GREMLIN Database
P22_AR_N - P22_AR N-terminal domain
PFAM: PF10547 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (108)
Sequences: 2654 (2223)
Seq/√Len: 213.9
META: 0.852

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D102_D3.5161.00
52_V55_T3.0311.00
75_G78_F2.6471.00
38_R42_K2.6021.00
35_S38_R2.3561.00
8_D92_K2.1751.00
56_V63_Q2.1591.00
44_D97_Q1.9991.00
58_T61_G1.9201.00
60_G63_Q1.8411.00
36_S39_R1.8141.00
57_P61_G1.7801.00
105_Y109_T1.7431.00
39_R55_T1.7421.00
49_S98_R1.7361.00
33_D36_S1.7221.00
34_W38_R1.7221.00
38_R66_L1.6931.00
35_S51_V1.6771.00
59_D63_Q1.6681.00
4_P7_G1.6091.00
27_C76_W1.4991.00
35_S39_R1.4391.00
53_E64_E1.4391.00
26_I73_L1.3761.00
102_D106_E1.3751.00
75_G101_Y1.3651.00
22_P67_C1.3561.00
81_N84_R1.3371.00
22_P25_P1.3301.00
57_P63_Q1.3211.00
12_A19_I1.3051.00
40_R79_G1.3031.00
33_D55_T1.2971.00
6_H95_R1.2961.00
100_C104_L1.2861.00
20_Y67_C1.2711.00
18_E69_P1.2681.00
36_S52_V1.2171.00
94_I97_Q1.2001.00
36_S40_R1.1991.00
14_E17_G1.1901.00
106_E110_K1.1811.00
27_C32_L1.1751.00
74_P105_Y1.1661.00
40_R43_R1.1571.00
56_V61_G1.1501.00
72_Y98_R1.1491.00
12_A108_F1.1131.00
95_R99_E1.1101.00
35_S55_T1.1001.00
36_S55_T1.0701.00
79_G97_Q1.0641.00
45_E94_I1.0621.00
45_E97_Q1.0521.00
33_D39_R1.0391.00
50_G63_Q1.0261.00
39_R43_R1.0031.00
78_F101_Y1.0031.00
23_L41_I1.0011.00
4_P9_E1.0001.00
57_P65_M0.9991.00
78_F100_C0.9661.00
39_R52_V0.9531.00
72_Y101_Y0.9441.00
30_L93_L0.9400.99
56_V60_G0.9330.99
24_K34_W0.9120.99
33_D52_V0.9120.99
56_V59_D0.9000.99
103_V107_Y0.8950.99
44_D79_G0.8880.99
82_P85_V0.8760.99
69_P72_Y0.8720.99
8_D29_A0.8690.99
45_E83_N0.8680.99
29_A96_Y0.8660.99
39_R54_I0.8610.99
21_V26_I0.8610.99
51_V54_I0.8580.99
32_L80_I0.8520.99
58_T63_Q0.8510.99
85_V93_L0.8450.99
23_L34_W0.8420.99
50_G56_V0.8330.99
70_L73_L0.8240.99
86_K89_L0.8180.99
55_T62_P0.8040.98
51_V66_L0.8000.98
24_K28_E0.7970.98
87_P90_R0.7930.98
91_E94_I0.7930.98
91_E95_R0.7900.98
46_V97_Q0.7860.98
47_L101_Y0.7710.98
89_L93_L0.7690.98
8_D96_Y0.7560.98
71_D105_Y0.7510.98
15_E19_I0.7400.97
44_D47_L0.7360.97
82_P97_Q0.7200.97
50_G61_G0.7190.97
36_S54_I0.7180.97
82_P94_I0.7160.97
69_P73_L0.7080.96
36_S43_R0.7060.96
50_G72_Y0.6980.96
53_E66_L0.6980.96
38_R51_V0.6970.96
14_E20_Y0.6960.96
96_Y100_C0.6890.96
70_L105_Y0.6870.96
50_G57_P0.6770.95
34_W66_L0.6650.95
14_E19_I0.6630.95
35_S52_V0.6590.95
23_L27_C0.6520.94
5_F10_L0.6460.94
43_R83_N0.6410.94
107_Y110_K0.6360.94
92_K95_R0.6340.94
89_L92_K0.6320.93
37_Q40_R0.6320.93
25_P28_E0.6300.93
90_R94_I0.6170.93
41_I66_L0.6150.93
49_S63_Q0.6140.93
21_V70_L0.6130.92
11_L25_P0.6100.92
22_P26_I0.6070.92
94_I98_R0.5940.91
57_P60_G0.5930.91
85_V90_R0.5920.91
85_V89_L0.5920.91
58_T65_M0.5900.91
99_E107_Y0.5860.91
42_K51_V0.5840.91
27_C37_Q0.5830.90
46_V94_I0.5800.90
106_E109_T0.5740.90
9_E12_A0.5660.89
15_E18_E0.5570.88
45_E82_P0.5560.88
23_L66_L0.5560.88
75_G100_C0.5480.88
100_C107_Y0.5440.87
50_G69_P0.5440.87
102_D105_Y0.5400.87
54_I67_C0.5390.87
19_I70_L0.5380.87
25_P29_A0.5290.86
46_V72_Y0.5290.86
85_V91_E0.5230.85
56_V65_M0.5200.85
51_V55_T0.5170.84
47_L50_G0.5160.84
54_I84_R0.5150.84
74_P101_Y0.5130.84
7_G92_K0.5100.84
18_E71_D0.5070.83
37_Q76_W0.5060.83
6_H11_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j9iA 2 0.5965 32.8 0.896 Contact Map
1z4hA 1 0.5789 22.8 0.904 Contact Map
1z3iX 4 0.6754 20.9 0.905 Contact Map
1spuA 2 0.8158 19.4 0.906 Contact Map
3tgnA 2 0.886 17.1 0.909 Contact Map
2dbbA 4 0.8947 16.7 0.909 Contact Map
4un1A 1 0.8596 15.4 0.911 Contact Map
3rh2A 2 1 14.9 0.911 Contact Map
1y6uA 1 0.5175 14.6 0.912 Contact Map
2a61A 2 0.9386 14.1 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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