GREMLIN Database
Frag1 - Frag1/DRAM/Sfk1 family
PFAM: PF10277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 218 (213)
Sequences: 1739 (1280)
Seq/√Len: 87.7
META: 0.305

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_L123_G4.5321.00
44_I202_A4.4911.00
104_G123_G3.6841.00
16_A60_G3.5501.00
157_S161_R3.4991.00
43_Y46_D3.3741.00
29_H53_E3.1821.00
16_A20_C3.1651.00
104_G130_G2.8021.00
174_L197_F2.6541.00
10_A210_L2.6001.00
104_G126_L2.5111.00
43_Y194_A2.4671.00
62_A110_N2.4201.00
112_Q115_D2.3691.00
136_L169_F2.3641.00
20_C24_A2.0931.00
48_G57_F2.0901.00
178_F193_V2.0731.00
21_Y25_V2.0351.00
76_Y92_K1.9941.00
92_K96_V1.9781.00
58_R62_A1.9601.00
48_G199_W1.9551.00
210_L213_A1.9261.00
105_L108_L1.9171.00
177_V181_Q1.8931.00
22_I26_A1.8771.00
117_H121_D1.8161.00
158_F162_L1.7241.00
105_L127_F1.7191.00
19_A23_I1.6941.00
166_L170_I1.6831.00
20_C47_I1.6411.00
21_Y29_H1.6121.00
79_L83_G1.5951.00
42_P120_H1.5941.00
37_Y40_P1.5841.00
155_R159_R1.5761.00
24_A30_V1.5741.00
46_D113_S1.5521.00
124_A128_F1.5371.00
27_L53_E1.5281.00
120_H124_A1.5231.00
69_L99_L1.5141.00
81_P84_S1.4991.00
84_S87_E1.4700.99
111_F116_H1.4600.99
41_F195_A1.4520.99
53_E112_Q1.4150.99
72_V98_G1.4120.99
159_R163_I1.4000.99
94_A137_L1.3960.99
112_Q116_H1.3320.99
154_L157_S1.2810.99
59_I110_N1.2750.98
161_R215_D1.2710.98
4_L7_L1.2570.98
68_R101_G1.2510.98
205_F209_F1.2500.98
42_P45_S1.2240.98
161_R175_F1.2220.98
51_P54_S1.2200.98
55_C112_Q1.2170.98
13_P20_C1.2130.98
74_L78_R1.2040.98
167_L200_I1.1900.98
62_A106_I1.1880.98
108_L124_A1.1830.97
57_F110_N1.1730.97
119_V123_G1.1420.97
23_I56_I1.1400.97
68_R102_A1.1170.96
121_D124_A1.1060.96
95_L216_F1.1040.96
47_I57_F1.1030.96
35_N39_Y1.1000.96
59_I106_I1.0950.96
45_S198_E1.0950.96
213_A217_R1.0920.96
108_L112_Q1.0710.95
42_P47_I1.0680.95
47_I53_E1.0670.95
143_Y158_F1.0670.95
138_Q208_F1.0640.95
35_N40_P1.0520.95
43_Y113_S1.0500.95
100_I130_G1.0490.95
95_L99_L1.0480.95
79_L86_S1.0470.95
51_P55_C1.0430.95
162_L166_L1.0370.95
28_G31_K1.0360.95
52_P55_C1.0310.94
130_G135_M1.0260.94
122_I126_L1.0240.94
14_L206_I1.0140.94
75_R138_Q1.0120.94
21_Y199_W1.0110.94
201_L205_F1.0080.94
17_L20_C1.0050.94
121_D125_I1.0010.94
7_L11_L0.9990.93
44_I58_R0.9880.93
36_H40_P0.9870.93
63_L67_L0.9820.93
47_I54_S0.9720.92
79_L82_L0.9690.92
9_L13_P0.9660.92
4_L8_I0.9640.92
100_I122_I0.9560.92
75_R212_F0.9520.92
126_L130_G0.9520.92
83_G87_E0.9490.92
208_F216_F0.9480.92
23_I26_A0.9430.91
90_L140_A0.9420.91
118_D122_I0.9360.91
32_P41_F0.9290.91
63_L78_R0.9260.91
123_G127_F0.9240.90
191_Y194_A0.9210.90
43_Y58_R0.9110.90
14_L18_L0.9090.90
57_F61_I0.9080.90
58_R112_Q0.9040.89
117_H179_F0.9030.89
195_A208_F0.9020.89
143_Y159_R0.8950.89
97_L210_L0.8940.89
80_R156_K0.8890.89
157_S171_L0.8880.89
58_R63_L0.8850.88
193_V196_I0.8840.88
93_L97_L0.8830.88
206_I210_L0.8810.88
50_Y114_T0.8710.88
93_L96_V0.8700.88
143_Y148_H0.8690.88
75_R78_R0.8680.88
90_L137_L0.8610.87
43_Y191_Y0.8610.87
111_F205_F0.8610.87
166_L173_I0.8590.87
72_V78_R0.8520.87
13_P17_L0.8440.86
124_A194_A0.8440.86
14_L203_F0.8400.86
135_M208_F0.8350.85
190_A197_F0.8340.85
207_L210_L0.8330.85
24_A29_H0.8270.85
158_F161_R0.8270.85
46_D49_A0.8270.85
16_A59_I0.8260.85
113_S117_H0.8260.85
57_F199_W0.8230.85
69_L103_L0.8150.84
32_P35_N0.8050.83
193_V197_F0.8020.83
81_P85_R0.8010.83
212_F216_F0.7950.82
6_P10_A0.7870.82
107_L111_F0.7870.82
34_S37_Y0.7790.81
43_Y124_A0.7780.81
46_D58_R0.7770.81
90_L152_P0.7760.81
