_E106_K0.7540.99
165_I220_I0.7520.99
194_K198_K0.7480.99
146_E150_G0.7470.99
265_K270_Q0.7460.99
129_Q167_K0.7450.99
226_F229_L0.7440.99
222_K230_E0.7440.99
248_Y252_L0.7430.99
239_G242_R0.7420.99
202_F206_Y0.7340.99
31_F92_K0.7330.99
57_L93_I0.7310.99
187_R190_Q0.7300.99
136_S143_W0.7270.99
184_I188_G0.7270.99
203_G207_N0.7270.99
117_V121_D0.7250.99
217_K221_A0.7240.99
183_H188_G0.7240.99
243_A251_A0.7230.99
69_Q114_Q0.7200.99
24_L77_A0.7190.99
247_Y251_A0.7180.99
145_Y149_R0.7170.99
255_Y258_K0.7120.99
160_P163_Q0.7110.99
224_I227_R0.7110.99
56_I59_L0.7040.99
49_G55_G0.7010.99
204_K207_N0.7010.99
37_I71_T0.6990.99
170_L173_A0.6990.99
263_L267_W0.6990.99
263_L272_I0.6950.99
126_D206_Y0.6950.99
47_D55_G0.6950.99
121_D167_K0.6930.99
169_D227_R0.6890.99
132_L219_L0.6880.99
203_G206_Y0.6820.99
262_D266_I0.6800.99
110_A115_N0.6790.99
148_K151_Q0.6790.99
74_I89_V0.6790.99
63_Q147_R0.6770.99
185_A189_K0.6750.99
267_W270_Q0.6730.98
16_N35_N0.6720.98
59_L63_Q0.6680.98
264_D267_W0.6660.98
276_L280_L0.6640.98
265_K271_K0.6640.98
20_R80_K0.6620.98
246_V250_L0.6590.98
277_E282_K0.6560.98
277_E280_L0.6540.98
73_S110_A0.6540.98
46_L54_L0.6530.98
11_A20_R0.6410.98
221_A225_L0.6400.98
66_N69_Q0.6390.98
94_I111_T0.6350.98
263_L269_K0.6350.98
102_E105_P0.6340.98
143_W146_E0.6340.98
113_S116_K0.6330.98
40_T63_Q0.6330.98
102_E130_K0.6320.98
216_Y220_I0.6300.98
128_F131_R0.6290.98
142_G163_Q0.6290.98
275_E278_E0.6270.98
146_E151_Q0.6260.98
72_A75_Y0.6250.98
271_K281_E0.6250.98
241_Y244_N0.6250.98
16_N73_S0.6220.97
26_E33_Y0.6200.97
54_L57_L0.6190.97
229_L250_L0.6170.97
82_A85_S0.6170.97
169_D173_A0.6150.97
267_W271_K0.6140.97
83_D86_D0.6130.97
230_E246_V0.6120.97
257_L261_I0.6100.97
266_I272_I0.6100.97
177_A181_K0.6070.97
25_N28_E0.6070.97
49_G53_G0.6060.97
147_R150_G0.6050.97
267_W272_I0.6050.97
245_I252_L0.6020.97
46_L55_G0.5980.97
38_T117_V0.5950.97
142_G147_R0.5930.97
269_K282_K0.5930.97
275_E281_E0.5920.97
244_N250_L0.5910.97
197_E200_L0.5910.97
40_T108_S0.5890.97
21_E26_E0.5880.96
47_D50_N0.5860.96
221_A224_I0.5840.96
225_L250_L0.5810.96
273_S276_L0.5810.96
202_F205_L0.5800.96
173_A222_K0.5770.96
232_L281_E0.5760.96
74_I84_L0.5750.96
123_R128_F0.5720.96
69_Q124_S0.5710.96
129_Q132_L0.5700.96
263_L270_Q0.5700.96
125_N175_N0.5680.96
208_E212_D0.5680.96
35_N69_Q0.5680.96
226_F233_I0.5670.96
238_D245_I0.5670.96
180_G251_A0.5660.96
265_K272_I0.5660.96
198_K202_F0.5650.96
251_A255_Y0.5650.96
247_Y252_L0.5630.96
63_Q68_G0.5620.95
84_L87_V0.5600.95
224_I230_E0.5570.95
212_D215_N0.5570.95
245_I250_L0.5550.95
32_A103_L0.5550.95
272_I276_L0.5540.95
264_D271_K0.5510.95
237_Y242_R0.5510.95
147_R152_Y0.5500.95
45_E57_L0.5500.95
167_K171_A0.5480.95
29_M106_K0.5480.95
40_T104_V0.5470.95
210_F214_L0.5450.95
222_K225_L0.5450.95
31_F113_S0.5440.95
19_I22_T0.5440.95
109_R113_S0.5420.95
175_N192_I0.5400.94
47_D58_K0.5390.94
48_R52_G0.5390.94
142_G145_Y0.5370.94
192_I199_D0.5370.94
196_W199_D0.5360.94
274_E281_E0.5350.94
110_A113_S0.5330.94
16_N19_I0.5320.94
16_N69_Q0.5320.94
271_K282_K0.5320.94
249_I253_L0.5310.94
47_D57_L0.5260.94
236_Q281_E0.5250.94
199_D210_F0.5250.94
223_A230_E0.5240.93
276_L282_K0.5220.93
100_D105_P0.5220.93
132_L170_L0.5220.93
24_L82_A0.5200.93
125_N167_K0.5190.93
269_K274_E0.5180.93
263_L276_L0.5180.93
216_Y222_K0.5170.93
246_V253_L0.5170.93
277_E283_I0.5150.93
265_K275_E0.5150.93
37_I64_I0.5120.93
171_A175_N0.5120.93
124_S148_K0.5110.93
253_L280_L0.5090.92
9_L12_T0.5080.92
116_K187_R0.5080.92
261_I264_D0.5070.92
202_F210_F0.5060.92
75_Y78_R0.5060.92
205_L209_I0.5050.92
97_P100_D0.5050.92
175_N179_L0.5050.92
274_E282_K0.5040.92
229_L232_L0.5020.92
10_G65_V0.5020.92
2_E13_G0.5010.92
186_S190_Q0.5000.92
31_F94_I0.5000.92
232_L236_Q0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nnoA 1 0.4456 7 0.958 Contact Map
4oxrA 2 0.4456 6.9 0.958 Contact Map
1pq4A 1 0.4286 5.7 0.96 Contact Map
4xrvA 1 0.4456 4.5 0.962 Contact Map
1el6A 3 0.2619 4.2 0.962 Contact Map
4utoA 1 0.449 4.2 0.962 Contact Map
1wh9A 1 0.2823 4.1 0.962 Contact Map
3zk9A 1 0.449 4 0.962 Contact Map
2o1eA 1 0.4422 3.4 0.964 Contact Map
4cl2A 1 0.4354 2.9 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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