GREMLIN Database
EPL1 - Enhancer of polycomb-like
PFAM: PF10513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 158 (156)
Sequences: 814 (625)
Seq/√Len: 50.0
META: 0.113

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_E153_D2.9341.00
120_M148_F2.6101.00
6_D9_K2.5621.00
85_T88_T2.5241.00
153_D157_K2.4461.00
31_I35_N2.3041.00
51_K54_E2.2151.00
47_T54_E2.1771.00
55_N60_V2.1111.00
48_G53_E2.0321.00
50_E54_E1.9320.99
127_W131_Y1.8710.99
144_S147_T1.8460.99
128_L132_N1.8150.99
46_E51_K1.8000.99
37_N40_N1.7610.99
126_A130_E1.7290.99
35_N39_E1.7020.98
47_T51_K1.6950.98
48_G51_K1.6560.98
64_A69_S1.6520.98
38_K41_S1.5980.98
35_N38_K1.5890.98
49_V54_E1.5800.98
63_A67_K1.5530.97
57_H62_S1.5500.97
33_E39_E1.4840.96
123_E153_D1.4700.96
59_Q64_A1.4410.96
36_S39_E1.4380.96
106_E120_M1.4370.96
43_P46_E1.4150.95
28_A34_C1.3840.95
50_E53_E1.3670.94
7_I127_W1.3620.94
28_A31_I1.3480.94
150_I153_D1.3400.94
69_S72_P1.3390.94
65_K70_G1.3320.93
121_D127_W1.3250.93
19_V22_L1.3240.93
111_E117_E1.3190.93
154_R157_K1.3140.93
109_E115_G1.3140.93
34_C39_E1.3100.93
116_V153_D1.3020.93
29_Q32_S1.3020.93
91_F97_P1.2970.92
46_E53_E1.2970.92
34_C37_N1.2870.92
30_E35_N1.2620.91
94_F97_P1.2610.91
118_Y149_E1.2300.90
34_C38_K1.2240.90
127_W132_N1.2220.90
69_S73_S1.2210.90
121_D155_L1.2200.90
67_K70_G1.2080.89
11_L126_A1.2060.89
47_T50_E1.2010.89
49_V53_E1.1970.89
83_A86_I1.1910.89
45_I54_E1.1710.88
71_S74_P1.1680.88
78_Q85_T1.1670.88
131_Y154_R1.1670.88
56_E61_I1.1610.88
30_E33_E1.1410.87
137_S142_P1.1400.87
51_K55_N1.1400.87
79_N88_T1.1330.86
50_E55_N1.1300.86
125_E129_E1.1230.86
120_M152_M1.0960.84
50_E58_H1.0950.84
65_K69_S1.0900.84
83_A87_P1.0890.84
146_D150_I1.0810.83
59_Q62_S1.0810.83
52_E57_H1.0760.83
61_I65_K1.0670.83
31_I34_C1.0660.83
103_R108_V1.0620.82
3_R6_D1.0520.82
136_K142_P1.0490.82
63_A66_K1.0410.81
48_G58_H1.0370.81
32_S37_N1.0350.81
70_G74_P1.0280.80
30_E40_N1.0140.79
111_E114_E1.0120.79
105_S108_V1.0090.79
3_R7_I1.0010.78
141_E155_L0.9980.78
141_E147_T0.9980.78
46_E49_V0.9940.78
105_S109_E0.9930.78
62_S143_I0.9830.77
36_S40_N0.9770.77
150_I154_R0.9710.76
147_T150_I0.9670.76
52_E127_W0.9670.76
64_A68_D0.9660.76
123_E150_I0.9560.75
104_F108_V0.9560.75
149_E156_E0.9420.74
56_E63_A0.9320.73
8_K107_T0.9320.73
103_R145_E0.9310.73
2_H6_D0.9310.73
118_Y124_D0.9220.72
125_E145_E0.9170.72
30_E36_S0.9140.72
2_H153_D0.9130.72
77_N146_D0.9100.71
66_K69_S0.8890.70
62_S65_K0.8850.69
60_V67_K0.8810.69
4_R145_E0.8790.69
32_S35_N0.8790.69
91_F130_E0.8770.69
33_E41_S0.8770.69
46_E50_E0.8610.67
53_E58_H0.8580.67
132_N149_E0.8580.67
