GREMLIN Database
Mu-like_gpT - Mu-like prophage major head subunit gpT
PFAM: PF10124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 289 (289)
Sequences: 1019 (786)
Seq/√Len: 46.2
META: 0.687

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_P256_L3.9911.00
71_K81_D3.9041.00
50_E70_K3.5031.00
23_Y29_T3.4831.00
71_K193_D3.4441.00
264_L283_L2.7651.00
181_M187_E2.7451.00
149_Q214_Y2.6851.00
84_E174_K2.6431.00
249_L284_L2.6261.00
266_A276_I2.6161.00
118_F215_G2.5951.00
114_L168_L2.4801.00
172_E175_K2.4391.00
35_A82_D2.4041.00
267_E278_Y2.3991.00
221_T224_N2.3871.00
161_T249_L2.3171.00
225_Y280_T2.2361.00
126_Q130_D2.2241.00
162_S248_T2.2071.00
225_Y229_R2.1981.00
161_T248_T2.1321.00
113_L207_F2.1201.00
150_G218_A2.1011.00
54_D192_R2.0861.00
229_R257_E2.0420.99
260_A283_L2.0370.99
25_K282_E2.0340.99
149_Q218_A2.0260.99
154_T253_P1.9850.99
77_G194_E1.9370.99
225_Y281_A1.9290.99
174_K200_D1.8960.99
170_F203_C1.8660.99
269_L273_A1.8600.99
47_G108_E1.8590.99
145_V210_W1.8570.99
28_T165_L1.8290.99
181_M196_L1.8230.99
118_F217_K1.8180.99
262_K276_I1.8090.99
57_I77_G1.7830.99
14_K96_Q1.7660.98
265_E279_G1.7310.98
97_E100_R1.6850.98
229_R280_T1.6740.98
29_T172_E1.6660.98
176_P201_A1.6480.98
193_D200_D1.5980.97
225_Y277_W1.5950.97
105_H176_P1.5830.97
229_R281_A1.5790.97
132_D144_S1.5750.97
262_K268_L1.5560.96
146_S149_Q1.5510.96
277_W281_A1.5390.96
270_A273_A1.5330.96
22_Q111_F1.5250.96
232_M235_F1.5160.96
154_T256_L1.5040.96
268_L273_A1.5030.96
261_R265_E1.5030.96
15_G96_Q1.5010.96
265_E278_Y1.4680.95
236_K242_P1.4580.95
146_S214_Y1.4510.95
97_E163_R1.4460.95
108_E241_R1.4360.94
209_F212_L1.4200.94
57_I191_M1.4150.94
81_D193_D1.4070.94
148_M215_G1.4050.94
268_L271_G1.4000.94
48_L176_P1.3870.93
79_D193_D1.3860.93
127_Y130_D1.3810.93
188_N196_L1.3760.93
183_D186_D1.3640.93
116_A120_T1.3610.93
191_M196_L1.3560.93
100_R104_A1.3520.92
176_P203_C1.3340.92
9_K37_N1.3310.92
226_A277_W1.3230.92
177_E184_P1.3040.91
170_F201_A1.2570.89
277_W280_T1.2570.89
233_M287_P1.2460.89
100_R164_A1.2460.89
64_G68_K1.2440.89
148_M214_Y1.2210.88
109_L205_A1.2150.88
149_Q224_N1.2150.88
67_I206_G1.2080.87
127_Y131_T1.2060.87
36_S66_T1.2040.87
79_D82_D1.2010.87
257_E280_T1.2010.87
257_E281_A1.1960.87
257_E285_V1.1950.87
37_N87_N1.1920.87
187_E196_L1.1910.87
110_V168_L1.1850.86
267_E274_S1.1800.86
81_D174_K1.1730.86
43_G63_H1.1730.86
5_F62_A1.1710.86
225_Y257_E1.1640.85
70_K204_N1.1630.85
257_E261_R1.1620.85
120_T207_F1.1560.85
268_L274_S1.1550.85
219_T223_A1.1490.85
8_F95_F1.1470.85
126_Q132_D1.1440.84
261_R283_L1.1390.84
257_E277_W1.1250.83
226_A262_K1.1180.83
160_D248_T1.1130.83
258_A277_W1.1130.83
11_A92_S1.1120.83
24_E29_T1.1120.83
261_R277_W1.1070.82
90_I93_P1.1070.82
219_T259_A1.0990.82
226_A257_E1.0890.81
69_N85_D1.0840.81
79_D194_E1.0840.81
120_T127_Y1.0790.81
266_A273_A1.0660.80
121_L127_Y1.0640.80
101_A108_E1.0590.79
226_A230_A1.0580.79
159_L251_V1.0560.79
226_A258_A1.0560.79
136_L239_G1.0460.79
221_T263_L1.0440.79
25_K249_L1.0430.78
57_I75_T1.0310.78
118_F157_F1.0300.78
232_M247_P1.0280.77
72_F203_C1.0250.77
