GREMLIN Database
OpgC_C - OpgC protein
PFAM: PF10129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 358 (356)
Sequences: 4822 (3267)
Seq/√Len: 173.1
META: 0.815

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_A198_L5.8431.00
45_F274_F4.9551.00
305_Q354_S3.2441.00
140_L144_L2.9611.00
124_G129_R2.9331.00
313_L349_V2.8651.00
50_T54_V2.7401.00
192_N265_N2.6301.00
19_D30_T2.6291.00
35_G273_H2.5241.00
6_D9_R2.5101.00
37_S273_H2.4601.00
151_V201_V2.4551.00
81_A312_C2.4051.00
151_V162_V2.3811.00
75_A146_L2.3561.00
117_D120_V2.3331.00
76_W80_V2.3191.00
19_D39_A2.2911.00
19_D31_L2.2651.00
173_A195_A2.2591.00
301_I305_Q2.2541.00
153_W157_R2.2461.00
199_L266_L2.2041.00
44_V140_L2.1891.00
286_P289_W2.1891.00
166_S197_Q2.1731.00
12_A42_G2.1641.00
224_L280_L2.1621.00
72_L75_A2.0641.00
154_L162_V2.0591.00
202_L275_L2.0371.00
17_F342_G2.0311.00
235_L239_L2.0291.00
262_D265_N2.0221.00
5_L46_L2.0171.00
225_A229_A1.9931.00
104_D107_E1.9531.00
230_Y234_A1.9521.00
170_Y174_Q1.9321.00
58_A70_R1.8981.00
274_F278_A1.8971.00
14_W300_L1.8521.00
150_L153_W1.8301.00
172_L176_F1.8181.00
290_R293_R1.8071.00
198_L202_L1.7711.00
41_E270_R1.7601.00
82_H139_P1.7471.00
347_I351_Y1.7371.00
26_L336_L1.7231.00
221_R225_A1.7111.00
5_L50_T1.7071.00
294_S297_L1.7051.00
148_F204_A1.6851.00
158_R161_L1.6651.00
71_L148_F1.6391.00
14_W343_I1.6231.00
234_A238_R1.6171.00
254_L258_L1.6171.00
165_A169_L1.6151.00
317_L345_L1.6071.00
86_F125_A1.6031.00
22_P26_L1.5911.00
15_L31_L1.5891.00
202_L271_L1.5881.00
227_A276_A1.5661.00
57_R61_R1.5581.00
302_L351_Y1.5541.00
159_P205_W1.5541.00
11_L15_L1.5471.00
149_P153_W1.5441.00
83_I126_L1.5351.00
231_L280_L1.5321.00
1_R6_D1.5211.00
224_L283_R1.5181.00
45_F52_A1.5121.00
166_S201_V1.5081.00
123_V127_L1.5031.00
102_N107_E1.4951.00
314_G318_S1.4901.00
331_G334_M1.4581.00
70_R77_Q1.4541.00
218_P221_R1.4301.00
255_P260_P1.4201.00
22_P25_V1.4191.00
78_L142_I1.4041.00
23_G26_L1.4031.00
263_K270_R1.3981.00
105_Y108_E1.3921.00
254_L260_P1.3851.00
352_L355_W1.3611.00
158_R162_V1.3601.00
255_P258_L1.3511.00
64_F153_W1.3381.00
163_L167_A1.3291.00
6_D10_G1.3251.00
174_Q195_A1.3131.00
163_L205_W1.3101.00
7_F300_L1.3011.00
131_Q139_P1.2941.00
309_E353_L1.2921.00
241_W244_P1.2911.00
31_L38_D1.2881.00
222_W225_A1.2831.00
313_L345_L1.2801.00
154_L157_R1.2761.00
257_L260_P1.2721.00
261_I269_L1.2701.00
352_L356_Y1.2481.00
49_Y206_L1.2431.00
321_G338_V1.2421.00
107_E112_A1.2421.00
255_P259_Y1.2421.00
240_S243_F1.2341.00
341_A345_L1.2321.00
110_N113_P1.2301.00
38_D263_K1.2291.00
32_R37_S1.2291.00
303_L347_I1.2281.00
51_A148_F1.2241.00
267_G270_R1.2241.00
310_V313_L1.2211.00
230_Y272_L1.2211.00
349_V353_L1.2191.00
86_F132_P1.2181.00
31_L42_G1.2151.00
24_N339_S1.2121.00
65_L68_A1.2071.00
335_Q339_S1.1951.00
47_S50_T1.1941.00
52_A207_G1.1921.00
