GREMLIN Database
RskA - Anti-sigma-K factor rskA
PFAM: PF10099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (177)
Sequences: 25990 (22024)
Seq/√Len: 1655.4
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_R10_L3.4121.00
117_K162_L3.1971.00
120_Q132_S3.1431.00
124_I159_A2.9911.00
123_L133_A2.7261.00
124_I157_A2.4271.00
124_I130_P2.3581.00
118_V166_G2.3561.00
4_A8_R2.2641.00
118_V135_V2.2011.00
114_P117_K2.0541.00
58_L61_L1.9551.00
123_L155_A1.9281.00
118_V165_A1.9191.00
116_G165_A1.9131.00
64_A69_R1.7501.00
92_A96_W1.7491.00
10_L13_I1.6921.00
66_A69_R1.6721.00
164_P168_S1.6561.00
97_S100_G1.6361.00
120_Q135_V1.6121.00
60_A64_A1.6071.00
57_Q62_Q1.6001.00
117_K164_P1.5391.00
46_A49_A1.5231.00
81_V85_P1.5071.00
130_P159_A1.5061.00
61_L65_L1.4891.00
57_Q60_A1.4881.00
7_A11_A1.4761.00
113_L162_L1.4611.00
61_L64_A1.4581.00
31_P35_R1.4331.00
58_L62_Q1.4291.00
64_A67_A1.4251.00
102_R105_L1.4141.00
164_P173_T1.4121.00
72_A75_A1.3991.00
65_L68_L1.3831.00
8_R12_A1.3811.00
172_P176_V1.3691.00
75_A78_V1.3551.00
62_Q66_A1.3351.00
65_L69_R1.3341.00
52_A56_G1.3301.00
103_A107_A1.3221.00
7_A10_L1.2781.00
60_A63_A1.2761.00
25_A28_A1.2761.00
161_T176_V1.2761.00
121_L158_L1.2721.00
68_L72_A1.2691.00
125_P129_A1.2601.00
81_V84_A1.2531.00
113_L116_G1.2531.00
168_S171_T1.2441.00
78_V82_L1.2301.00
78_V83_A1.2271.00
103_A106_V1.2211.00
120_Q167_G1.2201.00
62_Q65_L1.2191.00
63_A66_A1.2061.00
32_R35_R1.1961.00
44_A50_V1.1921.00
113_L119_Y1.1841.00
76_A80_A1.1721.00
45_A56_G1.1701.00
47_A50_V1.1601.00
29_R33_A1.1591.00
137_D141_S1.1551.00
12_A15_A1.1541.00
162_L177_V1.1491.00
71_A75_A1.1481.00
35_R39_R1.1431.00
4_A7_A1.1231.00
33_A37_R1.1161.00
72_A76_A1.1111.00
5_L9_I1.1101.00
35_R38_R1.1061.00
75_A79_V1.1051.00
69_R72_A1.1031.00
92_A95_V1.1001.00
59_A62_Q1.0831.00
102_R106_V1.0801.00
159_A176_V1.0781.00
32_R36_R1.0781.00
113_L117_K1.0681.00
92_A105_L1.0671.00
77_A80_A1.0631.00
57_Q61_L1.0511.00
123_L158_L1.0511.00
71_A74_A1.0431.00
125_P128_G1.0361.00
126_G129_A1.0191.00
168_S173_T1.0171.00
63_A67_A1.0121.00
28_A32_R1.0091.00
137_D140_G1.0051.00
146_L149_P1.0051.00
10_L14_A1.0031.00
33_A36_R0.9991.00
93_T96_W0.9951.00
77_A81_V0.9891.00
162_L175_P0.9731.00
142_G146_L0.9701.00
34_R37_R0.9621.00
90_A94_V0.9621.00
70_A73_A0.9571.00
79_V82_L0.9531.00
24_A28_A0.9511.00
36_R39_R0.9501.00
37_R41_R0.9471.00
6_R9_I0.9431.00
39_R42_W0.9351.00
133_A136_F0.9331.00
94_V97_S0.9251.00
93_T97_S0.9251.00
68_L71_A0.9231.00
48_A52_A0.9221.00
37_R40_R0.9191.00
24_A27_A0.9151.00
76_A79_V0.9111.00
80_A83_A0.9071.00
96_W99_S0.9031.00
132_S135_V0.8941.00
29_R32_R0.8931.00
107_A110_L0.8911.00
45_A48_A0.8901.00
30_P34_R0.8891.00
144_V147_P0.8851.00
80_A84_A0.8731.00
173_T176_V0.8701.00
26_A30_P0.8601.00
67_A70_A0.8561.00
52_A55_L0.8521.00
44_A51_L0.8511.00
163_E166_G0.8481.00
