GREMLIN Database
DUF2336 - Uncharacterized protein conserved in bacteria (DUF2336)
PFAM: PF10098 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 262 (260)
Sequences: 8461 (5712)
Seq/√Len: 354.2
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_D39_S5.0861.00
37_S63_G4.6021.00
52_R81_D3.7521.00
40_E65_R3.5611.00
7_E34_R3.5251.00
44_D70_G3.1021.00
34_R57_A3.0221.00
26_Q51_D3.0191.00
155_R186_L2.9251.00
158_H186_L2.8701.00
47_V70_G2.7841.00
13_S16_D2.6781.00
3_G7_E2.5561.00
165_E217_S2.3321.00
176_K179_E2.2761.00
25_S28_H2.1821.00
44_D67_S2.1761.00
21_A32_I2.1691.00
59_A74_L2.1211.00
33_A57_A2.1131.00
46_L54_V2.1131.00
211_C224_I2.1031.00
6_L32_I2.0661.00
10_P36_P2.0091.00
67_S70_G1.9961.00
38_L63_G1.9811.00
43_T66_F1.9521.00
75_V98_L1.9491.00
172_A180_F1.9251.00
164_T167_L1.9131.00
21_A45_A1.9011.00
56_R83_A1.8971.00
30_L57_A1.8841.00
29_L49_R1.8741.00
181_V199_L1.8091.00
68_E97_A1.7441.00
29_L51_D1.7421.00
38_L43_T1.7211.00
251_P255_Q1.7091.00
43_T58_L1.6801.00
48_E73_R1.6701.00
155_R159_R1.6631.00
165_E220_T1.6611.00
62_P92_P1.6481.00
153_L179_E1.6361.00
190_V195_V1.5921.00
19_E23_T1.5791.00
163_L183_A1.5441.00
168_L183_A1.5351.00
66_F70_G1.5061.00
26_Q29_L1.4891.00
113_R117_R1.4811.00
95_P98_L1.4701.00
169_L173_R1.4501.00
157_L163_L1.4461.00
18_V41_A1.4441.00
132_A136_A1.4371.00
90_L113_R1.4131.00
256_R260_F1.4061.00
242_A246_F1.4011.00
181_V196_E1.3901.00
18_V42_V1.3891.00
207_L211_C1.3781.00
56_R60_A1.3651.00
43_T70_G1.3491.00
14_D41_A1.3331.00
76_E79_E1.3211.00
151_R186_L1.3071.00
106_A110_L1.3051.00
151_R182_A1.3051.00
255_Q259_R1.3051.00
72_A98_L1.3031.00
198_L206_G1.2981.00
30_L54_V1.2821.00
39_S42_V1.2691.00
122_A126_Q1.2681.00
185_A188_A1.2651.00
124_E127_R1.2601.00
211_C221_F1.2481.00
185_A192_I1.2471.00
66_F71_F1.2321.00
253_T260_F1.2201.00
37_S65_R1.2111.00
6_L28_H1.2071.00
40_E67_S1.2031.00
58_L66_F1.1971.00
30_L33_A1.1951.00
71_F95_P1.1941.00
242_A245_L1.1911.00
245_L248_R1.1911.00
50_G77_R1.1901.00
21_A29_L1.1891.00
30_L53_E1.1851.00
30_L34_R1.1661.00
188_A195_V1.1621.00
116_A119_P1.1581.00
30_L51_D1.1521.00
60_A87_P1.1491.00
156_A160_A1.1441.00
157_L162_R1.1321.00
55_V77_R1.1291.00
56_R81_D1.1241.00
154_V183_A1.1201.00
38_L58_L1.1181.00
1_V4_P1.1151.00
61_N64_A1.1131.00
43_T64_A1.1061.00
180_F224_I1.0951.00
52_R83_A1.0911.00
73_R76_E1.0881.00
151_R155_R1.0841.00
22_R48_E1.0771.00
192_I196_E1.0691.00
24_K28_H1.0661.00
59_A87_P1.0611.00
22_R45_A1.0601.00
121_D124_E1.0571.00
181_V192_I1.0551.00
253_T257_V1.0531.00
257_V260_F1.0501.00
89_G110_L1.0401.00
5_V9_S1.0381.00
79_E105_K1.0351.00
153_L157_L1.0351.00
111_R115_L1.0281.00
85_A110_L1.0261.00
154_V182_A1.0261.00
12_L16_D1.0251.00
107_S133_A1.0161.00
26_Q54_V1.0151.00
96_P100_R1.0131.00
208_L212_K1.0111.00
154_V186_L1.0051.00
