GREMLIN Database
ORF6N - ORF6N domain
PFAM: PF10543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (83)
Sequences: 31705 (17968)
Seq/√Len: 1972.2
META: 0.965

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R30_Q4.1981.00
30_Q55_S2.7161.00
26_K59_T2.6891.00
30_Q58_V2.4771.00
55_S58_V2.4001.00
54_R68_Y2.2231.00
76_Q79_A2.0361.00
5_L10_K2.0361.00
27_R31_A1.6871.00
44_M71_Y1.6531.00
46_Q71_Y1.6481.00
60_S65_G1.6131.00
27_R58_V1.5671.00
26_K54_R1.5371.00
2_K19_E1.5291.00
49_K53_E1.4861.00
65_G68_Y1.4751.00
49_K69_L1.4681.00
54_R59_T1.4191.00
33_K71_Y1.4071.00
54_R60_S1.4051.00
26_K30_Q1.3881.00
79_A82_S1.3561.00
29_N46_Q1.3521.00
24_E27_R1.3281.00
32_V44_M1.3201.00
25_T29_N1.3101.00
4_Y12_M1.2941.00
79_A83_S1.2541.00
62_R65_G1.2471.00
27_R55_S1.2321.00
32_V73_F1.2061.00
60_S67_R1.1981.00
63_G67_R1.1951.00
4_Y16_D1.1641.00
60_S63_G1.1581.00
55_S59_T1.1521.00
64_G67_R1.1301.00
47_L72_A1.1091.00
61_S65_G1.0641.00
29_N33_K1.0611.00
15_S66_R1.0561.00
61_S64_G1.0321.00
50_E53_E1.0221.00
63_G66_R0.9951.00
34_R56_Q0.9801.00
2_K5_L0.9721.00
29_N71_Y0.9691.00
52_F69_L0.9541.00
60_S64_G0.9521.00
7_R51_E0.9501.00
52_F66_R0.9161.00
23_V28_L0.8861.00
52_F70_P0.8801.00
34_R58_V0.8791.00
78_V82_S0.8781.00
5_L9_Q0.8771.00
57_I60_S0.8711.00
12_M81_L0.8451.00
28_L44_M0.8441.00
60_S68_Y0.8391.00
42_D83_S0.8301.00
62_R66_R0.8301.00
29_N66_R0.8191.00
36_I44_M0.8141.00
14_D25_T0.8021.00
16_D19_E0.7971.00
64_G68_Y0.7891.00
49_K52_F0.7671.00
56_Q60_S0.7511.00
80_M83_S0.7491.00
13_L72_A0.7441.00
56_Q59_T0.7341.00
46_Q69_L0.7321.00
60_S66_R0.7261.00
23_V27_R0.7201.00
62_R67_R0.7171.00
33_K36_I0.7091.00
31_A34_R0.7081.00
76_Q83_S0.6971.00
5_L8_G0.6841.00
12_M16_D0.6831.00
43_F76_Q0.6731.00
26_K55_S0.6721.00
52_F63_G0.6671.00
57_I65_G0.6661.00
17_L78_V0.6641.00
61_S66_R0.6611.00
28_L81_L0.6571.00
24_E30_Q0.6431.00
41_E50_E0.6361.00
23_V31_A0.6351.00
54_R67_R0.6331.00
2_K16_D0.6271.00
21_Y78_V0.6261.00
61_S67_R0.6191.00
9_Q41_E0.6151.00
26_K58_V0.6131.00
2_K9_Q0.6011.00
76_Q82_S0.5991.00
40_P43_F0.5901.00
38_R83_S0.5831.00
17_L28_L0.5781.00
20_L82_S0.5681.00
78_V81_L0.5671.00
54_R66_R0.5631.00
54_R64_G0.5621.00
18_A28_L0.5551.00
75_E78_V0.5461.00
63_G68_Y0.5371.00
59_T68_Y0.5351.00
14_D29_N0.5331.00
33_K46_Q0.5291.00
30_Q33_K0.5261.00
54_R65_G0.5261.00
44_M72_A0.5241.00
55_S60_S0.5201.00
37_E41_E0.5191.00
46_Q70_P0.5181.00
3_I12_M0.5171.00
45_F72_A0.5081.00
20_L78_V0.5051.00
31_A55_S0.5001.00
62_R68_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y6uA 1 0.6667 42.5 0.852 Contact Map
1twfB 2 0.881 36.5 0.858 Contact Map
3h0gB 1 0.9048 33.4 0.86 Contact Map
1hsjA 2 0.8095 26.5 0.867 Contact Map
4c2mB 1 0.8929 24.4 0.87 Contact Map
2o38A 2 0.8333 23.8 0.87 Contact Map
4qiwB 1 0.9048 23.3 0.871 Contact Map
3g3zA 2 0.7738 22.8 0.871 Contact Map
2ethA 4 0.8095 22.7 0.871 Contact Map
2nyxA 2 0.8095 22.7 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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