DUF2339 - PFAM28P - GREMLIN Contacts

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DUF2339 - Predicted membrane protein (DUF2339)

PFAM:	PF10101	Sequences: GGNLLVKIGILILVLGVAFLLKYAIDHGLIPPELRVALGALAGLALLGAGERLRRKYRAFALVLQGGGIAVLYLTVFAAYRLYGLIPPTLAFALMVLVTAFAVALALRYNSQALAVLGLLGGFLAPFLLSTGSGNHVALFSYLALLNAGILAIAWFKRWRWLNLLGFAFTFLIGLLWGLLYYRPEHFASTEPFLLLFFLLFLAIALLFALLFLAARQPVDGTLLFGNPLVAFGLQYALLADFEYGLALSALALAALYLALAALLRRRKRADLRLLAEAFLALALAFLTLAIPLALDGNWTTLAWALEGAALLWLLGLRQRRRLARRFGLPLLLLAALSALLLALLLRRLALAWSALALLPLLLLLLLLGLGFLGPLAWLLLGYGLPAAALALAAWLLRRREDRLRRVLHAAALLLLLLLLALELRYLLDGGVLFAGAWASLAEAWLALPALLFLALALLLLRRRRRSARLARLYRLGAGALLLLALLLLLLLLLLVLANPLLSGEAVGGLPLLNPLDLAYLLPLLLLLLWARLLRRARPLAAGWLRRALAALALALALLLFLLLNAVLLRVLWQGDALAASALVQDAELAGLSILWGLLALALMVLGIRRRSRALRIAGLALLGLVVLKLFLVDLSGLGTLYRIISFIGLGLLLLVISFLYQRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	664 (653)
Sequences:	3873 (3474)
Seq/√Len:	135.9
META:	0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_K	26_D	5.484	1.00
110_N	157_K	4.374	1.00
10_I	67_G	4.188	1.00
69_I	102_A	4.087	1.00
43_G	71_V	3.999	1.00
31_P	34_L	3.886	1.00
122_G	146_L	3.879	1.00
87_P	90_L	3.796	1.00
50_G	65_Q	3.501	1.00
187_F	191_E	3.300	1.00
40_A	76_V	3.223	1.00
417_L	423_E	3.131	1.00
16_G	648_I	3.087	1.00
258_L	283_A	2.982	1.00
423_E	427_L	2.933	1.00
344_L	348_R	2.927	1.00
628_L	632_L	2.895	1.00
112_Q	161_W	2.769	1.00
48_G	52_R	2.741	1.00
15_L	19_F	2.694	1.00
47_L	68_G	2.691	1.00
3_N	7_K	2.604	1.00
248_L	252_A	2.587	1.00
246_L	249_S	2.583	1.00
558_L	562_L	2.558	1.00
99_T	122_G	2.556	1.00
616_R	661_Y	2.501	1.00
196_L	200_L	2.413	1.00
363_L	366_L	2.330	1.00
288_T	307_E	2.327	1.00
345_L	348_R	2.311	1.00
307_E	311_L	2.309	1.00
558_L	563_L	2.299	1.00
220_D	227_N	2.293	1.00
37_A	41_L	2.288	1.00
571_V	575_G	2.281	1.00
259_A	263_L	2.270	1.00
292_P	304_W	2.268	1.00
195_L	199_L	2.244	1.00
560_L	564_L	2.205	1.00
17_V	71_V	2.201	1.00
1_G	4_L	2.200	1.00
198_F	201_F	2.190	1.00
345_L	349_L	2.184	1.00
295_L	299_W	2.171	1.00
514_N	517_D	2.168	1.00
135_N	138_A	2.165	1.00
604_M	619_G	2.161	1.00
144_A	196_L	2.112	1.00
485_A	489_L	2.106	1.00
95_M	125_A	2.100	1.00
423_E	426_Y	2.094	1.00
366_L	369_G	2.056	1.00
43_G	68_G	2.051	1.00
197_F	201_F	2.045	1.00
46_L	67_G	2.014	1.00
291_I	303_A	2.007	1.00
291_I	300_T	2.001	1.00
344_L	349_L	1.996	1.00
244_Y	247_A	1.979	1.00
202_L	256_L	1.960	1.00
482_L	486_L	1.959	1.00
102_A	118_G	1.958	1.00
391_A	395_W	1.956	1.00
617_I	621_A	1.956	1.00
458_L	462_R	1.948	1.00
616_R	620_L	1.941	1.00
553_A	564_L	1.940	1.00
80_Y	91_A	1.903	1.00
516_L	519_A	1.864	1.00
191_E	195_L	1.854	1.00
489_L	494_L	1.832	1.00
76_V	98_V	1.829	1.00
511_P	514_N	1.811	1.00
80_Y	88_P	1.785	1.00
24_A	29_L	1.778	1.00
490_L	495_L	1.774	1.00
193_F	198_F	1.774	1.00
30_I	38_L	1.770	1.00
343_A	348_R	1.768	1.00
331_L	335_A	1.767	1.00
395_W	398_R	1.755	1.00
571_V	576_D	1.740	1.00
24_A	50_G	1.735	1.00
79_A	86_I	1.733	1.00
246_L	250_A	1.733	1.00
591_G	595_L	1.728	1.00
571_V	574_Q	1.706	1.00