244_A248_R0.9981.00
238_D241_A0.9901.00
188_A210_L0.9891.00
217_S220_T0.9881.00
29_L54_V0.9851.00
168_L187_L0.9811.00
18_V21_A0.9721.00
253_T256_R0.9681.00
51_D54_V0.9591.00
168_L180_F0.9581.00
215_G251_P0.9571.00
2_A28_H0.9571.00
115_L118_A0.9541.00
212_K218_W0.9541.00
256_R259_R0.9531.00
150_A154_V0.9511.00
168_L216_L0.9501.00
205_E209_I0.9491.00
29_L33_A0.9431.00
165_E216_L0.9411.00
222_R226_A0.9391.00
218_W247_E0.9381.00
181_V200_H0.9381.00
89_G114_L0.9251.00
78_A85_A0.9251.00
163_L187_L0.9231.00
250_S253_T0.9231.00
56_R87_P0.9181.00
195_V210_L0.9131.00
157_L167_L0.9111.00
208_L221_F0.9031.00
47_V77_R0.8991.00
6_L20_I0.8991.00
21_A46_L0.8921.00
45_A49_R0.8891.00
205_E208_L0.8851.00
187_L216_L0.8831.00
211_C216_L0.8811.00
183_A187_L0.8801.00
82_D85_A0.8751.00
109_A112_R0.8711.00
107_S110_L0.8701.00
243_L247_E0.8641.00
171_A179_E0.8631.00
76_E101_R0.8631.00
153_L156_A0.8611.00
27_A53_E0.8601.00
158_H161_G0.8561.00
86_E90_L0.8551.00
44_D73_R0.8541.00
101_R105_K0.8451.00
252_E255_Q0.8451.00
72_A101_R0.8331.00
165_E187_L0.8331.00
68_E98_L0.8291.00
74_L88_L0.8291.00
73_R77_R0.8291.00
254_A259_R0.8291.00
185_A195_V0.8281.00
15_A41_A0.8271.00
154_V171_A0.8241.00
14_D18_V0.8241.00
188_A214_A0.8231.00
245_L249_L0.8211.00
16_D20_I0.8161.00
99_A103_L0.8161.00
18_V45_A0.8131.00
240_E244_A0.8071.00
102_L105_K0.8041.00
21_A49_R0.8001.00
154_V163_L0.8001.00
26_Q53_E0.8001.00
209_I213_A0.7921.00
108_E111_R0.7921.00
59_A84_L0.7901.00
65_R93_D0.7861.00
89_G113_R0.7831.00
245_L253_T0.7801.00
81_D84_L0.7781.00
248_R251_P0.7751.00
111_R129_L0.7751.00
78_A84_L0.7731.00
42_V45_A0.7631.00
246_F256_R0.7621.00
250_S254_A0.7621.00
157_L179_E0.7591.00
248_R253_T0.7561.00
237_A241_A0.7551.00
40_E43_T0.7481.00
47_V58_L0.7441.00
190_V210_L0.7411.00
78_A102_L0.7411.00
55_V74_L0.7401.00
120_L125_I0.7371.00
167_L170_R0.7361.00
14_D37_S0.7301.00
156_A162_R0.7240.99
187_L214_A0.7210.99
222_R243_L0.7210.99
68_E72_A0.7210.99
207_L221_F0.7190.99
167_L179_E0.7170.99
249_L254_A0.7160.99
208_L218_W0.7150.99
209_I257_V0.7090.99
125_I129_L0.7070.99
252_E256_R0.7060.99
170_R174_A0.7040.99
216_L220_T0.6980.99
113_R116_A0.6980.99
7_E31_A0.6930.99
49_R77_R0.6920.99
85_A102_L0.6910.99
132_A135_R0.6850.99
154_V179_E0.6740.99
247_E255_Q0.6650.99
115_L119_P0.6630.99
168_L184_L0.6620.99
250_S256_R0.6620.99
118_A125_I0.6600.99
251_P257_V0.6590.99
201_D204_G0.6570.99
216_L224_I0.6530.99
242_A250_S0.6520.99
130_A133_A0.6500.99
165_E168_L0.6490.99
182_A186_L0.6470.99
218_W243_L0.6450.99
173_R223_A0.6440.99
45_A48_E0.6400.99
237_A242_A0.6400.99
247_E251_P0.6390.99
244_A253_T0.6380.99
146_D149_A0.6360.99
217_S221_F0.6340.99
75_V102_L0.6330.99
244_A247_E0.6330.99
221_F246_F0.6310.99
130_A134_E0.6300.99
56_R59_A0.6300.99
52_R56_R0.6290.99
