GREMLIN Database
P63C - P63C domain
PFAM: PF10546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (92)
Sequences: 3716 (2512)
Seq/√Len: 261.9
META: 0.941

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_Y49_T3.3771.00
64_E67_E3.1811.00
50_N66_K3.1661.00
80_K83_Q3.1321.00
69_N81_H2.9121.00
24_E27_R2.6061.00
29_R48_L2.0941.00
79_H84_W2.0671.00
44_Y48_L2.0201.00
55_E62_L1.9491.00
15_K19_D1.7771.00
7_A11_R1.7251.00
72_D76_R1.6991.00
64_E68_K1.6611.00
31_W44_Y1.5901.00
51_D56_R1.5201.00
31_W45_V1.5111.00
68_K84_W1.4931.00
62_L66_K1.4841.00
21_F49_T1.4571.00
50_N62_L1.4421.00
63_E67_E1.4071.00
11_R87_E1.3791.00
26_F41_R1.3601.00
69_N84_W1.3421.00
19_D33_Y1.3141.00
3_E8_K1.2861.00
7_A10_L1.2841.00
16_T82_H1.2831.00
69_N77_R1.2821.00
25_I45_V1.2801.00
21_F25_I1.2511.00
72_D78_K1.2401.00
16_T91_H1.2361.00
77_R81_H1.2291.00
88_D91_H1.2061.00
71_K77_R1.1991.00
63_E66_K1.1961.00
20_E23_K1.1501.00
72_D75_G1.0861.00
10_L79_H1.0861.00
25_I48_L1.0801.00
11_R16_T1.0401.00
20_E24_E1.0361.00
38_V41_R1.0181.00
46_G50_N0.9741.00
44_Y47_K0.9651.00
65_L81_H0.9591.00
52_L56_R0.9501.00
48_L52_L0.9431.00
26_F42_P0.9321.00
51_D55_E0.9241.00
26_F31_W0.9141.00
36_G41_R0.9141.00
26_F38_V0.9031.00
36_G39_K0.8851.00
43_Q46_G0.8791.00
34_P37_S0.8721.00
66_K77_R0.8701.00
70_P77_R0.8681.00
13_W82_H0.8611.00
3_E11_R0.8521.00
19_D41_R0.8350.99
6_I68_K0.8290.99
5_Y58_A0.8040.99
57_L61_V0.7990.99
25_I52_L0.7990.99
29_R44_Y0.7950.99
58_A61_V0.7830.99
58_A93_K0.7790.99
5_Y93_K0.7720.99
34_P38_V0.7700.99
2_L5_Y0.7670.99
26_F45_V0.7660.99
77_R84_W0.7640.99
89_I93_K0.7640.99
11_R14_V0.7500.99
45_V48_L0.7430.99
25_I31_W0.7370.99
6_I86_T0.7300.98
32_P35_P0.7270.98
66_K81_H0.7240.98
43_Q47_K0.7200.98
60_G63_E0.7190.98
51_D59_P0.7180.98
25_I29_R0.7160.98
13_W16_T0.7160.98
51_D58_A0.7080.98
43_Q48_L0.7060.98
47_K50_N0.7020.98
6_I10_L0.7000.98
77_R83_Q0.6990.98
69_N79_H0.6920.98
50_N55_E0.6820.98
24_E28_L0.6750.97
47_K51_D0.6670.97
15_K18_P0.6650.97
33_Y36_G0.6630.97
35_P39_K0.6550.97
87_E91_H0.6550.97
71_K76_R0.6550.97
29_R51_D0.6510.97
88_D92_P0.6430.97
35_P38_V0.6310.96
79_H83_Q0.6270.96
22_Y26_F0.6270.96
64_E91_H0.6180.96
82_H91_H0.5990.95
33_Y39_K0.5930.95
8_K12_P0.5890.95
13_W19_D0.5860.94
75_G80_K0.5850.94
29_R52_L0.5830.94
3_E6_I0.5820.94
31_W47_K0.5810.94
50_N81_H0.5720.94
73_E76_R0.5720.94
81_H84_W0.5700.94
72_D77_R0.5690.93
3_E14_V0.5600.93
7_A12_P0.5580.93
47_K55_E0.5570.93
29_R49_T0.5490.92
79_H82_H0.5470.92
8_K11_R0.5460.92
7_A87_E0.5450.92
74_K78_K0.5370.91
6_I14_V0.5360.91
12_P93_K0.5300.91
42_P54_Y0.5270.91
76_R80_K0.5230.90
32_P36_G0.5200.90
39_K43_Q0.5160.90
57_L85_L0.5110.89
33_Y37_S0.5110.89
85_L89_I0.5040.89
6_I85_L0.5010.88
23_K32_P0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v5wA 1 0.8511 10.8 0.908 Contact Map
4in3B 1 0.383 10.3 0.909 Contact Map
2gigA 2 0.6489 7.6 0.914 Contact Map
1hc1A 5 0.9362 7.6 0.914 Contact Map
1pp7U 1 0.5 7.5 0.914 Contact Map
2h2wA 2 0.5638 7 0.916 Contact Map
3wkyA 5 0.9362 6.3 0.917 Contact Map
3iykA 3 0.383 5.8 0.918 Contact Map
3gwjA 5 0.9149 5.7 0.919 Contact Map
3ixvA 9 0.9255 4.5 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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