50_G	61_A	1.700	1.00
202_L	205_A	1.699	1.00
369_G	372_F	1.693	1.00
187_F	193_F	1.685	1.00
254_A	257_Y	1.683	1.00
249_S	252_A	1.678	1.00
78_A	82_L	1.667	1.00
553_A	562_L	1.663	1.00
247_A	250_A	1.658	1.00
14_V	70_A	1.646	1.00
227_N	231_A	1.645	1.00
77_F	81_R	1.644	1.00
554_L	558_L	1.643	1.00
43_G	72_L	1.643	1.00
445_W	449_P	1.642	1.00
126_P	142_Y	1.641	1.00
220_D	224_L	1.640	1.00
608_I	661_Y	1.638	1.00
607_G	616_R	1.635	1.00
613_R	617_I	1.635	1.00
193_F	201_F	1.634	1.00
193_F	197_F	1.625	1.00
486_L	490_L	1.621	1.00
343_A	346_L	1.615	1.00
299_W	303_A	1.609	1.00
529_L	533_L	1.605	1.00
187_F	192_P	1.603	1.00
553_A	557_A	1.602	1.00
608_I	616_R	1.598	1.00
198_F	205_A	1.590	1.00
80_Y	131_T	1.582	1.00
552_L	556_L	1.581	1.00
186_H	189_S	1.575	1.00
498_A	501_L	1.572	1.00
69_I	105_L	1.570	1.00
412_A	416_L	1.568	1.00
4_L	7_K	1.559	1.00
174_G	178_G	1.556	1.00
73_Y	121_G	1.550	1.00
150_I	166_G	1.550	1.00
43_G	75_T	1.538	1.00
602_A	606_L	1.537	1.00
244_Y	249_S	1.529	1.00
47_L	72_L	1.524	1.00
21_L	39_G	1.509	1.00
203_A	207_L	1.478	1.00
44_L	48_G	1.473	1.00
17_V	21_L	1.468	1.00
624_G	628_L	1.460	1.00
445_W	448_L	1.457	1.00
557_A	564_L	1.456	1.00
522_L	525_L	1.456	1.00
606_L	610_R	1.453	1.00
417_L	420_L	1.450	1.00
190_T	193_F	1.440	1.00
316_G	324_A	1.440	1.00
393_A	397_L	1.439	1.00
104_A	108_R	1.438	1.00
232_F	293_L	1.431	1.00
89_T	93_A	1.430	1.00
569_L	584_V	1.430	1.00
555_A	559_L	1.428	1.00
6_V	63_V	1.425	1.00
353_W	357_A	1.423	1.00
262_A	266_R	1.422	1.00
20_L	29_L	1.417	1.00
191_E	198_F	1.393	1.00
549_L	564_L	1.390	1.00
340_L	343_A	1.387	1.00
557_A	561_F	1.386	1.00
187_F	190_T	1.385	1.00
424_L	427_L	1.383	1.00
334_L	338_S	1.379	1.00
198_F	204_I	1.377	1.00
62_L	111_S	1.377	1.00
357_A	360_P	1.374	1.00
643_R	646_S	1.367	1.00
619_G	626_V	1.366	1.00
333_L	337_L	1.364	1.00
295_L	303_A	1.363	1.00
486_L	489_L	1.362	1.00
198_F	202_L	1.357	1.00
466_R	469_R	1.351	1.00
205_A	208_F	1.349	1.00
72_L	98_V	1.349	1.00
60_F	64_L	1.341	1.00
475_R	479_G	1.340	1.00
123_F	147_N	1.336	1.00
207_L	210_L	1.336	1.00
123_F	146_L	1.330	1.00
191_E	235_Q	1.330	1.00
490_L	494_L	1.322	1.00
518_L	522_L	1.321	1.00
629_K	634_D	1.320	1.00
483_L	487_L	1.318	1.00
641_L	645_I	1.315	1.00
83_Y	126_P	1.313	1.00
103_V	152_A	1.309	1.00
246_L	252_A	1.300	1.00
498_A	502_L	1.295	1.00
321_R	324_A	1.293	1.00
552_L	559_L	1.291	1.00
525_L	529_L	1.290	1.00
193_F	200_L	1.288	1.00
554_L	561_F	1.287	1.00
190_T	198_F	1.287	1.00
560_L	563_L	1.285	1.00
528_L	532_R	1.283	1.00
465_R	469_R	1.280	1.00
558_L	561_F	1.279	1.00
73_Y	99_T	1.278	1.00
32_P	35_R	1.276	1.00
427_L	431_G	1.272	1.00
188_A	192_P	1.271	1.00
198_F	208_F	1.269	1.00
594_I	649_G	1.265	1.00
54_R	108_R	1.264	1.00
457_A	461_L	1.256	1.00
600_A	623_L	1.254	1.00
246_L	253_L	1.253	1.00
189_S	192_P	1.251	1.00
557_A	562_L	1.250	1.00
600_A	654_L	1.247	1.00
17_V	20_L	1.246	1.00
519_A	523_P	1.240	1.00
33_E	37_A	1.233	1.00
527_L	531_A	1.232	1.00
99_T	149_G	1.229	1.00
261_A	280_L	1.227	1.00
137_V	141_S	1.225	1.00
