GREMLIN Database
Halogen_Hydrol - 5-bromo-4-chloroindolyl phosphate hydrolysis protein
PFAM: PF10112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (185)
Sequences: 2853 (2418)
Seq/√Len: 177.8
META: 0.753

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_R163_D3.5571.00
76_K129_P3.5011.00
79_E136_E3.1481.00
42_L45_P3.0561.00
98_R170_E2.8741.00
38_L42_L2.5561.00
39_L42_L2.4141.00
113_D116_D2.3321.00
41_Y44_D2.2671.00
73_A107_F2.2371.00
36_G40_L2.1691.00
37_G41_Y2.1011.00
40_L44_D2.1011.00
109_T113_D2.0251.00
36_G39_L1.9951.00
81_R100_E1.9931.00
36_G43_F1.9841.00
15_F19_A1.8851.00
40_L45_P1.8341.00
69_A117_L1.7951.00
84_N93_S1.7771.00
11_A15_F1.7681.00
98_R166_E1.7481.00
36_G44_D1.7431.00
38_L43_F1.7411.00
8_G12_A1.6751.00
7_A11_A1.6671.00
39_L43_F1.6641.00
153_E157_E1.6281.00
37_G43_F1.6181.00
40_L43_F1.5991.00
41_Y45_P1.5911.00
39_L44_D1.5681.00
102_I170_E1.5461.00
92_L162_L1.5361.00
185_D189_E1.5221.00
7_A10_L1.5121.00
116_D179_D1.5091.00
22_L25_P1.5051.00
142_E155_L1.5021.00
77_L103_A1.4761.00
109_T112_E1.4661.00
79_E132_R1.4091.00
26_L29_A1.4061.00
14_V18_A1.4021.00
135_T158_I1.3921.00
34_A42_L1.3901.00
35_L40_L1.3891.00
47_P50_K1.3781.00
81_R104_R1.3611.00
47_P51_K1.3581.00
95_R166_E1.3551.00
110_V117_L1.3471.00
84_N96_L1.3371.00
49_K53_L1.3351.00
102_I166_E1.3211.00
91_E159_E1.3061.00
161_L164_D1.2901.00
38_L44_D1.2901.00
37_G42_L1.2831.00
46_K50_K1.2711.00
68_E72_E1.2711.00
11_A19_A1.2591.00
156_A160_A1.2591.00
34_A39_L1.2461.00
38_L45_P1.2461.00
35_L39_L1.2381.00
36_G41_Y1.2361.00
89_D159_E1.2311.00
92_L159_E1.2231.00
66_V69_A1.2201.00
30_L33_A1.2201.00
12_A15_F1.2121.00
96_L135_T1.2111.00
134_L158_I1.2071.00
110_V120_A1.2051.00
19_A23_G1.1961.00
182_L186_V1.1901.00
36_G42_L1.1901.00
34_A43_F1.1761.00
46_K51_K1.1731.00
13_L17_L1.1621.00
49_K52_G1.1551.00
79_E83_A1.1511.00
10_L13_L1.1491.00
48_K51_K1.1441.00
39_L45_P1.1301.00
19_A29_A1.1271.00
126_Y130_G1.1191.00
83_A139_A1.1091.00
85_D93_S1.1011.00
133_K137_K1.0991.00
48_K53_L1.0991.00
18_A21_G1.0871.00
11_A14_V1.0721.00
47_P52_G1.0611.00
146_V150_E1.0551.00
142_E145_G1.0531.00
131_A169_F1.0501.00
94_A98_R1.0461.00
100_E104_R1.0401.00
48_K52_G1.0340.99
15_F20_F1.0250.99
131_A165_L1.0220.99
108_R111_E1.0170.99
71_D75_E1.0150.99
84_N97_D1.0110.99
150_E155_L1.0010.99
22_L28_L0.9930.99
15_F18_A0.9800.99
142_E146_V0.9710.99
50_K53_L0.9610.99
23_G29_A0.9610.99
14_V19_A0.9570.99
10_L15_F0.9430.99
109_T116_D0.9410.99
81_R97_D0.9340.99
74_E78_A0.9270.99
37_G44_D0.9260.99
113_D179_D0.9260.99
25_P29_A0.9200.99
37_G45_P0.9130.99
14_V17_L0.9040.99
46_K49_K0.9030.99
151_I154_T0.8820.98
83_A136_E0.8810.98
107_F124_L0.8770.98
37_G40_L0.8750.98
133_K183_D0.8740.98
58_L61_E0.8710.98
112_E140_D0.8670.98
52_G55_A0.8650.98
20_F23_G0.8600.98
22_L29_A0.8560.98
87_I93_S0.8510.98
69_A73_A0.8410.98
66_V117_L0.8370.98
116_D180_D0.8260.98
38_L41_Y0.8240.97
59_D62_E0.8220.97
142_E147_K0.8150.97
24_L28_L0.8120.97
35_L38_L0.8060.97
149_E153_E0.8050.97
87_I92_L0.8000.97
150_E174_D0.7890.97
