GREMLIN Database
Mu-like_Pro - Mu-like prophage I protein
PFAM: PF10123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 329 (320)
Sequences: 1738 (1532)
Seq/√Len: 85.6
META: 0.741

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_E235_K5.4551.00
261_K265_R3.7531.00
168_T171_E3.6301.00
323_S326_D3.5451.00
68_E80_R3.3561.00
224_V227_L3.3521.00
249_A253_D3.1181.00
89_A93_A3.0551.00
314_L324_P3.0171.00
106_D109_T2.9971.00
99_I118_A2.7451.00
11_G125_A2.7161.00
72_R78_W2.7011.00
86_R95_E2.6901.00
227_L231_L2.5501.00
158_L172_I2.4711.00
43_V50_T2.4111.00
75_D78_W2.3751.00
24_D111_R2.3451.00
154_L169_E2.3041.00
82_E94_K2.2741.00
88_A92_A2.2431.00
87_A91_I2.2361.00
267_L274_A2.2351.00
223_T228_Q2.1921.00
46_Y63_A2.1521.00
324_P328_A2.1391.00
41_D67_K2.0531.00
242_E276_K2.0211.00
51_L117_S2.0031.00
46_Y87_A1.9771.00
106_D111_R1.9641.00
241_A245_A1.9561.00
155_K165_E1.9321.00
85_P93_A1.9051.00
46_Y95_E1.8891.00
41_D98_Y1.8821.00
260_Q282_A1.8601.00
29_A33_A1.8531.00
278_F282_A1.8351.00
273_A276_K1.8351.00
176_L179_L1.8061.00
232_A236_A1.8051.00
244_E265_R1.7821.00
221_V225_T1.7601.00
67_K82_E1.7571.00
41_D97_R1.7381.00
316_V319_A1.6991.00
315_A319_A1.6771.00
3_L118_A1.6761.00
28_A32_I1.6551.00
310_S313_E1.6531.00
175_A178_A1.6411.00
6_A71_W1.6221.00
256_I264_A1.6101.00
90_A95_E1.6031.00
86_R90_A1.5781.00
102_V117_S1.5741.00
24_D27_S1.5741.00
262_D266_A1.5481.00
248_D261_K1.5331.00
251_L261_K1.5271.00
2_Q129_L1.5231.00
240_E269_K1.4960.99
255_K284_P1.4960.99
243_A268_A1.4890.99
62_A65_W1.4880.99
70_E78_W1.4760.99
155_K158_L1.4620.99
50_T60_A1.4600.99
231_L234_L1.4420.99
154_L158_L1.4420.99
85_P88_A1.4350.99
166_D171_E1.4320.99
313_E317_C1.4280.99
275_F279_L1.3980.99
322_L327_F1.3930.99
276_K280_A1.3900.99
160_A173_L1.3850.99
214_D217_K1.3830.99
237_E242_E1.3580.99
8_E22_R1.3570.99
66_I79_A1.3550.99
22_R111_R1.3540.99
325_E328_A1.3460.99
257_T260_Q1.3390.99
213_P218_F1.3250.99
23_L28_A1.3140.99
197_D200_A1.3070.99
286_A289_G1.3040.99
277_A280_A1.2970.99
49_Q56_N1.2920.98
250_A279_L1.2860.98
25_D29_A1.2820.98
85_P89_A1.2700.98
87_A90_A1.2620.98
322_L326_D1.2560.98
34_A114_R1.2510.98
65_W97_R1.2480.98
319_A322_L1.2430.98
315_A318_K1.2370.98
226_A230_E1.2340.98
248_D252_K1.2320.98
247_V265_R1.2240.98
316_V320_L1.2210.98
66_I118_A1.2180.98
53_A58_Q1.2150.98
240_E244_E1.2130.98
223_T226_A1.2040.98
271_D274_A1.1990.98
77_L115_L1.1950.97
313_E327_F1.1930.97
72_R75_D1.1930.97
249_A252_K1.1830.97
317_C324_P1.1830.97
46_Y90_A1.1770.97
87_A95_E1.1750.97
317_C327_F1.1750.97