333_L	336_A	1.225	1.00
212_F	215_A	1.224	1.00
194_L	197_F	1.224	1.00
339_A	343_A	1.221	1.00
659_F	663_R	1.214	1.00
554_L	564_L	1.212	1.00
54_R	61_A	1.206	1.00
392_L	396_L	1.206	1.00
193_F	196_L	1.206	1.00
39_G	75_T	1.202	1.00
459_L	463_R	1.198	1.00
191_E	201_F	1.194	1.00
620_L	661_Y	1.194	1.00
551_A	554_L	1.191	1.00
623_L	654_L	1.190	1.00
224_L	227_N	1.189	1.00
619_G	623_L	1.186	0.99
205_A	209_A	1.183	0.99
36_V	85_L	1.182	0.99
346_L	349_L	1.179	0.99
174_G	177_W	1.175	0.99
206_L	209_A	1.172	0.99
175_L	180_L	1.172	0.99
188_A	191_E	1.171	0.99
643_R	647_F	1.169	0.99
559_L	562_L	1.168	0.99
374_G	377_A	1.168	0.99
481_L	490_L	1.167	0.99
274_L	278_A	1.166	0.99
51_E	65_Q	1.165	0.99
23_Y	27_H	1.164	0.99
121_G	126_P	1.163	0.99
196_L	201_F	1.161	0.99
204_I	208_F	1.159	0.99
332_L	336_A	1.157	0.99
221_G	227_N	1.157	0.99
635_L	643_R	1.151	0.99
361_L	366_L	1.150	0.99
449_P	452_L	1.149	0.99
11_L	15_L	1.145	0.99
197_F	202_L	1.142	0.99
45_A	49_A	1.139	0.99
98_V	102_A	1.138	0.99
190_T	197_F	1.138	0.99
23_Y	644_I	1.137	0.99
239_L	242_F	1.135	0.99
227_N	233_G	1.134	0.99
459_L	464_R	1.134	0.99
245_G	248_L	1.131	0.99
36_V	83_Y	1.130	0.99
438_W	441_L	1.128	0.99
94_L	98_V	1.125	0.99
51_E	55_R	1.124	0.99
336_A	343_A	1.122	0.99
53_L	60_F	1.122	0.99
630_L	650_L	1.120	0.99
607_G	620_L	1.120	0.99
292_P	300_T	1.119	0.99
80_Y	95_M	1.116	0.99
26_D	35_R	1.113	0.99
561_F	564_L	1.113	0.99
328_G	331_L	1.111	0.99
631_F	654_L	1.111	0.99
273_R	277_E	1.108	0.99
373_L	376_L	1.107	0.99
413_L	417_L	1.106	0.99
340_L	344_L	1.105	0.99
496_V	500_P	1.102	0.99
425_R	429_D	1.102	0.99
116_V	165_L	1.098	0.99
175_L	179_L	1.097	0.99
449_P	453_F	1.097	0.99
470_L	474_Y	1.097	0.99
99_T	121_G	1.094	0.99
306_L	309_A	1.091	0.99
317_L	325_R	1.091	0.99
65_Q	109_Y	1.088	0.99
95_M	129_L	1.088	0.99
593_S	629_K	1.087	0.99
154_A	163_N	1.087	0.99
460_L	463_R	1.085	0.99
568_L	595_L	1.079	0.99
123_F	169_F	1.077	0.99
420_L	423_E	1.076	0.99
389_A	396_L	1.075	0.99
220_D	228_P	1.073	0.99
341_L	344_L	1.069	0.99
558_L	564_L	1.069	0.99
136_H	140_F	1.068	0.99
86_I	90_L	1.062	0.99
308_G	312_L	1.057	0.99
352_A	357_A	1.057	0.99
491_L	495_L	1.057	0.99
365_L	369_G	1.055	0.99
343_A	347_R	1.050	0.99
650_L	654_L	1.046	0.99
316_G	328_G	1.045	0.99
387_A	391_A	1.042	0.99
517_D	520_Y	1.039	0.99
428_L	431_G	1.038	0.99
194_L	201_F	1.037	0.99
12_I	630_L	1.035	0.99
362_L	366_L	1.031	0.99
175_L	234_L	1.031	0.99
417_L	427_L	1.029	0.99
278_A	281_A	1.027	0.99
554_L	559_L	1.025	0.99
148_A	200_L	1.025	0.99
362_L	365_L	1.019	0.98
483_L	486_L	1.018	0.98
95_M	149_G	1.017	0.98
572_L	575_G	1.017	0.98
194_L	198_F	1.016	0.98
531_A	535_R	1.016	0.98
604_M	608_I	1.014	0.98
195_L	198_F	1.011	0.98
115_A	162_L	1.009	0.98
17_V	42_A	1.007	0.98
607_G	661_Y	1.006	0.98
197_F	200_L	1.006	0.98
457_A	460_L	1.005	0.98
331_L	336_A	1.004	0.98
448_L	452_L	1.003	0.98
24_A	35_R	1.002	0.98
254_A	283_A	1.000	0.98
462_R	466_R	1.000	0.98
341_L	349_L	0.998	0.98
5_L	657_I	0.994	0.98
66_G	125_A	0.993	0.98
344_L	347_R	0.993	0.98
497_L	500_P	0.989	0.98
