GREMLIN Database
MULE - MULE transposase domain
PFAM: PF10551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (78)
Sequences: 43704 (18318)
Seq/√Len: 2074.1
META: 0.879

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_S81_W4.2131.00
86_V90_R3.5671.00
39_A70_A3.5151.00
43_L74_A2.9641.00
43_L75_V2.8451.00
47_R75_V2.3671.00
39_A43_L2.1491.00
39_A74_A2.1151.00
21_D25_R2.0161.00
60_V72_I2.0161.00
43_L47_R1.9041.00
48_G52_R1.7561.00
64_G83_R1.7061.00
32_W45_F1.7041.00
32_W48_G1.6471.00
21_D27_E1.6431.00
60_V79_A1.6271.00
69_K81_W1.5841.00
62_S72_I1.4781.00
36_S41_S1.4051.00
34_G41_S1.3881.00
17_A45_F1.3171.00
73_E81_W1.3041.00
48_G51_R1.2921.00
85_I89_I1.2571.00
32_W44_E1.2181.00
62_S69_K1.1551.00
38_S41_S1.1351.00
69_K73_E1.1061.00
50_K76_F1.0751.00
59_L80_P1.0311.00
70_A74_A1.0291.00
59_L82_Q1.0011.00
86_V89_I0.9911.00
19_G29_L0.9881.00
60_V76_F0.9511.00
46_L68_L0.9381.00
28_V31_L0.9291.00
49_L53_G0.9261.00
43_L71_A0.9231.00
18_L26_K0.9131.00
64_G88_K0.9101.00
69_K83_R0.8941.00
64_G69_K0.8821.00
65_H68_L0.8511.00
34_G44_E0.8441.00
51_R54_L0.8381.00
66_K70_A0.8311.00
50_K75_V0.8301.00
62_S68_L0.8251.00
82_Q85_I0.8231.00
42_W65_H0.8211.00
44_E47_R0.8201.00
30_G48_G0.8191.00
71_A75_V0.8141.00
49_L52_R0.7881.00
51_R55_G0.7651.00
61_V82_Q0.7641.00
60_V68_L0.7581.00
46_L76_F0.7541.00
57_P79_A0.7531.00
24_G27_E0.7331.00
40_E43_L0.7301.00
48_G53_G0.7241.00
39_A65_H0.7181.00
35_E41_S0.7131.00
66_K69_K0.7031.00
57_P76_F0.7031.00
42_W45_F0.6861.00
36_S77_P0.6851.00
64_G91_N0.6771.00
50_K54_L0.6741.00
68_L72_I0.6611.00
70_A73_E0.6511.00
47_R74_A0.6471.00
67_G70_A0.6391.00
15_A35_E0.6361.00
52_R55_G0.6351.00
46_L75_V0.6341.00
30_G45_F0.6231.00
47_R50_K0.6171.00
57_P60_V0.6151.00
40_E44_E0.6141.00
65_H69_K0.6141.00
28_V32_W0.6061.00
88_K92_V0.6021.00
49_L54_L0.6021.00
42_W67_G0.6011.00
68_L81_W0.5931.00
88_K91_N0.5881.00
18_L28_V0.5831.00
16_V28_V0.5791.00
34_G45_F0.5731.00
62_S83_R0.5711.00
41_S44_E0.5701.00
72_I81_W0.5691.00
50_K55_G0.5651.00
39_A67_G0.5611.00
34_G42_W0.5571.00
80_P83_R0.5461.00
36_S65_H0.5461.00
20_V24_G0.5461.00
37_E67_G0.5421.00
17_A26_K0.5411.00
47_R51_R0.5361.00
31_L89_I0.5351.00
20_V26_K0.5341.00
22_A27_E0.5301.00
71_A74_A0.5281.00
83_R91_N0.5261.00
42_W68_L0.5191.00
58_L80_P0.5151.00
31_L92_V0.5141.00
65_H70_A0.5071.00
37_E84_C0.5071.00
37_E65_H0.5021.00
74_A77_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bw3A 3 0.9355 29.9 0.863 Contact Map
4u7bA 2 0.9462 20.1 0.874 Contact Map
3kksA 2 0.8817 15.5 0.88 Contact Map
1bcoA 1 0.9785 15.2 0.88 Contact Map
4fcyA 4 0.9785 15 0.881 Contact Map
4fw1A 2 0.9355 14.8 0.881 Contact Map
1cxqA 2 0.9032 13.9 0.883 Contact Map
3hphA 3 0.8817 12.9 0.884 Contact Map
2nrtA 1 0.914 12.3 0.885 Contact Map
4fw2A 2 0.8817 11.3 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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