GREMLIN Database
MTP18 - Mitochondrial 18 KDa protein (MTP18)
PFAM: PF10558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 159 (142)
Sequences: 502 (303)
Seq/√Len: 25.4
META: 0.333

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_G93_M5.7671.00
115_I143_V5.0081.00
116_V136_P3.7991.00
40_W43_R3.3571.00
119_S139_L2.9371.00
34_R42_V2.5080.99
47_G51_A2.3830.98
147_L150_P2.3460.98
24_A27_S2.3380.98
84_P87_E2.2750.98
119_S123_L2.2640.98
44_A47_G2.2620.98
33_F100_Q2.1600.97
59_D63_K2.1450.97
99_F156_E2.1280.97
50_W101_S2.0230.95
58_A61_G1.8520.93
22_Y100_Q1.8040.92
49_S105_M1.6940.89
123_L135_G1.6370.87
61_G65_Y1.6350.87
107_L151_I1.6280.87
117_A121_K1.6200.87
151_I155_V1.5760.85
148_P154_P1.5570.84
32_A142_A1.5340.83
32_A137_T1.5330.83
49_S111_T1.4370.79
22_Y45_A1.4330.79
45_A49_S1.4010.77
105_M109_A1.3930.77
64_A67_R1.3820.76
113_H116_V1.3820.76
100_Q155_V1.3650.75
14_T18_S1.3410.74
147_L154_P1.3250.73
70_R89_V1.3210.73
35_P136_P1.2900.71
54_L58_A1.2870.71
37_V41_L1.2770.70
22_Y33_F1.2590.69
153_E157_H1.2570.69
60_E63_K1.2380.68
50_W54_L1.2290.67
145_P152_D1.2260.67
24_A28_D1.2130.66
107_L155_V1.2130.66
49_S153_E1.2020.65
27_S105_M1.1710.63
24_A99_F1.1580.63
10_A15_I1.1500.62
128_N132_R1.1410.61
32_A101_S1.1170.60
34_R110_F1.1070.59
10_A14_T1.1060.59
99_F148_P1.0940.58
39_P43_R1.0750.57
148_P151_I1.0740.57
27_S113_H1.0730.57
100_Q105_M1.0490.55
62_Y122_A1.0320.54
94_V119_S1.0210.53
82_H86_L1.0140.52
61_G89_V1.0120.52
101_S106_A1.0120.52
39_P44_A1.0010.51
98_V124_K0.9960.51
27_S100_Q0.9940.51
72_L130_R0.9880.50
64_A92_V0.9760.49
98_V110_F0.9580.48
28_D144_I0.9570.48
24_A100_Q0.9560.48
13_R149_Y0.9550.48
57_V61_G0.9270.46
10_A17_L0.9250.46
49_S109_A0.9240.46
141_L145_P0.9170.45
20_H23_L0.9140.45
84_P88_D0.9120.45
39_P136_P0.9110.45
12_L16_L0.9100.45
12_L15_I0.9080.45
23_L102_L0.9050.44
38_P43_R0.9010.44
64_A69_Q0.8980.44
38_P142_A0.8920.43
100_Q140_G0.8880.43
90_R97_A0.8770.42
48_V59_D0.8770.42
37_V53_V0.8660.42
115_I119_S0.8570.41
107_L113_H0.8570.41
50_W105_M0.8520.41
90_R93_M0.8520.41
86_L93_M0.8450.40
61_G101_S0.8430.40
51_A153_E0.8370.39
106_A110_F0.8340.39
39_P116_V0.8340.39
32_A90_R0.8270.39
35_P50_W0.8190.38
73_E85_P0.8170.38
54_L98_V0.8160.38
10_A98_V0.8090.38
47_G66_L0.8060.37
54_L97_A0.7980.37
140_G145_P0.7940.37
82_H85_P0.7900.36
28_D147_L0.7870.36
24_A109_A0.7830.36
129_P135_G0.7830.36
71_P158_A0.7790.36
