GREMLIN Database
DUF2452 - Protein of unknown function (DUF2452)
PFAM: PF10504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (126)
Sequences: 534 (324)
Seq/√Len: 28.9
META: 0.762

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_H125_S4.6371.00
57_E64_E3.3491.00
124_G128_L2.9401.00
29_D38_D2.8391.00
126_Y129_E2.7961.00
57_E65_Q2.7291.00
83_E103_Q2.6281.00
31_V41_D2.5090.99
124_G129_E2.3310.99
63_Q67_R2.0630.97
20_P24_L2.0590.97
49_Q53_D2.0120.97
97_Y100_R1.9620.96
72_R76_D1.9380.96
48_A73_A1.9340.96
109_L113_E1.9190.96
43_V46_A1.8580.95
80_H88_K1.8430.95
19_Y22_S1.7460.93
43_V47_H1.7450.93
53_D57_E1.6820.92
59_I63_Q1.6660.91
96_L106_F1.6630.91
105_Y109_L1.6180.90
32_D35_K1.5620.88
47_H50_Q1.5520.88
129_E135_T1.5510.88
92_Q108_M1.5460.88
64_E68_E1.5380.87
123_L126_Y1.5050.86
89_V92_Q1.4950.86
51_K72_R1.4940.86
98_R121_E1.4860.85
65_Q68_E1.4760.85
124_G127_R1.4610.84
17_S20_P1.4600.84
87_Q134_W1.4180.83
24_L50_Q1.4120.82
32_D37_I1.3980.82
82_A104_T1.3050.77
30_L34_A1.2760.75
97_Y107_S1.2610.74
19_Y23_R1.2470.74
125_S129_E1.2370.73
123_L127_R1.2250.72
18_P22_S1.2220.72
97_Y102_G1.2090.71
71_E75_R1.2050.71
34_A41_D1.1830.70
74_E78_A1.1790.69
14_A21_T1.1720.69
125_S128_L1.1370.66
41_D81_H1.1020.64
98_R123_L1.0610.61
98_R101_D1.0590.61
93_I137_V1.0540.60
36_Q39_I1.0480.60
31_V34_A1.0360.59
86_F108_M1.0210.58
85_N103_Q1.0160.58
46_A69_I1.0040.57
71_E74_E1.0030.57
105_Y120_H0.9960.56
123_L129_E0.9960.56
22_S26_P0.9960.56
20_P23_R0.9850.55
83_E99_R0.9770.55
82_A96_L0.9750.54
109_L120_H0.9740.54
80_H114_W0.9640.54
89_V104_T0.9390.52
119_P132_M0.9290.51
76_D133_S0.9080.49
47_H90_P0.8950.48
107_S113_E0.8870.48
43_V90_P0.8730.46
60_R67_R0.8620.46
98_R104_T0.8520.45
97_Y103_Q0.8330.43
21_T33_V0.8310.43
60_R69_I0.8300.43
20_P28_F0.8290.43
69_I74_E0.8250.43
31_V80_H0.8030.41
14_A112_D0.8010.41
20_P34_A0.7990.41
19_Y24_L0.7970.41
59_I77_D0.7910.40
108_M134_W0.7880.40
88_K134_W0.7870.40
64_E67_R0.7870.40
23_R26_P0.7810.39
29_D48_A0.7800.39
90_P128_L0.7710.39
19_Y25_G0.7710.39
70_L74_E0.7650.38
51_K54_V0.7570.38
46_A91_G0.7560.38
14_A17_S0.7380.36
55_I65_Q0.7290.36
43_V128_L0.7270.36
50_Q69_I0.7210.35
60_R115_G0.7200.35
88_K97_Y0.7170.35
54_V138_D0.7130.35
100_R138_D0.7110.34
15_N18_P0.7030.34
61_V139_E0.7020.34
97_Y101_D0.6970.33
39_I42_N0.6940.33
25_G28_F0.6940.33
34_A37_I0.6840.33
46_A115_G0.6780.32
51_K133_S0.6760.32
82_A119_P0.6750.32
99_R103_Q0.6700.32
103_Q107_S0.6690.31
88_K133_S0.6610.31
25_G122_Y0.6600.31
54_V133_S0.6500.30
102_G120_H0.6460.30
48_A69_I0.6440.30
108_M133_S0.6430.30
105_Y110_S0.6430.30
65_Q82_A0.6430.30
54_V122_Y0.6420.30
44_A51_K0.6410.30
88_K135_T0.6400.30
67_R135_T0.6400.30
93_I97_Y0.6400.30
82_A110_S0.6390.30
79_L106_F0.6390.30
90_P135_T0.6370.29
93_I125_S0.6340.29
17_S26_P0.6280.29
75_R78_A0.6240.29
102_G107_S0.6220.28
45_R134_W0.6170.28
19_Y26_P0.6150.28
82_A134_W0.6090.28
39_I43_V0.6080.28
78_A99_R0.6040.27
41_D48_A0.6030.27
63_Q104_T0.6030.27
28_F35_K0.6000.27
84_C88_K0.6000.27
78_A104_T0.5940.27
123_L128_L0.5920.27
42_N104_T0.5880.26
85_N105_Y0.5870.26
128_L135_T0.5860.26
83_E127_R0.5810.26
55_I103_Q0.5800.26
50_Q54_V0.5770.26
27_K30_L0.5700.25
33_V85_N0.5700.25
120_H123_L0.5670.25
64_E139_E0.5660.25
42_N134_W0.5640.25
79_L84_C0.5630.25
93_I113_E0.5600.25
44_A49_Q0.5570.24
57_E60_R0.5520.24
34_A124_G0.5520.24
28_F44_A0.5520.24
38_D61_V0.5480.24
33_V77_D0.5480.24
59_I65_Q0.5480.24
110_S118_P0.5430.24
72_R136_E0.5410.24
110_S116_T0.5400.24
92_Q110_S0.5350.23
89_V128_L0.5310.23
97_Y105_Y0.5310.23
99_R105_Y0.5300.23
41_D128_L0.5290.23
88_K106_F0.5260.23
130_G136_E0.5240.23
45_R130_G0.5230.23
116_T119_P0.5170.22
80_H128_L0.5160.22
33_V87_Q0.5130.22
43_V89_V0.5090.22
113_E137_V0.5090.22
34_A88_K0.5060.22
42_N45_R0.5060.22
20_P26_P0.5030.22
34_A70_L0.5020.21
114_W128_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d1zA 1 0.4452 9.3 0.96 Contact Map
2mctA 1 0.6323 8.1 0.961 Contact Map
4xx6A 2 0.4516 7.7 0.962 Contact Map
1xqoA 1 0.6194 7.7 0.962 Contact Map
1wb9A 2 0.9355 7.5 0.962 Contact Map
1t95A 1 0.7419 7.3 0.962 Contact Map
2rlwA 1 0.2129 7.1 0.962 Contact Map
4ghnA 1 0.3806 6.8 0.962 Contact Map
2wbmA 1 0.7161 6.7 0.963 Contact Map
1v0lA 1 0.4387 6.5 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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