GREMLIN Database
McrBC - McrBC 5-methylcytosine restriction system component
PFAM: PF10117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 320 (311)
Sequences: 7282 (5889)
Seq/√Len: 333.9
META: 0.793

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_V280_T4.3891.00
93_E122_R4.2701.00
129_D167_S3.9931.00
283_K299_D3.5061.00
104_D107_R3.4111.00
141_E168_D3.2051.00
96_L121_C3.2041.00
104_D122_R3.1881.00
229_A244_A2.9581.00
181_L192_L2.7391.00
90_V127_S2.6351.00
78_E155_R2.6191.00
95_N120_A2.5761.00
93_E104_D2.5301.00
307_A315_G2.4761.00
95_N112_N2.3591.00
99_L103_I2.3431.00
136_L191_L2.2921.00
186_A189_R2.2851.00
129_D134_R2.2851.00
196_R200_E2.2811.00
138_A168_D2.2461.00
139_A195_C2.2371.00
94_E123_Y2.1451.00
137_K141_E2.1361.00
99_L119_F2.1321.00
76_E191_L2.1171.00
304_F308_K2.1021.00
230_R233_R2.0701.00
297_S301_Y2.0481.00
91_R122_R2.0341.00
278_I318_L2.0101.00
107_R111_R1.9791.00
182_N185_N1.9501.00
266_I280_T1.9301.00
20_I217_L1.9111.00
283_K287_T1.8931.00
189_R193_E1.8671.00
86_Y130_N1.8621.00
108_Q120_A1.8591.00
191_L195_C1.8541.00
283_K286_D1.8511.00
102_R122_R1.8351.00
141_E160_L1.8341.00
107_R110_R1.7901.00
140_L156_L1.7861.00
149_S153_R1.7741.00
80_L187_H1.7631.00
144_L157_R1.7321.00
242_V245_Q1.7311.00
229_A280_T1.7291.00
74_L156_L1.7071.00
229_A266_I1.6501.00
73_F77_L1.6491.00
93_E107_R1.6481.00
237_P240_L1.6431.00
73_F195_C1.6291.00
137_K168_D1.6191.00
103_I119_F1.6061.00
149_S152_N1.5921.00
296_S299_D1.5781.00
266_I278_I1.5751.00
5_N221_N1.5731.00
142_L199_L1.5721.00
143_L156_L1.5701.00
77_L136_L1.5621.00
77_L140_L1.5511.00
136_L195_C1.5481.00
227_F231_F1.5291.00
140_L159_L1.5281.00
262_L301_Y1.5141.00
76_E190_P1.4711.00
83_R187_H1.4691.00
88_E130_N1.4591.00
134_R169_I1.4551.00
172_S175_D1.4491.00
181_L189_R1.4391.00
87_R128_E1.4371.00
171_I199_L1.4281.00
93_E120_A1.4041.00
222_R226_K1.4011.00
104_D120_A1.3991.00
219_D222_R1.3901.00
137_K160_L1.3621.00
106_S110_R1.3601.00
70_A143_L1.3591.00
80_L191_L1.3461.00
96_L123_Y1.3421.00
64_N67_E1.3411.00
303_M307_A1.3291.00
303_M315_G1.3261.00
177_S196_R1.3251.00
108_Q112_N1.3201.00
108_Q119_F1.3141.00
71_A155_R1.3131.00
142_L146_L1.2921.00
86_Y185_N1.2801.00
277_I310_Y1.2771.00
241_K269_R1.2631.00
269_R272_G1.2581.00
71_A75_K1.2411.00
139_A199_L1.2401.00
245_Q263_R1.2371.00
244_A247_S1.2341.00
91_R124_D1.2251.00
243_K246_G1.2081.00
280_T318_L1.2011.00
138_A199_L1.1931.00
241_K244_A1.1891.00
240_L244_A1.1871.00
128_E165_E1.1811.00
135_I192_L1.1761.00
