GREMLIN Database
FIST_C - FIST C domain
PFAM: PF10442 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (129)
Sequences: 23836 (16804)
Seq/√Len: 1479.5
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_E46_G3.6301.00
55_P58_S2.8481.00
42_D45_D2.8021.00
42_D47_S2.4231.00
79_E112_A2.3281.00
25_G63_M2.3201.00
99_G102_I2.1541.00
89_F124_T2.1191.00
36_R52_G2.1141.00
101_R104_E2.1081.00
4_V7_E2.0401.00
75_R108_A1.9551.00
75_R112_A1.9431.00
42_D49_A1.9301.00
39_L51_A1.9161.00
6_K43_P1.8621.00
78_L81_A1.8061.00
73_D77_A1.7471.00
10_G13_A1.7221.00
15_E19_S1.6691.00
35_V63_M1.6511.00
108_A111_E1.6481.00
86_A117_V1.5681.00
71_I75_R1.5681.00
11_E14_R1.5641.00
12_D15_E1.5461.00
40_G49_A1.5021.00
50_F54_V1.4651.00
24_L60_V1.4581.00
78_L82_K1.4521.00
15_E18_A1.4051.00
3_E6_K1.3841.00
68_D72_E1.3611.00
88_L119_L1.3581.00
99_G103_E1.3581.00
75_R79_E1.3551.00
100_P103_E1.3501.00
16_L19_S1.3021.00
26_L58_S1.2831.00
4_V8_Y1.2811.00
66_D69_S1.2721.00
86_A119_L1.2681.00
16_L20_G1.2681.00
74_L78_L1.2491.00
77_A81_A1.2481.00
27_V33_F1.2401.00
41_V44_E1.2351.00
76_R79_E1.2261.00
122_F125_Y1.2191.00
91_C127_E1.2181.00
25_G33_F1.2101.00
76_R80_E1.1831.00
10_G16_L1.1521.00
37_N93_G1.1471.00
74_L77_A1.1451.00
71_I108_A1.1301.00
110_R119_L1.1301.00
13_A16_L1.1291.00
104_E107_E1.1101.00
72_E76_R1.0901.00
5_Y23_P1.0361.00
107_E110_R1.0291.00
72_E75_R1.0171.00
110_R115_D1.0131.00
114_G117_V1.0131.00
17_P21_L1.0031.00
23_P26_L0.9871.00
73_D76_R0.9861.00
102_I123_F0.9761.00
75_R111_E0.9641.00
107_E111_E0.9581.00
3_E7_E0.9541.00
80_E83_A0.9451.00
88_L109_V0.9381.00
14_R17_P0.9311.00
69_S72_E0.9221.00
33_F61_Q0.9111.00
82_K112_A0.9081.00
37_N51_A0.9061.00
99_G105_E0.9051.00
13_A17_P0.9011.00
102_I105_E0.8991.00
106_L110_R0.8981.00
10_G14_R0.8941.00
70_A98_L0.8921.00
113_L117_V0.8911.00
6_K46_G0.8901.00
87_L120_A0.8871.00
28_I34_L0.8841.00
11_E15_E0.8751.00
10_G19_S0.8711.00
86_A113_L0.8691.00
108_A112_A0.8681.00
90_S94_R0.8521.00
2_L6_K0.8471.00
39_L49_A0.8461.00
25_G28_I0.8431.00
73_D78_L0.8431.00
14_R18_A0.8421.00
17_P20_G0.8421.00
12_D16_L0.8421.00
79_E82_K0.8371.00
28_I58_S0.8341.00
23_P27_V0.8331.00
79_E83_A0.8231.00
68_D71_I0.8181.00
23_P29_D0.8101.00
99_G104_E0.8041.00
25_G35_V0.7981.00
16_L21_L0.7981.00
13_A19_S0.7901.00
100_P104_E0.7871.00
74_L82_K0.7841.00
12_D17_P0.7801.00
85_G118_P0.7701.00
95_G123_F0.7671.00
89_F122_F0.7661.00
5_Y9_L0.7621.00
14_R19_S0.7571.00
54_V58_S0.7561.00
24_L50_F0.7431.00
18_A21_L0.7421.00
109_V119_L0.7381.00
12_D19_S0.7381.00
71_I74_L0.7251.00
85_G120_A0.7251.00
41_V48_L0.7221.00
90_S123_F0.7201.00
6_K9_L0.7091.00
37_N92_V0.7011.00
77_A82_K0.6931.00
78_L112_A0.6931.00
8_Y62_F0.6921.00
23_P28_I0.6841.00
67_A101_R0.6761.00
109_V113_L0.6721.00
36_R128_I0.6691.00
26_L60_V0.6651.00
110_R114_G0.6591.00
5_Y48_L0.6591.00
77_A80_E0.6551.00
27_V61_Q0.6461.00
101_R107_E0.6441.00
51_A93_G0.6401.00
67_A71_I0.6351.00
11_E19_S0.6331.00
13_A18_A0.6321.00
27_V59_T0.6301.00
36_R94_R0.6281.00
5_Y62_F0.6231.00
38_I50_F0.6221.00
6_K13_A0.6211.00
1_A4_V0.6091.00
33_F63_M0.6051.00
106_L119_L0.6031.00
71_I104_E0.6021.00
92_V125_Y0.5981.00
37_N91_C0.5981.00
103_E107_E0.5961.00
65_R69_S0.5941.00
64_V130_P0.5911.00
94_R127_E0.5861.00
38_I48_L0.5851.00
111_E114_G0.5841.00
11_E16_L0.5831.00
28_I32_D0.5811.00
94_R105_E0.5751.00
86_A109_V0.5711.00
88_L118_P0.5701.00
106_L109_V0.5671.00
37_N125_Y0.5661.00
75_R78_L0.5611.00
110_R117_V0.5601.00
92_V96_L0.5581.00
4_V62_F0.5571.00
54_V60_V0.5561.00
123_F130_P0.5521.00
9_L17_P0.5491.00
26_L54_V0.5481.00
34_L52_G0.5461.00
2_L41_V0.5431.00
10_G15_E0.5411.00
50_F60_V0.5381.00
27_V30_G0.5351.00
81_A113_L0.5351.00
85_G89_F0.5341.00
51_A92_V0.5341.00
33_F59_T0.5311.00
20_G48_L0.5281.00
53_D56_E0.5221.00
67_A70_A0.5221.00
74_L108_A0.5201.00
67_A98_L0.5181.00
13_A20_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zuwA 2 0.7462 12.7 0.903 Contact Map
4jvoA 2 0.6615 10.8 0.906 Contact Map
4injA 2 0.6462 10.5 0.906 Contact Map
4e5sA 2 0.6462 9.8 0.908 Contact Map
2ve7A 1 0.6615 8.2 0.911 Contact Map
4eysA 3 0.5769 7.5 0.912 Contact Map
2gzmA 3 0.7462 7.2 0.913 Contact Map
4wesB 2 0.8923 6.5 0.915 Contact Map
3pdiB 2 0.8769 6.2 0.915 Contact Map
1s99A 2 0.8 5.9 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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