295_P298_R1.1881.00
13_L16_I1.1751.00
153_W156_R1.1731.00
112_A116_D1.1721.00
96_V323_F1.1711.00
288_D291_G1.1701.00
150_L154_L1.1621.00
302_L305_Q1.1601.00
51_A55_Y1.1441.00
145_L148_F1.1411.00
75_A142_I1.1321.00
252_D256_D1.1301.00
344_A348_A1.1261.00
5_L82_H1.1221.00
120_V124_G1.1201.00
31_L34_F1.1171.00
174_Q177_G1.1101.00
237_I241_W1.1101.00
3_L301_I1.1031.00
31_L39_A1.0991.00
230_Y233_F1.0981.00
262_D267_G1.0971.00
276_A279_Y1.0961.00
63_G66_A1.0961.00
223_L279_Y1.0941.00
7_F301_I1.0811.00
5_L47_S1.0811.00
106_L115_L1.0781.00
14_W303_L1.0771.00
52_A204_A1.0701.00
64_F68_A1.0671.00
299_P347_I1.0661.00
237_I240_S1.0641.00
228_A280_L1.0631.00
38_D41_E1.0591.00
143_V147_L1.0571.00
154_L158_R1.0561.00
122_L125_A1.0400.99
345_L349_V1.0390.99
239_L244_P1.0380.99
78_L145_L1.0380.99
306_H354_S1.0350.99
236_V240_S1.0330.99
51_A71_L1.0320.99
223_L238_R1.0110.99
60_R156_R1.0110.99
30_T39_A1.0080.99
49_Y207_G1.0080.99
229_A233_F1.0000.99
57_R60_R0.9930.99
231_L273_H0.9900.99
234_A273_H0.9890.99
84_L88_I0.9880.99
251_P254_L0.9880.99
351_Y355_W0.9820.99
268_P272_L0.9770.99
58_A62_R0.9760.99
235_L238_R0.9740.99
298_R302_L0.9670.99
247_G250_L0.9640.99
218_P279_Y0.9610.99
165_A168_A0.9600.99
263_K266_L0.9600.99
92_L96_V0.9590.99
133_V137_I0.9530.99
31_L37_S0.9510.99
129_R181_P0.9500.99
244_P247_G0.9490.99
167_A202_L0.9490.99
261_I267_G0.9420.99
159_P209_G0.9420.99
277_L282_A0.9410.99
230_Y236_V0.9410.99
46_L50_T0.9400.99
162_V205_W0.9390.99
238_R241_W0.9310.99
332_L336_L0.9270.99
103_P108_E0.9200.99
312_C316_F0.9160.99
251_P255_P0.9120.99
252_D255_P0.9110.99
93_I96_V0.9060.99
190_F264_T0.9030.98
201_V205_W0.9030.98
261_I268_P0.9010.98
302_L347_I0.9000.98
62_R66_A0.8990.98
31_L35_G0.8980.98
79_Y83_I0.8970.98
113_P116_D0.8920.98
45_F49_Y0.8910.98
151_V165_A0.8860.98
80_V84_L0.8830.98
60_R208_L0.8810.98
326_A330_G0.8750.98
98_L101_D0.8740.98
48_G200_F0.8730.98
128_L142_I0.8720.98
82_H135_L0.8710.98
78_L312_C0.8610.98
87_L122_L0.8540.98
220_S224_L0.8510.98
141_Y145_L0.8500.98
51_A145_L0.8450.98
230_Y238_R0.8440.98
107_E110_N0.8420.98
103_P111_L0.8390.98
219_R283_R0.8380.98
30_T33_N0.8380.98
219_R222_W0.8360.98
343_I347_I0.8350.97
32_R36_F0.8320.97
22_P27_S0.8310.97
172_L175_L0.8310.97
69_A73_R0.8280.97
3_L305_Q0.8280.97
198_L271_L0.8220.97
1_R9_R0.8220.97
25_V335_Q0.8220.97
328_A334_M0.8210.97
337_L341_A0.8200.97
33_N36_F0.8190.97
155_L205_W0.8180.97
106_L110_N0.8160.97
231_L234_A0.8160.97
285_V289_W0.8140.97
205_W209_G0.8140.97
264_T268_P0.8140.97
90_L125_A0.8120.97
240_S244_P0.8120.97
232_L236_V0.8100.97
285_V288_D0.8070.97
103_P106_L0.8060.97
133_V136_D0.8050.97
160_W164_A0.8000.97
180_L194_F0.7970.97
237_I243_F0.7960.97
243_F246_L0.7960.97
155_L208_L0.7950.97
325_L335_Q0.7950.97
225_A228_A0.7930.97
130_Y139_P0.7920.97
