GREMLIN Database
GPDPase_memb - Membrane domain of glycerophosphoryl diester phosphodiesterase
PFAM: PF10110 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 320 (292)
Sequences: 1430 (1230)
Seq/√Len: 72.0
META: 0.664

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_F160_A5.1151.00
157_F163_G4.8271.00
83_E87_L4.1101.00
150_P153_I4.0611.00
19_E23_K3.6891.00
159_K163_G3.6001.00
160_A163_G3.1491.00
272_P282_L3.1461.00
202_E205_R3.1411.00
62_S65_G3.0851.00
188_L202_E2.9761.00
279_T282_L2.9351.00
157_F161_A2.8961.00
181_R207_T2.8961.00
158_L161_A2.6231.00
279_T283_Y2.2981.00
274_F282_L2.2841.00
157_F162_L2.2131.00
272_P279_T2.1391.00
274_F279_T2.1341.00
177_Y181_R2.0831.00
161_A164_L2.0721.00
23_K83_E2.0631.00
42_L45_S2.0581.00
194_K202_E2.0491.00
282_L286_L1.9941.00
157_F164_L1.9451.00
150_P154_T1.9241.00
90_I105_A1.9031.00
178_L181_R1.9021.00
156_E159_K1.8881.00
156_E160_A1.8861.00
204_W207_T1.8501.00
158_L162_L1.8441.00
275_S278_L1.8441.00
148_D151_Y1.8421.00
149_I152_F1.8391.00
218_L229_L1.8321.00
185_A200_L1.8281.00
18_F22_Y1.8121.00
105_A109_S1.7991.00
192_E202_E1.7981.00
278_L282_L1.7901.00
88_I187_P1.7791.00
158_L164_L1.7371.00
272_P275_S1.7331.00
156_E163_G1.7301.00
147_I150_P1.7261.00
18_F86_G1.7141.00
195_S198_E1.6931.00
181_R204_W1.6711.00
276_A279_T1.6531.00
277_A280_S1.6431.00
182_W204_W1.6290.99
264_W282_L1.5660.99
127_Y179_L1.5580.99
101_S104_D1.5450.99
279_T286_L1.5430.99
49_Y54_N1.5340.99
276_A280_S1.5300.99
221_W240_L1.4980.99
189_V196_F1.4950.99
171_L175_L1.4900.99
277_A282_L1.4670.99
168_Y172_L1.4640.99
147_I153_I1.4390.99
102_L105_A1.4320.99
15_L19_E1.4160.98
22_Y26_A1.4130.98
275_S279_T1.4110.98
19_E22_Y1.4040.98
264_W283_Y1.4020.98
264_W267_S1.3970.98
277_A281_L1.3890.98
264_W268_F1.3890.98
257_V260_L1.3640.98
169_L173_L1.3560.98
93_A100_I1.3520.98
218_L221_W1.3520.98
137_L140_A1.3430.98
254_L258_L1.3310.98
158_L163_G1.3140.98
268_F271_T1.3080.97
144_L148_D1.2930.97
188_L192_E1.2810.97
88_I191_L1.2720.97
282_L287_Y1.2710.97
50_L175_L1.2630.97
63_P66_L1.2540.97
157_F165_G1.2510.97
81_F86_G1.2490.97
167_L173_L1.2430.97
41_L58_F1.2420.97
202_E206_L1.2150.96
267_S282_L1.2140.96
219_L222_L1.2080.96
280_S284_A1.2050.96
188_L282_L1.2010.96
54_N65_G1.1870.96
152_F160_A1.1770.95
291_E294_E1.1700.95
36_L40_L1.1400.94
15_L94_A1.1290.94
112_R115_R1.1270.94
82_L86_G1.1260.94
278_L281_L1.1220.94
148_D152_F1.1190.94
222_L226_L1.1190.94
282_L285_Y1.1160.94
177_Y207_T1.1160.94
257_V261_L1.1100.94
229_L240_L1.1090.94
18_F23_K1.1050.93
144_L149_I1.0990.93
74_L77_L1.0970.93
281_L285_Y1.0970.93
188_L206_L1.0940.93
19_E83_E1.0930.93
290_G294_E1.0920.93
178_L267_S1.0920.93
280_S283_Y1.0890.93
203_S207_T1.0850.93
150_P156_E1.0730.92
147_I151_Y1.0680.92
182_W200_L1.0610.92
107_R111_R1.0590.92
18_F90_I1.0540.92
287_Y290_G1.0500.92
139_L142_S1.0490.92
160_A164_L1.0460.91
93_A98_R1.0460.91
274_F277_A1.0290.91
10_R97_G1.0220.90
19_E87_L1.0140.90
52_N65_G1.0100.90
150_P157_F1.0090.90
238_L242_L1.0090.90
268_F279_T1.0080.90
62_S91_A1.0040.90
284_A287_Y1.0020.90
236_L242_L0.9990.89
227_L231_L0.9970.89
287_Y291_E0.9960.89
11_N94_A0.9950.89
