GREMLIN Database
DUF2373 - Uncharacterised conserved protein (DUF2373)
PFAM: PF10180 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (62)
Sequences: 605 (492)
Seq/√Len: 62.5
META: 0.428

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_D12_N4.8551.00
28_F60_A2.6421.00
7_K43_E2.5141.00
54_E58_E2.3381.00
58_E62_E2.2121.00
27_M41_L2.1861.00
22_W26_H2.0441.00
16_N19_R1.9661.00
6_W38_F1.6300.99
1_E4_R1.6270.99
18_N21_T1.5560.99
34_P37_Y1.5100.98
18_N25_K1.5080.98
23_L41_L1.4090.98
24_L56_L1.4060.97
33_I41_L1.4040.97
38_F42_L1.3670.97
40_A43_E1.3530.97
57_L61_E1.3420.97
22_W32_K1.3390.97
35_D38_F1.3080.96
15_F53_R1.1800.93
35_D59_K1.1720.93
8_T49_Q1.1160.91
4_R37_Y1.1100.91
55_R58_E1.0600.89
14_K17_K1.0490.88
33_I42_L1.0240.87
7_K40_A1.0220.87
41_L45_L1.0030.86
20_Q50_G0.9790.84
24_L48_L0.9590.83
21_T59_K0.9460.82
3_L41_L0.9230.81
5_Q12_N0.9210.81
16_N51_G0.8960.79
2_Y14_K0.8930.79
6_W37_Y0.8750.77
29_D32_K0.8720.77
4_R8_T0.8650.76
21_T25_K0.8600.76
30_E35_D0.8520.75
32_K46_E0.8390.74
5_Q9_D0.8360.74
20_Q29_D0.8130.72
11_S46_E0.8090.71
16_N25_K0.8030.71
5_Q10_R0.7900.70
18_N55_R0.7860.69
4_R46_E0.7700.68
51_G55_R0.7600.67
46_E54_E0.7540.66
54_E57_L0.7530.66
4_R7_K0.7400.64
18_N28_F0.7340.64
55_R59_K0.7310.64
26_H32_K0.7300.63
48_L56_L0.7120.61
1_E7_K0.7110.61
28_F56_L0.6970.60
4_R36_E0.6870.59
2_Y17_K0.6720.57
1_E5_Q0.6630.56
30_E43_E0.6600.56
58_E61_E0.6460.54
29_D52_A0.6430.54
24_L32_K0.6410.54
15_F19_R0.6330.53
28_F59_K0.6280.52
10_R47_G0.6270.52
26_H29_D0.6140.50
51_G54_E0.5920.48
19_R22_W0.5880.47
26_H41_L0.5870.47
33_I51_G0.5780.46
2_Y44_Y0.5750.46
6_W10_R0.5680.45
24_L41_L0.5660.45
17_K34_P0.5620.45
33_I50_G0.5620.45
17_K56_L0.5520.43
8_T12_N0.5490.43
2_Y13_W0.5410.42
22_W31_E0.5330.41
5_Q40_A0.5320.41
51_G62_E0.5310.41
35_D62_E0.5300.41
29_D45_L0.5210.40
39_P43_E0.5210.40
14_K45_L0.5160.39
3_L44_Y0.5160.39
7_K11_S0.5060.38
31_E57_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4by6C 1 0.7302 54.2 0.833 Contact Map
4by6B 1 0.7302 34.5 0.852 Contact Map
4c0dB 1 1 25.6 0.861 Contact Map
4c0dC 1 0.7143 25.4 0.862 Contact Map
4c0gA 2 0.7778 20.3 0.867 Contact Map
4c0fA 2 1 9.5 0.886 Contact Map
1f75A 2 0.8095 9.3 0.886 Contact Map
4q9mA 2 1 9.2 0.886 Contact Map
2d2rA 2 0.8413 7.2 0.892 Contact Map
2vg0A 2 1 6.3 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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