135_L315_V0.7920.97
28_W34_F0.7890.96
338_V341_A0.7880.96
265_N268_P0.7880.96
170_Y178_W0.7870.96
1_R4_R0.7860.96
223_L226_L0.7840.96
23_G28_W0.7830.96
85_L316_F0.7810.96
189_W193_P0.7800.96
230_Y235_L0.7800.96
242_L246_L0.7780.96
27_S32_R0.7780.96
170_Y268_P0.7770.96
282_A286_P0.7760.96
303_L310_V0.7760.96
33_N38_D0.7760.96
16_I314_G0.7750.96
302_L350_A0.7730.96
309_E349_V0.7730.96
59_M67_A0.7700.96
306_H353_L0.7680.96
131_Q136_D0.7660.96
344_A347_I0.7660.96
226_L229_A0.7660.96
333_W336_L0.7650.96
161_L164_A0.7630.96
298_R301_I0.7630.96
343_I349_V0.7620.96
324_V328_A0.7600.96
273_H277_L0.7580.96
54_V57_R0.7550.95
168_A172_L0.7550.95
113_P117_D0.7540.95
296_L299_P0.7510.95
148_F200_F0.7490.95
72_L146_L0.7480.95
242_L245_P0.7460.95
241_W245_P0.7420.95
56_G60_R0.7420.95
172_L178_W0.7400.95
68_A153_W0.7380.95
121_A125_A0.7380.95
50_T53_L0.7360.95
253_W257_L0.7350.95
33_N37_S0.7350.95
30_T270_R0.7330.95
49_Y210_G0.7330.95
21_I318_S0.7320.95
103_P107_E0.7310.95
24_N27_S0.7300.95
277_L280_L0.7300.95
306_H350_A0.7290.95
82_H311_F0.7290.95
170_Y195_A0.7260.94
237_I242_L0.7230.94
17_F21_I0.7230.94
302_L354_S0.7230.94
240_S246_L0.7230.94
228_A232_L0.7200.94
310_V346_M0.7200.94
233_F237_I0.7190.94
340_L343_I0.7170.94
231_L276_A0.7160.94
213_G218_P0.7130.94
259_Y267_G0.7130.94
332_L335_Q0.7130.94
325_L338_V0.7080.94
45_F202_L0.7070.94
19_D24_N0.7060.94
52_A208_L0.7020.93
18_I26_L0.7020.93
209_G213_G0.7020.93
271_L274_F0.7000.93
125_A130_Y0.7000.93
236_V242_L0.6980.93
7_F12_A0.6980.93
105_Y109_L0.6980.93
136_D139_P0.6960.93
137_I311_F0.6940.93
266_L270_R0.6930.93
222_W226_L0.6920.93
166_S198_L0.6910.93
43_F48_G0.6910.93
167_A171_L0.6900.93
207_G210_G0.6900.93
234_A241_W0.6890.93
236_V244_P0.6890.93
18_I339_S0.6880.93
239_L242_L0.6880.93
302_L306_H0.6880.93
217_L220_S0.6870.93
285_V291_G0.6870.93
147_L151_V0.6860.93
32_R38_D0.6830.92
170_Y177_G0.6810.92
288_D292_L0.6800.92
161_L165_A0.6790.92
138_L141_Y0.6780.92
231_L235_L0.6750.92
121_A124_G0.6750.92
25_V28_W0.6750.92
280_L284_L0.6750.92
114_F118_P0.6680.92
244_P250_L0.6660.91
319_F322_H0.6660.91
353_L356_Y0.6660.91
89_Y92_L0.6650.91
19_D32_R0.6650.91
237_I244_P0.6620.91
147_L150_L0.6600.91
347_I352_L0.6590.91
137_I141_Y0.6580.91
18_I30_T0.6570.91
179_N264_T0.6550.91
51_A78_L0.6540.91
251_P260_P0.6520.91
254_L259_Y0.6510.91
36_F234_A0.6510.91
88_I95_Y0.6500.90
15_L19_D0.6500.90
82_H86_F0.6490.90
258_L261_I0.6490.90
90_L95_Y0.6480.90
91_A94_A0.6450.90
69_A355_W0.6440.90
310_V353_L0.6440.90
254_L257_L0.6390.90
3_L7_F0.6380.90
82_H128_L0.6380.90
51_A307_S0.6370.90
238_R245_P0.6350.89
34_F235_L0.6340.89
223_L227_A0.6330.89
116_D120_V0.6330.89
253_W256_D0.6320.89
174_Q269_L0.6320.89
19_D33_N0.6320.89
47_S54_V0.6300.89
15_L30_T0.6270.89
134_N315_V0.6270.89
215_A219_R0.6240.89
121_A130_Y0.6210.88