155_R158_F0.7750.81
192_S195_A0.7710.81
151_H155_R0.7670.80
28_G53_E0.7640.80
57_F60_G0.7640.80
139_T162_L0.7630.80
42_P195_A0.7580.79
93_L100_I0.7570.79
97_L133_L0.7570.79
57_F98_G0.7550.79
185_H200_I0.7500.79
157_S160_L0.7480.78
28_G122_I0.7440.78
84_S118_D0.7400.78
214_L217_R0.7400.78
57_F128_F0.7330.77
209_F212_F0.7300.77
120_H195_A0.7290.77
96_V100_I0.7270.76
65_A106_I0.7270.76
198_E201_L0.7270.76
188_P191_Y0.7230.76
98_G102_A0.7230.76
6_P13_P0.7210.76
43_Y49_A0.7180.76
108_L120_H0.7150.75
203_F207_L0.7110.75
48_G113_S0.7100.75
136_L140_A0.7080.75
58_R110_N0.7030.74
9_L12_L0.7010.74
22_I28_G0.6980.74
101_G209_F0.6970.73
3_W12_L0.6960.73
64_T209_F0.6930.73
21_Y42_P0.6900.73
91_N95_L0.6890.73
119_V122_I0.6880.72
163_I166_L0.6870.72
157_S165_A0.6870.72
187_G190_A0.6860.72
95_L98_G0.6850.72
82_L85_R0.6820.72
103_L119_V0.6790.71
167_L170_I0.6740.71
5_L144_R0.6740.71
18_L203_F0.6730.71
165_A168_A0.6730.71
59_I63_L0.6710.71
43_Y179_F0.6680.70
43_Y195_A0.6650.70
86_S97_L0.6610.69
29_H32_P0.6610.69
157_S164_L0.6610.69
142_S161_R0.6550.69
22_I25_V0.6540.69
168_A172_L0.6480.68
174_L178_F0.6480.68
48_G54_S0.6450.68
25_V29_H0.6420.67
45_S216_F0.6420.67
22_I166_L0.6400.67
178_F197_F0.6390.67
57_F194_A0.6390.67
170_I177_V0.6370.67
157_S162_L0.6340.66
175_F179_F0.6340.66
12_L16_A0.6320.66
159_R162_L0.6310.66
167_L171_L0.6290.66
138_Q141_L0.6280.66
156_K163_I0.6250.65
142_S146_G0.6250.65
197_F201_L0.6230.65
28_G44_I0.6160.64
111_F208_F0.6150.64
23_I53_E0.6110.63
28_G34_S0.6110.63
53_E57_F0.6060.63
142_S158_F0.6050.63
42_P161_R0.6040.63
154_L161_R0.6040.63
48_G123_G0.6040.63
97_L130_G0.6030.62
83_G164_L0.6030.62
34_S38_G0.6020.62
171_L197_F0.6000.62
108_L127_F0.5990.62
22_I210_L0.5990.62
18_L63_L0.5920.61
18_L22_I0.5900.61
18_L26_A0.5890.61
124_A205_F0.5890.61
22_I30_V0.5850.60
45_S111_F0.5790.59
84_S159_R0.5780.59
129_V170_I0.5780.59
80_R84_S0.5780.59
191_Y198_E0.5750.59
194_A199_W0.5730.59
113_S191_Y0.5710.58
68_R205_F0.5690.58
12_L15_A0.5680.58
203_F213_A0.5680.58
156_K160_L0.5660.58
79_L138_Q0.5650.57
55_C105_L0.5620.57
169_F174_L0.5600.57
69_L190_A0.5590.57
157_S200_I0.5580.57
66_F106_I0.5580.57
198_E202_A0.5580.57
133_L137_L0.5580.57
80_R93_L0.5570.56
112_Q131_G0.5530.56
55_C111_F0.5520.56
127_F205_F0.5520.56
170_I180_I0.5510.56
9_L66_F0.5480.55
73_Y90_L0.5480.55
104_G208_F0.5470.55
83_G89_V0.5390.54
17_L47_I0.5390.54
93_L137_L0.5380.54
129_V176_I0.5380.54
7_L213_A0.5380.54
11_L99_L0.5370.54
48_G61_I0.5360.54
82_L99_L0.5360.54
36_H39_Y0.5320.53
108_L195_A0.5310.53
71_L216_F0.5290.53
162_L165_A0.5290.53
47_I56_I0.5270.52
194_A209_F0.5260.52
64_T102_A0.5230.52
6_P48_G0.5190.51
112_Q117_H0.5180.51
202_A206_I0.5160.51
113_S124_A0.5140.51
140_A155_R0.5130.50
97_L211_T0.5120.50
35_N38_G0.5120.50
20_C132_L0.5090.50
152_P167_L0.5050.49
177_V180_I0.5050.49
129_V139_T0.5040.49
104_G108_L0.5040.49
51_P60_G0.5030.49
68_R179_F0.5030.49
13_P24_A0.5020.49
10_A31_K0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.7936 4.7 0.935 Contact Map
3j2wE 1 0.211 4 0.937 Contact Map
2mmuA 1 0.2202 4 0.937 Contact Map
4zwjA 1 0.9954 3.4 0.939 Contact Map
3m73A 3 0.5826 2.7 0.942 Contact Map
4xp4A 1 0.9312 2.5 0.943 Contact Map
2z73A 2 0.9862 2.4 0.943 Contact Map
3pjzA 2 0.8486 2.1 0.945 Contact Map
3rqwA 4 0.4587 1.9 0.947 Contact Map
2wswA 3 0.4541 1.7 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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