GREMLIN Database
Mit_KHE1 - Mitochondrial K+-H+ exchange-related
PFAM: PF10173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 186 (178)
Sequences: 533 (434)
Seq/√Len: 32.5
META: 0.467

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_V160_I3.2471.00
37_L41_L3.1711.00
151_F154_V3.1261.00
143_L147_L2.9001.00
107_L119_V2.7481.00
94_R99_L2.7151.00
149_A162_F2.6311.00
37_L40_R2.5911.00
61_K65_G2.4861.00
82_K171_S2.4200.99
84_I107_L2.2930.99
44_K48_T2.2340.99
93_Q96_L2.2320.99
78_E82_K2.2160.99
45_A49_W2.1440.99
133_R137_W2.1100.98
138_L145_L1.9950.98
94_R97_W1.9740.98
79_W82_K1.8920.97
44_K47_E1.8250.96
145_L169_A1.8160.96
78_E81_L1.8070.96
49_W53_E1.7990.96
138_L142_L1.7890.96
14_L164_Y1.7470.95
76_Y79_W1.7290.95
145_L162_F1.7190.94
162_F166_A1.6690.94
148_T154_V1.6310.93
87_L95_L1.6040.92
97_W100_R1.5800.91
167_F178_G1.5630.91
138_L169_A1.5620.91
181_H184_F1.5620.91
77_E81_L1.5110.90
159_N168_R1.5100.90
40_R44_K1.5070.89
40_R47_E1.5060.89
30_A33_A1.5000.89
175_A178_G1.5000.89
93_Q97_W1.4870.89
107_L123_L1.4730.88
176_L184_F1.4720.88
93_Q99_L1.4720.88
96_L99_L1.4570.88
87_L94_R1.4230.86
9_T84_I1.4100.86
178_G181_H1.4020.86
94_R100_R1.3810.85
175_A179_A1.3780.85
155_P159_N1.3740.84
115_S118_Q1.3710.84
151_F161_P1.3590.84
152_A162_F1.3530.84
164_Y168_R1.3430.83
162_F171_S1.3100.81
158_P172_H1.3040.81
79_W83_S1.2960.81
55_A58_G1.2920.81
71_L75_P1.2850.80
95_L183_E1.2670.79
4_L17_E1.2570.79
96_L100_R1.2320.77
166_A170_W1.2280.77
158_P163_F1.2260.77
40_R52_W1.2260.77
154_V161_P1.2240.77
137_W140_I1.2210.77
149_A152_A1.2060.76
53_E56_E1.1600.73
48_T53_E1.1590.73
161_P169_A1.1460.72
87_L98_E1.1450.72
78_E146_P1.1350.71
95_L98_E1.1290.71
176_L179_A1.1250.70
123_L126_L1.1200.70
141_S165_F1.1120.70
175_A182_L1.0930.68
139_I143_L1.0850.68
68_N80_G1.0750.67
162_F165_F1.0610.66
150_P153_L1.0600.66
49_W52_W1.0540.65
151_F163_F1.0530.65
95_L99_L1.0300.64
134_H172_H1.0280.63
66_Y69_R1.0250.63
132_P135_R1.0220.63
78_E83_S1.0190.63
113_L121_R1.0190.63
145_L149_A1.0130.62
93_Q100_R1.0070.62
97_W114_L0.9900.60
137_W141_S0.9870.60
158_P162_F0.9800.60
155_P168_R0.9780.59
146_P163_F0.9730.59
170_W174_R0.9710.59
74_I78_E0.9630.58
49_W55_A0.9560.58
114_L127_L0.9430.57
136_K154_V0.9420.57
150_P162_F0.9410.56
1_R12_Y0.9280.55
171_S175_A0.9270.55
109_Y113_L0.9260.55
34_K42_T0.9190.55
67_G71_L0.9190.55
150_P161_P0.9180.55
16_C184_F0.9160.54
29_A32_P0.9090.54
68_N71_L0.9040.53
65_G69_R0.8910.52
55_A60_K0.8830.52
71_L79_W0.8780.51
67_G70_L0.8780.51
129_R133_R0.8710.51
60_K67_G0.8660.50
69_R72_D0.8580.50
162_F173_W0.8560.49
64_V83_S0.8550.49
88_S98_E0.8480.49
149_A161_P0.8470.49
171_S179_A0.8360.48
14_L84_I0.8360.48
84_I138_L0.8310.47
59_W67_G0.8260.47
121_R125_R0.8240.47
3_F14_L0.8190.46
88_S93_Q0.8140.46
67_G146_P0.8070.45
159_N172_H0.8030.45
167_F181_H0.8020.45
165_F181_H0.7990.45
94_R101_G0.7980.45
167_F171_S0.7910.44
5_L13_L0.7860.44
59_W146_P0.7850.44
5_L169_A0.7790.43