266_L273_L0.9910.89
264_W275_S0.9900.89
270_L278_L0.9880.89
157_F167_L0.9870.89
220_L223_L0.9860.89
58_F65_G0.9690.88
276_A282_L0.9650.88
207_T210_R0.9630.88
59_L134_F0.9620.88
139_L176_L0.9580.87
187_P283_Y0.9570.87
97_G104_D0.9510.87
33_L40_L0.9500.87
192_E206_L0.9480.87
16_L25_L0.9470.87
125_L173_L0.9450.87
278_L287_Y0.9410.86
283_Y287_Y0.9390.86
181_R203_S0.9350.86
283_Y286_L0.9340.86
287_Y296_P0.9340.86
86_G109_S0.9310.86
89_L112_R0.9230.85
229_L238_L0.9220.85
207_T214_I0.9220.85
89_L184_F0.9210.85
285_Y289_E0.9210.85
122_L126_L0.9210.85
217_L220_L0.9180.85
269_L273_L0.9160.85
164_L167_L0.9130.85
230_L234_A0.9120.85
220_L238_L0.9120.85
159_K162_L0.9060.84
222_L240_L0.9060.84
73_L231_L0.9050.84
263_L267_S0.9030.84
42_L58_F0.9020.84
59_L63_P0.8990.84
264_W278_L0.8930.83
270_L282_L0.8930.83
113_L134_F0.8890.83
236_L240_L0.8880.83
54_N62_S0.8860.83
149_I153_I0.8850.83
266_L276_A0.8790.82
219_L226_L0.8730.82
75_L98_R0.8680.82
74_L81_F0.8660.81
180_L208_K0.8650.81
275_S283_Y0.8570.81
85_A109_S0.8530.80
201_K205_R0.8500.80
286_L291_E0.8480.80
221_W225_L0.8430.80
132_L190_L0.8420.80
8_F13_R0.8400.79
194_K199_A0.8370.79
152_F155_D0.8370.79
214_I222_L0.8370.79
46_G132_L0.8330.79
6_R97_G0.8320.79
6_R67_L0.8270.78
233_L237_L0.8260.78
41_L65_G0.8260.78
265_L269_L0.8170.77
184_F214_I0.8160.77
252_A255_L0.8150.77
246_L265_L0.8080.77
267_S271_T0.8070.77
26_A129_L0.8050.76
220_L231_L0.8050.76
138_G142_S0.7990.76
229_L233_L0.7980.76
59_L137_L0.7970.76
91_A187_P0.7960.76
180_L211_R0.7950.76
216_L226_L0.7880.75
266_L271_T0.7840.75
110_L251_L0.7810.74
28_L229_L0.7800.74
264_W272_P0.7790.74
222_L233_L0.7780.74
272_P276_A0.7760.74
39_R269_L0.7740.74
240_L245_D0.7630.72
149_I154_T0.7620.72
163_G170_L0.7610.72
83_E214_I0.7540.72
83_E187_P0.7530.72
226_L237_L0.7500.71
82_L88_I0.7470.71
122_L197_R0.7450.71
54_N189_V0.7440.71
27_L81_F0.7400.70
81_F116_L0.7380.70
82_L89_L0.7380.70
264_W279_T0.7370.70
65_G86_G0.7360.70
153_I170_L0.7330.69
294_E297_K0.7330.69
80_I84_F0.7330.69
47_Y54_N0.7320.69
28_L37_L0.7300.69
284_A288_E0.7280.69
234_A238_L0.7270.69
182_W185_A0.7260.69
274_F278_L0.7250.69
123_L196_F0.7220.68
267_S272_P0.7110.67
200_L204_W0.7110.67
226_L229_L0.7110.67
141_S153_I0.7060.67
49_Y65_G0.7060.67
11_N54_N0.7040.66
272_P277_A0.7020.66
288_E294_E0.7020.66
93_A105_A0.7000.66
275_S282_L0.6980.66
247_L252_A0.6950.65
245_D250_S0.6950.65
51_T131_L0.6940.65
45_S65_G0.6940.65
267_S276_A0.6930.65
189_V199_A0.6880.65
267_S277_A0.6870.64
227_L230_L0.6840.64
171_L242_L0.6840.64
174_L247_L0.6840.64
231_L243_L0.6830.64
73_L104_D0.6800.64
165_G169_L0.6780.63
105_A143_L0.6760.63
268_F272_P0.6750.63
182_W203_S0.6730.63
59_L206_L0.6720.63
59_L240_L0.6710.63
220_L225_L0.6680.62
71_L169_L0.6670.62
251_L257_V0.6660.62
223_L250_S0.6660.62
50_L123_L0.6660.62
105_A189_V0.6640.62
83_E90_I0.6640.62
182_W207_T0.6620.62
157_F175_L0.6610.61
269_L281_L0.6610.61
268_F282_L0.6610.61
277_A285_Y0.6600.61
271_T279_T0.6580.61
272_P283_Y0.6570.61
128_L153_I0.6560.61
99_R102_L0.6560.61
266_L277_A0.6530.61
269_L272_P0.6510.60
22_Y30_L0.6500.60
265_L271_T0.6500.60
73_L130_L0.6480.60
112_R193_G0.6480.60