244_E248_D1.1740.97
61_P96_Y1.1640.97
36_A68_E1.1630.97
224_V228_Q1.1580.97
163_L167_A1.1530.97
50_T117_S1.1430.97
177_T181_A1.1420.97
225_T228_Q1.1370.97
236_A240_E1.1350.97
187_A190_L1.1300.96
117_S123_T1.1040.96
44_I99_I1.0990.96
201_A204_A1.0990.96
63_A87_A1.0970.96
56_N59_P1.0970.96
41_D82_E1.0860.96
273_A277_A1.0850.95
264_A267_L1.0720.95
239_A243_A1.0710.95
215_P218_F1.0670.95
25_D73_E1.0660.95
196_A201_A1.0660.95
272_L276_K1.0640.95
49_Q60_A1.0640.95
59_P86_R1.0640.95
32_I69_L1.0610.95
131_P135_L1.0610.95
59_P90_A1.0550.95
91_I133_A1.0530.95
63_A95_E1.0510.95
202_A205_V1.0500.95
219_V224_V1.0410.94
67_K80_R1.0400.94
28_A77_L1.0360.94
225_T229_A1.0350.94
192_L197_D1.0320.94
3_L79_A1.0310.94
263_W278_F1.0260.94
157_L176_L1.0240.94
43_V117_S1.0230.94
49_Q61_P1.0230.94
313_E316_V1.0180.94
47_E90_A1.0060.93
11_G17_P1.0040.93
264_A275_F1.0000.93
157_L160_A0.9830.92
260_Q263_W0.9830.92
64_G91_I0.9800.92
23_L27_S0.9790.92
247_V251_L0.9790.92
156_A169_E0.9790.92
228_Q232_A0.9790.92
317_C328_A0.9790.92
64_G81_V0.9730.92
86_R89_A0.9700.92
314_L317_C0.9690.92
167_A172_I0.9670.92
10_R16_P0.9670.92
260_Q264_A0.9630.92
263_W267_L0.9550.91
49_Q58_Q0.9550.91
262_D265_R0.9550.91
246_L276_K0.9540.91
200_A203_A0.9530.91
314_L318_K0.9450.91
320_L327_F0.9420.91
238_L241_A0.9390.91
84_T95_E0.9390.91
230_E233_A0.9370.91
134_A137_A0.9290.90
309_L327_F0.9290.90
186_V190_L0.9260.90
31_V112_V0.9230.90
2_Q78_W0.9230.90
69_L115_L0.9150.89
30_A33_A0.9130.89
103_F114_R0.9130.89
264_A278_F0.9110.89
245_A248_D0.9080.89
243_A247_V0.9060.89
201_A205_V0.9060.89
51_L116_L0.9040.89
44_I118_A0.9000.89
51_L102_V0.8990.89
229_A233_A0.8980.89
222_A226_A0.8930.88
267_L278_F0.8830.88
198_L201_A0.8800.88
9_F110_G0.8800.88
9_F23_L0.8760.87
231_L235_K0.8730.87
217_K222_A0.8720.87
245_A249_A0.8710.87
246_L279_L0.8680.87
143_T146_E0.8650.87
43_V47_E0.8650.87
169_E172_I0.8570.86
199_A203_A0.8550.86
192_L201_A0.8550.86
50_T61_P0.8510.86
47_E61_P0.8420.85
231_L238_L0.8390.85
176_L180_K0.8370.85
309_L313_E0.8360.85
142_E145_E0.8360.85
61_P95_E0.8350.85
308_A317_C0.8350.85
29_A71_W0.8340.85
35_F42_L0.8320.84
318_K324_P0.8310.84
266_A269_K0.8300.84
57_G60_A0.8290.84
89_A92_A0.8290.84
316_V322_L0.8220.84
23_L77_L0.8180.83
152_E156_A0.8170.83
184_A188_A0.8130.83
32_I71_W0.8100.83
156_A159_A0.8090.83
2_Q130_D0.8060.83
47_E96_Y0.8060.83
96_Y122_N0.7990.82
42_L118_A0.7960.82
317_C320_L0.7950.82
193_A196_A0.7940.82
282_A285_I0.7900.81
9_F112_V0.7890.81
268_A271_D0.7870.81
4_L101_P0.7870.81
209_K212_A0.7860.81