88_S94_R0.7770.43
49_W56_E0.7770.43
6_P164_Y0.7730.43
105_V110_P0.7670.42
57_K153_L0.7640.42
45_A53_E0.7600.42
48_T55_A0.7580.41
67_G161_P0.7560.41
33_A37_L0.7520.41
16_C164_Y0.7510.41
47_E148_T0.7480.41
82_K162_F0.7430.40
118_Q125_R0.7420.40
142_L146_P0.7410.40
144_G164_Y0.7410.40
48_T52_W0.7400.40
94_R183_E0.7370.40
1_R162_F0.7360.40
89_A114_L0.7350.40
4_L178_G0.7340.40
99_L184_F0.7320.39
7_I119_V0.7300.39
164_Y181_H0.7290.39
150_P154_V0.7260.39
50_A173_W0.7200.38
120_L123_L0.7140.38
74_I77_E0.7050.37
5_L20_D0.6980.37
39_D42_T0.6980.37
83_S176_L0.6980.37
88_S99_L0.6970.37
71_L80_G0.6960.37
105_V123_L0.6950.37
102_Q108_V0.6930.36
14_L137_W0.6890.36
94_R98_E0.6880.36
38_V154_V0.6880.36
5_L149_A0.6880.36
122_L136_K0.6840.36
95_L100_R0.6820.36
4_L15_Y0.6800.35
71_L76_Y0.6760.35
41_L54_K0.6700.35
47_E84_I0.6620.34
41_L51_G0.6610.34
103_T109_Y0.6450.33
60_K138_L0.6440.33
121_R156_G0.6430.33
141_S164_Y0.6430.33
77_E83_S0.6400.32
41_L89_A0.6390.32
167_F170_W0.6270.31
11_R15_Y0.6250.31
161_P165_F0.6250.31
7_I177_R0.6190.31
97_W112_S0.6190.31
78_E126_L0.6170.31
1_R73_R0.6150.31
7_I34_K0.6140.31
13_L167_F0.6140.31
81_L84_I0.6120.30
87_L99_L0.6110.30
168_R172_H0.6110.30
2_L119_V0.6100.30
13_L171_S0.6090.30
37_L121_R0.6050.30
36_G113_L0.6050.30
137_W144_G0.6050.30
144_G147_L0.6040.30
87_L114_L0.6020.30
75_P78_E0.6010.30
5_L136_K0.5980.29
113_L118_Q0.5960.29
43_R124_R0.5960.29
134_H158_P0.5940.29
38_V136_K0.5940.29
143_L151_F0.5930.29
100_R108_V0.5920.29
94_R184_F0.5890.29
131_Q183_E0.5880.29
142_L149_A0.5860.29
45_A52_W0.5860.29
3_F15_Y0.5860.29
38_V41_L0.5850.29
140_I144_G0.5840.28
4_L176_L0.5800.28
16_C167_F0.5780.28
53_E127_L0.5730.28
118_Q121_R0.5720.28
64_V68_N0.5710.28
95_L112_S0.5710.28
158_P166_A0.5690.27
40_R48_T0.5660.27
89_A93_Q0.5660.27
118_Q122_L0.5660.27
158_P168_R0.5590.27
163_F172_H0.5580.27
109_Y116_E0.5500.26
41_L139_I0.5480.26
26_P152_A0.5480.26
49_W67_G0.5450.26
155_P158_P0.5430.26
163_F169_A0.5420.26
124_R156_G0.5400.26
32_P151_F0.5340.25
60_K70_L0.5340.25
43_R104_K0.5330.25
27_S37_L0.5330.25
67_G79_W0.5320.25
83_S174_R0.5310.25
109_Y131_Q0.5290.25
40_R45_A0.5290.25
5_L116_E0.5280.25
1_R112_S0.5280.25
165_F172_H0.5250.25
147_L181_H0.5250.25
33_A69_R0.5240.25
77_E82_K0.5230.25
143_L152_A0.5220.24
14_L40_R0.5210.24
103_T118_Q0.5190.24
73_R82_K0.5180.24
34_K38_V0.5150.24
82_K173_W0.5140.24
153_L166_A0.5100.24
66_Y71_L0.5040.23
77_E80_G0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l8wA 4 0.629 4.1 0.96 Contact Map
1xc0A 1 0.1774 3.7 0.961 Contact Map
3swyA 3 0.2473 3.7 0.961 Contact Map
3fblA 1 0.1989 3.4 0.961 Contact Map
3w54A 2 0.5591 3.1 0.962 Contact Map
1faoA 1 0.1935 2.7 0.963 Contact Map
4n2xA 4 0.3441 2.5 0.964 Contact Map
2onkC 2 0.2742 2.4 0.964 Contact Map
1tjnA 4 0.2419 2.1 0.965 Contact Map
4lugA 3 0.3871 2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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