GREMLIN Database
PIG-H - GPI-GlcNAc transferase complex, PIG-H component
PFAM: PF10181 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (65)
Sequences: 505 (375)
Seq/√Len: 46.5
META: 0.366

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_A54_Y4.8181.00
57_I70_V2.5461.00
13_S29_T2.3521.00
43_N54_Y2.3361.00
15_S27_E2.2371.00
38_Q60_E2.1981.00
9_G31_F2.0000.99
46_F51_V1.8850.99
37_I57_I1.8660.99
32_I57_I1.7660.98
21_P25_G1.7120.98
32_I68_V1.6860.98
10_V57_I1.5950.97
2_L70_V1.3860.93
11_Q14_T1.3810.93
41_V58_L1.3800.93
45_A56_A1.3320.92
41_V60_E1.3310.92
34_T37_I1.2720.90
46_F49_F1.2450.89
43_N53_Y1.2180.88
7_G55_L1.1750.86
2_L12_L1.1660.86
2_L51_V1.1580.85
30_R68_V1.1520.85
43_N56_A1.1440.85
39_D70_V1.1420.84
39_D49_F1.1310.84
33_P36_K1.0960.82
37_I40_I1.0830.81
5_I25_G1.0740.81
5_I33_P1.0660.80
67_L71_F1.0600.80
13_S27_E1.0530.79
42_I53_Y1.0450.79
56_A67_L1.0230.77
41_V56_A0.9660.73
42_I58_L0.9560.72
6_R61_G0.9490.72
30_R62_E0.9180.69
36_K60_E0.9010.68
7_G59_V0.8900.67
52_R55_L0.8860.66
22_Y26_R0.8470.63
21_P28_S0.8240.61
6_R29_T0.8080.59
64_E67_L0.8010.59
58_L62_E0.7980.58
27_E57_I0.7920.58
12_L49_F0.7760.56
7_G28_S0.7710.56
2_L68_V0.7640.55
35_S60_E0.7570.54
3_L23_Y0.7530.54
14_T22_Y0.7400.53
59_V68_V0.7360.52
59_V62_E0.7350.52
69_V72_P0.7340.52
13_S40_I0.7300.52
34_T59_V0.7240.51
46_F52_R0.6940.48
46_F70_V0.6930.48
27_E33_P0.6900.48
7_G34_T0.6810.47
10_V46_F0.6790.47
30_R57_I0.6730.46
48_G52_R0.6470.43
55_L62_E0.6460.43
37_I68_V0.6430.43
8_L11_Q0.6370.42
39_D54_Y0.6270.42
38_Q53_Y0.6200.41
34_T45_A0.6070.40
1_S45_A0.6060.40
26_R59_V0.5950.38
49_F58_L0.5900.38
32_I45_A0.5790.37
11_Q32_I0.5790.37
29_T55_L0.5740.37
14_T28_S0.5720.36
5_I35_S0.5700.36
22_Y29_T0.5670.36
24_S35_S0.5630.36
2_L63_E0.5620.35
30_R72_P0.5610.35
5_I47_T0.5560.35
36_K61_G0.5510.34
40_I54_Y0.5500.34
1_S30_R0.5370.33
40_I55_L0.5370.33
64_E72_P0.5320.33
14_T30_R0.5280.32
41_V68_V0.5230.32
49_F69_V0.5210.32
8_L14_T0.5200.32
12_L22_Y0.5170.31
34_T50_E0.5150.31
12_L32_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j0gA 1 0.5278 5.8 0.883 Contact Map
4djgA 2 0.25 4.2 0.891 Contact Map
5a21H 1 0.3333 4.1 0.891 Contact Map
3j7yf 1 0.1111 2.7 0.901 Contact Map
2xlkA 1 0.6528 2.4 0.904 Contact Map
1wkyA 1 0.4444 1.9 0.909 Contact Map
2i1jA 3 0.7917 1.8 0.91 Contact Map
3vu9B 1 0.7639 1.5 0.913 Contact Map
4jk8A 1 0.6111 1.5 0.914 Contact Map
1azoA 1 0.8333 1.5 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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