66_I69_L0.7840.81
11_G16_P0.7820.81
307_A328_A0.7800.80
197_D201_A0.7800.80
214_D218_F0.7780.80
135_L138_A0.7770.80
27_S32_I0.7750.80
4_L103_F0.7710.80
270_K274_A0.7660.79
39_G128_G0.7660.79
268_A272_L0.7620.79
44_I66_I0.7600.79
23_L31_V0.7590.79
258_P261_K0.7590.79
317_C322_L0.7580.79
12_R40_N0.7580.79
46_Y86_R0.7530.78
178_A182_A0.7520.78
167_A171_E0.7510.78
217_K220_P0.7500.78
242_E272_L0.7500.78
126_L129_L0.7480.78
268_A275_F0.7480.78
61_P90_A0.7460.77
263_W271_D0.7430.77
39_G127_D0.7410.77
243_A265_R0.7390.77
31_V103_F0.7390.77
21_W105_Y0.7390.77
25_D28_A0.7350.76
256_I263_W0.7340.76
152_E155_K0.7330.76
155_K159_A0.7330.76
163_L175_A0.7310.76
308_A328_A0.7310.76
263_W275_F0.7300.76
267_L270_K0.7300.76
71_W75_D0.7280.76
11_G21_W0.7280.76
55_P58_Q0.7270.76
35_F66_I0.7270.76
185_A188_A0.7260.76
173_L177_T0.7220.75
86_R93_A0.7220.75
143_T147_E0.7200.75
238_L242_E0.7190.75
84_T87_A0.7150.74
42_L117_S0.7140.74
264_A268_A0.7140.74
215_P219_V0.7140.74
44_I81_V0.7090.74
316_V327_F0.7080.74
198_L202_A0.7070.74
308_A311_A0.7060.73
233_A237_E0.7050.73
83_W120_L0.7000.73
47_E59_P0.6990.73
2_Q40_N0.6990.73
266_A270_K0.6980.73
248_D251_L0.6970.73
177_T180_K0.6970.73
202_A206_A0.6950.72
154_L172_I0.6940.72
285_I289_G0.6930.72
204_A207_A0.6920.72
260_Q278_F0.6910.72
187_A191_G0.6900.72
253_D284_P0.6870.71
21_W125_A0.6840.71
324_P327_F0.6820.71
13_D16_P0.6820.71
191_G195_D0.6800.71
230_E234_L0.6800.71
163_L172_I0.6760.70
158_L167_A0.6760.70
102_V123_T0.6720.70
313_E320_L0.6700.70
267_L271_D0.6680.69
52_L55_P0.6680.69
156_A177_T0.6670.69
255_K282_A0.6670.69
30_A111_R0.6660.69
43_V102_V0.6630.69
52_L56_N0.6610.69
161_L176_L0.6600.68
234_L238_L0.6550.68
314_L320_L0.6520.67
44_I63_A0.6520.67
274_A278_F0.6510.67
160_A177_T0.6500.67
87_A92_A0.6490.67
221_V224_V0.6490.67
307_A310_S0.6460.67
197_D202_A0.6450.67
216_A219_V0.6430.66
38_R114_R0.6420.66
320_L324_P0.6400.66
312_E315_A0.6390.66
42_L66_I0.6390.66
159_A165_E0.6380.66
220_P224_V0.6370.66
267_L275_F0.6370.66
218_F221_V0.6360.66
186_V191_G0.6360.66
2_Q75_D0.6350.65
246_L250_A0.6330.65
29_A32_I0.6330.65
192_L195_D0.6330.65
45_D50_T0.6310.65
275_F278_F0.6310.65
251_L255_K0.6300.65
78_W129_L0.6240.64
4_L23_L0.6240.64
60_A96_Y0.6230.64
190_L195_D0.6210.64
263_W274_A0.6210.64
323_S328_A0.6170.63
67_K94_K0.6160.63
320_L326_D0.6150.63
4_L115_L0.6120.63
169_E175_A0.6090.62
199_A202_A0.6080.62
171_E174_A0.6060.62
50_T116_L0.6060.62
306_A320_L0.6050.62
43_V61_P0.6040.62
133_A136_A0.6040.62
116_L123_T0.6040.62
41_D132_L0.6020.61
