GREMLIN Database
OpcA_G6PD_assem - Glucose-6-phosphate dehydrogenase subunit
PFAM: PF10128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 254 (249)
Sequences: 5416 (3761)
Seq/√Len: 238.3
META: 0.835

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_R252_E4.5421.00
136_L168_L4.1181.00
105_D108_A3.9871.00
158_G165_A3.4021.00
195_R205_S3.1831.00
173_A178_W3.0321.00
197_E202_R2.9831.00
174_S253_A2.8391.00
193_S205_S2.7611.00
191_I194_V2.6921.00
246_R251_E2.5511.00
170_G174_S2.5441.00
71_L86_L2.5291.00
191_I198_R2.4841.00
125_A164_S2.4801.00
193_S207_E2.4351.00
127_T240_E2.4141.00
26_R48_G2.3581.00
71_L93_A2.3501.00
155_T195_R2.3261.00
170_G253_A2.2651.00
49_G52_A2.0871.00
157_E193_S2.0791.00
209_P212_R2.0631.00
78_P81_P2.0521.00
99_D128_R1.9881.00
202_R205_S1.9791.00
216_L219_P1.9611.00
15_L59_V1.8861.00
215_T219_P1.8191.00
198_R202_R1.8021.00
232_S235_E1.7941.00
95_R122_T1.7751.00
47_L58_V1.7491.00
155_T197_E1.7381.00
112_R115_E1.7201.00
224_R228_L1.6851.00
191_I208_R1.6801.00
154_V172_L1.6661.00
140_F148_L1.6591.00
191_I196_L1.6471.00
80_P83_D1.6211.00
204_I208_R1.5841.00
82_A87_G1.5831.00
194_V208_R1.5761.00
190_G196_L1.5641.00
217_S223_E1.5371.00
153_S197_E1.5251.00
154_V178_W1.5141.00
210_D213_T1.5061.00
103_W109_A1.5041.00
28_D31_V1.4991.00
103_W106_P1.4811.00
198_R201_G1.4751.00
174_S252_E1.4731.00
192_T207_E1.4711.00
14_V42_Q1.4701.00
106_P110_L1.4521.00
224_R227_P1.4521.00
214_A219_P1.4501.00
142_Q145_R1.4401.00
81_P84_D1.4101.00
154_V180_V1.4071.00
30_E46_R1.4051.00
126_W167_L1.4041.00
170_G173_A1.3991.00
156_V169_A1.3981.00
130_T240_E1.3851.00
90_A93_A1.3611.00
215_T218_R1.3541.00
96_R121_D1.3531.00
27_L32_R1.3441.00
108_A111_R1.3381.00
155_T183_E1.3171.00
209_P213_T1.3161.00
239_E242_R1.3041.00
152_T199_A1.2981.00
30_E33_A1.2971.00
234_A238_A1.2951.00
201_G204_I1.2891.00
3_E6_R1.2871.00
191_I204_I1.2811.00
149_E200_D1.2631.00
230_R235_E1.2441.00
80_P116_G1.2311.00
193_S196_L1.2281.00
135_L224_R1.2281.00
35_G38_V1.2131.00
192_T198_R1.1991.00
27_L51_A1.1971.00
196_L199_A1.1911.00
180_V183_E1.1771.00
125_A163_P1.1651.00
166_L182_R1.1631.00
13_I43_I1.1631.00
146_P149_E1.1391.00
33_A39_C1.1371.00
137_A140_F1.1331.00
125_A129_L1.1261.00
111_R114_A1.1211.00
240_E243_R1.1181.00
101_A128_R1.1091.00
218_R221_Q1.1021.00
127_T130_T1.0991.00
99_D136_L1.0971.00
81_P87_G1.0831.00
195_R202_R1.0731.00
27_L33_A1.0691.00
193_S198_R1.0631.00
157_E195_R1.0611.00
182_R185_S1.0521.00
111_R115_E1.0511.00
27_L31_V1.0491.00
154_V169_A1.0451.00
21_G24_E1.0441.00