32_S69_N1.0250.77
23_Y27_A1.0230.77
105_H203_C1.0230.77
127_Y132_D1.0220.77
229_R277_W1.0210.77
44_Q79_D1.0110.76
48_L105_H1.0040.76
188_N194_E1.0020.76
184_P195_F1.0000.75
97_E101_A0.9950.75
4_L83_I0.9780.74
117_G207_F0.9740.73
112_G116_A0.9720.73
214_Y231_A0.9710.73
71_K200_D0.9560.72
258_A262_K0.9510.72
174_K193_D0.9470.71
97_E164_A0.9460.71
25_K248_T0.9440.71
261_R280_T0.9440.71
233_M254_P0.9440.71
106_P170_F0.9440.71
135_V145_V0.9430.71
232_M245_I0.9380.71
154_T255_S0.9370.71
160_D246_R0.9340.70
74_S101_A0.9320.70
38_T64_G0.9310.70
81_D84_E0.9310.70
11_A15_G0.9280.70
116_A207_F0.9260.70
46_P74_S0.9220.69
258_A276_I0.9180.69
155_P217_K0.9150.69
165_L212_L0.9130.69
22_Q286_V0.9120.68
152_A219_T0.9120.68
36_S68_K0.8990.67
105_H201_A0.8970.67
237_G241_R0.8960.67
15_G99_G0.8890.66
76_V95_F0.8880.66
264_L281_A0.8870.66
67_I204_N0.8830.66
80_R177_E0.8800.66
162_S246_R0.8750.65
187_E192_R0.8740.65
80_R195_F0.8720.65
150_G214_Y0.8720.65
261_R264_L0.8710.65
58_K74_S0.8710.65
28_T212_L0.8670.64
159_L213_A0.8630.64
118_F148_M0.8590.64
46_P58_K0.8590.64
188_N192_R0.8580.64
179_V200_D0.8560.63
174_K184_P0.8550.63
6_T38_T0.8540.63
114_L251_V0.8500.63
21_S107_D0.8490.63
242_P288_W0.8480.63
81_D200_D0.8450.62
3_A38_T0.8440.62
82_D87_N0.8420.62
172_E176_P0.8390.62
80_R84_E0.8390.62
71_K174_K0.8370.62
118_F155_P0.8350.62
179_V184_P0.8340.61
218_A227_A0.8320.61
16_L103_A0.8250.61
234_S255_S0.8220.60
174_K179_V0.8180.60
155_P215_G0.8150.60
10_A14_K0.8120.59
28_T209_F0.8100.59
258_A278_Y0.8100.59
177_E200_D0.8060.59
149_Q217_K0.8050.59
77_G196_L0.8040.59
148_M218_A0.8010.58
227_A231_A0.8000.58
46_P97_E0.7980.58
150_G153_G0.7980.58
216_S228_A0.7930.58
233_M257_E0.7910.57
137_D143_T0.7860.57
214_Y245_I0.7790.56
266_A274_S0.7750.56
226_A229_R0.7740.56
157_F215_G0.7730.56
95_F178_F0.7660.55
55_R200_D0.7650.55
48_L101_A0.7630.55
138_G239_G0.7620.55
86_D89_G0.7580.54
50_E204_N0.7570.54
110_V205_A0.7520.54
58_K239_G0.7510.53
95_F99_G0.7500.53
82_D91_Y0.7490.53
266_A277_W0.7480.53
15_G209_F0.7470.53
226_A281_A0.7470.53
82_D88_L0.7450.53
263_L279_G0.7450.53
7_G37_N0.7430.53
34_T87_N0.7390.52
48_L74_S0.7390.52
128_F207_F0.7390.52
44_Q97_E0.7370.52
19_A22_Q0.7370.52
212_L245_I0.7340.52
230_A234_S0.7330.52
174_K177_E0.7330.52
158_L229_R0.7310.52
175_K201_A0.7300.51
13_Q17_A0.7280.51
172_E203_C0.7280.51
65_Y209_F0.7230.51
214_Y235_F0.7220.51
101_A241_R0.7220.51
24_E103_A0.7200.50
181_M191_M0.7190.50
181_M186_D0.7150.50
74_S98_M0.7100.49
214_Y232_M0.7050.49
96_Q164_A0.7030.49
25_K161_T0.6980.48
75_T190_F0.6970.48
21_S103_A0.6970.48
180_A183_D0.6970.48
8_F40_G0.6940.48
262_K273_A0.6940.48
218_A224_N0.6940.48
46_P101_A0.6920.48
48_L199_V0.6910.48
153_G217_K0.6900.47
57_I196_L0.6880.47
35_A87_N0.6870.47
48_L201_A0.6870.47
21_S24_E0.6860.47
72_F204_N0.6820.47
261_R276_I0.6800.46
250_L264_L0.6780.46
274_S278_Y0.6780.46
85_D202_R0.6780.46
45_F58_K0.6740.46
63_H123_Y0.6710.46
37_N69_N0.6700.46
214_Y228_A0.6690.45
1_L195_F0.6680.45
222_A262_K0.6630.45
50_E72_F0.6620.45
44_Q94_L0.6590.44
158_L281_A0.6580.44
135_V236_K0.6580.44
45_F97_E0.6560.44