600_A	657_I	0.988	0.98
10_I	117_L	0.987	0.98
232_F	236_Y	0.987	0.98
6_V	10_I	0.985	0.98
382_G	386_P	0.984	0.98
324_A	328_G	0.978	0.98
13_L	23_Y	0.977	0.98
152_A	156_F	0.976	0.98
489_L	492_L	0.976	0.98
136_H	189_S	0.975	0.98
638_L	650_L	0.975	0.98
553_A	556_L	0.975	0.98
220_D	223_L	0.974	0.98
362_L	369_G	0.969	0.98
203_A	206_L	0.968	0.98
658_S	661_Y	0.967	0.98
457_A	463_R	0.967	0.98
201_F	208_F	0.966	0.98
304_W	307_E	0.966	0.98
201_F	205_A	0.965	0.98
32_P	36_V	0.965	0.98
25_I	39_G	0.962	0.98
286_F	292_P	0.962	0.98
483_L	490_L	0.960	0.98
36_V	39_G	0.958	0.98
25_I	28_G	0.956	0.98
131_T	134_G	0.950	0.98
40_A	72_L	0.948	0.98
139_L	142_Y	0.945	0.97
226_G	235_Q	0.943	0.97
446_L	449_P	0.943	0.97
482_L	489_L	0.942	0.97
643_R	649_G	0.937	0.97
417_L	428_L	0.936	0.97
341_L	345_L	0.935	0.97
144_A	200_L	0.935	0.97
659_F	662_Q	0.932	0.97
599_L	603_L	0.932	0.97
638_L	642_Y	0.931	0.97
195_L	231_A	0.931	0.97
475_R	478_A	0.929	0.97
76_V	94_L	0.928	0.97
413_L	423_E	0.927	0.97
627_V	654_L	0.924	0.97
553_A	561_F	0.924	0.97
205_A	210_L	0.923	0.97
197_F	203_A	0.922	0.97
616_R	662_Q	0.920	0.97
50_G	60_F	0.919	0.97
245_G	249_S	0.918	0.97
479_G	485_A	0.917	0.97
244_Y	248_L	0.917	0.97
244_Y	250_A	0.916	0.97
383_Y	386_P	0.916	0.97
186_H	190_T	0.913	0.97
202_L	206_L	0.913	0.97
220_D	299_W	0.911	0.97
7_K	10_I	0.911	0.97
219_V	225_F	0.910	0.97
351_L	354_S	0.909	0.97
559_L	563_L	0.907	0.97
616_R	663_R	0.906	0.97
92_F	95_M	0.906	0.97
484_L	490_L	0.906	0.97
474_Y	477_G	0.905	0.97
620_L	658_S	0.904	0.97
462_R	465_R	0.902	0.97
51_E	54_R	0.900	0.97
6_V	658_S	0.900	0.97
359_L	362_L	0.898	0.97
123_F	150_I	0.892	0.96
484_L	495_L	0.891	0.96
409_H	412_A	0.888	0.96
606_L	615_L	0.888	0.96
100_A	104_A	0.887	0.96
393_A	412_A	0.886	0.96
499_N	502_L	0.885	0.96
113_A	117_L	0.885	0.96
5_L	600_A	0.885	0.96
134_G	138_A	0.884	0.96
360_P	363_L	0.883	0.96
520_Y	524_L	0.880	0.96
190_T	201_F	0.879	0.96
419_L	423_E	0.878	0.96
66_G	105_L	0.876	0.96
50_G	68_G	0.876	0.96
621_A	625_L	0.876	0.96
590_A	593_S	0.875	0.96
103_V	107_L	0.875	0.96
76_V	91_A	0.872	0.96
651_G	654_L	0.872	0.96
227_N	235_Q	0.871	0.96
471_A	475_R	0.870	0.96
147_N	201_F	0.868	0.96
247_A	252_A	0.865	0.96
388_A	392_L	0.864	0.96
254_A	258_L	0.864	0.96
652_L	656_V	0.863	0.96
552_L	564_L	0.863	0.96
4_L	8_I	0.863	0.96
83_Y	121_G	0.862	0.96
248_L	251_L	0.861	0.96
598_L	602_A	0.861	0.96
554_L	563_L	0.860	0.96
148_A	152_A	0.860	0.96
232_F	286_F	0.860	0.96
342_L	345_L	0.859	0.96
253_L	257_Y	0.859	0.96
107_L	156_F	0.859	0.96
14_V	18_A	0.856	0.96
427_L	432_V	0.853	0.95
648_I	652_L	0.853	0.95
574_Q	577_A	0.853	0.95
330_P	338_S	0.851	0.95
14_V	74_L	0.851	0.95
2_G	7_K	0.851	0.95
324_A	334_L	0.849	0.95
480_A	483_L	0.848	0.95
135_N	139_L	0.847	0.95
130_S	134_G	0.847	0.95
375_P	378_W	0.847	0.95
250_A	253_L	0.846	0.95
13_L	16_G	0.846	0.95
618_A	621_A	0.844	0.95
247_A	253_L	0.843	0.95
424_L	428_L	0.842	0.95
183_R	186_H	0.840	0.95
364_L	369_G	0.840	0.95
395_W	399_R	0.838	0.95
575_G	580_A	0.836	0.95