84_D87_G1.0421.00
78_P82_A1.0331.00
72_W128_R1.0321.00
109_A112_R1.0221.00
69_V93_A1.0181.00
248_P252_E1.0181.00
209_P215_T1.0171.00
129_L164_S1.0131.00
25_S50_E1.0061.00
215_T223_E1.0051.00
129_L168_L1.0021.00
85_P90_A1.0001.00
100_S125_A0.9981.00
16_V44_V0.9981.00
151_I154_V0.9951.00
71_L90_A0.9951.00
96_R119_P0.9851.00
22_A25_S0.9801.00
108_A112_R0.9681.00
134_E138_A0.9671.00
169_A178_W0.9631.00
86_L90_A0.9621.00
19_D22_A0.9591.00
37_A42_Q0.9531.00
194_V204_I0.9471.00
110_L114_A0.9461.00
87_G90_A0.9451.00
30_E42_Q0.9451.00
81_P86_L0.9391.00
70_V125_A0.9371.00
192_T204_I0.9361.00
182_R187_G0.9341.00
147_P198_R0.9301.00
49_G73_W0.9281.00
244_L247_D0.9271.00
130_T239_E0.9271.00
249_V253_A0.9241.00
56_P60_L0.9211.00
110_L113_L0.9211.00
201_G208_R0.9181.00
137_A141_D0.9111.00
193_S197_E0.9101.00
192_T200_D0.8991.00
20_P23_G0.8931.00
155_T181_E0.8900.99
97_I122_T0.8900.99
222_P226_V0.8880.99
198_R208_R0.8880.99
146_P150_E0.8810.99
106_P109_A0.8760.99
181_E184_V0.8710.99
130_T243_R0.8690.99
37_A40_S0.8680.99
179_P182_R0.8670.99
100_S103_W0.8580.99
17_A21_G0.8570.99
122_T244_L0.8510.99
151_I178_W0.8470.99
196_L204_I0.8460.99
39_C42_Q0.8460.99
65_P69_V0.8390.99
184_V188_G0.8390.99
147_P150_E0.8380.99
198_R204_I0.8350.99
58_V61_P0.8280.99
79_P82_A0.8270.99
212_R217_S0.8260.99
213_T218_R0.8240.99
196_L208_R0.8230.99
129_L139_A0.8190.99
56_P61_P0.8170.99
157_E183_E0.8070.99
36_D39_C0.8010.99
217_S220_G0.7990.99
157_E186_E0.7980.99
3_E234_A0.7960.99
13_I16_V0.7930.99
47_L61_P0.7890.99
47_L55_L0.7870.99
104_P108_A0.7850.99
181_E186_E0.7810.99
33_A38_V0.7800.99
240_E244_L0.7730.99
27_L30_E0.7580.98
84_D88_R0.7550.98
151_I196_L0.7540.98
190_G198_R0.7540.98
182_R186_E0.7540.98
152_T155_T0.7530.98
15_L55_L0.7490.98
214_A218_R0.7450.98
65_P127_T0.7360.98
210_D215_T0.7360.98
127_T239_E0.7350.98
35_G40_S0.7330.98
216_L220_G0.7240.98
244_L249_V0.7240.98
245_D248_P0.7150.98
189_P192_T0.7070.97
10_S67_L0.7040.97
221_Q228_L0.7030.97
205_S209_P0.6980.97
213_T216_L0.6920.97
199_A207_E0.6900.97
25_S31_V0.6880.97
227_P246_R0.6860.97
20_P48_G0.6860.97
158_G161_D0.6860.97
94_D237_L0.6840.97
150_E199_A0.6820.97
191_I201_G0.6820.97
10_S40_S0.6810.97
153_S181_E0.6800.97
59_V89_L0.6780.97
212_R215_T0.6760.97
238_A242_R0.6750.97
103_W107_L0.6750.97
15_L47_L0.6750.97
222_P228_L0.6730.97
54_H61_P0.6730.97
185_S188_G0.6710.97
62_L191_I0.6710.97
73_W120_G0.6700.96
211_G217_S0.6680.96
64_L95_R0.6660.96
51_A54_H0.6640.96
225_V228_L0.6600.96
45_L62_L0.6520.96
100_S123_D0.6490.96
86_L133_R0.6430.96