219_T224_N0.6560.44
34_T37_N0.6560.44
137_D239_G0.6520.44
45_F98_M0.6520.44
184_P197_Y0.6500.44
224_N227_A0.6500.44
234_S254_P0.6460.43
15_G18_G0.6460.43
208_G212_L0.6450.43
225_Y258_A0.6410.43
62_A91_Y0.6410.43
261_R278_Y0.6390.42
262_K278_Y0.6370.42
110_V114_L0.6370.42
221_T259_A0.6370.42
39_Y171_Q0.6280.41
268_L278_Y0.6270.41
187_E191_M0.6250.41
244_G287_P0.6190.41
261_R266_A0.6170.40
190_F198_G0.6170.40
179_V193_D0.6160.40
118_F149_Q0.6150.40
113_L204_N0.6080.40
105_H170_F0.6070.39
80_R200_D0.6060.39
158_L225_Y0.6060.39
115_K157_F0.6060.39
144_S210_W0.6050.39
150_G154_T0.6040.39
251_V284_L0.6040.39
127_Y144_S0.6030.39
19_A35_A0.6000.39
266_A271_G0.6000.39
40_G88_L0.5970.39
44_Q100_R0.5960.38
44_Q82_D0.5950.38
49_R54_D0.5930.38
269_L278_Y0.5910.38
94_L97_E0.5910.38
264_L280_T0.5900.38
4_L8_F0.5880.38
158_L228_A0.5880.38
264_L279_G0.5880.38
237_G243_L0.5870.38
2_A6_T0.5860.37
70_K112_G0.5840.37
103_A106_P0.5800.37
258_A281_A0.5800.37
9_K177_E0.5780.37
35_A68_K0.5770.37
43_G123_Y0.5760.37
226_A280_T0.5740.36
264_L278_Y0.5730.36
29_T170_F0.5720.36
149_Q227_A0.5710.36
34_T38_T0.5710.36
26_I110_V0.5700.36
185_T188_N0.5690.36
153_G219_T0.5680.36
32_S37_N0.5680.36
265_E276_I0.5680.36
137_D140_G0.5680.36
5_F87_N0.5670.36
69_N171_Q0.5660.36
48_L57_I0.5660.36
32_S39_Y0.5650.36
135_V238_D0.5650.36
128_F213_A0.5650.36
174_K201_A0.5610.35
214_Y224_N0.5600.35
38_T66_T0.5590.35
137_D141_A0.5580.35
222_A269_L0.5580.35
252_V285_V0.5560.35
94_L163_R0.5530.34
131_T148_M0.5520.34
186_D196_L0.5510.34
2_A5_F0.5500.34
261_R281_A0.5490.34
233_M247_P0.5490.34
190_F196_L0.5480.34
257_E279_G0.5450.34
262_K269_L0.5430.34
45_F74_S0.5420.34
104_A163_R0.5420.34
146_S224_N0.5410.33
222_A277_W0.5380.33
130_D144_S0.5380.33
162_S249_L0.5360.33
259_A262_K0.5360.33
48_L58_K0.5350.33
60_L94_L0.5350.33
163_R244_G0.5350.33
132_D151_G0.5340.33
226_A261_R0.5340.33
181_M188_N0.5340.33
13_Q16_L0.5330.33
222_A263_L0.5280.32
12_F98_M0.5280.32
52_I209_F0.5280.32
117_G129_F0.5270.32
182_D197_Y0.5260.32
214_Y218_A0.5250.32
229_R233_M0.5220.32
71_K79_D0.5210.32
9_K92_S0.5200.32
258_A280_T0.5190.32
49_R53_G0.5150.31
180_A197_Y0.5150.31
35_A81_D0.5150.31
26_I286_V0.5130.31
230_A277_W0.5130.31
225_Y263_L0.5130.31
96_Q100_R0.5120.31
128_F159_L0.5110.31
80_R174_K0.5100.31
113_L205_A0.5100.31
266_A278_Y0.5100.31
265_E282_E0.5100.31
268_L272_G0.5100.31
30_V37_N0.5090.31
46_P76_V0.5090.31
266_A269_L0.5080.31
63_H90_I0.5070.31
48_L72_F0.5060.30
168_L205_A0.5060.30
92_S96_Q0.5040.30
63_H66_T0.5020.30
84_E200_D0.5010.30
32_S85_D0.5000.30
138_G141_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vwcA 1 0.4221 31.1 0.974 Contact Map
4gwgA 2 0.4118 17.8 0.976 Contact Map
5cd6A 2 0.4152 16.6 0.977 Contact Map
7ceiB 1 0.0657 14.7 0.977 Contact Map
4v0pA 2 0.564 12.1 0.978 Contact Map
2cjrA 2 0.2976 11.9 0.978 Contact Map
2xwsA 2 0.2318 11.7 0.978 Contact Map
4pmoA 1 0.2768 11.3 0.978 Contact Map
3i3wA 2 0.2664 11 0.979 Contact Map
2wa0A 1 0.5329 9.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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