135_I176_F1.1701.00
243_K269_R1.1611.00
247_S263_R1.1591.00
301_Y305_A1.1571.00
134_R167_S1.1491.00
7_V220_M1.1481.00
298_A301_Y1.1471.00
174_A178_R1.1461.00
95_N108_Q1.1371.00
283_K288_Q1.1361.00
132_E185_N1.1311.00
312_A315_G1.1301.00
74_L159_L1.1211.00
181_L185_N1.1161.00
142_L201_G1.1031.00
139_A143_L1.1031.00
112_N120_A1.0901.00
226_K229_A1.0791.00
80_L188_Y1.0751.00
95_N118_R1.0731.00
220_M282_Y1.0681.00
107_R120_A1.0681.00
236_L242_V1.0671.00
140_L160_L1.0661.00
139_A198_I1.0631.00
225_E245_Q1.0611.00
92_R125_E1.0611.00
11_Q17_T1.0541.00
240_L243_K1.0481.00
173_A200_E1.0381.00
193_E196_R1.0301.00
37_F41_M1.0271.00
260_F297_S1.0261.00
238_P242_V1.0221.00
304_F309_N1.0191.00
138_A142_L1.0101.00
205_T209_G1.0071.00
73_F140_L0.9981.00
305_A308_K0.9981.00
77_L191_L0.9951.00
132_E179_I0.9921.00
251_L254_E0.9841.00
40_Y43_S0.9841.00
19_E35_R0.9841.00
74_L78_E0.9831.00
237_P242_V0.9801.00
74_L155_R0.9741.00
236_L239_G0.9721.00
130_N133_N0.9711.00
247_S250_Y0.9701.00
269_R275_V0.9681.00
143_L198_I0.9671.00
262_L309_N0.9621.00
141_E145_R0.9611.00
302_Q306_Y0.9611.00
241_K245_Q0.9601.00
224_F280_T0.9581.00
86_Y132_E0.9571.00
47_D230_R0.9561.00
239_G242_V0.9491.00
229_A233_R0.9461.00
295_I300_L0.9461.00
75_K155_R0.9351.00
173_A177_S0.9241.00
41_M45_A0.9201.00
56_A59_E0.9201.00
95_N111_R0.9071.00
157_R160_L0.9071.00
29_D38_L0.9041.00
246_G249_K0.9021.00
89_Y126_F0.9021.00
264_P267_V0.9011.00
57_S60_T0.8951.00
132_E192_L0.8951.00
249_K252_L0.8891.00
144_L160_L0.8851.00
46_K49_P0.8831.00
58_L63_D0.8831.00
278_I316_V0.8811.00
105_I109_I0.8791.00
254_E259_L0.8731.00
276_L316_V0.8721.00
57_S62_D0.8711.00
40_Y227_F0.8711.00
270_K275_V0.8651.00
140_L143_L0.8581.00
86_Y188_Y0.8571.00
291_D294_G0.8571.00
58_L62_D0.8561.00
240_L246_G0.8551.00
74_L140_L0.8521.00
260_F300_L0.8511.00
115_R118_R0.8451.00
48_L51_K0.8451.00
169_I175_D0.8411.00
252_L255_D0.8401.00
78_E159_L0.8391.00
245_Q250_Y0.8381.00
78_E158_R0.8311.00
77_L159_L0.8301.00
54_D57_S0.8281.00
81_L162_A0.8261.00
81_L163_F0.8251.00
46_K226_K0.8241.00
271_D274_K0.8241.00
279_D283_K0.8171.00
158_R162_A0.8161.00
243_K247_S0.8131.00
45_A48_L0.8121.00
129_D166_V0.8041.00
48_L53_F0.8041.00
247_S261_R0.8011.00
246_G263_R0.8001.00
242_V246_G0.8001.00
229_A245_Q0.7941.00
262_L305_A0.7941.00
9_V17_T0.7931.00
238_P241_K0.7921.00
225_E229_A0.7921.00
256_G259_L0.7901.00
49_P53_F0.7891.00
221_N224_F0.7891.00
108_Q114_G0.7891.00
248_R251_L0.7891.00
171_I175_D0.7881.00
268_L271_D0.7861.00
