GREMLIN Database
Pet191_N - Cytochrome c oxidase assembly protein PET191
PFAM: PF10203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (66)
Sequences: 516 (324)
Seq/√Len: 39.9
META: 0.395

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T30_E3.5271.00
56_G67_N3.0411.00
26_K30_E2.8141.00
6_G10_A2.3821.00
8_R50_F2.3001.00
15_L28_P1.8990.98
11_L32_L1.8310.98
19_D23_K1.8100.98
3_S67_N1.7580.97
34_E37_D1.7160.97
63_R66_G1.6760.96
17_E22_K1.6210.96
61_R65_R1.5560.95
54_K65_R1.5170.94
55_R59_D1.5100.94
60_M63_R1.4320.92
21_V28_P1.4180.91
29_K59_D1.3940.91
8_R64_F1.3830.90
20_C31_C1.3790.90
41_E45_Q1.3450.89
47_R51_F1.2770.86
7_L46_L1.2090.83
9_E34_E1.2080.83
62_K67_N1.1920.82
29_K33_K1.1680.81
57_M64_F1.1530.80
17_E42_E1.1170.78
61_R66_G1.0960.77
45_Q48_K1.0900.76
32_L47_R1.0770.75
13_E17_E1.0760.75
23_K40_P1.0400.73
19_D22_K0.9780.68
41_E44_Q0.9440.65
7_L49_A0.9390.65
19_D46_L0.9380.65
22_K25_G0.9250.64
48_K52_E0.9170.63
12_K16_L0.8840.60
13_E49_A0.8790.60
24_E38_E0.8660.58
40_P52_E0.8600.58
52_E55_R0.8590.58
32_L52_E0.8510.57
28_P54_K0.8500.57
56_G59_D0.8110.53
11_L61_R0.7930.52
16_L19_D0.7890.51
9_E13_E0.7770.50
12_K64_F0.7750.50
10_A54_K0.7650.49
8_R67_N0.7470.48
59_D64_F0.7460.47
3_S60_M0.7460.47
12_K35_P0.7420.47
10_A46_L0.7370.47
5_K50_F0.7320.46
33_K36_D0.7080.44
9_E38_E0.7040.44
8_R12_K0.6940.43
42_E47_R0.6850.42
44_Q48_K0.6830.42
18_S40_P0.6830.42
13_E29_K0.6830.42
4_C14_C0.6820.42
56_G62_K0.6730.41
2_S67_N0.6730.41
14_C20_C0.6690.41
26_K36_D0.6680.40
33_K37_D0.6660.40
11_L14_C0.6600.40
10_A57_M0.6530.39
15_L33_K0.6490.39
22_K42_E0.6480.39
15_L38_E0.6320.37
28_P39_L0.6280.37
19_D40_P0.6280.37
12_K27_T0.6280.37
7_L45_Q0.6150.36
15_L21_V0.6090.35
33_K51_F0.6000.35
19_D30_E0.5990.35
16_L21_V0.5980.34
5_K60_M0.5910.34
59_D63_R0.5830.33
34_E44_Q0.5810.33
5_K9_E0.5740.32
11_L51_F0.5640.32
16_L45_Q0.5460.30
61_R64_F0.5370.30
3_S56_G0.5360.30
21_V40_P0.5350.29
28_P46_L0.5310.29
5_K12_K0.5280.29
34_E41_E0.5120.28
17_E32_L0.5020.27
55_R58_L0.5020.27
37_D41_E0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lqlA 1 0.8209 25.8 0.867 Contact Map
1ei0A 1 0.5672 19.7 0.874 Contact Map
2lqtA 1 0.7164 12 0.886 Contact Map
4ux8C 1 0.8955 7 0.897 Contact Map
1hp8A 1 0.6567 4.4 0.906 Contact Map
5aj3m 1 0.7313 3.5 0.911 Contact Map
2kjxA 1 0.8806 2 0.922 Contact Map
2k3jA 1 0.5672 1.9 0.922 Contact Map
1v54H 2 0.7761 1.2 0.93 Contact Map
4xizM 1 0.8507 1.2 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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