22_Y148_P0.7780.35
114_S118_Y0.7730.35
100_Q109_A0.7620.34
93_M156_E0.7540.34
148_P156_E0.7520.34
12_L40_W0.7440.33
50_W98_V0.7430.33
131_L146_F0.7350.33
104_S112_I0.7310.32
33_F111_T0.7290.32
54_L106_A0.7250.32
25_Y30_G0.7250.32
27_S109_A0.7240.32
48_V63_K0.7240.32
10_A13_R0.7220.32
59_D97_A0.7100.31
69_Q73_E0.7090.31
141_L152_D0.7090.31
29_V131_L0.6990.30
43_R50_W0.6960.30
27_S57_V0.6890.30
146_F155_V0.6840.29
137_T140_G0.6790.29
110_F114_S0.6750.29
144_I151_I0.6690.29
24_A45_A0.6690.29
36_V134_W0.6610.28
13_R17_L0.6580.28
135_G139_L0.6570.28
10_A16_L0.6560.28
85_P130_R0.6540.28
147_L151_I0.6540.28
121_K124_K0.6520.28
33_F141_L0.6500.27
110_F113_H0.6480.27
25_Y104_S0.6400.27
81_G84_P0.6380.27
71_P81_G0.6370.27
40_W86_L0.6350.27
98_V131_L0.6310.26
24_A105_M0.6280.26
32_A100_Q0.6220.26
68_N89_V0.6200.26
33_F137_T0.6200.26
110_F143_V0.6190.26
109_A150_P0.6110.25
99_F109_A0.6110.25
65_Y137_T0.6030.25
30_G46_Y0.6020.25
65_Y89_V0.6000.25
11_R14_T0.5980.24
29_V133_T0.5930.24
37_V114_S0.5910.24
98_V102_L0.5900.24
45_A109_A0.5900.24
91_V95_D0.5850.24
128_N131_L0.5800.24
28_D99_F0.5790.23
68_N90_R0.5790.23
149_Y154_P0.5780.23
48_V86_L0.5770.23
32_A35_P0.5690.23
31_E46_Y0.5660.23
51_A66_L0.5620.23
11_R15_I0.5580.22
99_F154_P0.5580.22
114_S117_A0.5570.22
35_P135_G0.5570.22
28_D60_E0.5550.22
21_R24_A0.5530.22
109_A151_I0.5530.22
22_Y32_A0.5520.22
93_M97_A0.5510.22
125_N131_L0.5460.22
122_A146_F0.5450.22
49_S104_S0.5440.22
49_S117_A0.5420.22
125_N132_R0.5380.21
85_P88_D0.5370.21
53_V109_A0.5370.21
83_V129_P0.5360.21
24_A57_V0.5330.21
123_L126_A0.5300.21
53_V146_F0.5290.21
150_P154_P0.5290.21
47_G122_A0.5260.21
81_G85_P0.5250.21
85_P91_V0.5240.21
53_V97_A0.5220.21
120_G136_P0.5200.21
53_V60_E0.5180.20
54_L94_V0.5130.20
38_P41_L0.5120.20
60_E96_R0.5110.20
10_A23_L0.5110.20
68_N73_E0.5100.20
99_F103_A0.5100.20
45_A53_V0.5070.20
37_V134_W0.5010.20
107_L129_P0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75L 1 0 7.6 0.956 Contact Map
1wvhA 1 0.2767 1.6 0.969 Contact Map
1fryA 1 0.1824 1.5 0.969 Contact Map
3nrtA 2 0.195 1.4 0.97 Contact Map
1jcnA 6 0.3648 1.4 0.97 Contact Map
1gvfA 3 0.4403 1.3 0.97 Contact Map
2cqkA 1 0.2893 1.3 0.971 Contact Map
3zv0C 2 0.3396 1.1 0.972 Contact Map
2i53A 1 0.6164 1.1 0.972 Contact Map
1irzA 1 0.3962 1 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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