137_K183_D0.7820.97
161_L165_L0.7810.97
76_K79_E0.7810.97
74_E104_R0.7810.97
119_Q176_L0.7800.97
73_A128_L0.7770.96
18_A22_L0.7750.96
96_L100_E0.7630.96
130_G187_E0.7430.95
70_L74_E0.7430.95
113_D180_D0.7410.95
79_E82_D0.7350.95
24_L29_A0.7350.95
19_A22_L0.7330.95
158_I184_L0.7330.95
8_G14_V0.7280.95
136_E140_D0.7280.95
109_T180_D0.7270.95
74_E111_E0.7260.95
14_V21_G0.7260.95
105_K174_D0.7260.95
50_K54_K0.7250.95
99_I166_E0.7220.95
144_Q147_K0.7210.95
21_G26_L0.7200.95
15_F26_L0.7170.94
84_N100_E0.7150.94
174_D177_L0.7120.94
106_I123_F0.7070.94
18_A24_L0.7050.94
81_R85_D0.6990.94
69_A107_F0.6940.93
73_A124_L0.6880.93
16_L27_L0.6850.93
60_R63_I0.6720.92
93_S96_L0.6720.92
15_F22_L0.6720.92
57_G60_R0.6710.92
29_A32_I0.6690.92
76_K132_R0.6670.92
35_L44_D0.6630.92
12_A16_L0.6620.92
106_I172_Q0.6610.92
184_L188_I0.6590.92
86_R139_A0.6590.92
19_A27_L0.6570.91
103_A169_F0.6560.91
51_K55_A0.6540.91
167_T171_K0.6530.91
77_L100_E0.6490.91
36_G45_P0.6460.91
84_N92_L0.6440.91
127_Y169_F0.6440.91
22_L26_L0.6430.91
137_K180_D0.6430.91
87_I138_Y0.6400.90
18_A25_P0.6390.90
75_E78_A0.6370.90
109_T177_L0.6350.90
177_L180_D0.6350.90
26_L30_L0.6340.90
16_L20_F0.6310.90
147_K155_L0.6290.90
101_A105_K0.6210.89
105_K173_L0.6180.89
156_A159_E0.6140.88
13_L16_L0.6140.88
83_A132_R0.6130.88
23_G26_L0.6120.88
130_G134_L0.6120.88
80_I135_T0.6090.88
21_G24_L0.6080.88
17_L20_F0.6060.88
108_R112_E0.5930.87
155_L158_I0.5910.87
43_F46_K0.5890.86
16_L19_A0.5880.86
106_I176_L0.5870.86
99_I165_L0.5840.86
12_A19_A0.5800.85
123_F172_Q0.5750.85
19_A25_P0.5750.85
80_I131_A0.5750.85
17_L21_G0.5720.85
72_E76_K0.5680.84
66_V70_L0.5670.84
24_L27_L0.5640.84
120_A129_P0.5620.84
126_Y168_A0.5610.84
147_K150_E0.5600.83
72_E125_N0.5580.83
162_L166_E0.5570.83
78_A81_R0.5550.83
21_G25_P0.5530.83
17_L27_L0.5500.82
33_A42_L0.5500.82
21_G27_L0.5490.82
53_L56_E0.5480.82
163_D167_T0.5450.82
15_F21_G0.5440.82
105_K144_Q0.5430.82
178_E182_L0.5430.82
137_K164_D0.5420.81
174_D178_E0.5420.81
56_E59_D0.5410.81
10_L14_V0.5410.81
172_Q176_L0.5410.81
20_F26_L0.5360.81
35_L43_F0.5350.81
80_I100_E0.5340.81
80_I132_R0.5340.81
9_L12_A0.5330.80
67_A70_L0.5330.80
173_L177_L0.5300.80
83_A135_T0.5290.80
82_D86_R0.5280.80
35_L45_P0.5270.80
73_A186_V0.5220.79
22_L27_L0.5200.79
122_K127_Y0.5180.78
86_R140_D0.5170.78
18_A29_A0.5150.78
56_E61_E0.5150.78
55_A59_D0.5140.78
57_G61_E0.5140.78
74_E107_F0.5110.78
93_S100_E0.5110.78
142_E150_E0.5060.77
34_A37_G0.5020.76
110_V176_L0.5010.76
78_A82_D0.5010.76
99_I176_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aurA 1 0.5602 34.3 0.908 Contact Map
3l1lA 2 0.2932 33.6 0.908 Contact Map
2mi2A 1 0.5445 32.8 0.908 Contact Map
4ltoA 3 0.4188 30.7 0.91 Contact Map
4cbcA 3 0.2042 27.6 0.912 Contact Map
2mmuA 1 0.2251 24.8 0.914 Contact Map
2j69A 1 0.7435 22.4 0.916 Contact Map
4w6vA 1 0.267 17.5 0.92 Contact Map
2msvA 1 0.644 17 0.92 Contact Map
3giaA 1 0.3089 16.7 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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