GREMLIN Database
HlyU - Transcriptional activator HlyU
PFAM: PF10115 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (90)
Sequences: 2404 (1694)
Seq/√Len: 178.6
META: 0.847

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_E26_G2.4251.00
68_R72_V2.4241.00
34_Y41_Q2.3411.00
44_G59_F2.3031.00
42_T65_F2.2321.00
48_K88_D1.9641.00
24_Y84_D1.9571.00
36_E41_Q1.8951.00
30_R47_E1.8891.00
81_Q85_E1.8821.00
59_F82_I1.7941.00
67_S70_D1.7871.00
47_E56_E1.7851.00
70_D73_E1.7491.00
69_D73_E1.6441.00
25_K84_D1.6401.00
21_P30_R1.6231.00
65_F74_F1.6061.00
41_Q64_T1.5651.00
42_T74_F1.5621.00
49_E54_V1.5301.00
32_A45_V1.5171.00
35_K40_Y1.4911.00
28_R47_E1.4711.00
31_P76_L1.4481.00
40_Y68_R1.4441.00
72_V75_S1.4161.00
39_Q64_T1.3811.00
30_R45_V1.3781.00
39_Q66_A1.3631.00
22_V76_L1.3581.00
35_K38_G1.3291.00
50_I53_E1.3201.00
49_E52_G1.3181.00
32_A43_A1.2271.00
44_G75_S1.1951.00
44_G82_I1.1751.00
76_L80_K1.1701.00
47_E54_V1.1601.00
50_I55_K1.1591.00
28_R49_E1.1561.00
19_A72_V1.1551.00
33_P72_V1.1531.00
22_V73_E1.1351.00
42_T75_S1.1281.00
21_P28_R1.0971.00
45_V56_E1.0501.00
23_E28_R1.0060.99
19_A68_R0.9990.99
83_I90_L0.9790.99
43_A58_R0.9770.99
34_Y60_I0.9640.99
29_I83_I0.9270.99
27_F88_D0.9250.99
86_Q90_L0.9170.99
82_I90_L0.9120.99
61_R78_K0.9100.99
22_V80_K0.9050.99
82_I86_Q0.8940.99
7_F10_G0.8830.98
65_F75_S0.8820.98
9_G12_G0.8800.98
2_F5_K0.8590.98
73_E77_R0.8570.98
86_Q89_R0.8490.98
70_D74_F0.8350.98
71_A75_S0.8330.98
77_R80_K0.8210.97
34_Y40_Y0.8180.97
17_K68_R0.8130.97
34_Y58_R0.8030.97
76_L83_I0.7990.97
18_A21_P0.7890.97
36_E39_Q0.7840.97
63_D85_E0.7820.97
79_A83_I0.7680.96
63_D79_A0.7680.96
62_A80_K0.7570.96
44_G61_R0.7530.96
69_D72_V0.7510.96
45_V58_R0.7340.95
35_K39_Q0.7270.95
34_Y43_A0.7250.95
5_K9_G0.7140.94
46_I82_I0.7100.94
57_H90_L0.7100.94
21_P31_P0.6980.94
31_P72_V0.6980.94
11_G14_A0.6970.94
27_F57_H0.6970.94
80_K84_D0.6950.94
65_F70_D0.6940.94
60_I74_F0.6870.93
66_A70_D0.6800.93
77_R81_Q0.6750.93
44_G78_K0.6700.92
27_F91_F0.6610.92
27_F48_K0.6600.92
74_F77_R0.6550.91
2_F8_G0.6500.91
27_F50_I0.6430.91
4_K7_F0.6390.90
13_A16_A0.6300.90
28_R54_V0.6290.90
75_S82_I0.6280.90
63_D78_K0.6220.89
24_Y29_I0.6150.89
20_E73_E0.6140.89
32_A58_R0.6140.89
65_F71_A0.6110.88
74_F82_I0.6070.88
44_G79_A0.5990.87
35_K68_R0.5970.87
10_G13_A0.5960.87
42_T59_F0.5900.87
43_A81_Q0.5890.86
70_D77_R0.5860.86
34_Y64_T0.5820.86
5_K10_G0.5560.83
27_F90_L0.5480.82
62_A82_I0.5460.82
50_I88_D0.5460.82
3_L7_F0.5420.82
33_P71_A0.5410.81
43_A60_I0.5410.81
6_L13_A0.5390.81
36_E65_F0.5320.80
5_K11_G0.5260.80
23_E27_F0.5250.80
5_K59_F0.5190.79
13_A17_K0.5090.77
77_R85_E0.5090.77
37_G64_T0.5010.76
36_E64_T0.5010.76
10_G14_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2konA 1 0.8022 75.5 0.866 Contact Map
1gtkA 1 0.7802 19.2 0.909 Contact Map
4htgA 2 0.7143 12.5 0.916 Contact Map
3lpzA 1 0.2198 11.1 0.918 Contact Map
4mlvA 1 0.7692 8.2 0.923 Contact Map
1iq8A 2 0.7802 6.7 0.926 Contact Map
4tndA 1 0 6.7 0.926 Contact Map
1eu1A 1 0.9341 4.3 0.932 Contact Map
3owaA 3 0.7802 4 0.933 Contact Map
1r2jA 1 0.9121 3.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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