GREMLIN Database
MethyTransf_Reg - Predicted methyltransferase regulatory domain
PFAM: PF10119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (83)
Sequences: 10245 (7816)
Seq/√Len: 857.9
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F82_L3.0121.00
17_V25_R2.5971.00
26_A82_L2.5481.00
61_D64_L2.5201.00
54_A57_A2.1721.00
18_Y21_E1.9911.00
4_Y9_Y1.9461.00
19_F23_A1.8101.00
35_G42_M1.8051.00
23_A63_V1.7991.00
27_A32_Q1.7991.00
20_H67_Q1.7691.00
4_Y8_E1.7671.00
56_L59_A1.6251.00
53_Q57_A1.5651.00
21_E24_A1.5641.00
25_R28_A1.5461.00
18_Y71_F1.5171.00
23_A27_A1.3621.00
48_L51_V1.3601.00
17_V22_F1.3481.00
24_A63_V1.3461.00
49_P52_A1.3401.00
23_A26_A1.3111.00
48_L52_A1.3041.00
11_E14_N1.3011.00
54_A58_L1.3001.00
25_R29_H1.2841.00
59_A68_Y1.2351.00
34_L83_C1.2331.00
20_H24_A1.2141.00
67_Q71_F1.2091.00
38_D79_R1.2051.00
7_H11_E1.1931.00
41_D75_R1.1591.00
52_A72_L1.1341.00
47_L51_V1.0981.00
33_Y36_E1.0841.00
60_P64_L1.0681.00
69_L73_R1.0581.00
49_P53_Q1.0531.00
38_D41_D1.0491.00
56_L65_R1.0371.00
39_L42_M1.0241.00
41_D73_R1.0191.00
44_D65_R1.0181.00
50_E54_A1.0051.00
19_F33_Y1.0001.00
8_E11_E0.9921.00
53_Q56_L0.9701.00
24_A27_A0.9641.00
22_F25_R0.9341.00
70_D75_R0.9161.00
50_E53_Q0.9061.00
66_E69_L0.9021.00
18_Y67_Q0.8991.00
19_F66_E0.8941.00
43_L46_L0.8871.00
19_F67_Q0.8861.00
55_L58_L0.8861.00
41_D79_R0.8721.00
32_Q83_C0.8611.00
34_L81_L0.8501.00
41_D45_A0.8431.00
55_L59_A0.8381.00
6_A9_Y0.8191.00
40_S46_L0.8171.00
6_A11_E0.8031.00
48_L56_L0.8021.00
51_V56_L0.8011.00
19_F63_V0.7991.00
15_E21_E0.7911.00
64_L68_Y0.7891.00
15_E25_R0.7881.00
24_A28_A0.7821.00
52_A56_L0.7791.00
80_D83_C0.7711.00
27_A63_V0.7661.00
23_A82_L0.7631.00
62_P66_E0.7601.00
48_L54_A0.7571.00
68_Y72_L0.7181.00
68_Y71_F0.7111.00
26_A80_D0.7041.00
39_L43_L0.6921.00
36_E80_D0.6901.00
5_L10_L0.6891.00
73_R76_R0.6761.00
20_H63_V0.6711.00
44_D69_L0.6691.00
9_Y14_N0.6641.00
26_A29_H0.6611.00
3_S6_A0.6531.00
39_L81_L0.6461.00
20_H64_L0.6381.00
22_F26_A0.6141.00
62_P65_R0.6121.00
36_E41_D0.6041.00
59_A65_R0.6011.00
60_P65_R0.5951.00
51_V58_L0.5901.00
57_A60_P0.5881.00
65_R69_L0.5851.00
65_R68_Y0.5811.00
66_E78_R0.5721.00
36_E75_R0.5491.00
13_D16_P0.5491.00
32_Q62_P0.5461.00
42_M69_L0.5441.00
46_L65_R0.5441.00
33_Y80_D0.5391.00
59_A64_L0.5391.00
8_E77_F0.5391.00
38_D42_M0.5241.00
30_G64_L0.5241.00
15_E18_Y0.5221.00
9_Y13_D0.5211.00
76_R79_R0.5191.00
46_L73_R0.5171.00
37_A81_L0.5061.00
40_S44_D0.5061.00
17_V21_E0.5001.00
41_D69_L0.5001.00
43_L56_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1snnA 2 0.5238 7.2 0.89 Contact Map
2bpoA 1 0.9167 5.8 0.895 Contact Map
1tksA 2 0.5357 4.8 0.899 Contact Map
1g57A 2 0.6071 4.1 0.902 Contact Map
1ddgA 1 0.9167 3.8 0.904 Contact Map
3qfsA 1 0.9286 3.8 0.904 Contact Map
4p6dA 2 0.6071 3.7 0.905 Contact Map
3mioA 2 0.5595 3.6 0.905 Contact Map
4a2qA 1 0.9762 3.6 0.905 Contact Map
3cl6A 3 0.5952 3.3 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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