635_L	638_L	0.834	0.95
571_V	585_Q	0.834	0.95
655_L	659_F	0.833	0.95
421_A	427_L	0.832	0.95
195_L	201_F	0.830	0.95
325_R	328_G	0.828	0.95
197_F	205_A	0.827	0.95
572_L	577_A	0.826	0.95
471_A	474_Y	0.826	0.95
186_H	191_E	0.826	0.95
321_R	328_G	0.825	0.95
423_E	428_L	0.824	0.94
352_A	360_P	0.824	0.94
335_A	338_S	0.822	0.94
573_W	577_A	0.821	0.94
202_L	208_F	0.819	0.94
231_A	235_Q	0.818	0.94
550_A	564_L	0.817	0.94
36_V	79_A	0.817	0.94
553_A	558_L	0.815	0.94
219_V	224_L	0.815	0.94
18_A	22_K	0.813	0.94
447_A	450_A	0.811	0.94
282_L	286_F	0.811	0.94
32_P	83_Y	0.810	0.94
352_A	362_L	0.807	0.94
420_L	424_L	0.806	0.94
530_W	533_L	0.806	0.94
191_E	197_F	0.804	0.94
36_V	40_A	0.802	0.94
247_A	251_L	0.802	0.94
557_A	563_L	0.801	0.94
460_L	465_R	0.801	0.94
353_W	360_P	0.801	0.94
230_V	234_L	0.800	0.94
492_L	495_L	0.797	0.93
30_I	71_V	0.796	0.93
7_K	17_V	0.795	0.93
325_R	329_L	0.794	0.93
416_L	423_E	0.794	0.93
247_A	294_A	0.792	0.93
487_L	491_L	0.791	0.93
131_T	135_N	0.790	0.93
322_R	326_R	0.790	0.93
7_K	113_A	0.790	0.93
236_Y	246_L	0.790	0.93
518_L	521_L	0.788	0.93
88_P	129_L	0.788	0.93
391_A	396_L	0.785	0.93
220_D	235_Q	0.785	0.93
51_E	109_Y	0.785	0.93
389_A	393_A	0.782	0.93
316_G	325_R	0.778	0.93
254_A	287_L	0.777	0.93
460_L	464_R	0.777	0.93
549_L	562_L	0.776	0.93
597_G	626_V	0.776	0.93
25_I	35_R	0.775	0.92
79_A	85_L	0.774	0.92
601_L	605_V	0.773	0.92
324_A	327_F	0.773	0.92
14_V	17_V	0.773	0.92
144_A	148_A	0.772	0.92
631_F	650_L	0.772	0.92
126_P	162_L	0.766	0.92
596_W	599_L	0.766	0.92
121_G	142_Y	0.765	0.92
187_F	194_L	0.765	0.92
224_L	228_P	0.765	0.92
551_A	562_L	0.764	0.92
228_P	232_F	0.763	0.92
324_A	333_L	0.762	0.92
553_A	563_L	0.761	0.92
30_I	39_G	0.759	0.92
95_M	99_T	0.758	0.92
324_A	331_L	0.758	0.92
553_A	559_L	0.757	0.92
455_A	462_R	0.757	0.92
67_G	71_V	0.755	0.91
227_N	230_V	0.753	0.91
13_L	46_L	0.753	0.91
106_A	115_A	0.751	0.91
189_S	193_F	0.750	0.91
423_E	432_V	0.750	0.91
445_W	452_L	0.749	0.91
277_E	280_L	0.748	0.91
563_L	570_R	0.745	0.91
249_S	253_L	0.744	0.91
627_V	643_R	0.744	0.91
482_L	494_L	0.743	0.91
52_R	55_R	0.743	0.91
224_L	232_F	0.742	0.91
363_L	368_L	0.742	0.91
658_S	662_Q	0.742	0.91
481_L	485_A	0.742	0.91
341_L	348_R	0.741	0.91
417_L	424_L	0.740	0.91
313_W	318_R	0.738	0.91
6_V	61_A	0.737	0.90
456_L	460_L	0.735	0.90
3_N	12_I	0.734	0.90
223_L	230_V	0.734	0.90
62_L	125_A	0.734	0.90
463_R	466_R	0.733	0.90
229_L	233_G	0.733	0.90
470_L	473_L	0.732	0.90
573_W	576_D	0.731	0.90
557_A	560_L	0.731	0.90
621_A	624_G	0.730	0.90
36_V	75_T	0.730	0.90
12_I	19_F	0.729	0.90
529_L	532_R	0.729	0.90
457_A	462_R	0.726	0.90
339_A	344_L	0.725	0.90
10_I	60_F	0.724	0.90
405_R	409_H	0.723	0.90
226_G	232_F	0.723	0.90
572_L	576_D	0.722	0.90
300_T	304_W	0.719	0.89
390_L	394_A	0.719	0.89
486_L	493_L	0.717	0.89
49_A	53_L	0.716	0.89
244_Y	252_A	0.716	0.89
115_A	159_W	0.716	0.89
552_L	560_L	0.716	0.89
83_Y	142_Y	0.714	0.89
635_L	640_T	0.713	0.89
550_A	553_A	0.713	0.89
460_L	466_R	0.710	0.89
458_L	461_L	0.710	0.89
528_L	531_A	0.710	0.89
