GREMLIN Database
WGG - Pre-rRNA-processing protein TSR2
PFAM: PF10273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 751 (558)
Seq/√Len: 62.7
META: 0.336

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_G31_K3.4561.00
35_L61_V2.4821.00
19_V28_S2.4571.00
8_V78_V2.4311.00
13_T17_L2.2581.00
9_L39_I2.2091.00
34_W38_A2.1801.00
25_G28_S2.1411.00
73_G76_E2.1031.00
59_L75_A1.9661.00
24_G28_S1.8791.00
25_G31_K1.8221.00
3_E7_L1.7320.99
17_L68_T1.6970.99
70_V75_A1.6310.99
27_D30_E1.6160.99
34_W65_E1.6070.99
34_W61_V1.6040.99
62_M70_V1.5500.99
19_V32_R1.5470.99
5_V40_V1.5370.99
60_Q64_D1.4480.98
61_V65_E1.3910.97
39_I57_F1.3790.97
63_E69_V1.3150.96
55_E76_E1.3000.96
18_A23_W1.2640.95
9_L36_A1.2560.95
53_D56_D1.2080.94
22_G59_L1.1930.94
55_E59_L1.1330.92
4_G8_V1.1150.91
38_A65_E1.0640.89
1_F43_F1.0580.89
21_N68_T1.0530.88
6_A10_S1.0390.88
19_V29_A1.0330.88
15_L28_S1.0160.87
10_S32_R1.0140.87
29_A33_D1.0100.86
4_G7_L1.0080.86
62_M68_T1.0080.86
28_S31_K0.9920.85
24_G62_M0.9790.85
53_D57_F0.9710.84
38_A61_V0.9590.83
16_Q20_E0.9440.82
42_L49_L0.9260.81
12_W15_L0.8810.78
38_A41_D0.8810.78
74_S79_A0.8660.77
2_E40_V0.8430.75
38_A57_F0.8400.74
34_W37_G0.8150.72
19_V26_P0.8140.72
16_Q49_L0.7880.69
2_E6_A0.7840.69
31_K34_W0.7670.67
3_E6_A0.7640.67
4_G23_W0.7590.67
42_L53_D0.7530.66
33_D39_I0.7490.66
26_P67_N0.7470.65
22_G67_N0.7390.65
31_K65_E0.7370.64
14_A17_L0.7280.63
52_D56_D0.7260.63
14_A72_D0.7230.63
38_A70_V0.7180.62
22_G26_P0.7150.62
4_G43_F0.7110.62
61_V66_F0.7070.61
59_L63_E0.7050.61
23_W31_K0.7030.61
33_D37_G0.6970.60
4_G62_M0.6950.60
16_Q32_R0.6890.59
55_E75_A0.6820.58
59_L69_V0.6700.57
30_E34_W0.6650.56
46_N49_L0.6610.56
2_E5_V0.6510.55
40_V43_F0.6490.55
23_W28_S0.6460.54
42_L57_F0.6440.54
45_S51_A0.6400.54
68_T75_A0.6340.53
27_D68_T0.6270.52
55_E73_G0.6220.52
15_L54_L0.6190.51
28_S32_R0.6170.51
60_Q78_V0.6140.51
2_E7_L0.6130.50
22_G48_D0.6070.50
54_L57_F0.5980.49
62_M66_F0.5960.49
3_E11_R0.5960.49
5_V31_K0.5960.49
40_V54_L0.5910.48
6_A36_A0.5870.47
16_Q42_L0.5680.45
24_G68_T0.5670.45
20_E29_A0.5620.45
29_A41_D0.5570.44
28_S66_F0.5540.44
3_E42_L0.5510.43
2_E42_L0.5360.42
49_L52_D0.5350.42
20_E61_V0.5270.41
57_F73_G0.5250.40
1_F4_G0.5240.40
11_R77_E0.5220.40
23_W66_F0.5090.39
17_L21_N0.5080.39
3_E8_V0.5050.38
51_A56_D0.5010.38
51_A59_L0.5000.38
56_D75_A0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u84A 1 0.85 49 0.85 Contact Map
2y1eA 2 0.9875 28 0.869 Contact Map
4wj3B 2 0.725 19.9 0.878 Contact Map
1q0qA 2 0.9625 17.2 0.881 Contact Map
4zn6A 2 0.9625 15.2 0.884 Contact Map
1r0kA 2 0.9625 14.9 0.884 Contact Map
4oiyA 1 0.55 13.9 0.886 Contact Map
3au8A 2 0.975 13.2 0.887 Contact Map
4y67A 2 0.975 12.5 0.888 Contact Map
3kfuF 2 0.7625 10.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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