GREMLIN Database
DUF2439 - Protein of unknown function (DUF2439)
PFAM: PF10382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (75)
Sequences: 558 (431)
Seq/√Len: 49.8
META: 0.323

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K18_K4.3981.00
60_E69_E3.4891.00
12_K62_E3.4471.00
9_T67_L2.6831.00
6_V35_L2.6241.00
11_Q14_K2.5941.00
23_F40_G2.1531.00
35_L66_Y2.1061.00
63_L68_V2.0361.00
11_Q18_K1.9730.99
14_K67_L1.7340.99
18_K32_R1.7240.99
3_E25_K1.5640.97
10_H69_E1.5340.97
34_M42_L1.4940.96
8_Y39_D1.4710.96
2_K76_T1.4350.96
32_R45_S1.4150.95
24_L58_G1.4100.95
9_T20_Q1.3850.95
5_R74_V1.3570.94
55_L59_E1.3530.94
29_F34_M1.3290.93
43_L66_Y1.3140.93
12_K67_L1.2980.92
4_F19_W1.2680.91
37_D41_N1.2420.91
44_G47_F1.2260.90
27_H32_R1.1720.88
6_V47_F1.1180.85
14_K69_E1.0990.84
2_K73_P1.0330.80
28_T34_M0.9700.76
58_G69_E0.9660.76
36_Y48_L0.9620.75
2_K12_K0.9560.75
43_L46_R0.9530.75
4_F71_G0.9490.74
27_H30_N0.9280.73
25_K29_F0.9150.72
23_F59_E0.9090.71
36_Y42_L0.8870.69
32_R54_E0.8760.68
56_Q59_E0.8690.68
9_T12_K0.8580.67
12_K19_W0.8450.65
10_H40_G0.8070.62
55_L70_V0.8000.61
37_D48_L0.7860.60
25_K54_E0.7790.59
37_D68_V0.7760.59
14_K64_D0.7550.57
55_L61_L0.7530.57
57_E72_E0.7500.56
21_D34_M0.7470.56
39_D42_L0.7340.55
73_P76_T0.7290.54
33_V63_L0.7270.54
23_F64_D0.7190.53
21_D32_R0.7180.53
73_P77_T0.7170.53
30_N47_F0.7140.53
4_F58_G0.7090.52
65_R70_V0.7090.52
4_F7_L0.7030.51
38_E72_E0.6880.50
65_R73_P0.6840.50
31_K38_E0.6770.49
46_R63_L0.6690.48
4_F33_V0.6670.48
7_L69_E0.6630.47
29_F32_R0.6610.47
57_E75_G0.6530.46
9_T16_A0.6400.45
30_N45_S0.6400.45
23_F55_L0.6310.44
46_R53_E0.6300.44
22_G35_L0.6270.44
55_L58_G0.6230.43
5_R32_R0.6230.43
7_L10_H0.6200.43
2_K26_L0.6180.43
20_Q53_E0.6120.42
7_L29_F0.6110.42
24_L53_E0.6050.42
14_K42_L0.6020.41
8_Y20_Q0.6020.41
38_E64_D0.6010.41
37_D46_R0.5920.40
12_K71_G0.5870.40
61_L70_V0.5710.38
49_K59_E0.5660.38
30_N63_L0.5650.38
19_W57_E0.5650.38
15_K68_V0.5620.37
6_V34_M0.5590.37
3_E29_F0.5560.37
8_Y77_T0.5520.36
35_L44_G0.5440.36
41_N74_V0.5330.35
41_N45_S0.5290.34
28_T32_R0.5260.34
3_E69_E0.5220.34
7_L61_L0.5210.34
5_R72_E0.5200.33
2_K8_Y0.5130.33
15_K26_L0.5060.32
3_E40_G0.5040.32
25_K70_V0.5030.32
42_L70_V0.5030.32
24_L33_V0.5020.32
48_L55_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b5uA 1 0.8272 26.6 0.863 Contact Map
4by2A 1 0.1111 10.7 0.886 Contact Map
4ld1A 1 0.358 8.3 0.891 Contact Map
4nooA 1 0.5556 6.6 0.897 Contact Map
1e6yB 2 0.5185 5.6 0.9 Contact Map
3sqgB 2 0.5062 5 0.902 Contact Map
1hbnB 2 0.5556 4.4 0.905 Contact Map
3u2gA 2 0.9877 3.4 0.909 Contact Map
3ecqA 1 0.8765 2.9 0.913 Contact Map
2bbrA 1 0.321 2.5 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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