243_A271_D0.6020.61
235_K239_A0.6020.61
162_G178_A0.6010.61
251_L258_P0.6000.61
163_L168_T0.5990.61
60_A87_A0.5980.61
255_K283_P0.5970.61
158_L162_G0.5970.61
27_S111_R0.5970.61
104_L114_R0.5930.60
65_W122_N0.5870.59
291_T294_G0.5850.59
6_A23_L0.5830.59
320_L328_A0.5810.59
246_L275_F0.5810.59
192_L202_A0.5800.58
162_G165_E0.5800.58
153_L158_L0.5800.58
286_A290_G0.5780.58
6_A73_E0.5770.58
254_G286_A0.5750.58
174_A177_T0.5740.58
70_E80_R0.5710.57
147_E151_E0.5700.57
79_A99_I0.5700.57
174_A181_A0.5680.57
46_Y49_Q0.5680.57
186_V192_L0.5680.57
94_K97_R0.5630.56
305_G308_A0.5630.56
121_T124_P0.5620.56
118_A126_L0.5610.56
72_R80_R0.5600.56
196_A200_A0.5570.55
32_I35_F0.5540.55
157_L161_L0.5520.55
21_W103_F0.5520.55
188_A191_G0.5490.54
173_L182_A0.5480.54
23_L32_I0.5480.54
263_W282_A0.5480.54
292_Q295_G0.5470.54
260_Q281_A0.5460.54
40_N43_V0.5440.54
192_L204_A0.5430.54
156_A170_E0.5430.54
205_V208_L0.5430.54
254_G284_P0.5420.53
30_A34_A0.5410.53
153_L169_E0.5400.53
186_V194_A0.5390.53
16_P21_W0.5370.53
71_W78_W0.5350.53
307_A317_C0.5340.52
34_A38_R0.5330.52
177_T319_A0.5330.52
22_R27_S0.5330.52
159_A162_G0.5330.52
263_W266_A0.5320.52
77_L121_T0.5320.52
251_L265_R0.5320.52
246_L272_L0.5310.52
319_A324_P0.5300.52
61_P102_V0.5280.52
35_F69_L0.5280.52
175_A183_A0.5270.51
313_E328_A0.5260.51
158_L169_E0.5260.51
47_E58_Q0.5240.51
159_A175_A0.5220.51
217_K221_V0.5220.51
317_C326_D0.5210.51
263_W270_K0.5190.50
90_A93_A0.5190.50
308_A324_P0.5180.50
264_A274_A0.5170.50
188_A194_A0.5170.50
45_D102_V0.5170.50
158_L164_P0.5160.50
190_L204_A0.5150.50
95_E98_Y0.5130.50
306_A323_S0.5130.50
117_S120_L0.5120.49
83_W101_P0.5120.49
42_L79_A0.5100.49
50_T57_G0.5090.49
46_Y84_T0.5090.49
28_A31_V0.5080.49
307_A311_A0.5070.49
129_L135_L0.5070.49
310_S317_C0.5060.49
194_A201_A0.5060.49
28_A132_L0.5050.48
11_G15_R0.5040.48
142_E146_E0.5040.48
158_L165_E0.5030.48
257_T282_A0.5030.48
291_T295_G0.5020.48
32_I36_A0.5010.48
216_A221_V0.5010.48
35_F77_L0.5010.48
157_L172_I0.5000.48
98_Y124_P0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aieA 3 0.3982 26.8 0.954 Contact Map
1m2dA 2 0.1185 23.1 0.955 Contact Map
1npbA 3 0.2736 11.2 0.961 Contact Map
2k48A 1 0.3191 8.7 0.963 Contact Map
1ei5A 2 0.3556 8.2 0.963 Contact Map
2aqeA 1 0.1307 8.2 0.963 Contact Map
2ckkA 1 0.1459 7.6 0.964 Contact Map
2eljA 1 0.1246 7.2 0.964 Contact Map
2ou3A 2 0.3556 6.8 0.965 Contact Map
4tvcA 1 0.3435 6.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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