44_Y227_F0.7831.00
133_N188_Y0.7831.00
35_R282_Y0.7811.00
60_T63_D0.7811.00
37_F40_Y0.7801.00
132_E181_L0.7731.00
44_Y231_F0.7641.00
100_R123_Y0.7621.00
267_V310_Y0.7571.00
131_P178_R0.7571.00
41_M227_F0.7561.00
137_K166_V0.7561.00
96_L99_L0.7541.00
245_Q248_R0.7531.00
59_E62_D0.7521.00
85_L128_E0.7511.00
45_A226_K0.7511.00
10_I217_L0.7500.99
137_K164_D0.7500.99
97_S118_R0.7490.99
9_V19_E0.7460.99
237_P241_K0.7460.99
147_T152_N0.7430.99
235_K238_P0.7400.99
312_A316_V0.7370.99
270_K274_K0.7340.99
81_L159_L0.7330.99
79_R82_R0.7290.99
79_R187_H0.7270.99
269_R274_K0.7260.99
246_G250_Y0.7240.99
242_V247_S0.7180.99
49_P54_D0.7130.99
72_L76_E0.7080.99
99_L123_Y0.7070.99
47_D51_K0.7060.99
247_S251_L0.7050.99
237_P246_G0.7050.99
234_K237_P0.7030.99
112_N118_R0.7020.99
311_G315_G0.7020.99
150_P153_R0.7010.99
112_N115_R0.7010.99
114_G117_G0.7000.99
77_L80_L0.6990.99
253_D256_G0.6970.99
285_L288_Q0.6950.99
271_D275_V0.6950.99
294_G297_S0.6950.99
246_G251_L0.6950.99
260_F265_D0.6940.99
70_A147_T0.6940.99
236_L240_L0.6930.99
87_R126_F0.6920.99
71_A152_N0.6910.99
224_F228_V0.6900.99
149_S154_R0.6900.99
66_L146_L0.6900.99
46_K50_F0.6880.99
220_M224_F0.6850.99
171_I174_A0.6830.99
88_E126_F0.6820.99
98_F119_F0.6810.99
179_I192_L0.6780.99
95_N115_R0.6780.99
222_R225_E0.6780.99
88_E182_N0.6750.99
173_A176_F0.6730.99
179_I196_R0.6720.99
160_L163_F0.6720.99
138_A171_I0.6710.99
75_K79_R0.6690.99
79_R83_R0.6670.99
216_F282_Y0.6660.99
247_S252_L0.6650.99
265_D268_L0.6640.99
250_Y253_D0.6620.99
290_Y294_G0.6620.99
130_N134_R0.6580.99
290_Y293_Y0.6580.99
5_N219_D0.6580.99
12_L15_G0.6560.99
51_K54_D0.6550.99
243_K248_R0.6540.99
151_E154_R0.6540.99
284_R287_T0.6540.99
131_P134_R0.6530.99
255_D259_L0.6520.99
84_G188_Y0.6510.99
222_R229_A0.6510.99
189_R192_L0.6460.99
38_L41_M0.6460.99
111_R120_A0.6450.98
260_F264_P0.6440.98
235_K240_L0.6440.98
157_R161_L0.6440.98
148_R153_R0.6430.98
236_L241_K0.6420.98
67_E152_N0.6410.98
262_L306_Y0.6400.98
158_R161_L0.6380.98
39_L43_S0.6380.98
113_L116_K0.6370.98
136_L188_Y0.6350.98
70_A73_F0.6320.98
176_F179_I0.6310.98
192_L196_R0.6270.98
213_L216_F0.6270.98
129_D138_A0.6250.98
47_D226_K0.6220.98
65_L69_L0.6220.98
285_L295_I0.6210.98
270_K273_E0.6190.98
111_R115_R0.6190.98
72_L194_L0.6150.98
92_R96_L0.6150.98
81_L85_L0.6140.98
244_A250_Y0.6120.98
203_S206_T0.6120.98
242_V250_Y0.6110.98
262_L265_D0.6080.98
108_Q113_L0.6060.98
56_A61_E0.6030.98
244_A248_R0.6010.98
297_S300_L0.6010.98
305_A309_N0.6000.98
35_R41_M0.5960.97
