GREMLIN Database
ORF6C - ORF6C domain
PFAM: PF10552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (106)
Sequences: 1076 (867)
Seq/√Len: 84.2
META: 0.653

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R27_E6.0391.00
15_R20_E4.3071.00
19_V23_V3.0461.00
12_L16_I3.0271.00
83_V89_I2.7561.00
77_L89_I2.6591.00
93_D96_E2.3661.00
5_L9_I2.3421.00
6_L10_E2.2831.00
44_V74_Y2.0631.00
9_I12_L1.9921.00
5_L8_A1.8021.00
90_P93_D1.7871.00
8_A13_D1.7821.00
16_I19_V1.7661.00
23_V26_L1.7611.00
41_Q45_K1.6071.00
76_D80_R1.5931.00
74_Y86_Y1.5110.99
48_V70_F1.5050.99
6_L9_I1.4780.99
34_P37_Q1.4730.99
39_E94_F1.4110.99
34_P88_D1.4080.99
8_A12_L1.3770.99
43_A98_L1.3640.99
43_A102_E1.3320.99
62_D66_R1.3210.99
5_L11_E1.3030.98
54_G57_S1.2820.98
20_E27_E1.2620.98
44_V77_L1.2560.98
47_R50_E1.2390.98
74_Y77_L1.2140.98
57_S60_Y1.1880.97
84_P88_D1.1600.97
73_I101_I1.1460.97
10_E13_D1.1320.96
5_L13_D1.1300.96
13_D17_D1.1200.96
47_R51_L1.1160.96
31_T88_D1.1110.96
77_L97_A1.0910.95
54_G60_Y1.0400.94
44_V73_I1.0330.94
5_L12_L1.0310.94
35_G88_D1.0180.93
75_R79_R1.0020.93
8_A11_E1.0000.93
105_E111_K0.9950.93
40_L101_I0.9890.92
100_F109_N0.9890.92
6_L12_L0.9680.92
36_Q91_R0.9630.91
94_F98_L0.9530.91
37_Q85_S0.9490.91
31_T34_P0.9290.90
85_S88_D0.9230.89
74_Y78_K0.9150.89
45_K48_V0.9080.89
33_D36_Q0.9060.89
78_K84_P0.8940.88
66_R70_F0.8880.88
76_D104_W0.8820.87
40_L97_A0.8790.87
76_D100_F0.8580.86
38_R87_K0.8570.86
47_R101_I0.8550.86
24_E28_N0.8490.85
37_Q88_D0.8490.85
9_I13_D0.8480.85
42_K79_R0.8420.85
10_E14_E0.8420.85
5_L10_E0.8380.84
43_A46_K0.8300.84
51_L106_P0.8270.84
72_D104_W0.8240.83
45_K70_F0.8200.83
72_D79_R0.8170.83
36_Q94_F0.8130.83
108_T111_K0.8010.82
40_L89_I0.7980.81
38_R42_K0.7970.81
81_F97_A0.7950.81
84_P87_K0.7590.78
7_Q10_E0.7500.77
81_F96_E0.7390.76
78_K85_S0.7350.76
76_D79_R0.7310.75
31_T37_Q0.7270.75
40_L74_Y0.7140.74
38_R85_S0.7060.73
95_D99_E0.7000.72
99_E103_N0.6980.72
53_G60_Y0.6980.72
74_Y85_S0.6880.71
7_Q13_D0.6770.70
41_Q74_Y0.6760.70
15_R19_V0.6690.69
49_V52_L0.6600.68
7_Q11_E0.6510.67
107_P110_L0.6500.67
11_E16_I0.6490.66
52_L60_Y0.6440.66
12_L19_V0.6380.65
78_K86_Y0.6270.64
98_L102_E0.6270.64
95_D98_L0.6240.63
32_L40_L0.6220.63
43_A101_I0.6220.63
20_E24_E0.6190.63
37_Q87_K0.6170.63
53_G59_A0.6160.62
10_E16_I0.6150.62
41_Q78_K0.6150.62
32_L37_Q0.6120.62
52_L57_S0.6110.62
86_Y110_L0.6100.62
17_D20_E0.6100.62
9_I17_D0.6090.62
67_R70_F0.6090.62
53_G57_S0.6000.60
100_F104_W0.5970.60
8_A17_D0.5960.60
67_R71_S0.5940.60
45_K87_K0.5880.59
9_I16_I0.5860.59
77_L83_V0.5810.58
73_I106_P0.5770.57
22_R25_E0.5770.57
54_G59_A0.5720.57
21_E24_E0.5700.57
50_E102_E0.5690.56
107_P111_K0.5660.56
56_D61_K0.5640.56
40_L94_F0.5620.55
10_E17_D0.5600.55
72_D107_P0.5550.55
48_V104_W0.5510.54
44_V89_I0.5500.54
89_I101_I0.5420.53
29_N91_R0.5400.53
24_E27_E0.5400.53
100_F103_N0.5350.52
81_F100_F0.5350.52
35_G82_G0.5310.51
36_Q90_P0.5290.51
51_L108_T0.5270.51
44_V48_V0.5260.51
21_E105_E0.5230.50
96_E99_E0.5230.50
84_P105_E0.5220.50
38_R41_Q0.5180.50
69_V110_L0.5180.50
6_L15_R0.5110.49
52_L55_K0.5090.48
89_I97_A0.5080.48
11_E17_D0.5040.48
10_E15_R0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4y66B 1 0.8509 47.2 0.862 Contact Map
3wprA 3 0.307 25.2 0.881 Contact Map
3wp8A 3 0.2719 23.5 0.883 Contact Map
3rrkA 1 0.4386 22.1 0.884 Contact Map
2yo0A 3 0.2895 21.4 0.885 Contact Map
3ziaJ 1 0.0088 21.3 0.885 Contact Map
3ci9A 5 0.2719 13.6 0.895 Contact Map
4hjbC 3 0.2368 10.8 0.899 Contact Map
1gcvB 1 0.7018 10.5 0.9 Contact Map
3mtuE 2 0.4474 10.3 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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