174_L181_R0.6470.60
32_P131_L0.6470.60
6_R193_G0.6440.59
170_L220_L0.6400.59
273_L281_L0.6370.59
290_G296_P0.6340.58
148_D153_I0.6330.58
32_P182_W0.6320.58
107_R110_L0.6320.58
43_K130_L0.6310.58
166_L170_L0.6310.58
30_L79_L0.6280.58
173_L216_L0.6250.57
280_S286_L0.6240.57
291_E296_P0.6230.57
239_L243_L0.6230.57
290_G293_P0.6210.57
11_N23_K0.6190.56
152_F157_F0.6190.56
171_L181_R0.6150.56
271_T275_S0.6130.56
185_A196_F0.6100.55
20_L256_A0.6090.55
18_F52_N0.6090.55
228_L256_A0.6080.55
287_Y293_P0.6080.55
108_F117_L0.6070.55
17_L42_L0.6070.55
230_L237_L0.6060.55
264_W276_A0.6060.55
59_L251_L0.6060.55
255_L260_L0.6050.55
194_K198_E0.6050.55
162_L169_L0.6040.55
101_S115_R0.6020.54
143_L149_I0.6010.54
276_A284_A0.6010.54
267_S270_L0.5980.54
160_A178_L0.5970.54
267_S274_F0.5970.54
288_E292_L0.5970.54
54_N120_G0.5950.54
161_A165_G0.5940.53
18_F83_E0.5910.53
134_F182_W0.5910.53
216_L237_L0.5900.53
35_S78_L0.5880.53
227_L232_L0.5870.53
134_F188_L0.5860.52
60_L65_G0.5830.52
131_L135_L0.5830.52
241_A245_D0.5820.52
32_P52_N0.5820.52
232_L239_L0.5790.52
33_L199_A0.5770.51
23_K38_L0.5770.51
234_A240_L0.5750.51
14_T17_L0.5740.51
179_L190_L0.5730.51
206_L210_R0.5720.51
50_L72_L0.5690.50
52_N56_L0.5680.50
67_L265_L0.5650.50
25_L125_L0.5650.50
103_R135_L0.5650.50
127_Y150_P0.5610.49
70_L197_R0.5600.49
40_L44_L0.5600.49
98_R101_S0.5600.49
232_L237_L0.5590.49
7_D11_N0.5580.49
183_I199_A0.5570.49
8_F183_I0.5570.49
97_G173_L0.5560.49
186_L190_L0.5530.48
195_S234_A0.5520.48
125_L129_L0.5520.48
79_L82_L0.5520.48
79_L109_S0.5460.48
231_L280_S0.5450.47
184_F196_F0.5420.47
272_P287_Y0.5420.47
62_S80_I0.5410.47
64_L71_L0.5410.47
284_A290_G0.5400.47
127_Y180_L0.5400.47
7_D41_L0.5390.47
244_L251_L0.5370.46
204_W223_L0.5370.46
188_L194_K0.5330.46
140_A152_F0.5330.46
235_L255_L0.5320.46
233_L241_A0.5310.46
84_F90_I0.5290.45
41_L72_L0.5280.45
228_L278_L0.5280.45
31_I68_A0.5270.45
37_L262_L0.5260.45
121_L132_L0.5260.45
278_L283_Y0.5250.45
281_L286_L0.5250.45
170_L229_L0.5250.45
84_F187_P0.5250.45
40_L43_K0.5250.45
140_A148_D0.5240.45
60_L262_L0.5230.45
260_L264_W0.5210.44
210_R213_R0.5210.44
164_L169_L0.5200.44
228_L237_L0.5190.44
78_L208_K0.5190.44
36_L191_L0.5190.44
136_G143_L0.5180.44
221_W237_L0.5170.44
232_L297_K0.5170.44
123_L185_A0.5160.44
165_G171_L0.5150.44
104_D190_L0.5140.44
233_L238_L0.5130.44
142_S187_P0.5130.44
7_D15_L0.5100.43
42_L47_Y0.5100.43
222_L235_L0.5100.43
133_P182_W0.5100.43
270_L274_F0.5090.43
121_L127_Y0.5090.43
222_L230_L0.5080.43
123_L140_A0.5070.43
21_L225_L0.5060.43
179_L182_W0.5050.43
72_L81_F0.5040.42
29_L155_D0.5030.42
275_S280_S0.5020.42
293_P297_K0.5010.42
94_A228_L0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.3563 11 0.95 Contact Map
3w4tA 1 0.3531 10.4 0.951 Contact Map
4tquM 1 0.8406 9.4 0.952 Contact Map
3mp7A 1 0.2531 6.7 0.955 Contact Map
4w251 1 0.2969 5 0.958 Contact Map
4humA 1 0.35 4.9 0.958 Contact Map
4tquN 1 0.7656 4.9 0.958 Contact Map
3mp7B 1 0.1688 4.7 0.958 Contact Map
3dinC 1 0.3125 4 0.959 Contact Map
3dl8G 1 0.3094 3.9 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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