90_A94_D0.6420.96
248_P251_E0.6420.96
32_R44_V0.6400.95
192_T195_R0.6390.95
57_S71_L0.6380.95
124_L237_L0.6380.95
78_P83_D0.6350.95
107_L113_L0.6340.95
232_S236_L0.6300.95
226_V232_S0.6260.95
32_R43_I0.6240.95
154_V173_A0.6240.95
189_P205_S0.6240.95
184_V197_E0.6230.95
173_A176_L0.6230.95
181_E185_S0.6220.95
37_A45_L0.6210.95
191_I202_R0.6200.95
5_S36_D0.6190.95
14_V44_V0.6180.95
82_A85_P0.6180.95
4_A42_Q0.6170.94
84_D124_L0.6160.94
8_H70_V0.6160.94
5_S39_C0.6150.94
173_A179_P0.6130.94
183_E187_G0.6120.94
231_R239_E0.6100.94
65_P95_R0.6080.94
249_V252_E0.6070.94
146_P198_R0.6050.94
85_P88_R0.6030.94
36_D42_Q0.6020.94
26_R32_R0.6000.94
32_R40_S0.5980.94
20_P25_S0.5970.93
29_A32_R0.5970.93
207_E210_D0.5960.93
192_T208_R0.5940.93
81_P116_G0.5930.93
101_A159_A0.5920.93
70_V164_S0.5890.93
47_L54_H0.5890.93
210_D219_P0.5890.93
18_R21_G0.5880.93
180_V185_S0.5880.93
176_L220_G0.5870.93
105_D111_R0.5860.93
239_E245_D0.5860.93
57_S163_P0.5840.93
14_V41_E0.5840.93
32_R37_A0.5820.93
122_T240_E0.5820.93
197_E200_D0.5800.92
226_V238_A0.5800.92
85_P89_L0.5770.92
10_S14_V0.5760.92
138_A142_Q0.5760.92
30_E36_D0.5760.92
73_W96_R0.5710.92
111_R197_E0.5710.92
33_A37_A0.5690.92
63_L94_D0.5690.92
9_P27_L0.5680.92
27_L45_L0.5680.92
36_D40_S0.5650.91
37_A41_E0.5640.91
30_E44_V0.5630.91
231_R244_L0.5620.91
130_T134_E0.5600.91
70_V240_E0.5570.91
243_R246_R0.5550.91
215_T220_G0.5550.91
138_A224_R0.5540.91
16_V46_R0.5520.91
222_P229_P0.5510.90
44_V167_L0.5510.90
30_E38_V0.5510.90
229_P239_E0.5500.90
70_V138_A0.5490.90
125_A128_R0.5480.90
192_T210_D0.5470.90
61_P132_W0.5470.90
104_P109_A0.5460.90
207_E211_G0.5450.90
140_F151_I0.5440.90
197_E201_G0.5440.90
106_P163_P0.5430.90
135_L138_A0.5410.90
13_I33_A0.5410.90
48_G52_A0.5390.89
213_T219_P0.5390.89
95_R127_T0.5380.89
148_L198_R0.5380.89
42_Q66_D0.5350.89
79_P83_D0.5340.89
147_P200_D0.5330.89
65_P68_P0.5320.89
190_G206_L0.5300.89
231_R235_E0.5300.89
60_L89_L0.5300.89
32_R39_C0.5290.89
41_E131_P0.5290.89
5_S38_V0.5290.89
155_T193_S0.5270.88
212_R218_R0.5260.88
63_L69_V0.5240.88
87_G156_V0.5210.88
140_F154_V0.5200.88
81_P85_P0.5190.88
227_P243_R0.5170.87
107_L112_R0.5160.87
181_E187_G0.5160.87
251_E254_L0.5140.87
167_L250_Y0.5140.87
236_L249_V0.5130.87
42_Q45_L0.5130.87
106_P115_E0.5120.87
244_L250_Y0.5110.87
194_V198_R0.5100.87
183_E186_E0.5100.87
182_R191_I0.5080.87
191_I195_R0.5050.86
214_A221_Q0.5040.86
63_L138_A0.5030.86
70_V95_R0.5030.86
159_A210_D0.5020.86
185_S189_P0.5010.86
174_S249_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.