266_R	269_R	0.709	0.89
21_L	78_A	0.709	0.89
130_S	133_S	0.708	0.89
574_Q	579_A	0.707	0.89
88_P	95_M	0.707	0.89
220_D	231_A	0.707	0.89
472_R	476_L	0.705	0.88
327_F	333_L	0.704	0.88
419_L	424_L	0.704	0.88
6_V	109_Y	0.703	0.88
22_K	142_Y	0.703	0.88
199_L	256_L	0.703	0.88
251_L	290_A	0.703	0.88
200_L	204_I	0.703	0.88
228_P	231_A	0.702	0.88
420_L	427_L	0.701	0.88
235_Q	249_S	0.700	0.88
421_A	424_L	0.700	0.88
222_T	227_N	0.699	0.88
601_L	656_V	0.697	0.88
6_V	9_G	0.697	0.88
70_A	74_L	0.695	0.88
486_L	494_L	0.694	0.88
373_L	377_A	0.694	0.88
63_V	114_L	0.694	0.88
223_L	228_P	0.693	0.88
91_A	129_L	0.692	0.88
40_A	75_T	0.692	0.88
516_L	523_P	0.691	0.87
245_G	250_A	0.691	0.87
491_L	494_L	0.691	0.87
26_D	29_L	0.690	0.87
225_F	229_L	0.690	0.87
118_G	125_A	0.690	0.87
126_P	139_L	0.690	0.87
136_H	190_T	0.689	0.87
409_H	423_E	0.689	0.87
109_Y	114_L	0.688	0.87
193_F	204_I	0.688	0.87
54_R	109_Y	0.686	0.87
605_V	624_G	0.686	0.87
77_F	80_Y	0.684	0.87
326_R	333_L	0.684	0.87
351_L	357_A	0.683	0.87
561_F	595_L	0.682	0.87
363_L	369_G	0.682	0.87
575_G	579_A	0.682	0.87
600_A	622_L	0.681	0.87
330_P	333_L	0.681	0.87
291_I	304_W	0.680	0.87
285_A	327_F	0.680	0.87
412_A	431_G	0.679	0.87
517_D	524_L	0.678	0.86
496_V	499_N	0.677	0.86
519_A	529_L	0.676	0.86
229_L	235_Q	0.675	0.86
63_V	117_L	0.673	0.86
105_L	109_Y	0.672	0.86
340_L	345_L	0.671	0.86
639_G	642_Y	0.670	0.86
414_L	424_L	0.670	0.86
319_Q	325_R	0.670	0.86
172_L	179_L	0.669	0.86
403_R	407_V	0.669	0.86
513_L	517_D	0.668	0.86
9_G	655_L	0.668	0.86
38_L	42_A	0.667	0.86
330_P	334_L	0.665	0.85
193_F	202_L	0.664	0.85
243_E	246_L	0.662	0.85
307_E	310_A	0.661	0.85
479_G	492_L	0.661	0.85
490_L	493_L	0.661	0.85
420_L	452_L	0.659	0.85
422_L	425_R	0.659	0.85
61_A	95_M	0.657	0.85
414_L	418_L	0.657	0.85
19_F	647_F	0.656	0.85
482_L	492_L	0.655	0.85
364_L	367_L	0.654	0.84
487_L	493_L	0.654	0.84
394_A	401_E	0.654	0.84
12_I	24_A	0.654	0.84
537_A	540_L	0.652	0.84
603_L	622_L	0.652	0.84
452_L	455_A	0.652	0.84
393_A	396_L	0.651	0.84
608_I	620_L	0.651	0.84
143_L	147_N	0.651	0.84
283_A	290_A	0.648	0.84
532_R	536_R	0.647	0.84
359_L	363_L	0.645	0.84
28_G	35_R	0.644	0.84
119_L	149_G	0.644	0.84
333_L	338_S	0.643	0.83
223_L	226_G	0.643	0.83
448_L	451_L	0.643	0.83
478_A	486_L	0.642	0.83
63_V	67_G	0.642	0.83
329_L	332_L	0.640	0.83
654_L	662_Q	0.639	0.83
331_L	338_S	0.639	0.83
356_L	360_P	0.639	0.83
387_A	393_A	0.639	0.83
41_L	45_A	0.638	0.83
573_W	585_Q	0.637	0.83
225_F	228_P	0.636	0.83
35_R	83_Y	0.635	0.83
475_R	480_A	0.635	0.83
13_L	60_F	0.634	0.83
203_A	210_L	0.634	0.83
77_F	82_L	0.633	0.82
95_M	128_L	0.633	0.82
88_P	149_G	0.633	0.82
480_A	488_L	0.632	0.82
54_R	62_L	0.632	0.82
524_L	528_L	0.632	0.82
102_A	105_L	0.628	0.82
453_F	464_R	0.628	0.82
351_L	362_L	0.628	0.82
10_I	63_V	0.627	0.82
115_A	153_I	0.624	0.82
221_G	225_F	0.623	0.81
532_R	535_R	0.622	0.81
334_L	337_L	0.621	0.81
604_M	627_V	0.620	0.81
21_L	25_I	0.620	0.81
593_S	634_D	0.619	0.81
563_L	566_A	0.619	0.81
225_F	232_F	0.616	0.81