100_S104_F0.8570.67
10_P144_S0.8520.66
109_E112_L0.8500.66
103_R106_E0.8460.66
135_R140_V0.8330.65
116_V157_K0.8270.64
66_K70_G0.8250.64
104_F111_E0.8250.64
70_G73_S0.8230.64
94_F123_E0.8190.63
98_P111_E0.8170.63
131_Y152_M0.8150.63
117_E154_R0.8150.63
31_I38_K0.8120.63
127_W157_K0.8060.62
30_E34_C0.8020.62
13_I33_E0.8010.62
48_G54_E0.7930.61
86_I135_R0.7930.61
121_D149_E0.7890.60
42_V46_E0.7870.60
44_Q47_T0.7750.59
25_D29_Q0.7610.58
23_D27_T0.7560.57
29_Q33_E0.7530.57
107_T115_G0.7490.56
117_E157_K0.7460.56
126_A131_Y0.7450.56
48_G95_E0.7440.56
48_G56_E0.7440.56
91_F138_E0.7430.56
120_M128_L0.7420.56
148_F152_M0.7400.55
33_E37_N0.7340.55
121_D153_D0.7320.55
100_S107_T0.7320.55
79_N87_P0.7310.55
49_V58_H0.7210.54
91_F94_F0.7200.53
132_N135_R0.7160.53
35_N40_N0.7090.52
52_E56_E0.7020.52
9_K105_S0.6740.49
45_I49_V0.6740.49
33_E36_S0.6650.48
94_F98_P0.6640.48
136_K157_K0.6630.48
27_T31_I0.6630.48
125_E136_K0.6630.48
34_C40_N0.6620.47
35_N41_S0.6570.47
16_E154_R0.6530.47
43_P57_H0.6530.47
117_E135_R0.6500.46
16_E101_Y0.6500.46
2_H12_P0.6500.46
37_N41_S0.6460.46
94_F115_G0.6450.46
108_V111_E0.6440.46
69_S74_P0.6270.44
17_D119_D0.6230.44
2_H127_W0.6180.43
33_E38_K0.6120.42
64_A71_S0.6100.42
23_D40_N0.6090.42
103_R146_D0.6090.42
24_D28_A0.6080.42
31_I41_S0.6070.42
31_I39_E0.6060.42
17_D28_A0.6010.41
44_Q48_G0.5950.41
123_E155_L0.5920.40
65_K133_E0.5910.40
73_S76_D0.5910.40
119_D132_N0.5900.40
120_M132_N0.5890.40
47_T53_E0.5840.40
10_P13_I0.5760.39
63_A69_S0.5760.39
16_E144_S0.5730.39
134_K142_P0.5730.39
125_E140_V0.5720.38
91_F95_E0.5710.38
60_V68_D0.5670.38
49_V56_E0.5650.38
7_I117_E0.5650.38
106_E146_D0.5600.37
65_K71_S0.5540.37
66_K73_S0.5530.37
14_I18_E0.5510.36
90_S141_E0.5490.36
22_L66_K0.5460.36
101_Y134_K0.5450.36
106_E110_E0.5450.36
122_E132_N0.5430.36
68_D71_S0.5430.36
53_E56_E0.5410.36
61_I64_A0.5370.35
16_E127_W0.5370.35
103_R122_E0.5350.35
124_D156_E0.5330.35
119_D153_D0.5250.34
125_E146_D0.5230.34
26_P41_S0.5190.33
37_N45_I0.5130.33
126_A134_K0.5120.33
84_L87_P0.5120.33
1_R8_K0.5000.32
17_D112_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zckA 1 0.3671 5 0.94 Contact Map
2jqtA 1 0.1835 4.6 0.941 Contact Map
2hueC 1 0.4873 3.6 0.945 Contact Map
2y0mB 3 0.1329 3.1 0.946 Contact Map
3b0cT 1 0.4177 3 0.946 Contact Map
1qs0A 2 0.519 2.8 0.948 Contact Map
4noxA 1 0 2.4 0.949 Contact Map
2jtdA 1 0.2089 2.3 0.95 Contact Map
1tafB 1 0.443 1.9 0.952 Contact Map
3tz1A 1 0.2278 1.7 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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