GREMLIN Database
DUF2341 - Domain of unknown function (DUF2341)
PFAM: PF10102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (73)
Sequences: 17772 (13817)
Seq/√Len: 1617.2
META: 0.979

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_G68_F2.7541.00
2_G22_W2.6041.00
16_P34_K2.5621.00
19_I31_I2.5441.00
2_G24_S2.5421.00
8_T49_Y2.0301.00
21_S30_V1.8921.00
60_N63_A1.7811.00
9_D36_P1.7491.00
20_E32_W1.7481.00
5_I31_I1.6961.00
9_D13_T1.6541.00
7_F48_M1.5781.00
35_V46_I1.5161.00
52_N55_A1.5131.00
18_W65_F1.4691.00
7_F33_V1.4531.00
7_F31_I1.4521.00
21_S28_T1.4161.00
65_F68_F1.4021.00
8_T14_T1.3841.00
14_T58_A1.3761.00
20_E30_V1.2931.00
39_S44_T1.2581.00
22_W29_A1.2431.00
2_G29_A1.2371.00
16_P63_A1.2181.00
3_S57_S1.1841.00
6_R58_A1.1681.00
8_T12_G1.1351.00
68_F71_F1.1261.00
24_S29_A1.1121.00
2_G23_D1.0941.00
11_D14_T1.0831.00
23_D26_T1.0631.00
15_L46_I1.0481.00
5_I48_M1.0371.00
9_D44_T1.0311.00
24_S27_G1.0301.00
18_W64_V1.0281.00
18_W61_G0.9841.00
17_Y58_A0.9681.00
67_F71_F0.9551.00
70_D73_G0.9391.00
61_G65_F0.9151.00
39_S42_S0.9061.00
24_S28_T0.8711.00
7_F17_Y0.8501.00
17_Y57_S0.8391.00
32_W65_F0.8321.00
6_R55_A0.8271.00
16_P60_N0.8241.00
3_S59_S0.8161.00
61_G64_V0.8121.00
65_F71_F0.8041.00
12_G49_Y0.7971.00
33_V46_I0.7951.00
19_I57_S0.7931.00
41_S44_T0.7911.00
38_I44_T0.7901.00
67_F70_D0.7901.00
34_K64_V0.7831.00
8_T47_Y0.7741.00
3_S55_A0.7701.00
66_D69_D0.7661.00
26_T29_A0.7581.00
3_S19_I0.7581.00
9_D14_T0.7571.00
65_F70_D0.7521.00
15_L36_P0.7471.00
40_A43_D0.7321.00
6_R14_T0.7271.00
23_D28_T0.7201.00
37_S40_A0.7181.00
10_S45_T0.7151.00
15_L33_V0.7021.00
22_W31_I0.6981.00
14_T17_Y0.6911.00
6_R52_N0.6751.00
23_D27_G0.6721.00
66_D70_D0.6681.00
37_S44_T0.6651.00
4_D51_G0.6581.00
66_D71_F0.6561.00
35_V38_I0.6561.00
65_F69_D0.6531.00
49_Y52_N0.6521.00
23_D29_A0.6521.00
9_D15_L0.6341.00
69_D72_S0.6221.00
67_F73_G0.6101.00
7_F46_I0.6101.00
42_S45_T0.6061.00
38_I41_S0.6021.00
18_W32_W0.5941.00
6_R17_Y0.5851.00
55_A58_A0.5771.00
17_Y33_V0.5731.00
19_I23_D0.5691.00
10_S13_T0.5661.00
40_A44_T0.5601.00
12_G47_Y0.5551.00
68_F72_S0.5511.00
17_Y59_S0.5281.00
49_Y55_A0.5181.00
3_S56_T0.5181.00
35_V44_T0.5181.00
3_S58_A0.5171.00
10_S47_Y0.5141.00
9_D12_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hykA 1 0.2619 23.6 0.866 Contact Map
3azyA 1 0.2857 20.8 0.869 Contact Map
3dgtA 1 0.3571 19.8 0.871 Contact Map
2vy0A 1 0.4048 16.9 0.875 Contact Map
1o7dC 1 0.5952 16.3 0.875 Contact Map
3juuA 1 0.4881 13.5 0.88 Contact Map
4ateA 1 0.369 12.3 0.882 Contact Map
1dypA 1 0.4048 10.9 0.885 Contact Map
1upsA 1 0.4167 8 0.892 Contact Map
4bpzA 1 0.3333 7.3 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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