550_A	554_L	0.615	0.81
455_A	458_L	0.614	0.81
289_L	303_A	0.613	0.80
343_A	349_L	0.613	0.80
352_A	355_A	0.612	0.80
120_L	169_F	0.612	0.80
337_L	341_L	0.611	0.80
117_L	146_L	0.609	0.80
593_S	599_L	0.609	0.80
203_A	209_A	0.609	0.80
272_L	275_L	0.609	0.80
357_A	361_L	0.608	0.80
410_A	414_L	0.608	0.80
191_E	194_L	0.607	0.80
342_L	348_R	0.607	0.80
147_N	150_I	0.606	0.80
23_Y	132_G	0.606	0.80
74_L	129_L	0.605	0.80
647_F	651_G	0.604	0.79
524_L	534_L	0.603	0.79
488_L	494_L	0.603	0.79
20_L	24_A	0.601	0.79
191_E	200_L	0.601	0.79
410_A	417_L	0.600	0.79
650_L	663_R	0.599	0.79
332_L	338_S	0.599	0.79
485_A	493_L	0.599	0.79
342_L	407_V	0.599	0.79
55_R	58_R	0.598	0.79
193_F	208_F	0.597	0.79
112_Q	116_V	0.597	0.79
318_R	321_R	0.596	0.79
34_L	38_L	0.595	0.78
73_Y	122_G	0.595	0.78
65_Q	69_I	0.595	0.78
571_V	578_L	0.595	0.78
58_R	110_N	0.594	0.78
227_N	239_L	0.594	0.78
87_P	636_S	0.593	0.78
575_G	578_L	0.593	0.78
39_G	43_G	0.593	0.78
63_V	113_A	0.592	0.78
99_T	129_L	0.591	0.78
199_L	203_A	0.591	0.78
591_G	594_I	0.590	0.78
482_L	493_L	0.587	0.78
381_L	385_L	0.587	0.78
553_A	560_L	0.586	0.77
409_H	417_L	0.586	0.77
571_V	581_S	0.586	0.77
6_V	60_F	0.585	0.77
396_L	399_R	0.585	0.77
382_G	385_L	0.583	0.77
50_G	109_Y	0.583	0.77
557_A	599_L	0.582	0.77
321_R	325_R	0.582	0.77
192_P	201_F	0.581	0.77
362_L	368_L	0.581	0.77
411_A	417_L	0.580	0.77
593_S	630_L	0.580	0.77
257_Y	260_L	0.580	0.77
571_V	577_A	0.580	0.77
319_Q	322_R	0.579	0.77
33_E	85_L	0.578	0.76
484_L	488_L	0.575	0.76
136_H	169_F	0.575	0.76
630_L	642_Y	0.574	0.76
485_A	488_L	0.574	0.76
519_A	524_L	0.573	0.76
288_T	291_I	0.572	0.76
219_V	226_G	0.572	0.76
73_Y	98_V	0.572	0.76
361_L	367_L	0.572	0.76
22_K	25_I	0.571	0.76
519_A	532_R	0.571	0.76
479_G	483_L	0.571	0.76
276_A	281_A	0.570	0.75
551_A	564_L	0.570	0.75
68_G	643_R	0.569	0.75
359_L	366_L	0.569	0.75
51_E	60_F	0.569	0.75
127_F	173_I	0.569	0.75
73_Y	113_A	0.568	0.75
219_V	223_L	0.567	0.75
325_R	332_L	0.566	0.75
489_L	493_L	0.565	0.75
349_L	353_W	0.565	0.75
225_F	231_A	0.564	0.75
96_V	99_T	0.564	0.75
9_G	654_L	0.563	0.75
359_L	365_L	0.562	0.74
125_A	159_W	0.562	0.74
350_A	360_P	0.561	0.74
365_L	368_L	0.560	0.74
477_G	480_A	0.560	0.74
627_V	631_F	0.560	0.74
330_P	336_A	0.560	0.74
171_F	234_L	0.559	0.74
191_E	207_L	0.559	0.74
9_G	16_G	0.558	0.74
92_F	139_L	0.558	0.74
487_L	496_V	0.558	0.74
453_F	457_A	0.557	0.74
453_F	462_R	0.557	0.74
197_F	208_F	0.557	0.74
367_L	371_G	0.557	0.74
235_Q	239_L	0.556	0.74
296_D	300_T	0.556	0.74
325_R	333_L	0.555	0.74
187_F	197_F	0.555	0.74
273_R	276_A	0.555	0.74
398_R	401_E	0.555	0.74
253_L	256_L	0.554	0.73
506_A	509_G	0.554	0.73
327_F	334_L	0.554	0.73
556_L	563_L	0.554	0.73
574_Q	578_L	0.554	0.73
608_I	619_G	0.554	0.73
482_L	488_L	0.554	0.73
622_L	629_K	0.552	0.73
428_L	432_V	0.552	0.73
411_A	419_L	0.551	0.73
60_F	113_A	0.550	0.73
487_L	490_L	0.550	0.73
597_G	600_A	0.550	0.73
92_F	130_S	0.549	0.73
623_L	657_I	0.549	0.73
147_N	170_T	0.549	0.73
337_L	343_A	0.548	0.73
16_G	32_P	0.548	0.73
484_L	491_L	0.548	0.73