246_F253_T0.6270.99
9_S20_I0.6270.99
247_E252_E0.6260.98
3_G27_A0.6260.98
223_A227_A0.6240.98
14_D42_V0.6230.98
38_L44_D0.6210.98
236_A239_L0.6200.98
240_E243_L0.6170.98
209_I214_A0.6140.98
157_L171_A0.6120.98
17_L32_I0.6090.98
225_L229_A0.6090.98
161_G164_T0.6020.98
234_I237_A0.6000.98
18_V22_R0.5970.98
194_V197_R0.5970.98
75_V105_K0.5970.98
149_A152_R0.5970.98
53_E83_A0.5960.98
55_V84_L0.5960.98
82_D86_E0.5960.98
131_E135_R0.5930.98
146_D178_E0.5930.98
158_H182_A0.5920.98
5_V12_L0.5920.98
153_L167_L0.5900.98
215_G255_Q0.5900.98
251_P254_A0.5890.98
247_E256_R0.5890.98
126_Q130_A0.5890.98
248_R252_E0.5880.98
75_V85_A0.5880.98
86_E113_R0.5870.98
63_G66_F0.5870.98
27_A30_L0.5870.98
178_E181_V0.5870.98
238_D242_A0.5860.98
29_L32_I0.5850.98
231_A234_I0.5840.98
3_G31_A0.5830.98
177_F181_V0.5830.98
124_E128_A0.5830.98
112_R116_A0.5820.98
44_D48_E0.5790.98
245_L257_V0.5790.98
20_I24_K0.5760.97
125_I128_A0.5750.97
106_A114_L0.5730.97
153_L176_K0.5720.97
245_L252_E0.5720.97
165_E180_F0.5690.97
218_W221_F0.5680.97
2_A5_V0.5680.97
186_L189_G0.5660.97
61_N91_R0.5660.97
236_A240_E0.5650.97
252_E259_R0.5650.97
40_E44_D0.5630.97
98_L101_R0.5630.97
221_F225_L0.5620.97
154_V157_L0.5610.97
235_S238_D0.5610.97
196_E200_H0.5600.97
246_F249_L0.5570.97
150_A178_E0.5540.97
39_S43_T0.5540.97
249_L256_R0.5540.97
184_L214_A0.5530.97
246_F254_A0.5520.97
249_L253_T0.5510.97
184_L199_L0.5510.97
5_V11_R0.5480.97
253_T258_L0.5480.97
242_A247_E0.5470.96
230_A234_I0.5410.96
5_V20_I0.5400.96
75_V94_L0.5390.96
235_S240_E0.5380.96
138_A141_A0.5370.96
111_R114_L0.5370.96
137_T144_S0.5360.96
246_F257_V0.5350.96
213_A218_W0.5340.96
50_G54_V0.5330.96
75_V88_L0.5330.96
5_V8_R0.5320.96
88_L170_R0.5310.96
184_L195_V0.5310.96
55_V78_A0.5290.96
137_T140_L0.5280.96
245_L256_R0.5260.96
100_R104_A0.5250.96
203_R206_G0.5240.96
145_R178_E0.5240.96
247_E257_V0.5230.95
121_D128_A0.5230.95
154_V158_H0.5220.95
180_F199_L0.5200.95
235_S239_L0.5180.95
209_I212_K0.5170.95
29_L50_G0.5160.95
170_R175_G0.5150.95
191_P194_V0.5140.95
24_K110_L0.5140.95
143_A146_D0.5140.95
3_G28_H0.5130.95
10_P37_S0.5100.95
157_L164_T0.5090.95
190_V194_V0.5060.95
85_A89_G0.5040.95
198_L210_L0.5040.95
54_V61_N0.5030.94
148_A151_R0.5020.94
255_Q258_L0.5010.94
243_L257_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fhrB 1 0.4809 48.6 0.929 Contact Map
4o8bA 2 0.3321 46.6 0.93 Contact Map
2ictA 2 0.3473 44.5 0.931 Contact Map
1b0nA 2 0.3511 40.7 0.932 Contact Map
2ypfA 1 0.9656 38.7 0.933 Contact Map
4ndwA 2 0.3817 36.4 0.934 Contact Map
3qwgA 2 0.2977 34.1 0.935 Contact Map
4jcyA 2 0.3244 33.6 0.936 Contact Map
1lrvA 1 0.7595 32.9 0.936 Contact Map
1xi4A 8 0.8053 31.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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