106_S109_I0.5960.97
241_K247_S0.5950.97
220_M223_L0.5950.97
156_L160_L0.5940.97
148_R152_N0.5910.97
152_N155_R0.5890.97
131_P171_I0.5880.97
317_L320_P0.5850.97
51_K57_S0.5830.97
69_L198_I0.5820.97
131_P175_D0.5800.97
215_A218_F0.5790.97
251_L255_D0.5790.97
283_K302_Q0.5770.97
47_D50_F0.5760.97
285_L296_S0.5750.97
139_A142_L0.5750.97
171_I176_F0.5750.97
57_S61_E0.5740.97
45_A50_F0.5740.97
99_L108_Q0.5740.97
232_L266_I0.5730.97
86_Y182_N0.5730.97
92_R127_S0.5710.97
50_F54_D0.5700.97
41_M44_Y0.5700.97
50_F53_F0.5700.97
308_K311_G0.5690.97
76_E79_R0.5690.97
266_I279_D0.5650.97
21_L25_D0.5650.97
301_Y309_N0.5630.96
140_L163_F0.5600.96
64_N72_L0.5600.96
175_D178_R0.5590.96
96_L119_F0.5580.96
40_Y44_Y0.5560.96
10_I18_I0.5550.96
141_E144_L0.5530.96
268_L274_K0.5530.96
255_D258_G0.5500.96
246_G267_V0.5500.96
295_I298_A0.5490.96
144_L156_L0.5490.96
225_E281_K0.5460.96
102_R110_R0.5430.96
283_K296_S0.5430.96
240_L245_Q0.5410.96
69_L194_L0.5410.96
48_L61_E0.5400.96
44_Y48_L0.5400.96
135_I181_L0.5400.96
78_E82_R0.5380.95
86_Y133_N0.5380.95
54_D60_T0.5370.95
67_E70_A0.5370.95
299_D302_Q0.5350.95
250_Y254_E0.5350.95
181_L186_A0.5350.95
242_V249_K0.5340.95
246_G269_R0.5340.95
73_F139_A0.5340.95
241_K272_G0.5320.95
239_G245_Q0.5310.95
281_K302_Q0.5310.95
267_V277_I0.5310.95
155_R158_R0.5300.95
221_N282_Y0.5280.95
306_Y309_N0.5240.95
57_S63_D0.5240.95
24_I27_D0.5230.95
260_F295_I0.5230.95
76_E80_L0.5210.95
140_L144_L0.5200.95
73_F194_L0.5190.94
77_L163_F0.5190.94
169_I172_S0.5180.94
228_V266_I0.5180.94
279_D303_M0.5180.94
107_R122_R0.5160.94
21_L35_R0.5160.94
132_E188_Y0.5140.94
248_R252_L0.5140.94
12_L18_I0.5140.94
109_I112_N0.5130.94
181_L196_R0.5120.94
177_S180_R0.5120.94
53_F56_A0.5120.94
142_L202_L0.5110.94
67_E147_T0.5100.94
100_R121_C0.5090.94
194_L198_I0.5090.94
188_Y192_L0.5080.94
264_P310_Y0.5070.94
6_Y20_I0.5060.94
35_R44_Y0.5050.94
26_K29_D0.5040.94
240_L268_L0.5030.94
135_I171_I0.5030.94
220_M306_Y0.5010.93
68_L72_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ic1A 5 0.4781 88.1 0.921 Contact Map
2e52A 2 0.4469 41.2 0.945 Contact Map
3s1sA 1 0.3 40.3 0.945 Contact Map
1y88A 5 0.2562 35.3 0.947 Contact Map
3h1tA 1 0.2938 32.3 0.948 Contact Map
4r5qA 1 0.5312 20.2 0.953 Contact Map
1gefA 2 0.2562 14.1 0.956 Contact Map
2eo0A 2 0.2437 9.1 0.96 Contact Map
1xmxA 2 0.8594 7.5 0.961 Contact Map
2w00A 1 0.5188 7 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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