45_A50_V0.8431.00
59_A63_A0.8431.00
23_A26_A0.8321.00
135_V167_G0.8301.00
71_A76_A0.8291.00
91_S96_W0.8271.00
91_S94_V0.8271.00
142_G145_T0.8211.00
45_A52_A0.8181.00
2_P8_R0.8161.00
43_A47_A0.8151.00
18_A21_P0.8101.00
20_A23_A0.8061.00
27_A30_P0.8051.00
66_A70_A0.8031.00
27_A31_P0.8031.00
138_A142_G0.7991.00
73_A76_A0.7981.00
121_L133_A0.7971.00
70_A74_A0.7921.00
25_A29_R0.7891.00
36_R40_R0.7851.00
9_I12_A0.7781.00
96_W103_A0.7761.00
67_A71_A0.7711.00
38_R42_W0.7701.00
45_A49_A0.7671.00
34_R39_R0.7661.00
10_L15_A0.7651.00
30_P33_A0.7551.00
44_A56_G0.7521.00
46_A50_V0.7511.00
106_V109_G0.7501.00
6_R13_I0.7491.00
94_V103_A0.7491.00
31_P34_R0.7471.00
50_V53_L0.7431.00
23_A28_A0.7381.00
21_P24_A0.7371.00
126_G156_A0.7361.00
53_L56_G0.7331.00
143_T146_L0.7281.00
50_V54_A0.7261.00
38_R41_R0.7251.00
37_R42_W0.7171.00
44_A48_A0.7101.00
43_A46_A0.7101.00
44_A47_A0.7101.00
114_P162_L0.7061.00
16_E19_A0.7041.00
79_V83_A0.7031.00
36_R41_R0.6991.00
138_A144_V0.6961.00
110_L178_L0.6921.00
119_Y160_V0.6911.00
121_L136_F0.6891.00
137_D142_G0.6881.00
78_V85_P0.6871.00
11_A15_A0.6871.00
74_A78_V0.6811.00
17_P20_A0.6801.00
138_A141_S0.6721.00
12_A16_E0.6711.00
19_A22_A0.6701.00
87_A90_A0.6661.00
174_G178_L0.6651.00
103_A123_L0.6611.00
49_A52_A0.6601.00
5_L8_R0.6581.00
20_A24_A0.6581.00
28_A31_P0.6571.00
26_A29_R0.6501.00
78_V81_V0.6501.00
64_A68_L0.6491.00
22_A25_A0.6471.00
57_Q65_L0.6411.00
44_A54_A0.6391.00
92_A107_A0.6351.00
94_V98_P0.6351.00
91_S95_V0.6311.00
60_A65_L0.6311.00
34_R38_R0.6301.00
136_F160_V0.6291.00
144_V148_L0.6281.00
82_L85_P0.6191.00
74_A77_A0.6151.00
2_P5_L0.6141.00
110_L119_Y0.6111.00
147_P150_P0.6101.00
170_P174_G0.6061.00
94_V158_L0.6061.00
3_P7_A0.5971.00
30_P35_R0.5941.00
67_A72_A0.5931.00
22_A26_A0.5911.00
76_A82_L0.5881.00
96_W100_G0.5881.00
90_A93_T0.5821.00
79_V84_A0.5781.00
143_T147_P0.5781.00
125_P130_P0.5771.00
90_A96_W0.5761.00
123_L156_A0.5741.00
43_A48_A0.5701.00
6_R12_A0.5621.00
35_R40_R0.5571.00
89_G94_V0.5571.00
30_P36_R0.5521.00
65_L71_A0.5471.00
145_T149_P0.5441.00
18_A22_A0.5421.00
9_I13_I0.5391.00
135_V166_G0.5391.00
25_A30_P0.5361.00
49_A56_G0.5321.00
159_A162_L0.5301.00
120_Q133_A0.5301.00
32_R37_R0.5301.00
95_V106_V0.5291.00
31_P36_R0.5281.00
11_A14_A0.5221.00
127_G156_A0.5151.00
125_P156_A0.5141.00
35_R42_W0.5111.00
44_A49_A0.5091.00
29_R34_R0.5091.00
75_A80_A0.5021.00
29_R35_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aqzA 1 0.7278 4.1 0.931 Contact Map
4v3iA 2 0.1222 4.1 0.931 Contact Map
1or7C 1 0.0889 3.3 0.934 Contact Map
2pftA 1 0.3278 3.2 0.934 Contact Map
4v33A 1 0.5 2.8 0.937 Contact Map
3q48A 1 0.4778 2.4 0.938 Contact Map
2w0cP 4 0.1278 2.4 0.938 Contact Map
2kt5B 1 0.2167 1.6 0.944 Contact Map
1rq6A 1 0.1167 1.4 0.946 Contact Map
1s4zC 1 0.0611 1.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.