GREMLIN Database
Erf4 - Golgin subfamily A member 7/ERF4 family
PFAM: PF10256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (114)
Sequences: 534 (392)
Seq/√Len: 36.7
META: 0.245

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T97_Y5.7081.00
91_E95_E3.6041.00
98_N103_K3.2051.00
37_T104_I3.0191.00
47_E81_R2.8321.00
41_I89_I2.7401.00
89_I104_I2.5491.00
7_D11_G2.4191.00
69_L73_C2.1120.99
54_K83_K2.0060.99
31_E35_R2.0040.99
98_N102_L1.8240.97
19_T34_F1.7570.97
75_E83_K1.7520.96
46_I58_L1.6210.95
3_R110_T1.6070.94
44_I88_W1.5710.94
21_Y24_E1.4920.92
87_K91_E1.4860.92
66_T70_S1.4810.91
109_R113_L1.4490.90
44_I81_R1.4200.90
3_R113_L1.4030.89
3_R12_D1.3580.87
36_E88_W1.3270.86
77_H80_K1.3160.86
30_S33_E1.3130.85
60_G71_D1.3130.85
51_P59_D1.3020.85
85_L104_I1.2590.83
106_S112_Y1.2390.82
34_F38_I1.2340.82
37_T88_W1.2200.81
80_K84_K1.2100.80
17_F82_L1.2090.80
110_T113_L1.2030.80
41_I103_K1.1550.77
21_Y25_L1.1500.77
3_R112_Y1.1360.76
89_I105_I1.1310.76
2_I44_I1.1200.75
63_G68_Y1.1060.74
63_G71_D1.1020.74
61_V73_C1.0880.73
37_T92_W1.0810.72
29_I33_E1.0670.71
104_I111_G1.0590.71
97_Y104_I1.0480.70
92_W97_Y1.0430.69
7_D68_Y1.0350.69
68_Y82_L1.0030.66
67_G113_L0.9980.66
17_F52_Y0.9790.65
40_T88_W0.9730.64
43_E46_I0.9680.64
76_T79_K0.9660.63
34_F69_L0.9630.63
47_E54_K0.9630.63
2_I9_S0.9560.63
35_R79_K0.9550.63
86_E115_L0.9540.62
3_R108_R0.9480.62
24_E27_G0.9450.62
32_E39_N0.9450.62
82_L85_L0.9440.62
47_E66_T0.9430.62
48_A59_D0.9420.61
38_I89_I0.9420.61
40_T55_R0.9220.60
50_S94_E0.9110.59
39_N99_P0.9090.59
103_K115_L0.9090.59
51_P74_G0.9080.59
44_I84_K0.9040.58
58_L62_L0.9010.58
81_R85_L0.8990.58
33_E62_L0.8930.57
18_S56_N0.8920.57
29_I97_Y0.8710.55
8_Y68_Y0.8600.54
32_E87_K0.8430.53
31_E79_K0.8280.52
4_I9_S0.8280.52
47_E53_S0.8190.51
69_L74_G0.8120.50
3_R114_S0.7910.48
29_I37_T0.7890.48
88_W92_W0.7860.48
70_S74_G0.7850.48
75_E80_K0.7830.48
88_W94_E0.7720.47
45_L108_R0.7720.47
43_E84_K0.7690.46
5_Q114_S0.7670.46
37_T78_Y0.7660.46
4_I102_L0.7650.46
58_L95_E0.7600.46
97_Y100_R0.7570.45
3_R15_P0.7560.45
34_F84_K0.7450.44
108_R113_L0.7370.44
61_V86_E0.7370.44
29_I98_N0.7340.43
61_V111_G0.7330.43
38_I53_S0.7300.43
16_Q45_L0.7280.43
99_P102_L0.7240.43
2_I19_T0.7190.42
14_A112_Y0.7140.42
28_R98_N0.7130.42
6_R11_G0.7120.42
66_T90_E0.7080.41
2_I15_P0.7070.41
85_L89_I0.7060.41
95_E102_L0.7030.41
39_N53_S0.7000.41
75_E78_Y0.6980.40
6_R66_T0.6950.40
36_E95_E0.6940.40
9_S78_Y0.6910.40
5_Q18_S0.6910.40
29_I52_Y0.6850.39
46_I99_P0.6830.39
4_I11_G0.6800.39
2_I6_R0.6630.37
4_I30_S0.6570.37
96_V99_P0.6550.37
3_R45_L0.6470.36
12_D45_L0.6360.35
46_I85_L0.6300.35
42_N93_N0.6270.35
22_P104_I0.6260.34
38_I78_Y0.6250.34
99_P111_G0.6230.34
92_W96_V0.6200.34
84_K87_K0.6180.34
30_S43_E0.6150.34
33_E37_T0.6120.33
26_D31_E0.6110.33
8_Y59_D0.6050.33
28_R102_L0.5990.32
103_K116_D0.5950.32
62_L109_R0.5930.32
54_K96_V0.5910.32
32_E99_P0.5890.32
18_S35_R0.5860.31
58_L94_E0.5830.31
43_E55_R0.5820.31
32_E60_G0.5800.31
18_S29_I0.5760.31
80_K85_L0.5740.30
84_K90_E0.5630.30
86_E106_S0.5600.29
18_S21_Y0.5560.29
49_F64_C0.5540.29
47_E50_S0.5540.29
110_T114_S0.5540.29
43_E61_V0.5510.29
111_G114_S0.5480.29
30_S64_C0.5480.29
77_H81_R0.5460.28
49_F59_D0.5450.28
5_Q8_Y0.5430.28
48_A66_T0.5430.28
83_K109_R0.5370.28
57_F61_V0.5330.27
39_N46_I0.5310.27
29_I77_H0.5220.27
108_R112_Y0.5150.26
39_N95_E0.5140.26
48_A91_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nw0A 1 0.6293 15.4 0.913 Contact Map
3fqdA 1 0.6897 13.1 0.915 Contact Map
3a1jA 1 0.431 6.3 0.927 Contact Map
2z37A 1 0.7586 5.9 0.928 Contact Map
3cqlA 1 0.7586 4.8 0.93 Contact Map
2ougA 1 0.4052 4.8 0.931 Contact Map
3g65A 1 0.431 4.4 0.932 Contact Map
1ji5A 6 0.6897 4.4 0.932 Contact Map
2fefA 3 0.9397 3.9 0.933 Contact Map
3w3eA 1 0.75 3.5 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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