604_M	616_R	0.548	0.73
274_L	277_E	0.547	0.72
397_L	401_E	0.547	0.72
304_W	308_G	0.547	0.72
199_L	202_L	0.546	0.72
190_T	200_L	0.546	0.72
551_A	558_L	0.546	0.72
66_G	74_L	0.545	0.72
80_Y	92_F	0.545	0.72
76_V	95_M	0.545	0.72
342_L	346_L	0.544	0.72
329_L	333_L	0.544	0.72
59_A	63_V	0.542	0.72
417_L	421_A	0.542	0.72
538_R	542_A	0.541	0.72
83_Y	91_A	0.541	0.72
61_A	111_S	0.540	0.71
412_A	423_E	0.539	0.71
44_L	72_L	0.539	0.71
411_A	426_Y	0.538	0.71
387_A	412_A	0.538	0.71
122_G	142_Y	0.537	0.71
52_R	56_K	0.537	0.71
487_L	492_L	0.537	0.71
176_L	179_L	0.537	0.71
122_G	149_G	0.535	0.71
125_A	143_L	0.535	0.71
387_A	394_A	0.535	0.71
412_A	417_L	0.535	0.71
342_L	349_L	0.535	0.71
29_L	39_G	0.535	0.71
526_L	529_L	0.534	0.71
631_F	636_S	0.534	0.71
4_L	61_A	0.534	0.71
18_A	21_L	0.533	0.71
461_L	466_R	0.532	0.70
554_L	562_L	0.531	0.70
511_P	518_L	0.530	0.70
484_L	487_L	0.530	0.70
517_D	531_A	0.530	0.70
228_P	235_Q	0.529	0.70
334_L	343_A	0.529	0.70
320_R	326_R	0.528	0.70
223_L	227_N	0.528	0.70
590_A	599_L	0.527	0.70
25_I	30_I	0.527	0.70
22_K	92_F	0.527	0.70
297_G	300_T	0.526	0.70
318_R	327_F	0.526	0.70
512_L	516_L	0.526	0.70
497_L	502_L	0.525	0.69
163_N	167_F	0.525	0.69
6_V	20_L	0.525	0.69
187_F	198_F	0.525	0.69
319_Q	323_L	0.525	0.69
20_L	42_A	0.525	0.69
110_N	173_I	0.524	0.69
611_R	618_A	0.524	0.69
513_L	516_L	0.523	0.69
512_L	515_P	0.523	0.69
34_L	37_A	0.522	0.69
633_V	655_L	0.522	0.69
360_P	364_L	0.521	0.69
60_F	63_V	0.521	0.69
20_L	38_L	0.521	0.69
471_A	477_G	0.521	0.69
341_L	346_L	0.520	0.69
245_G	252_A	0.520	0.69
421_A	426_Y	0.519	0.69
102_A	125_A	0.518	0.68
454_L	460_L	0.518	0.68
489_L	495_L	0.517	0.68
540_L	543_G	0.517	0.68
647_F	657_I	0.517	0.68
265_R	268_K	0.516	0.68
273_R	281_A	0.516	0.68
9_G	73_Y	0.515	0.68
561_F	567_V	0.515	0.68
130_S	135_N	0.515	0.68
60_F	73_Y	0.515	0.68
405_R	408_L	0.514	0.68
308_G	328_G	0.514	0.68
340_L	348_R	0.513	0.68
629_K	651_G	0.513	0.68
42_A	46_L	0.512	0.67
324_A	335_A	0.512	0.67
538_R	541_A	0.511	0.67
392_L	395_W	0.511	0.67
576_D	580_A	0.511	0.67
412_A	427_L	0.511	0.67
452_L	456_L	0.510	0.67
191_E	209_A	0.509	0.67
60_F	67_G	0.509	0.67
17_V	70_A	0.509	0.67
41_L	44_L	0.508	0.67
374_G	378_W	0.508	0.67
130_S	139_L	0.507	0.67
260_L	264_L	0.506	0.67
431_G	434_F	0.505	0.66
182_Y	187_F	0.505	0.66
323_L	327_F	0.505	0.66
192_P	198_F	0.504	0.66
488_L	492_L	0.503	0.66
521_L	532_R	0.502	0.66
334_L	347_R	0.501	0.66
10_I	28_G	0.501	0.66
57_Y	149_G	0.500	0.66
106_A	129_L	0.500	0.66
325_R	334_L	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ksfA	1	0.1611	12.7	0.971	Contact Map
3o7qA	1	0.1581	3.3	0.978	Contact Map
4b19A	1	0.0452	3.2	0.978	Contact Map
4m5bA	1	0.1265	3.1	0.978	Contact Map
3j1rA	5	0.0392	2.7	0.979	Contact Map
3j01B	1	0.0813	1.9	0.98	Contact Map
2kixA	3	0.0497	1.9	0.98	Contact Map
2mmuA	1	0.0753	1.7	0.981	Contact Map
4cbfA	7	0.1054	1.5	0.982	Contact Map
1scfA	4	0	1.2	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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