16_I21_I0.6210.88
179_N188_G0.6200.88
220_S225_A0.6180.88
94_A98_L0.6180.88
339_S343_I0.6180.88
40_A266_L0.6160.88
275_L278_A0.6160.88
112_A115_L0.6130.88
86_F135_L0.6100.87
105_Y114_F0.6090.87
311_F314_G0.6090.87
23_G27_S0.6080.87
317_L342_G0.6080.87
57_R211_A0.6060.87
106_L112_A0.6040.87
146_L149_P0.6030.87
135_L311_F0.6030.87
271_L277_L0.6010.87
152_L157_R0.5990.87
132_P136_D0.5980.86
230_Y276_A0.5970.86
332_L341_A0.5960.86
89_Y96_V0.5950.86
94_A97_A0.5940.86
131_Q137_I0.5930.86
218_P223_L0.5920.86
154_L161_L0.5910.86
54_V145_L0.5890.86
46_L51_A0.5880.85
270_R273_H0.5880.85
307_S310_V0.5880.85
38_D314_G0.5880.85
155_L158_R0.5870.85
283_R286_P0.5870.85
233_F236_V0.5860.85
88_I91_A0.5860.85
34_F37_S0.5820.85
286_P293_R0.5800.85
155_L162_V0.5770.84
54_V59_M0.5770.84
195_A265_N0.5750.84
183_Y187_G0.5750.84
22_P136_D0.5720.84
110_N114_F0.5720.84
248_A344_A0.5710.84
111_L115_L0.5700.84
15_L42_G0.5670.83
24_N28_W0.5670.83
279_Y283_R0.5660.83
287_R290_R0.5650.83
287_R292_L0.5650.83
58_A67_A0.5650.83
228_A231_L0.5640.83
114_F117_D0.5640.83
167_A271_L0.5610.83
338_V342_G0.5600.83
89_Y319_F0.5580.82
239_L243_F0.5570.82
286_P291_G0.5570.82
101_D104_D0.5570.82
239_L247_G0.5540.82
233_F240_S0.5520.82
35_G38_D0.5500.82
219_R224_L0.5500.82
304_G307_S0.5490.81
1_R5_L0.5480.81
162_V165_A0.5470.81
182_A185_S0.5470.81
136_D263_K0.5460.81
19_D27_S0.5450.81
173_A176_F0.5450.81
42_G52_A0.5450.81
131_Q135_L0.5440.81
134_N139_P0.5440.81
163_L202_L0.5420.81
6_D13_L0.5400.80
37_S42_G0.5390.80
113_P120_V0.5380.80
131_Q134_N0.5380.80
175_L178_W0.5380.80
246_L251_P0.5370.80
234_A240_S0.5370.80
81_A309_E0.5360.80
191_F195_A0.5360.80
259_Y276_A0.5360.80
115_L120_V0.5340.80
163_L198_L0.5340.80
90_L94_A0.5330.79
88_I92_L0.5300.79
50_T203_G0.5290.79
52_A71_L0.5290.79
130_Y136_D0.5290.79
34_F38_D0.5290.79
102_N106_L0.5260.79
162_V201_V0.5250.78
110_N115_L0.5250.78
108_E115_L0.5230.78
13_L17_F0.5200.78
78_L92_L0.5200.78
288_D294_S0.5190.78
46_L91_A0.5170.77
333_W337_L0.5170.77
88_I316_F0.5160.77
41_E271_L0.5160.77
109_L112_A0.5160.77
51_A56_G0.5130.77
330_G334_M0.5130.77
36_F39_A0.5120.77
141_Y197_Q0.5120.77
20_H43_F0.5110.77
286_P290_R0.5090.76
202_L205_W0.5060.76
243_F247_G0.5050.76
135_L138_L0.5020.75
262_D266_L0.5010.75
89_Y93_I0.5000.75
159_P162_V0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uc1A 3 0.3408 9.7 0.962 Contact Map
4nv5A 1 0.3715 7.7 0.964 Contact Map
2mgyA 1 0.3659 6.1 0.965 Contact Map
2l9uA 2 0.095 5 0.967 Contact Map
4px7A 1 0.2654 2.4 0.971 Contact Map
1cmxA 2 0.1564 2.3 0.972 Contact Map
4ryoA 1 0.3268 2.3 0.972 Contact Map
2m20A 2 0.0866 2.2 0.972 Contact Map
2mofA 1 0.0978 1.9 0.973 Contact Map
2l2tA 2 0.1061 1.8 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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