GREMLIN Database
NKWYS - Putative capsular polysaccharide synthesis protein
PFAM: PF10364 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (121)
Sequences: 1287 (1176)
Seq/√Len: 106.9
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_R77_D4.0601.00
76_E138_Y3.9501.00
64_E69_D3.4311.00
102_G107_Y3.3751.00
38_D42_K3.1281.00
52_H63_Y2.6821.00
47_I70_L2.6401.00
41_L70_L2.5811.00
34_L131_S2.4491.00
77_D80_R2.3081.00
100_N105_K2.0561.00
48_D51_A2.0441.00
38_D132_K1.9941.00
31_D127_R1.8031.00
81_L84_A1.7511.00
71_L88_F1.6841.00
125_L129_Y1.6841.00
113_E117_R1.6251.00
62_I69_D1.5751.00
82_E95_K1.5541.00
79_D98_N1.4831.00
23_F27_Y1.4811.00
45_F68_V1.4561.00
98_N101_V1.4541.00
56_K139_S1.4491.00
20_L23_F1.4311.00
124_Y128_M1.4161.00
50_Y136_H1.4121.00
22_E26_E1.4081.00
85_I94_F1.3671.00
25_L28_F1.3601.00
41_L45_F1.3290.99
55_D58_K1.3010.99
19_L25_L1.2960.99
50_Y133_Y1.2900.99
47_I65_N1.2740.99
122_E126_D1.2660.99
24_F27_Y1.2610.99
54_F59_G1.2540.99
130_S135_R1.2520.99
40_E44_V1.2280.99
71_L84_A1.2210.99
131_S134_A1.2200.99
82_E94_F1.2010.99
126_D130_S1.1780.99
19_L23_F1.1490.98
102_G105_K1.1490.98
76_E129_Y1.0980.98
34_L128_M1.0950.98
53_P136_H1.0940.98
42_K48_D1.0910.98
83_E87_E1.0610.97
65_N68_V1.0440.97
24_F28_F1.0250.97
113_E116_E1.0240.97
101_V104_E0.9940.96
102_G111_Y0.9850.96
114_F124_Y0.9850.96
75_L78_L0.9710.96
101_V105_K0.9690.96
59_G77_D0.9650.95
112_R115_K0.9590.95
50_Y132_K0.9580.95
55_D61_Q0.9550.95
19_L24_F0.9530.95
40_E43_P0.9510.95
35_D39_R0.9380.95
30_H124_Y0.9330.94
118_I121_P0.9280.94
120_L124_Y0.9140.94
86_G92_P0.9130.94
75_L102_G0.9030.93
73_L79_D0.9030.93
49_V72_L0.9020.93
73_L81_L0.8950.93
30_H128_M0.8940.93
73_L84_A0.8920.93
103_S112_R0.8770.92
50_Y137_F0.8760.92
21_E25_L0.8710.92
77_D81_L0.8700.92
129_Y134_A0.8660.92
78_L81_L0.8630.92
36_W41_L0.8400.91
128_M134_A0.8350.90
86_G91_L0.8310.90
63_Y72_L0.8180.90
122_E125_L0.8130.89
121_P124_Y0.8120.89
60_Y81_L0.8040.89
114_F138_Y0.8030.89
19_L27_Y0.7990.88
96_L99_A0.7980.88
69_D88_F0.7930.88
134_A138_Y0.7930.88
82_E93_D0.7810.87
60_Y87_E0.7810.87
37_F49_V0.7750.87
50_Y131_S0.7650.86
28_F32_Y0.7630.86
52_H65_N0.7570.86
22_E25_L0.7550.85
23_F28_F0.7530.85
63_Y70_L0.7520.85
111_Y129_Y0.7490.85
53_P135_R0.7450.85
19_L22_E0.7410.84
52_H61_Q0.7390.84
102_G108_A0.7370.84
75_L81_L0.7300.84
23_F26_E0.7220.83
78_L129_Y0.7210.83
77_D138_Y0.7130.82
59_G76_E0.7050.81
126_D129_Y0.7010.81
37_F40_E0.6800.79
54_F57_E0.6790.79
109_D113_E0.6670.78
60_Y84_A0.6660.78
76_E84_A0.6640.77
58_K87_E0.6500.76
85_I89_L0.6490.76
81_L86_G0.6460.75
65_N69_D0.6440.75
45_F81_L0.6420.75
55_D59_G0.6370.74
106_W117_R0.6330.74
54_F137_F0.6290.73
62_I88_F0.6260.73
21_E118_I0.6260.73
107_Y111_Y0.6220.73
25_L121_P0.6190.72
43_P53_P0.6180.72
91_L94_F0.6170.72
79_D96_L0.6150.72
77_D129_Y0.6140.72
96_L100_N0.6080.71
131_S137_F0.6070.71
83_E86_G0.6060.71
95_K123_E0.6050.71
53_P57_E0.6050.71
33_P113_E0.6040.70
74_R138_Y0.5970.70
20_L27_Y0.5970.70
40_E45_F0.5950.69
41_L44_V0.5950.69
38_D50_Y0.5940.69
86_G94_F0.5910.69
108_A115_K0.5840.68
49_V136_H0.5830.68
49_V89_L0.5810.67
77_D84_A0.5780.67
48_D136_H0.5780.67
54_F63_Y0.5760.67
58_K130_S0.5700.66
39_R43_P0.5690.66
59_G74_R0.5660.65
37_F102_G0.5660.65
68_V129_Y0.5630.65
22_E83_E0.5600.65
24_F30_H0.5580.64
118_I124_Y0.5490.63
129_Y139_S0.5490.63
20_L24_F0.5430.62
57_E112_R0.5300.60
78_L96_L0.5300.60
66_G69_D0.5290.60
41_L133_Y0.5280.60
52_H98_N0.5220.59
56_K74_R0.5210.59
73_L120_L0.5190.59
35_D56_K0.5190.59
86_G93_D0.5180.59
86_G89_L0.5150.58
30_H33_P0.5120.58
80_R119_R0.5100.58
40_E47_I0.5070.57
71_L85_I0.5070.57
58_K135_R0.5060.57
92_P95_K0.5040.57
75_L79_D0.5030.57
33_P124_Y0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcrA 2 0.3885 8.9 0.932 Contact Map
1nu0A 1 0.6547 4.2 0.941 Contact Map
4gdfA 2 0.446 4 0.942 Contact Map
1ghhA 1 0.2446 3.7 0.943 Contact Map
1vhxA 2 0.6619 3.1 0.945 Contact Map
1texA 2 0.7266 3 0.946 Contact Map
1iv0A 1 0.6187 2.6 0.947 Contact Map
3tr4A 5 0.7842 2.1 0.95 Contact Map
1sxvA 5 0.7914 2.1 0.95 Contact Map
4j1jD 3 0.4173 1.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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