GREMLIN Database
Phage_ASH - Ash protein family
PFAM: PF10554 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (102)
Sequences: 533 (304)
Seq/√Len: 30.1
META: 0.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_K91_K4.3211.00
19_L90_L3.9541.00
20_K64_P3.5831.00
64_P91_K3.4021.00
14_G80_G3.2571.00
56_Q60_W3.0831.00
6_P10_A2.8731.00
65_V90_L2.8691.00
19_L65_V2.6741.00
78_E82_S2.5731.00
14_G69_A2.5340.99
15_N68_I2.4960.99
53_R73_R2.4780.99
69_A80_G2.2120.98
15_N81_N2.1010.98
61_P67_G1.8710.96
68_I81_N1.7790.94
5_A11_A1.7530.94
94_A97_A1.7440.94
12_G16_P1.6310.91
13_R79_I1.6090.91
57_P60_W1.4830.87
72_V76_T1.4420.85
52_A74_A1.4080.84
55_G71_P1.4000.83
13_R70_N1.3870.83
96_M99_T1.2950.78
78_E81_N1.2060.73
62_V66_A1.1920.72
70_N79_I1.1920.72
54_A72_V1.1730.71
13_R68_I1.1650.70
24_D27_P1.1120.66
65_V89_L1.0970.65
69_A81_N1.0960.65
15_N69_A1.0960.65
15_N70_N1.0590.63
18_L89_L1.0470.62
96_M100_P1.0170.59
56_Q59_G1.0120.59
73_R76_T0.9990.58
19_L64_P0.9870.57
51_V75_T0.9610.55
70_N76_T0.9510.54
70_N81_N0.9420.53
64_P90_L0.9310.53
65_V91_K0.9060.51
15_N79_I0.9020.50
53_R74_A0.9000.50
70_N75_T0.8970.50
14_G79_I0.8820.49
68_I80_G0.8670.48
14_G81_N0.8590.47
18_L65_V0.8450.46
20_K90_L0.8410.45
35_A38_H0.8380.45
42_G45_F0.8370.45
95_I99_T0.8360.45
68_I79_I0.8340.45
69_A79_I0.8300.45
13_R81_N0.8260.44
14_G68_I0.8000.42
74_A85_S0.7980.42
20_K65_V0.7820.41
97_A100_P0.7820.41
1_Y5_A0.7810.41
18_L66_A0.7720.40
15_N80_G0.7670.40
28_A31_F0.7610.39
72_V75_T0.7590.39
52_A73_R0.7400.38
68_I76_T0.7390.38
98_T102_T0.7360.37
99_T102_T0.7360.37
39_P42_G0.7350.37
68_I71_P0.7270.37
96_M102_T0.7240.36
6_P11_A0.7230.36
19_L66_A0.7140.36
7_A10_A0.7100.35
14_G70_N0.7090.35
43_Q46_A0.7000.35
22_T25_A0.6950.34
6_P9_S0.6930.34
66_A90_L0.6920.34
60_W68_I0.6770.33
75_T84_G0.6700.33
95_I100_P0.6640.32
49_S52_A0.6630.32
34_V38_H0.6450.31
41_F44_W0.6450.31
2_S6_P0.6440.31
44_W48_Q0.6410.31
21_A25_A0.6410.31
73_R85_S0.6350.30
33_V37_P0.6310.30
92_E95_I0.6260.30
29_V32_R0.6260.30
13_R80_G0.6260.30
41_F45_F0.6260.30
95_I98_T0.6230.29
29_V33_V0.6220.29
68_I77_P0.6190.29
19_L91_K0.6140.29
95_I102_T0.6060.28
71_P75_T0.6050.28
12_G67_G0.6030.28
13_R69_A0.5990.28
31_F37_P0.5990.28
5_A10_A0.5950.28
36_T45_F0.5930.27
53_R85_S0.5920.27
99_T104_S0.5920.27
36_T40_F0.5920.27
93_A102_T0.5850.27
12_G15_N0.5800.27
35_A39_P0.5730.26
23_N32_R0.5700.26
44_W47_I0.5700.26
49_S77_P0.5630.26
52_A85_S0.5600.25
8_K21_A0.5580.25
40_F43_Q0.5490.25
32_R38_H0.5470.25
65_V88_N0.5470.25
43_Q47_I0.5470.25
49_S104_S0.5400.24
70_N80_G0.5390.24
34_V39_P0.5350.24
3_F6_P0.5310.24
71_P81_N0.5310.24
12_G61_P0.5290.24
18_L88_N0.5290.24
28_A93_A0.5290.24
94_A98_T0.5270.23
31_F34_V0.5250.23
8_K13_R0.5240.23
27_P31_F0.5240.23
73_R77_P0.5210.23
2_S10_A0.5190.23
16_P67_G0.5180.23
29_V36_T0.5180.23
9_S17_N0.5140.23
84_G94_A0.5140.23
13_R16_P0.5110.23
24_D29_V0.5090.22
34_V40_F0.5080.22
94_A99_T0.5080.22
93_A99_T0.5060.22
54_A57_P0.5040.22
25_A31_F0.5010.22
22_T29_V0.5010.22
41_F46_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lajA 7 0.2222 2.6 0.942 Contact Map
1q38A 1 0.3611 2 0.946 Contact Map
3qwqB 1 0.2407 1.7 0.948 Contact Map
2zy4A 6 0.8796 1.6 0.948 Contact Map
2kbgA 1 0.2963 1.6 0.949 Contact Map
2ee3A 1 0.3333 1.5 0.95 Contact Map
2pc4A 4 0.3148 1.3 0.951 Contact Map
1iarB 1 0.2407 1 0.955 Contact Map
3tgoC 2 0.3148 1 0.955 Contact Map
2b8kG 1 0 1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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