GREMLIN Database
G8 - G8 domain
PFAM: PF10162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (118)
Sequences: 5893 (3997)
Seq/√Len: 367.9
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_P20_H2.8741.00
53_V56_I2.7181.00
39_T63_E2.5001.00
63_E107_T2.4821.00
21_T41_S2.3751.00
42_F77_A2.3011.00
50_E80_T2.2721.00
50_E78_T2.2321.00
9_G12_D2.1861.00
58_V62_G2.0891.00
41_S65_E2.0581.00
48_D75_H1.9991.00
21_T39_T1.9281.00
66_I77_A1.8851.00
37_D59_H1.8751.00
52_T82_T1.8411.00
42_F66_I1.8391.00
34_L51_L1.8321.00
32_R54_E1.8261.00
102_V106_G1.8261.00
66_I110_L1.7831.00
13_R33_S1.6921.00
13_R32_R1.6211.00
30_A82_T1.5841.00
7_V26_V1.5641.00
39_T65_E1.5601.00
52_T80_T1.5591.00
102_V108_L1.5591.00
33_S55_W1.5281.00
44_D71_N1.4331.00
10_A30_A1.4251.00
15_T37_D1.3961.00
3_P6_K1.3721.00
1_T22_V1.3621.00
47_R75_H1.2971.00
16_I38_G1.2731.00
66_I79_I1.2681.00
16_I22_V1.2671.00
63_E109_D1.2451.00
73_I77_A1.2381.00
69_E111_H1.1661.00
98_K101_G1.1661.00
68_T71_N1.1621.00
53_V81_L1.1551.00
31_L34_L1.1521.00
115_K118_T1.1501.00
6_K12_D1.1281.00
45_D75_H1.1151.00
88_D91_D1.1021.00
48_D76_K1.0971.00
92_G96_G1.0971.00
24_L28_P1.0961.00
35_T59_H1.0901.00
13_R35_T1.0811.00
79_I83_G1.0591.00
44_D74_T1.0571.00
24_L27_S1.0451.00
43_A47_R1.0441.00
67_G111_H1.0361.00
18_A37_D1.0301.00
74_T113_A1.0281.00
36_I64_L1.0131.00
87_V91_D1.0131.00
15_T35_T1.0121.00
72_P114_P1.0011.00
85_P88_D0.9991.00
86_D89_G0.9981.00
24_L49_T0.9711.00
65_E109_D0.9631.00
44_D73_I0.9611.00
6_K9_G0.9311.00
66_I73_I0.9161.00
90_E93_P0.9161.00
58_V102_V0.9111.00
100_I108_L0.9041.00
16_I40_L0.9011.00
89_G92_G0.9001.00
91_D97_S0.8781.00
93_P98_K0.8651.00
34_L53_V0.8571.00
65_E68_T0.8521.00
30_A52_T0.8351.00
95_M98_K0.8351.00
23_V41_S0.8331.00
116_T120_T0.8311.00
92_G97_S0.8301.00
80_T83_G0.8291.00
92_G95_M0.8261.00
95_M101_G0.8041.00
67_G72_P0.8021.00
24_L40_L0.8011.00
59_H103_M0.8011.00
68_T72_P0.8001.00
86_D90_E0.7991.00
88_D93_P0.7991.00
42_F51_L0.7971.00
17_P37_D0.7891.00
64_L108_L0.7871.00
92_G99_G0.7741.00
93_P97_S0.7741.00
49_T77_A0.7671.00
28_P50_E0.7661.00
11_G31_L0.7621.00
58_V64_L0.7561.00
35_T57_M0.7541.00
36_I40_L0.7521.00
89_G95_M0.7521.00
95_M99_G0.7501.00
91_D98_K0.7491.00
85_P89_G0.7471.00
24_L42_F0.7391.00
91_D94_D0.7361.00
95_M103_M0.7271.00
37_D60_G0.7271.00
56_I79_I0.7261.00
96_G99_G0.7261.00
31_L51_L0.7241.00
34_L40_L0.7241.00
58_V106_G0.7241.00
51_L77_A0.7211.00
34_L56_I0.7090.99
87_V90_E0.7050.99
51_L56_I0.6890.99
93_P99_G0.6870.99
99_G102_V0.6730.99
81_L100_I0.6700.99
54_E82_T0.6530.99
78_T83_G0.6520.99
24_L31_L0.6470.99
77_A81_L0.6440.99
86_D92_G0.6370.99
94_D98_K0.6350.99
27_S50_E0.6330.99
36_I56_I0.6300.99
41_S71_N0.6150.99
58_V108_L0.6120.98
101_G104_S0.6100.98
64_L79_I0.6090.98
92_G98_K0.6050.98
94_D97_S0.6010.98
87_V92_G0.5910.98
17_P60_G0.5860.98
114_P119_W0.5840.98
45_D74_T0.5780.98
96_G100_I0.5780.98
114_P118_T0.5770.98
8_P12_D0.5770.98
57_M103_M0.5700.98
116_T121_K0.5690.98
69_E72_P0.5640.97
64_L100_I0.5590.97
77_A83_G0.5580.97
60_G105_G0.5570.97
113_A116_T0.5540.97
16_I19_G0.5520.97
24_L51_L0.5510.97
87_V97_S0.5500.97
81_L99_G0.5480.97
11_G32_R0.5430.97
13_R54_E0.5420.97
57_M104_S0.5410.97
28_P31_L0.5400.97
43_A75_H0.5390.97
89_G94_D0.5340.96
88_D97_S0.5330.96
10_A29_P0.5280.96
55_W99_G0.5280.96
43_A73_I0.5200.96
58_V100_I0.5200.96
40_L64_L0.5180.96
42_F79_I0.5080.95
33_S57_M0.5070.95
49_T53_V0.5070.95
83_G98_K0.5070.95
118_T121_K0.5060.95
85_P91_D0.5000.95
87_V93_P0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h09A 1 0.8293 55.5 0.854 Contact Map
3szeA 1 0.813 52.1 0.857 Contact Map
4om9A 1 0.813 48.9 0.859 Contact Map
3syjA 2 0.8293 48.2 0.86 Contact Map
1wxrA 1 0.8293 42.1 0.865 Contact Map
4peuA 1 0.8374 23 0.882 Contact Map
3uafA 2 0.5447 6.3 0.909 Contact Map
3qr8A 3 0.5935 5.7 0.91 Contact Map
1cpyA 1 0.6829 4.7 0.914 Contact Map
4w8qA 2 0.9268 4.4 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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